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Oral Lichen Planus

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1. Recurrent chromosomal and epigenetic alterations in oral squamous cell carcinoma and its putative premalignant condition oral lichen planus. Full Text available with Trip Pro

Recurrent chromosomal and epigenetic alterations in oral squamous cell carcinoma and its putative premalignant condition oral lichen planus. Head and neck squamous cell carcinoma (HNSCC) affects about 700.000 individuals per year worldwide with oral squamous cell carcinoma (OSCC) as a major subcategory. Despite a comprehensive treatment concept including surgery, radiation, and chemotherapy the 5-year survival rate is still only about 50 percent. Chronic inflammation is one of the hallmarks (...) of carcinogenesis. Until now, little is known about the premalignant status of oral lichen planus (OLP) and molecular alterations in OLP are still poorly characterized. Our study aims to delineate differential DNA methylation patterns in OLP, OSCC, and normal oral mucosa. By applying a bead chip approach, we identified altered chromosomal patterns characteristic for OSCC while finding no recurrent alterations in OLP. In contrast, we identified numerous alterations in the DNA methylation pattern in OLP

2019 PLoS ONE

2. Platelet-Rich Plasma (PRP) Rinses for the Treatment of Non-Responding Oral Lichen Planus: A Case Report Full Text available with Trip Pro

Platelet-Rich Plasma (PRP) Rinses for the Treatment of Non-Responding Oral Lichen Planus: A Case Report Platelet-rich plasma (PRP) has been proposed for different applications in the medical field and in maxillofacial surgery thanks to its many growth factors, such as epidermal growth factor (EGF), fibroblast growth factor (FGF), and keratinocyte growth factor (KGF). Oral lichen planus (OLP) is a disease that affects the oral mucosa in a chronic way. This disease frequently worsens the quality (...) of life of patients, particularly when clinical manifestations are of the erythematous or erosive/ulcerative type. The properties of PRP that are supported by scientific literature in both oral medicine and other medical fields have suggested the introduction of PRP in clinical practice for the medical treatment of different soft tissues diseases, such as when OLP patients do not respond to conventional therapies, or when conventional treatments have some contraindications or side effects. The aim

2018 Biomedicines

3. Oral lichen planus and other confounding factors in narrow band imaging (NBI) during routine inspection of oral cavity for early detection of oral squamous cell carcinoma: a retrospective pilot study. Full Text available with Trip Pro

Oral lichen planus and other confounding factors in narrow band imaging (NBI) during routine inspection of oral cavity for early detection of oral squamous cell carcinoma: a retrospective pilot study. Narrow Band Imaging is a noninvasive optical diagnostic tool. It allows the visualization of sub-mucosal vasculature; four patterns of shapes of submucosal capillaries can be recognized, increasingly associated with neoplastic transformation. With such characteristics, it has showed high (...) effectiveness for detection of Oral Squamous Cell Carcinoma. Still, scientific literature highlights several bias/confounding factors, such as Oral Lichen Planus. We performed a retrospective observational study on patients routinely examined with Narrow Band Imaging, investigating for bias, confounding factors and conditions that may limit its applicability.Age, sex, smoking, use of dentures, history of head & neck radiotherapy, history of Oral Squamous Cell Carcinoma, site of the lesion and thickness

2019 BMC Oral Health

4. Lichen planus

or ulceration of mucous membranes, nail deformity, scarring alopecia, and other types of skin lesions may also occur. Most patients develop the disease between the age of 30 and 60 years. Hepatitis C infection may increase susceptibility, especially to oral disease. Treatment may involve corticosteroids, retinoids, calcineurin inhibitors, immunosuppressants, and phototherapy. Definition Lichen planus (LP) is a pruritic, chronic inflammatory dermatosis resulting from keratinocyte apoptosis that affects (...) Lichen planus Lichen planus - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Lichen planus Last reviewed: February 2019 Last updated: December 2017 Summary An idiopathic inflammatory disease affecting the skin, hair, nails, and mucous membranes, usually self-limiting in nature. Characteristic eruption consists of itchy, shiny, flat-topped violaceous papules and plaques favouring the extremities. White net-like patches

2017 BMJ Best Practice

5. Effects of oral healthcare motivation in patients with gingival oral lichen planus: A randomized controlled trial. (Abstract)

Effects of oral healthcare motivation in patients with gingival oral lichen planus: A randomized controlled trial. The role of dental plaque in gingival lesions caused by oral lichen planus has not been fully defined. The aim of this clinical trial was to evaluate the effects of oral healthcare motivation on clinical variables in patients with gingival oral lichen planus.Oral lichen planus patients with symptomatic gingival lesions were randomized in control and intervention groups (...) and Escudier index in the intervention group compared to controls (p < 0.05). Pain did not prove significantly different (p = 0.408).Plaque control improved both OHIP-14 and gingival lesion clinical severity. Oral hygienists should be involved in the multidisciplinary management of patients affected by oral lichen planus with gingival lesions.© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.

2019 Oral diseases Controlled trial quality: uncertain

6. Oral lichen planus and oral lichenoid lesions - an analysis of clinical and histopathological features. (Abstract)

Oral lichen planus and oral lichenoid lesions - an analysis of clinical and histopathological features. In the oral mucosa, a precise classification of inflammatory lesions with a histopathological lichenoid inflammation represents a diagnostic challenge. Oral lichen planus (OLP) and oral lichenoid lesions (OLL) share several clinical and histopathological characteristics, therefore it is often difficult to distinguish between them. However, considering that the pathophysiologic mechanisms

2019 Journal of the European Academy of Dermatology and Venereology

7. Lichen Planus

be very painful and ulceration may lead to scarring. Appendageal lichen planus can lead to scarring, while alopecia and nail loss are often permanent. Cancer: Squamous cell carcinoma may arise from mucosal lesions (mouth, vulva, penile) and hypertrophic LP lesions (distal extremities). A 1% incidence of SCC has been reported among patients with oral lichen planus. 3 Proposed reasons for the increased risk include the following: • The oral mucosa affected by oral lichen planus may be more sensitive (...) @auth.gr Mobile: +306948109109 2 Table of Contents 1. Introduction 4 2. Methods 4 3. Definition 5 4. Epidemiology 6 5. Pathophysiology-etiopathogenesis 6 6. Clinical Picture 7 7. Diagnosis 9 8. Clinical Variants of Lichen Planus 11 Cutaneous LP 12 Appendegeal LP 13 Mucosal LP 14 Other Forms of LP 15 9. Complications 17 10. Therapeutic Management-Objectives 18 11. Management of cutaneous LP 18 12. Management of mucosal-oral LP-General measures 21 13. Management of oral LP 22 14. Management of genital LP

2018 European Dermatology Forum

8. Management of Reticular Oral Lichen Planus patients with Burning Mouth Syndrome-like oral symptoms: a pilot study. (Abstract)

Management of Reticular Oral Lichen Planus patients with Burning Mouth Syndrome-like oral symptoms: a pilot study. We sought to determine the efficacy of psychotropic drug in the management of BMS-like oral symptoms in patients with reticular oral lichen planus (R-OLP) refractory to conventional therapies, and its impact on anxious and depressive symptoms.We enrolled 28 cases of symptomatic R-OLP. The Numeric Rating Scale (NRS), the Total Pain Rating Index (T-PRI), the Hamilton rating scales (...) an improvement from time 0 [(median: 15.0 (IQR: 10.2-17.8) and 13.0 (IQR: 12.0-15.0), respectively] to time 2 [median: 6.0 (IQR: 4.0-7.0) (p < .001) and 5.5 (IQR: 4.25-6.0) (p < .001), respectively].Psychotropic drugs turned out to be effective in the management of BMS-like oral symptoms in R-OLP patients refractory to conventional immunosuppressive therapy, although in a long-term period.

2018 Journal of Dermatological Treatment

9. Prevalence of Oral Lichen Planus in Diabetes Mellitus: a Meta-Analysis Study. Full Text available with Trip Pro

Prevalence of Oral Lichen Planus in Diabetes Mellitus: a Meta-Analysis Study. Oral lichen planus (OLP) is associated with various other systemic conditions such as hypertension, diabetes mellitus (DM). This study evaluated the prevalence of OLP in DM patients compared with non-diabetic control subjects in a meta-analysis study.In this study from January 1973 to August 2016, we searched the studies in Web of Science, Medline/PubMed, Scopus, Science direct, SID (Scientific Information Database (...) ), Cochrane and Embase databases. Strategy search was the Medical Subject Heading (MeSH) term oral lichen planus or oral mucosa combined with diabetes in PubMed and this search in other databases. Heterogeneity between estimates was evaluated by the Q and I2 statistic. Also, publication bias was assessed through funnel plot analysis with the Kendall's and Egger's tests.From 831 studies were identified with different search strategies, 11 studies met the criteria to be included in meta-analysis (11 case

2017 Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH

10. The oral microbiome in oral lichen planus during a 1-year randomized clinical trial. Full Text available with Trip Pro

The oral microbiome in oral lichen planus during a 1-year randomized clinical trial. Several recent studies have investigated the oral bacteriome in oral lichen planus (OLP), but longitudinal changes in microbiome have not been investigated.To study the bacteriome and mycobiome in OLP over a 1-year period and the impact of topical treatment.Samples from 22 symptomatic OLP patients from a double-blinded, randomized intervention study were collected over a 1-year course at five visits. Bacterial (...) was seen in the antimycotic group, whereas the mycobiome was stable. Malassezia restricta was the most abundant fungus.The microbial composition of MW and CB differs in OLP. CB composition is less influenced by conventional and probiotic intervention. Initial antimycotic treatment influenced the bacteriome during the 1-year period. How the oral microbiome in health and disease is influenced by individual variability of fungi and bacteria, and Malassezia needs further investigation.© 2018 John Wiley

2018 Oral diseases Controlled trial quality: uncertain

11. Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions.

Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions. Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03509675 Recruitment Status : Not yet recruiting First Posted : April 26

2018 Clinical Trials

12. Differential metallothionein expression in oral lichen planus and amalgam-associated oral lichenoid lesions Full Text available with Trip Pro

Differential metallothionein expression in oral lichen planus and amalgam-associated oral lichenoid lesions Oral lichen planus (OLP) is a chronic inflammatory disease mediated by T cells, which manifests as reticular (white) or erosive (red) lesions, that are eventually painful. Oral lichenoid lesion (OLL) are distinguished from OLP by the presence of precipitating factors. The aim of this study was to evaluate whether the presence of metallothionein, which is involved in anti-apoptotic

2018 Medicina oral, patología oral y cirugía bucal

13. Role of Mast Cells in Oral Lichen Planus and Oral Lichenoid Reactions Full Text available with Trip Pro

Role of Mast Cells in Oral Lichen Planus and Oral Lichenoid Reactions Oral lichen planus (OLP) is a chronic T cell mediated disease of oral mucosa, skin, and its appendages with a prevalence of 0.5 to 2.6% worldwide. Oral lichenoid reactions (OLR) are a group of lesions with diverse aetiologies but have clinical and histological features similar to OLP, thereby posing a great challenge in differentiating both lesions. Mast cells are multifunctional immune cells that play a major role (...) in the pathogenesis of lichen planus by release of certain chemical mediators. Increased mast cell densities with significant percentage of degranulation have been observed as a consistent finding in pathogenesis of oral lichen planus.The current study was aimed at quantifying the mast cells in histopathological sections of OLP and OLR thereby aiding a means of distinguishing these lesions.The study group involved 21 cases of oral lichen planus, 21 cases of oral lichenoid reactions, and 10 control specimens

2018 Autoimmune diseases

14. LPS-induced Vitamin D Receptor Decrease in Oral Keratinocytes Is Associated With Oral Lichen Planus Full Text available with Trip Pro

LPS-induced Vitamin D Receptor Decrease in Oral Keratinocytes Is Associated With Oral Lichen Planus The suppressive function of vitamin D on oral lichen planus (OLP) have been documented previously. Vitamin D receptor (VDR) expression is down-regulated in OLP, but the molecular mechanism of its decrease and the related anti-inflammatory contributor of epithelial VDR signaling is unclear. Herein, we demonstrated that lipopolysaccharide (LPS) remarkedly down-regulated VDR expression (...) of keratinocytes, and the reduced regulation was dependent on tumor necrosis factor alpha (TNFα)-miR-346 pathway. In human specimen studies, VDR levels of oral mucosal epithelia from OLP patients decreased substantially accompanied with robust TNFα and miR-346 induction, compared to the normal tissues. In addition, vitamin D/VDR signaling inhibited LPS-induced p53-upregulated modulator of apoptosis (PUMA) induction in keratinocytes via impeding nuclear factor-κB (NF-κB) activation, resulting in keratinocytes

2018 Scientific reports

15. Immunoexpression of cytokeratin-19 in the oral lichen planus and related oral squamous cell carcinoma Full Text available with Trip Pro

Immunoexpression of cytokeratin-19 in the oral lichen planus and related oral squamous cell carcinoma Cytokeratin 19 (CK-19) is an epithelium-specific intermediate filament protein that has been investigated in oral lichen planus (OLP) lesions but has not been compared with the expression of CK-19 in the OLP-related oral squamous cell carcinoma (OSCC). The aim of the present study has been to objectively compare the immunohistochemical expression of the CK-19 in OLP lesions and subsequent OSCC

2018 Annali di stomatologia

16. Efficacy of 1064 Q switched Nd:YAG laser in the treatment of oral lichen planus. (Abstract)

Efficacy of 1064 Q switched Nd:YAG laser in the treatment of oral lichen planus. Background: The erosive-atrophic form of oral lichen planus (OLP) is usually presented with severe pain and burning sensation that is usually refractory to traditional treatment. Topical corticosteroid is considered the first line despite their adverse effects. Therefore, new therapeutic approaches are required. Aim: This study aimed to examine the effectiveness of Nd:YAG laser in the treatment of long-standing

2019 Journal of Dermatological Treatment

17. Oral lichen planus and thyroid gland diseases: possible associations. Full Text available with Trip Pro

Oral lichen planus and thyroid gland diseases: possible associations. Lichen planus (LP) is a chronic inflammatory mucocutaneous disease that commonly affects the oral cavity. Previous reports have suggested a possible association between LP and thyroid gland diseases (TGDs). The purpose of this study was to investigate possible associations between oral lichen planus (OLP) and TGDs.Patients diagnosed with OLP, both clinically and histopathologically (N = 102), were classified according

2019 BMC Oral Health

18. Comparison of the effect of photodynamic therapy and topical corticosteroid on oral lichen planus lesions. (Abstract)

Comparison of the effect of photodynamic therapy and topical corticosteroid on oral lichen planus lesions. In this study, the effect of photodynamic therapy with topical corticosteroid in oral lichen planus patients was compared.In this randomized, double-blind clinical trial, eight patients with bilateral oral OLP lesions were recruited. Toluidine blue was applied on the lesions of both sides; a 660-nm diode laser InGaAlP was irradiated for 10 min (power: 25 mW, fluence: 19.23 J/cm2 , probe (...) cross section: 0.78 cm2 ) for three sessions. In the control side of the oral mucosa, only sham laser was used. Follow-up sessions were held on weeks 3 and 7. In week 3, oral paste triamcinolone acetonide 0.1% was prescribed. Response rates were assessed clinically by VAS, Thongprasom sign scoring, clinical severity index, efficacy indices, and the amount of reduction in the size of the lesions. The Mann-Whitney test was used to evaluate the treatment outcomes.In spite of the control side, all

2019 Oral diseases Controlled trial quality: uncertain

19. Genotyping of the C&gt;T allele of rs16906252, predictor of O16-methylguanine-DNA methyltransferase (MGMT) promoter methylation status, in erosive atrophic lesions of oral lichen planus. (Abstract)

Genotyping of the C>T allele of rs16906252, predictor of O16-methylguanine-DNA methyltransferase (MGMT) promoter methylation status, in erosive atrophic lesions of oral lichen planus. DNA promoter methylation is usually an early stage in carcinogenesis process, including oral cancer. The purpose of this study was to investigate the association between T allele of specific single nucleotide polymorphism (SNP) C>T rs 16906252 and O16-methylguanine-DNA methyltransferase (MGMT) methylation (...) as prospective biomarkers of malignant transformation in oral lichen planus (OLP), a chronic autoimmune mucocutaneous disease.This research is an observational, analytical case-control study where a total of 85 subjects (43 control individuals and 42 OLP patients) participated. The samples (mouthwashes) from all volunteers were analyzed, and DNA extraction was carried out. The genotyping of the rs 16906252 SNP in the MGMT gene was performed by polymerase chain reaction-restriction fragment length

2019 International Journal of Dermatology

20. Topical pimecrolimus versus betamethasone for oral lichen planus: a randomized clinical trial. (Abstract)

Topical pimecrolimus versus betamethasone for oral lichen planus: a randomized clinical trial. Oral lichen plans (OLP) is a potentially malignant inflammatory mucocutaneous disease. CD133 is an investigated surface marker for cancer stem-like cells (CSCs) that may be involved in tumor initiation in head and neck carcinomas. We compared short-term clinical effectiveness of topical pimecrolimus as selective inflammatory cytokine release inhibitor with betamethasone cream for erosive/atrophic OLP

2019 Clinical oral investigations Controlled trial quality: uncertain

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