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Oral Mucositis

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1. Low-level laser therapy for preventing or treating oral mucositis caused by radiotherapy or chemotherapy

Low-level laser therapy for preventing or treating oral mucositis caused by radiotherapy or chemotherapy L Low-le ow-lev vel laser ther el laser therap apy for pre y for prev venting or treating enting or treating or oral mucositis caused b al mucositis caused by r y radiother adiotherap apy or y or chemother chemotherap apy y Interventional procedures guidance Published: 23 May 2018 nice.org.uk/guidance/ipg615 Y Y our responsibility our responsibility This guidance represents the view of NICE (...) possible. 1 1 Recommendations Recommendations 1.1 Current evidence on the safety of low-level laser therapy for oral mucositis shows no major safety concerns. Evidence on efficacy is adequate in quality and © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 1 of 4quantity. Therefore, this procedure can be used provided that standard arrangements are in place for clinical governance, consent and audit. 2 2 The condition

2018 National Institute for Health and Clinical Excellence - Interventional Procedures

2. Oral mucositis

Oral mucositis Oral mucositis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Oral mucositis Last reviewed: February 2019 Last updated: June 2018 Summary An acute inflammation of the oral mucosa following systemic chemotherapy and/or radiation. Diagnosis is typically based on clinical history and physical examination. Clinical presentation varies from erythema to patchy or confluent ulceration (often (...) with a superficial pseudomembranous membrane) or, rarely, overt necrosis. If severe, may warrant an undesirable chemotherapy dose-reduction and/or a break in radiotherapy. Lesions are often very painful. Treatment is symptomatic and includes oral hygiene and pain control. Preventive treatments include palifermin, low-level laser therapy, and use of ice-chips during chemotherapy infusion therapy. Definition Oral mucositis secondary to cancer therapy is an acute inflammation of the oral mucosa in response

2018 BMJ Best Practice

3. Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors. (PubMed)

Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors. Oral mucositis is a side effect of chemotherapy, head and neck radiotherapy, and targeted therapy, affecting over 75% of high-risk patients. Ulceration can lead to severe pain and difficulty with eating and drinking, which may necessitate opioid analgesics, hospitalisation and supplemental nutrition. These complications may disrupt cancer therapy, which may reduce survival (...) . There is also a risk of death from sepsis if pathogens enter the ulcers of immunocompromised patients. Ulcerative oral mucositis can be costly to healthcare systems, yet there are few preventive interventions proven to be beneficial. Cytokines and growth factors may help the regeneration of cells lining of the mouth, thus preventing or reducing oral mucositis and its negative effects.To assess the effects of cytokines and growth factors for preventing oral mucositis in patients with cancer who are receiving

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2017 Cochrane

4. Oral Cryotherapy Reduces the Prevalence of Oral Mucositis in Adults Receiving Chemotherapy

Oral Cryotherapy Reduces the Prevalence of Oral Mucositis in Adults Receiving Chemotherapy UTCAT3029, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Oral Cryotherapy Reduces the Prevalence of Oral Mucositis in Adults Receiving Chemotherapy Clinical Question Does oral cryotherapy reduce the prevalence of oral mucositis in adults receiving chemotherapy? Clinical Bottom Line In adult patients undergoing chemotherapy (...) , oral cryotherapy treatment reduces the presence of oral mucositis. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Riley/2015 1280 patients undergoing cancer treatment in 14 RCTs Systematic review of randomized trials Key results Adults receiving chemotherapy treatment along with oral cryotherapy showed a reduction in oral mucositis of any severity when compared to the control of standard care

2016 UTHSCSA Dental School CAT Library

5. Systemic hematogenous dissemination of mouse oral candidiasis is induced by oral mucositis (PubMed)

Systemic hematogenous dissemination of mouse oral candidiasis is induced by oral mucositis The causes of fungemia include immunosuppression and neutropenia stemming from diverse factors as well as the placement of central venous catheters. However, the relationship between fungemia and the oral cavity has not been substantiated. In this study, we explored the pathological conditions of Candida albicans-derived oral candidiasis in a mouse model, which always develops oral mucositis (...) as a complication. In oral candidiasis, the hyphae of C. albicans are believed to primarily invade the stratum granulosum, but not the subepithelium, of the mucous membrane. We provide histological evidence that in concomitant oral mucositis, the hyphae infiltrate the subepithelium and blood vessels. Blood cultures and tissue samples revealed the onset of fungemia only in the mucositis-induced groups. Positive numbers of colony-forming units were found in groups A (chemotherapy), B (chemotherapy + mucositis

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2018 Odontology

6. Oral mucosal lesions and risk of all-cause and cardiovascular mortality in people treated with long-term haemodialysis: The ORAL-D multinational cohort study. (PubMed)

Oral mucosal lesions and risk of all-cause and cardiovascular mortality in people treated with long-term haemodialysis: The ORAL-D multinational cohort study. Chronic kidney disease is a risk factor for oral diseases, which may be associated with premature death. We evaluated the risk of all-cause and cardiovascular mortality associated with oral mucosal lesions in adults with kidney failure treated with long-term haemodialysis.Oral mucosal lesions (herpes, ulceration, neoformation, white (...) lesion, red lesion, oral candidiasis, geographical tongue, petechial lesions, and fissured tongue) were evaluated within the Oral Diseases in Haemodialysis (ORAL-D) study, a multinational cohort study of 4726 haemodialysis adults. We conducted cox regression analyses adjusted for demographic and clinical variables to evaluate the association with all-cause and cardiovascular mortality.Overall, 4205 adults (mean age 61.6 ± 15.6 years) underwent oral mucosal examination with 40% affected by at least

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2019 PLoS ONE

7. Is ozone effective in the treatment of oral mucositis?

Is ozone effective in the treatment of oral mucositis? Q&A - mucositis cancer ozono - Trip Database NEW! or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example (...) not be considered definitive, be critical. We do not endorse or verify content posted by users. Thanks for your response, Thanks for your question, Responded 3 Sep 2019 · , Information specialist, UK Q re-worded to "Is ozone effective in the treatment of oral mucositis?" (after correspondence with the initial question asker)! We found very little on this topic, certainly nothing to instil confidence in it as an intervention! A 2013 paper “The effect of subgingival ozone and/or hydrogen peroxide

2019 Trip Community Q&A

8. Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy. (PubMed)

Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy. Oral mucositis is a side effect of chemotherapy, head and neck radiotherapy, and targeted therapy, affecting over 75% of high risk patients. Ulceration can lead to severe pain and difficulty eating and drinking, which may necessitate opioid analgesics, hospitalisation and nasogastric or intravenous nutrition. These complications may lead to interruptions or alterations to cancer therapy (...) , which may reduce survival. There is also a risk of death from sepsis if pathogens enter the ulcers of immunocompromised patients. Ulcerative oral mucositis can be costly to healthcare systems, yet there are few preventive interventions proven to be beneficial. Oral cryotherapy is a low-cost, simple intervention which is unlikely to cause side-effects. It has shown promise in clinical trials and warrants an up-to-date Cochrane review to assess and summarise the international evidence.To assess

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2015 Cochrane

9. Benign Oral Mucosal Lesions: Clinical and Pathological Findings Part I- Benign Oral Mucosal lesions. (PubMed)

Benign Oral Mucosal Lesions: Clinical and Pathological Findings Part I- Benign Oral Mucosal lesions. A diverse spectrum of benign oral mucosal lesions exists, presenting as either isolated oral findings or in association with dermatological conditions. Oral lesions can closely resemble one another; therefore, it is important for clinicians to be able to recognize their distinctive features and recognize benign versus malignant disease and when a biopsy is warranted. 1 In this continuing medical (...) education series, we review oral anatomy and the clinical attributes of several benign lesions of the oral cavity along with the appropriate management and therapeutic modalities.Copyright © 2018. Published by Elsevier Inc.

2018 Journal of American Academy of Dermatology

10. Effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients receiving radiotherapy with or without chemotherapy for oral cancer: a multicentre, phase II, randomized controlled trial. (PubMed)

Effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients receiving radiotherapy with or without chemotherapy for oral cancer: a multicentre, phase II, randomized controlled trial. The aim of this phase II, multicentre, randomized controlled trial was to evaluate the effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients with oral cancer receiving radiotherapy alone (...) spacers to cover the entire dentition, pilocarpine hydrochloride, and topical dexamethasone ointment for oral mucositis. The primary endpoint was the incidence of severe oral mucositis. The intervention was significantly associated with a decreased incidence of severe oral mucositis in patients receiving radiotherapy alone (P=0.046), but not in those receiving chemoradiotherapy (P=0.815). These findings suggest that an oral management protocol can prevent severe oral mucositis in patients with oral

2019 International Journal of Oral and Maxillofacial Surgery

11. Is oral glutamine really effective to prevent radiation-induced oral mucositis in adult patients with head and neck cancers? A meta-analysis of randomized controlled trials

Is oral glutamine really effective to prevent radiation-induced oral mucositis in adult patients with head and neck cancers? A meta-analysis of randomized controlled trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

12. Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. (PubMed)

Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. Oral mucositis causes substantial morbidity during head and neck radiotherapy. In a randomized study, doxepin mouthwash was shown to reduce oral mucositis-related pain. A common mouthwash comprising diphenhydramine-lidocaine-antacid is also widely used.To evaluate the effect of doxepin mouthwash or diphenhydramine (...) -lidocaine-antacid mouthwash for the treatment of oral mucositis-related pain.A phase 3 randomized trial was conducted from November 1, 2014, to May 16, 2016, at 30 US institutions and included 275 patients who underwent definitive head and neck radiotherapy, had an oral mucositis pain score of 4 points or greater (scale, 0-10), and were followed up for a maximum of 28 days.Ninety-two patients were randomized to doxepin mouthwash (25 mg/5 mL water); 91 patients to diphenhydramine-lidocaine-antacid

2019 JAMA

13. Randomized double-blind, placebo-controlled trial evaluating oral glutamine on radiation-induced oral mucositis and dermatitis in head and neck cancer patients. (PubMed)

Randomized double-blind, placebo-controlled trial evaluating oral glutamine on radiation-induced oral mucositis and dermatitis in head and neck cancer patients. Glutamine is the primary fuel for the gastrointestinal epithelium and maintains the mucosal structure. Oncologists frequently encounter oral mucositis, which can cause unplanned breaks in radiotherapy (RT).The aim of this study was to explore the association between oral glutamine and acute toxicities in patients with head and neck (...) 7 d before RT to 14 d after RT. The primary and secondary endpoints were radiation-induced oral mucositis and neck dermatitis, respectively. These were documented in agreement with the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.The study included 64 patients (placebo n = 33; glutamine n = 31) who completed RT for the completers' analysis. Based on multivariate analysis, glutamine had no significant effect on the severity of oral mucositis (OR: 0.3; 95% CI

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2019 American Journal of Clinical Nutrition

14. Prevention of Oral Mucositis After Using Chamomile Oral Cryotherapy Versus Oral Cryotherapy in Pediatric Cancer Patients Receiving Chemotherapy.

Prevention of Oral Mucositis After Using Chamomile Oral Cryotherapy Versus Oral Cryotherapy in Pediatric Cancer Patients Receiving Chemotherapy. Prevention of Oral Mucositis After Using Chamomile Oral Cryotherapy Versus Oral Cryotherapy in Pediatric Cancer Patients Receiving Chemotherapy. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Prevention of Oral Mucositis After Using Chamomile Oral Cryotherapy Versus Oral Cryotherapy in Pediatric Cancer Patients Receiving Chemotherapy. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your

2018 Clinical Trials

15. Instruments to measure the quality of life in patients with oral mucositis undergoing oncological treatment: a systematic review of the literature.

Instruments to measure the quality of life in patients with oral mucositis undergoing oncological treatment: a systematic review of the literature. Oral mucositis (OM) is an inflammatory reaction of the oropharyngeal mucosa to cumulative chemotherapy (CT) and radiation therapy (RT), affecting one or more parts of the digestive tract along with the quality of life (QoL) of the patient. The goal of this study was to identify valid and reliable tools to evaluate QoL related to OM.A systematic (...) multiple variables. The knowledge of this relationship is limited because general instruments of oral health or cancer therapy are commonly used for evaluation. However, valid instruments are already available for estimating the impact of OM on the QoL from the patient's perspective.Copyright © 2016 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

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2018 Boletin medico del Hospital Infantil de Mexico

16. Efficacy of palifermin on oral mucositis and acute GVHD after hematopoietic stem cell transplantation (HSCT) in hematology malignancy patients: a meta-analysis of trials. (PubMed)

Efficacy of palifermin on oral mucositis and acute GVHD after hematopoietic stem cell transplantation (HSCT) in hematology malignancy patients: a meta-analysis of trials. Herein, this meta-analysis study evaluated the efficacy of palifermin after HSCT on the incidence and severity of OM or aGVHD in hematologic malignancy patients in randomized clinical trials (RCTs).To compare the efficacy of palifermin on adverse events, OM and aGVHD compared with placebo, we searched databases of PubMed (...) = 0.11], but erythema as an adverse effect in palifermin group was higher than placebo group (OR = 1.86, 95% CI: 1.10-3.15, p = 0.02].This meta-analysis of six clinical trials found no statistically significant difference in OM and aGVHD grades in patients receiving 60 μg/kg/day dose of palifermin compared with those receiving a placebo. However, oral mucosal erythema was more prevalent among patients receiving palifermin than patients receiving a placebo.

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2018 Contemporary oncology (Poznan, Poland)

17. Oral cryotherapy reduces oral mucositis in patients receiving 5FU-based treatment for solid cancers

Oral cryotherapy reduces oral mucositis in patients receiving 5FU-based treatment for solid cancers Oral cryotherapy reduces oral mucositis Search National Elf Service Search National Elf Service » » » » Oral cryotherapy reduces oral mucositis in patients receiving 5FU-based treatment for solid cancers Jan 11 2016 Posted by Around 75% of patients receiving chemotherapy, radiotherapy of the head and neck, or targeted therapy suffer from oral mucositis. Ulceration is of varying severity but can (...) lead to difficulties with eating, swallowing, and talking leading to increase need for pain relief and nutritional support. It also has a negative effect on quality of life. The aim of this Cochrane review was to assess the effects of oral cryotherapy for preventing oral mucositis in patients with cancer who are receiving treatment. Methods Searches were conducted in the Cochrane Oral Health Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase

2016 The Dental Elf

18. Topical application of honey in the management of chemo/radiotherapy-induced oral mucositis: A systematic review and network meta-analysis

Topical application of honey in the management of chemo/radiotherapy-induced oral mucositis: A systematic review and network meta-analysis Mucositis is an inflammatory response of mucosal epithelial cells to the cytotoxic effects of chemotherapy and radiation therapy. To assess the comparative efficacy of honey for patients with cancer undergoing chemo/radiotherapy-induced oral mucositis through a systematic review and network meta-analysis.A network meta-analysis was used to identify evidence (...) from relevant randomized controlled trials (RCTs). We searched PubMed, Embase, and the Cochrane Library for publications up to November 2017. The prespecified primary efficacy outcome was the treatment effect of moderate-severe oral mucositis with honey. We performed subgroup analyses and meta-regressions according to the age group, cancer type, mucositis cause, honey type, control arm and type of assessment scale. Moreover, secondary efficacy outcomes were treatment completed, onset time

2018 EvidenceUpdates

19. Oral mucositis in cancer patients: no benefit from chlorhexidine mouthwash

Oral mucositis in cancer patients: no benefit from chlorhexidine mouthwash Oral mucositis in cancer patients: no benefit from chlorhexidine mouthwash - National Elf Service Search National Elf Service Search National Elf Service » » » » Oral mucositis in cancer patients: no benefit from chlorhexidine mouthwash Mar 15 2017 Posted by Chlorhexidine (CHX) is a topical antiseptic with bactericidal, fungicidal, and virucidal activities. In 2014 the advised against the use of CHX mouthwash for oral (...) . Methods Searches were conducted in the Medline, Cochrane Library and Web of Science databases. Randomised controlled trials (RCTs) on the efficacy of CHX compared to placebo group for treating oral mucositis in cancer patients treated with chemotherapy, radiotherapy, or both, and at least one oral mucositis outcome reported by trial authors (severity of mucositis and/or incidence of mucositis) were considered. 3 reviewers independently selected studies abstracted data and assessed study quality using

2017 The Dental Elf

20. Lactobacillus brevis CD2 lozenges prevent oral mucositis in patients undergoing high dose chemotherapy followed by haematopoietic stem cell transplantation (PubMed)

Lactobacillus brevis CD2 lozenges prevent oral mucositis in patients undergoing high dose chemotherapy followed by haematopoietic stem cell transplantation Oral mucositis is a common inflammatory complication in patients undergoing high-dose chemotherapy and radiation followed by haematopoietic stem cell transplantation (HSCT). Lactobacillus brevis CD2 has been proven efficacious in preventing chemoradiotherapy-induced oral mucositis in squamous cell carcinoma of head and neck.This phase II (...) study aimed to evaluate the safety and efficacy of L. brevis CD2 lozenges in preventing oral mucositis in patients undergoing HSCT. Eligible patients received four to six lozenges of L. brevis CD2 per day, beginning from 4 to 7 days before initiation of chemotherapy and continuing until resolution of mucositis or till day +24.Of 31 patients enrolled, 7 (22.6%) patients did not develop any mucositis, 6 (19.4%) patients developed grade 1, 12 (38.7%) patients developed grade 2, 4 (12.9%) and 2 (6.5

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2017 ESMO open

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