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Oral Squamous Cell Carcinoma

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1. Management of the Neck in Squamous Cell Carcinoma of the Oral Cavity and Oropharynx

Management of the Neck in Squamous Cell Carcinoma of the Oral Cavity and Oropharynx Management of the Neck in Squamous Cell Carcinoma of the Oral Cavity and Oropharynx: ASCO Clinical Practice Guideline | Journal of Clinical Oncology Search in: Menu Article Tools ASCO SPECIAL ARTICLE Article Tools OPTIONS & TOOLS COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.18.01921 Journal of Clinical Oncology - published online before print February 27, 2019 PMID: Management (...) of the Neck in Squamous Cell Carcinoma of the Oral Cavity and Oropharynx: ASCO Clinical Practice Guideline , MD 1 x Shlomo A. Koyfman ; , MD 2 x Nofisat Ismaila ; , MS 3 x Doug Crook ; , DNB 4 x Anil D'Cruz ; , MD 5 x Cristina P. Rodriguez ; , MD 6 x David J. Sher ; , MD 7 x Damian Silbermins ; , MD 8 x Erich M. Sturgis ; , MD 9 x Terance T. Tsue ; , MD 10 x Jared Weiss ; , MD, PhD 11 x Sue S. Yom ; and , MD 12 x F. Christopher Holsinger 1 Cleveland Clinic, Cleveland, OH 2 American Society of Clinical

2019 American Society of Clinical Oncology Guidelines

2. The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma

The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma | SpringerLink This service is more advanced with JavaScript available, learn more at Advertisement Hide Search SpringerLink March 2019 , Volume 46, , pp 623–637 | The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma Authors Francesco (...) Giammarile Clare Schilling Gopinanth Gnanasegaran Chandrasckhar Bal Wim J. G. Oyen Domenico Rubello Thomas Schwarz Girolamo Tartaglione Rodolfo Nuñez Miller Diana Paez Fijis W. B. van Leeuwen Renato A. Valdés Olmos Mark McGurk Roberto C. Delgado Bolton Open Access Guidelines First Online: 18 December 2018 2k Downloads Abstract Purpose Sentinel lymph node biopsy is an essential staging tool in patients with clinically localized oral cavity squamous cell carcinoma. The harvesting of a sentinel lymph node

2019 European Association of Nuclear Medicine

3. Recurrent chromosomal and epigenetic alterations in oral squamous cell carcinoma and its putative premalignant condition oral lichen planus. (PubMed)

Recurrent chromosomal and epigenetic alterations in oral squamous cell carcinoma and its putative premalignant condition oral lichen planus. Head and neck squamous cell carcinoma (HNSCC) affects about 700.000 individuals per year worldwide with oral squamous cell carcinoma (OSCC) as a major subcategory. Despite a comprehensive treatment concept including surgery, radiation, and chemotherapy the 5-year survival rate is still only about 50 percent. Chronic inflammation is one of the hallmarks (...) of carcinogenesis. Until now, little is known about the premalignant status of oral lichen planus (OLP) and molecular alterations in OLP are still poorly characterized. Our study aims to delineate differential DNA methylation patterns in OLP, OSCC, and normal oral mucosa. By applying a bead chip approach, we identified altered chromosomal patterns characteristic for OSCC while finding no recurrent alterations in OLP. In contrast, we identified numerous alterations in the DNA methylation pattern in OLP

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2019 PLoS ONE

4. Prevalence of p53 dysregulations in feline oral squamous cell carcinoma and non-neoplastic oral mucosa. (PubMed)

Prevalence of p53 dysregulations in feline oral squamous cell carcinoma and non-neoplastic oral mucosa. Squamous cell carcinoma is the most common malignant oral tumor in cats. The late presentation is one of the factors contributing to the detrimental prognosis of this disease. The immunohistochemical expression of the p53 tumor suppressor protein has been reported in 24% to 65% of feline oral squamous cell carcinomas, but no study has systematically evaluated in this tumor the presence of p53 (...) encoding gene (TP53) mutations. The aim of this retrospective study was to determine whether p53 immunohistochemistry accurately reflects the mutational status of the TP53 gene in feline oral squamous cell carcinoma. Additionally, the prevalence of p53 dysregulation in feline oral squamous cell carcinoma was compared with that of feline non-neoplastic oral mucosa, in order to investigate the relevance of these dysregulations in cancer development. The association between p53 dysregulations and exposure

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2019 PLoS ONE

5. Retinoids induce antagonism between FOXO3A and FOXM1 transcription factors in human oral squamous cell carcinoma (OSCC) cells. (PubMed)

Retinoids induce antagonism between FOXO3A and FOXM1 transcription factors in human oral squamous cell carcinoma (OSCC) cells. To gain a greater understanding of oral squamous cell carcinoma (OSCC) we investigated the actions of all-trans-retinoic acid (RA; a retinoid), bexarotene (a pan-RXR agonist), and forkhead box (FOX) transcription factors in human OSCC-derived cell lines. RA and bexarotene have been shown to limit several oncogenic pathways in many cell types. FOXO proteins typically (...) are associated with tumor suppressive activities, whereas FOXM1 acts as an oncogene when overexpressed in several cancers. RA and/or bexarotene increased the transcript levels of FOXO1, FOXO3A, and TRAIL receptors; reduced the transcript levels of FOXM1, Aurora kinase B (AURKB), and vascular endothelial growth factor A (VEGFA); and decreased the proliferation of OSCC-derived cell lines. Also, RA and/or bexarotene influenced the recruitment of FOXO3A and FOXM1 to target genes. Additionally, FOXM1 depletion

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2019 PLoS ONE

6. PKM2 enhances cancer invasion via ETS-1-dependent induction of matrix metalloproteinase in oral squamous cell carcinoma cells. (PubMed)

PKM2 enhances cancer invasion via ETS-1-dependent induction of matrix metalloproteinase in oral squamous cell carcinoma cells. This study aimed at investigating the molecular mechanism underlying PKM2-mediated cancer invasion.To optimize the investigation of PKM2-specific effects, we used two immortalized oral cell lines. The two cell lines drastically differed in PKM2 expression level, particularly in the level of nuclear PKM2, and subsequently in glucose metabolism (...) and tumorigenicity.Knockdown of PKM2 reduced not only the glucose metabolism but also the invasive activity by curtailing the expressions of matrix metalloproteinases (MMP): PKM2 could modulate MMP-9 expression by regulating ETS-1 inside the nucleus. These results were further confirmed in an oral squamous cell carcinoma (OSCC) cell line. In correspondence with in vitro findings, clinicopathological data from OSCC patients indicated strong association between PKM2 expression and poor survival rate. Additionally, upon

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2019 PLoS ONE

7. Management of the Neck in Squamous Cell Carcinoma of the Oral Cavity and Oropharynx: ASCO Clinical Practice Guideline

Management of the Neck in Squamous Cell Carcinoma of the Oral Cavity and Oropharynx: ASCO Clinical Practice Guideline The aim of the current work is to provide evidence-based recommendations to practicing physicians and others on the management of the neck in patients with squamous cell carcinoma of the oral cavity and oropharynx.ASCO convened an Expert Panel of medical oncology, surgery, radiation oncology, and advocacy experts to conduct a literature search, which included systematic reviews (...) devised; three for oral cavity cancer and three for oropharynx cancer, and recommendations were generated for each one.For oral cavity cancers, clinical scenarios focused on the indications for and the hallmarks of a high-quality neck dissection, indications for postoperative radiotherapy or chemoradiotherapy, and whether radiotherapy alone is sufficient elective treatment of an undissected neck compared with high-quality neck dissection. For oropharynx cancers, clinical scenarios focused on hallmarks

2019 EvidenceUpdates

8. Oral lichen planus and other confounding factors in narrow band imaging (NBI) during routine inspection of oral cavity for early detection of oral squamous cell carcinoma: a retrospective pilot study. (PubMed)

Oral lichen planus and other confounding factors in narrow band imaging (NBI) during routine inspection of oral cavity for early detection of oral squamous cell carcinoma: a retrospective pilot study. Narrow Band Imaging is a noninvasive optical diagnostic tool. It allows the visualization of sub-mucosal vasculature; four patterns of shapes of submucosal capillaries can be recognized, increasingly associated with neoplastic transformation. With such characteristics, it has showed high (...) effectiveness for detection of Oral Squamous Cell Carcinoma. Still, scientific literature highlights several bias/confounding factors, such as Oral Lichen Planus. We performed a retrospective observational study on patients routinely examined with Narrow Band Imaging, investigating for bias, confounding factors and conditions that may limit its applicability.Age, sex, smoking, use of dentures, history of head & neck radiotherapy, history of Oral Squamous Cell Carcinoma, site of the lesion and thickness

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2019 BMC Oral Health

9. Salivary Biomarkers Are An Effective Method Of Detecting Oral Squamous Cell Carcinoma

Salivary Biomarkers Are An Effective Method Of Detecting Oral Squamous Cell Carcinoma UTCAT3024, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Salivary Biomarkers Are An Effective Method Of Detecting Oral Squamous Cell Carcinoma Clinical Question In patients with oral squamous cell carcinoma, are salivary biomarkers an effective method for detecting undiagnosed disease? Clinical Bottom Line In a meta-analysis done (...) by Guerra (2015), five biomarkers (interleukin-8, choline, pipecolinic acid, L-phenylalanine, and s-carboxymethyl-l-cysteine) proved to have greater accuracy, specificity, and sensitivity when used in combination to predict early stages, rather than later stages, of oral squamous cell carcinomas. For patients with undiagnosed oral squamous cell carcinoma, testing of salivary bio-markers is a promising diagnostic tool. However, further research is needed to validate the use of salivary biomarkers

2016 UTHSCSA Dental School CAT Library

10. Detection of Second Primary Malignancies of the Esophagus and Hypophraynx in Oral Squamous Cell Carcinoma Patients (PubMed)

Detection of Second Primary Malignancies of the Esophagus and Hypophraynx in Oral Squamous Cell Carcinoma Patients To assess the usefulness of modified esophagogastroduodenoscopy (EGD) for the detection of second primary malignancies of the esophagus or hypopharynx in patients with oral squamous cell carcinoma and determine the association between the oral lesion subsite and esophageal or hypopharyngeal lesion occurrence.Retrospective review.In total, 166 patients with oral squamous cell (...) carcinoma without any established symptoms of esophageal or hypopharyngeal squamous cell carcinoma underwent modified EGD based on the Valsalva maneuver and U-turn method, image-enhanced endoscopy, and chromoendoscopy using Lugol's iodine for diagnosis. All suspected lesions were biopsied to determine the clinical stages and duplication rates. Odds ratios for the occurrence of duplicate lesions according to the oral lesion subsite were determined.In total, 37 esophageal and 16 hypopharyngeal lesions

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2018 Laryngoscope investigative otolaryngology

11. Correction: Epstein-Barr virus infection and oral squamous cell carcinoma risk: A meta-analysis. (PubMed)

Correction: Epstein-Barr virus infection and oral squamous cell carcinoma risk: A meta-analysis. [This corrects the article DOI: 10.1371/journal.pone.0186860.].

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2019 PLoS ONE

12. Fatty acids distribution and content in oral squamous cell carcinoma tissue and its adjacent microenvironment. (PubMed)

Fatty acids distribution and content in oral squamous cell carcinoma tissue and its adjacent microenvironment. Squamous cell carcinoma of the oral cavity mucosa grows under conditions of poor oxygenation and nutrient scarcity. Reprogramming of lipid biosynthesis accompanies tumor growth, but the conditions under which it occurs are not fully understood. The fatty acid content of the serum, tumor tissue and adjacent tumor microenvironment was measured by gas chromatography in 30 patients (...) with squamous cell carcinoma grade 1-3. Twenty-five fatty acids were identified; their frequencies and percentages in each of the environments were assessed. Nineteen of the twenty-five fatty acids were found in tumor tissue, tumor adjacent tissue and blood serum. Of them, 8 were found in all thirty patients. Percentages of C16:0 and C18:1n9 were highest in the tumor, C18:1n9 and C16:0 were highest in tumor adjacent tissue, and C16:0 and C18:0 were highest in blood serum. The frequencies and amounts of C22

2019 PLoS ONE

13. Sarcomatoid carcinoma after radiotherapy for early-stage oral squamous cell carcinoma: Case report. (PubMed)

Sarcomatoid carcinoma after radiotherapy for early-stage oral squamous cell carcinoma: Case report. Sarcomatoid carcinoma is a rare variant of squamous cell carcinoma (SCC) with poor prognosis. Previous radiation has been reported as one of the etiologic factors.We describe a case of a 57-year-old man presented with a painless mass in the left supraclavicular area. Five years before, he was diagnosed with SCC in floor of mouth (FOM) and underwent radiotherapy (RT).Sonography-guided biopsy (...) on the supraclavicular lymph node revealed diffuse spindle cell proliferation with a focus of squamous differentiation. Local recurrence on primary site or distant metastasis was not obvious on both computed tomography (CT) of the neck and F-fluorodeoxyglucose positron emission tomography CT. The final diagnosis was confirmed as sarcomatoid carcinoma via surgery.The patient underwent surgery including explorative resection of the mouth floor, excision of the submandibular gland, and modified radical neck dissection

2019 Medicine

14. Quality indicators for the management of head and neck squamous cell carcinoma

Hypopharynx 384 29 13.5 2 1 - 56 Larynx 1 227 55 22.0 11 1 - 170 Oral cavity 1 077 54 18.8 5.5 1 - 135 Oropharynx 811 46 17.0 5 1 - 115 Note: Not all cases presented in this table were squamous cell carcinoma. Source: BCR, Rare Cancers in the Flemish Region - 2014 13 a Vlaamse Liga tegen Kanker (...) Quality indicators for the management of head and neck squamous cell carcinoma 2018 www.kce.fgov.be KCE REPORT 305 QUALITY INDICATORS FOR THE MANAGEMENT OF HEAD AND NECK SQUAMOUS CELL CARCINOMA 2018 www.kce.fgov.be KCE REPORT 305 HEALTH SERVICES RESEARCH QUALITY INDICATORS FOR THE MANAGEMENT OF HEAD AND NECK SQUAMOUS CELL CARCINOMA ROOS LEROY, CINDY DE GENDT, SABINE STORDEUR, GEERT SILVERSMIT, LEEN VERLEYE, VIKI SCHILLEMANS, ISABELLE SAVOYE, KATRIJN VANSCHOENBEEK, JOAN VLAYEN, LIESBET VAN

2019 Belgian Health Care Knowledge Centre

15. Effects of arecoline on proliferation of oral squamous cell carcinoma cells by dysregulating c-Myc and miR-22, directly targeting oncostatin M. (PubMed)

Effects of arecoline on proliferation of oral squamous cell carcinoma cells by dysregulating c-Myc and miR-22, directly targeting oncostatin M. Arecoline, the major alkaloid of areca nut, is known to induce oral carcinogenesis, however, its mechanism is still needed to elucidate. This study investigated the effects of arecoline on cell viability and cell-cycle progression of oral squamous cell carcinoma (OSCC) cells as well as a relevant cellular gene expression. The results showed that a low (...) concentration of arecoline (0.025 μg/ml) increased OSCC cell viability, proportion of cells in G2/M phase and cell proliferation. Simultaneously, it induced IL-6, STAT3 and c-Myc expression. Interestingly, c-myc promoter activity was also induced by arecoline. MiR-22 expression in arecoline-treated OSCC cells was suppressed and comparable to an upregulated c-Myc expression. In arecoline-treated OSCC cells, oncostatin M (OSM) expression was significantly upregulated and inversely correlated with miR-22

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2018 PLoS ONE

16. Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysis. (PubMed)

Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysis. Various immune cells have been suggested as prognostic markers for cancer patients. In this article, we present a systematic review and meta-analysis of studies assessing the prognostic value of tissue-infiltrating immune cells in oral cancer and discuss the reporting quality of these studies.We performed a systematic literature search and included studies using (...) immunohistochemistry and survival analysis to assess the prognostic value of tumour-infiltrating T cells, B cells, macrophages, dendritic cells, mast cells and natural killer cells in oral cancer. We performed meta-analysis of studies providing necessary statistical data and investigated the studies' adherence to the REporting recommendations for tumour MARKer prognostic studies (REMARK) guidelines.Of the 1960 articles identified, 33 were eligible for this systematic review and 8 were included in the meta-analysis

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2019 British Journal of Cancer

17. Increased Phosphatidylserine on Blood Cells in Oral Squamous Cell Carcinoma. (PubMed)

Increased Phosphatidylserine on Blood Cells in Oral Squamous Cell Carcinoma. The specific function of phosphatidylserine (PS) in the context of the development of a hypercoagulable state among individuals with oral squamous cell carcinoma (OSCC) is uncertain. The goal of this study was therefore to assess the exposure of PS on microparticles (MPs) as well as on endothelial and blood cells and to assess procoagulant activity (PCA) as a function of the stage of OSCC progression. We recruited (...) patients with OSCC ( n = 63) as well as healthy controls ( n = 26) to participate in this study. PS exposure was then assessed via confocal microscopy and flow cytometry, revealing that patients with stage III/IV OSCC exhibited higher frequencies of PS-exposing blood cells, MPs, and serum-cultured endothelial cells (ECs) than did patients with stage I/II OSCC or healthy controls. When we conducted functional coagulation assays, we discovered that PS+ blood cells, MPs, and serum-cultured ECs from

2019 Journal of Dental Research

18. Regulatory T cells and M2-polarized tumour-associated macrophages are associated with the oncogenesis and progression of oral squamous cell carcinoma. (PubMed)

Regulatory T cells and M2-polarized tumour-associated macrophages are associated with the oncogenesis and progression of oral squamous cell carcinoma. Regulatory T cells (Tregs) and tumour-associated macrophages (TAMs) contribute to the tumour microenvironment by inhibiting anti-tumour immune responses. This study was performed to investigate the roles of Tregs and TAMs in oral squamous cell carcinoma (OSCC) and oral epithelial precursor lesions (OEPL). The expression of Treg markers CD25 (...) , invasive behaviour, and invasive depth. In OEPL, CD25, FoxP3, CD163, and CD204 immunoreactivities were significantly associated with sex, postoperative recurrence, and cancerization to OSCC. This study is novel in showing that the infiltration of Tregs and M2 TAMs is significantly associated with the progression of premalignant lesions to OSCC. This suggests that these cells represent prognostic biomarkers for premalignant lesion progression and that immunotherapeutic approaches to control Treg/M2 TAM

2019 International Journal of Oral and Maxillofacial Surgery

19. Role of induction chemotherapy for locally advanced oral squamous cell carcinoma systematic review and meta-analysis

Role of induction chemotherapy for locally advanced oral squamous cell carcinoma systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated (...) cell dose (linear); blinding of outcome assessment reported (stratified yes vs no). For stratified analyses, a minimum number of 8 studies per subgroup is required. ">Subgroup analyses A sensitivity analysis is conducted to assess the impact of decisions taken in the review process on the meta-analysis outcome. These decisions may have been made in various stages of the review, e.g. the decision to exclude certain disease models, the decision to pool certain units of measurement for an outcome

2019 PROSPERO

20. Prognostic value of tumor microenvironment biomarkers in oral tongue squamous cell carcinoma (OTSCC): a systematic review

Prognostic value of tumor microenvironment biomarkers in oral tongue squamous cell carcinoma (OTSCC): a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any (...) cell dose (linear); blinding of outcome assessment reported (stratified yes vs no). For stratified analyses, a minimum number of 8 studies per subgroup is required. ">Subgroup analyses A sensitivity analysis is conducted to assess the impact of decisions taken in the review process on the meta-analysis outcome. These decisions may have been made in various stages of the review, e.g. the decision to exclude certain disease models, the decision to pool certain units of measurement for an outcome

2019 PROSPERO

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