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Oral Mucositis

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1. Palliative care - oral: Scenario: Mouth ulcers and mucositis

Palliative care - oral: Scenario: Mouth ulcers and mucositis Scenario: Mouth ulcers and mucositis | Management | Palliative care - oral | CKS | NICE Search CKS… Menu Scenario: Mouth ulcers and mucositis Palliative care - oral: Scenario: Mouth ulcers and mucositis Last revised in October 2018 Scenario: Mouth ulcers and mucositis From age 16 years onwards. Aphthous ulcers Correct any underlying iron, folate, or vitamin B 12 deficiency if the prognosis allows. Treatment choices should be guided (...) . The dose is 100 mg in 10 mL four times a day and rinsed around the mouth for 2–3 minutes and then spat out [ ]. Chlorhexidine mouthwash: some evidence indicates that it reduces the duration and severity of aphthous ulcers [ ]. It can stain the plaque on teeth brown. Mucositis of the mouth before, during, and after treatment with chemotherapy or radiotherapy reduces the severity of mucositis and helps prevent secondary infection. Seek urgent specialist advice if mucositis is severe as it may limit

2019 NICE Clinical Knowledge Summaries

2. Low-level laser therapy for preventing or treating oral mucositis caused by radiotherapy or chemotherapy

intra-oral treatment the probe, which is about the size of a dental curing light, is introduced into the mouth. For extra-oral treatment the probe is positioned close to the cheek. The procedure typically takes 20 to 30 minutes, and is delivered 2 to 5 times a week for the duration of the oncology treatment. The procedure may be started before treatment with chemotherapy or radiotherapy begins, with the intention of preventing OM. Low-level laser therapy for preventing or treating oral mucositis (...) Low-level laser therapy for preventing or treating oral mucositis caused by radiotherapy or chemotherapy L Low-le ow-lev vel laser ther el laser therap apy for pre y for prev venting or treating enting or treating or oral mucositis caused b al mucositis caused by r y radiother adiotherap apy or y or chemother chemotherap apy y Interventional procedures guidance Published: 23 May 2018 nice.org.uk/guidance/ipg615 Y Y our responsibility our responsibility This guidance represents the view of NICE

2018 National Institute for Health and Clinical Excellence - Interventional Procedures

3. Oral mucositis

Oral mucositis Oral mucositis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Oral mucositis Last reviewed: February 2019 Last updated: June 2018 Summary An acute inflammation of the oral mucosa following systemic chemotherapy and/or radiation. Diagnosis is typically based on clinical history and physical examination. Clinical presentation varies from erythema to patchy or confluent ulceration (often (...) with a superficial pseudomembranous membrane) or, rarely, overt necrosis. If severe, may warrant an undesirable chemotherapy dose-reduction and/or a break in radiotherapy. Lesions are often very painful. Treatment is symptomatic and includes oral hygiene and pain control. Preventive treatments include palifermin, low-level laser therapy, and use of ice-chips during chemotherapy infusion therapy. Definition Oral mucositis secondary to cancer therapy is an acute inflammation of the oral mucosa in response

2018 BMJ Best Practice

4. The optimal oral biopsy site in the diagnosis of oral mucosal autoimmune bullous disorders: a systematic review and meta-analysis Full Text available with Trip Pro

The optimal oral biopsy site in the diagnosis of oral mucosal autoimmune bullous disorders: a systematic review and meta-analysis Inplasy Protocol 622 - INPLASY.COM International Platform of Registered Systematic Review and Meta-analysis Protocols Main Menu Share this: Copyright © 2021 INPLASY.COM Powered by INPLASY.COM

2020 INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols

5. Is ozone effective in the treatment of oral mucositis?

Is ozone effective in the treatment of oral mucositis? Q&A - mucositis cancer ozono - Trip Database NEW! or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example (...) not be considered definitive, be critical. We do not endorse or verify content posted by users. Thanks for your response, Thanks for your question, Responded 3 Sep 2019 · , Information specialist, UK Q re-worded to "Is ozone effective in the treatment of oral mucositis?" (after correspondence with the initial question asker)! We found very little on this topic, certainly nothing to instil confidence in it as an intervention! A 2013 paper “The effect of subgingival ozone and/or hydrogen peroxide

2019 Trip Community Q&A

6. Oral mucosal lesions and risk of all-cause and cardiovascular mortality in people treated with long-term haemodialysis: The ORAL-D multinational cohort study. Full Text available with Trip Pro

Oral mucosal lesions and risk of all-cause and cardiovascular mortality in people treated with long-term haemodialysis: The ORAL-D multinational cohort study. Chronic kidney disease is a risk factor for oral diseases, which may be associated with premature death. We evaluated the risk of all-cause and cardiovascular mortality associated with oral mucosal lesions in adults with kidney failure treated with long-term haemodialysis.Oral mucosal lesions (herpes, ulceration, neoformation, white (...) lesion, red lesion, oral candidiasis, geographical tongue, petechial lesions, and fissured tongue) were evaluated within the Oral Diseases in Haemodialysis (ORAL-D) study, a multinational cohort study of 4726 haemodialysis adults. We conducted cox regression analyses adjusted for demographic and clinical variables to evaluate the association with all-cause and cardiovascular mortality.Overall, 4205 adults (mean age 61.6 ± 15.6 years) underwent oral mucosal examination with 40% affected by at least

2019 PLoS ONE

7. Systemic hematogenous dissemination of mouse oral candidiasis is induced by oral mucositis Full Text available with Trip Pro

Systemic hematogenous dissemination of mouse oral candidiasis is induced by oral mucositis The causes of fungemia include immunosuppression and neutropenia stemming from diverse factors as well as the placement of central venous catheters. However, the relationship between fungemia and the oral cavity has not been substantiated. In this study, we explored the pathological conditions of Candida albicans-derived oral candidiasis in a mouse model, which always develops oral mucositis (...) as a complication. In oral candidiasis, the hyphae of C. albicans are believed to primarily invade the stratum granulosum, but not the subepithelium, of the mucous membrane. We provide histological evidence that in concomitant oral mucositis, the hyphae infiltrate the subepithelium and blood vessels. Blood cultures and tissue samples revealed the onset of fungemia only in the mucositis-induced groups. Positive numbers of colony-forming units were found in groups A (chemotherapy), B (chemotherapy + mucositis

2018 Odontology

8. Oral Cryotherapy Reduces the Prevalence of Oral Mucositis in Adults Receiving Chemotherapy

or no treatment (RR 0.61, 95% CI 0.52 to 0.72). When considering only the patients with moderate to severe oral mucositis, similar reduction of the condition occurred (RR 0.52, 95% CI 0.41 to 0.65). The patients with severe oral mucositis also showed reduction (RR 0.40, 95% CI 0.27 to 0.61). Patients with any level of severity of oral mucositis showed reduction of the symptoms with oral cryotherapy treatment. Evidence Search ("mouth"[MeSH Terms] OR "mouth"[All Fields] OR "oral"[All Fields]) AND ("cryotherapy (...) Oral Cryotherapy Reduces the Prevalence of Oral Mucositis in Adults Receiving Chemotherapy UTCAT3029, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Oral Cryotherapy Reduces the Prevalence of Oral Mucositis in Adults Receiving Chemotherapy Clinical Question Does oral cryotherapy reduce the prevalence of oral mucositis in adults receiving chemotherapy? Clinical Bottom Line In adult patients undergoing chemotherapy

2016 UTHSCSA Dental School CAT Library

9. Oral microbiome and onset of oral mucositis in patients with squamous cell carcinoma of the head and neck. (Abstract)

Oral microbiome and onset of oral mucositis in patients with squamous cell carcinoma of the head and neck. Oral mucositis (OM) is a debilitating sequela for patients treated for squamous cell carcinoma of the head and neck (HNSCC). This study investigated whether oral microbial features before treatment or during treatment are associated with the time to onset of severe OM in patients with HNSCC.This was a cohort study of newly diagnosed patients with locoregional HNSCC who received (...) chemotherapy with or without radiotherapy from April 2016 to September 2017. OM was based on the National Cancer Institute's Common Terminology Criteria for Adverse Events, version 4.0. The oral microbiome was characterized on the basis of the 16S ribosomal RNA V4 region with the Illumina platform. A mixture cure model was used to generate hazard ratios for the onset of severe OM.Eighty-six percent of the patients developed OM (n = 57 [33 nonsevere cases and 24 severe cases]) with a median time to onset

2020 Cancer

10. Oral Glutamine May Have No Clinical Benefits to Prevent Radiation-Induced Oral Mucositis in Adult Patients With Head and Neck Cancer: A Meta-Analysis of Randomized Controlled Trials Full Text available with Trip Pro

Oral Glutamine May Have No Clinical Benefits to Prevent Radiation-Induced Oral Mucositis in Adult Patients With Head and Neck Cancer: A Meta-Analysis of Randomized Controlled Trials Frontiers | Oral Glutamine May Have No Clinical Benefits to Prevent Radiation-Induced Oral Mucositis in Adult Patients With Head and Neck Cancer: A Meta-Analysis of Randomized Controlled Trials | Nutrition Toggle navigation Section University of Cagliari, Italy Reviewed by University of Sidi-Bel-Abbès, Algeria (...) Radiation-Induced Oral Mucositis in Adult Patients With Head and Neck Cancer: A Meta-Analysis of Randomized Controlled Trials Ting Shuai 1 † , 2 * † , Ling-Li Xu 2 † , Wei-Qing Chen 2 † , Yuan-Ping Pi 2 † , Lin Zhang 3 , Qiao-Qin Wan 4 and Xiu-E Li 3 * 1 Second Dental Center, Peking University School and Hospital of Stomatology, Beijing, China 2 Department of Gastroenterology, Chongqing University Cancer Hospital, Chongqing, China 3 Department of Nursing, Peking University School and Hospital

2020 Frontiers in nutrition

11. A case report of oral nicotine-associated keratosis and a review of oral mucosal changes in tobacco and similar products. (Abstract)

A case report of oral nicotine-associated keratosis and a review of oral mucosal changes in tobacco and similar products. There is a strong association between tobacco use and the development of oral mucosal lesions, often with malignant potential. Nicotine is the primary component of tobacco responsible for addiction. The use of nicotine replacement therapy (NRT) aims to replace nicotine from cigarettes, allowing smoother transition to complete smoking cessation and greatly reducing risks (...) of tobacco-related disease. The role of nicotine as a potential carcinogen is unknown. Use of NRT is associated with development of oral disorders, although it is rarely published. We detail the development of oral hyperkeratotic lesions directly associated with chronic overuse of nicotine replacement products. We also consider the current state of knowledge regarding development of oral lesions associated with other similar products. It is important for dental practitioners to be aware of oral effects

2020 British Dental Journal

12. [The Effects of Oral Cryotherapy on Oral Mucositis, Reactive Oxygen Series, Inflammatory Cytokines, and Oral Comfort in Gynecologic Cancer Patients Undergoing Chemotherapy: A Randomized Controlled Trial]. Full Text available with Trip Pro

[The Effects of Oral Cryotherapy on Oral Mucositis, Reactive Oxygen Series, Inflammatory Cytokines, and Oral Comfort in Gynecologic Cancer Patients Undergoing Chemotherapy: A Randomized Controlled Trial]. The purpose of this study was to examine the effects of oral cryotherapy on oral mucositis, reactive oxygen series, inflammatory cytokines, and oral comfort in patients undergoing chemotherapy for gynecologic cancers.Participants were randomly assigned to the experimental group (n=25 (...) , receiving oral cryotherapy during chemotherapy) and the control group (n=25, receiving the usual care consisting of 0.9% normal saline gargles three times before meals). Oral mucositis was assessed using the oral assessment guide, while oral comfort was assessed using the oral perception guide. Reactive oxygen series was measured as total oxidant stress, and the level of two inflammatory markers, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), were examined. The data were analyzed using t

2019 Journal of Korean Academy of Nursing Controlled trial quality: uncertain

13. Effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients receiving radiotherapy with or without chemotherapy for oral cancer: a multicentre, phase II, randomized controlled trial. (Abstract)

Effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients receiving radiotherapy with or without chemotherapy for oral cancer: a multicentre, phase II, randomized controlled trial. The aim of this phase II, multicentre, randomized controlled trial was to evaluate the effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients with oral cancer receiving radiotherapy alone (...) spacers to cover the entire dentition, pilocarpine hydrochloride, and topical dexamethasone ointment for oral mucositis. The primary endpoint was the incidence of severe oral mucositis. The intervention was significantly associated with a decreased incidence of severe oral mucositis in patients receiving radiotherapy alone (P=0.046), but not in those receiving chemoradiotherapy (P=0.815). These findings suggest that an oral management protocol can prevent severe oral mucositis in patients with oral

2019 International Journal of Oral and Maxillofacial Surgery Controlled trial quality: uncertain

14. Benign Oral Mucosal Lesions: Clinical and Pathological Findings Part I- Benign Oral Mucosal lesions. (Abstract)

Benign Oral Mucosal Lesions: Clinical and Pathological Findings Part I- Benign Oral Mucosal lesions. A diverse spectrum of benign oral mucosal lesions exists, presenting as either isolated oral findings or in association with dermatological conditions. Oral lesions can closely resemble one another; therefore, it is important for clinicians to be able to recognize their distinctive features and recognize benign versus malignant disease and when a biopsy is warranted. 1 In this continuing medical (...) education series, we review oral anatomy and the clinical attributes of several benign lesions of the oral cavity along with the appropriate management and therapeutic modalities.Copyright © 2018. Published by Elsevier Inc.

2018 Journal of American Academy of Dermatology

15. Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. Oral mucositis causes substantial morbidity during head and neck radiotherapy. In a randomized study, doxepin mouthwash was shown to reduce oral mucositis-related pain. A common mouthwash comprising diphenhydramine-lidocaine-antacid is also widely used.To evaluate the effect of doxepin mouthwash or diphenhydramine (...) -lidocaine-antacid mouthwash for the treatment of oral mucositis-related pain.A phase 3 randomized trial was conducted from November 1, 2014, to May 16, 2016, at 30 US institutions and included 275 patients who underwent definitive head and neck radiotherapy, had an oral mucositis pain score of 4 points or greater (scale, 0-10), and were followed up for a maximum of 28 days.Ninety-two patients were randomized to doxepin mouthwash (25 mg/5 mL water); 91 patients to diphenhydramine-lidocaine-antacid

2019 JAMA Controlled trial quality: predicted high

16. A Randomized Controlled Trial to Evaluate the Role and Efficacy of Oral Glutamine in the Treatment of Chemo-radiotherapy-induced Oral Mucositis and Dysphagia in Patients with Oropharynx and Larynx Carcinoma. Full Text available with Trip Pro

A Randomized Controlled Trial to Evaluate the Role and Efficacy of Oral Glutamine in the Treatment of Chemo-radiotherapy-induced Oral Mucositis and Dysphagia in Patients with Oropharynx and Larynx Carcinoma. To determine the role and efficacy of oral glutamine in the treatment of chemo-radiotherapy-induced oral mucositis and dysphagia in patients with carcinoma of the oropharynx and larynx. The primary objective of this study was to compare the incidence and severity of oral mucositis (...) and dysphagia between the glutamine group (oral glutamine, along with concurrent chemo-radiotherapy) and the control group (concurrent chemo-radiotherapy alone, no glutamine). Secondary objectives were to compare the time to onset of oral mucositis and dysphagia, the incidence of treatment breaks (more than three consecutive radiation fractions missed), and significant weight loss (more than 3 kilograms of weight loss from the baseline) between the two groups.A total of 60 patients with locally advanced

2019 Cureus Controlled trial quality: uncertain

17. Oral cryotherapy for oral mucositis management in patients receiving allogeneic hematopoietic stem cell transplantation: a prospective randomized study. (Abstract)

Oral cryotherapy for oral mucositis management in patients receiving allogeneic hematopoietic stem cell transplantation: a prospective randomized study. To explore the best schedule of oral cryotherapy for the prevention of oral mucositis in recipients of myeloablative hematopoietic stem cell transplantation (HSCT).A prospective randomized study was conducted to recruit allogeneic HSCT recipients, who were then randomly allocated into four arms to accept the following: oral cryotherapy during (...) the whole course (arm A) or second half of the course (arm B) of cytotoxic agents administration, regular oral cryotherapy twice a day (arm C), or conventional oral care without cryotherapy (arm D). Status of oral mucositis was daily assessed from the first day of conditioning to the 15th day post-HSCT. A myeloablative conditioning regimen was used which was composed of busulfan, cyclophosphamide, and cytarabine.Totally 160 cases were consecutively enrolled in this study, and 145 cases were eligible

2019 Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer Controlled trial quality: uncertain

18. Randomized double-blind, placebo-controlled trial evaluating oral glutamine on radiation-induced oral mucositis and dermatitis in head and neck cancer patients. Full Text available with Trip Pro

Randomized double-blind, placebo-controlled trial evaluating oral glutamine on radiation-induced oral mucositis and dermatitis in head and neck cancer patients. Glutamine is the primary fuel for the gastrointestinal epithelium and maintains the mucosal structure. Oncologists frequently encounter oral mucositis, which can cause unplanned breaks in radiotherapy (RT).The aim of this study was to explore the association between oral glutamine and acute toxicities in patients with head and neck (...) 7 d before RT to 14 d after RT. The primary and secondary endpoints were radiation-induced oral mucositis and neck dermatitis, respectively. These were documented in agreement with the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.The study included 64 patients (placebo n = 33; glutamine n = 31) who completed RT for the completers' analysis. Based on multivariate analysis, glutamine had no significant effect on the severity of oral mucositis (OR: 0.3; 95% CI

2019 American Journal of Clinical Nutrition Controlled trial quality: predicted high

19. Efficacy of oral and topical antioxidants in the prevention and treatment of oral mucositis in head and neck cancer patients.

Efficacy of oral and topical antioxidants in the prevention and treatment of oral mucositis in head and neck cancer patients. Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2021 PROSPERO

20. Guideline for the Prevention of Oral and Oro-pharyngeal Mucositis in Children Receiving Treatment for Cancer or Undergoing Hematopoietic Stem Cell Transplantation

-randomized Pediatric trials – all HSCT - Allogeneic – 3 - Autologous – 1 Recommendation 1.3: We suggest that KGF may be offered to children receiving HSCT conditioning with regimens associated with a high rate of severe mucositis. Weak Recommendation, High Quality Evidence Remarks: • High value – evidence efficacy adult trials • Weak recommendation – indirectness, particularly potential for harm in pediatric cancers and costs Oral Cryotherapy • Placing ice cubes or ice chips in the mouth and continually (...) Guideline for the Prevention of Oral and Oro-pharyngeal Mucositis in Children Receiving Treatment for Cancer or Undergoing Hematopoietic Stem Cell Transplantation Guideline for the Prevention of Oral and Oro-pharyngeal Mucositis in Children Receiving Treatment for Cancer or Undergoing Hematopoietic Stem Cell Transplantation Paul Gibson, MD Pediatric Oncologist Children’s Hospital, London Health Sciences Centre On Behalf of: The POGO Mucositis Prevention Panel Preaching to the Choir Oral

2015 SickKids Supportive Care Guidelines

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