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Oral Lesion

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1. Oral mucosal lesions and risk of all-cause and cardiovascular mortality in people treated with long-term haemodialysis: The ORAL-D multinational cohort study. (PubMed)

Oral mucosal lesions and risk of all-cause and cardiovascular mortality in people treated with long-term haemodialysis: The ORAL-D multinational cohort study. Chronic kidney disease is a risk factor for oral diseases, which may be associated with premature death. We evaluated the risk of all-cause and cardiovascular mortality associated with oral mucosal lesions in adults with kidney failure treated with long-term haemodialysis.Oral mucosal lesions (herpes, ulceration, neoformation, white (...) lesion, red lesion, oral candidiasis, geographical tongue, petechial lesions, and fissured tongue) were evaluated within the Oral Diseases in Haemodialysis (ORAL-D) study, a multinational cohort study of 4726 haemodialysis adults. We conducted cox regression analyses adjusted for demographic and clinical variables to evaluate the association with all-cause and cardiovascular mortality.Overall, 4205 adults (mean age 61.6 ± 15.6 years) underwent oral mucosal examination with 40% affected by at least

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2019 PLoS ONE

2. Increased Prevalence of Oral HPV in Saliva of Women with HPV-Positive Cervical Lesions

Increased Prevalence of Oral HPV in Saliva of Women with HPV-Positive Cervical Lesions UTCAT3211, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Increased Prevalence of Oral HPV in Saliva of Women with HPV-Positive Cervical Lesions Clinical Question In women with cervical cancer as compared to healthy women, are salivary biomarkers an effective method of detecting significant undiagnosed oral human papilloma virus (...) infection? Clinical Bottom Line In women with HPV-positive cervical lesions, the prevalence of oral HPV in the saliva samples is greater than in saliva samples from women with no HPV cervical lesions. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Visalli/2016 100 women with cervical HPV lesions and 25 healthy women (controls) Case control study Key results “The prevalence of oral HPV infection in saliva

2017 UTHSCSA Dental School CAT Library

3. Benign Oral Mucosal Lesions: Clinical and Pathological Findings Part I- Benign Oral Mucosal lesions. (PubMed)

Benign Oral Mucosal Lesions: Clinical and Pathological Findings Part I- Benign Oral Mucosal lesions. A diverse spectrum of benign oral mucosal lesions exists, presenting as either isolated oral findings or in association with dermatological conditions. Oral lesions can closely resemble one another; therefore, it is important for clinicians to be able to recognize their distinctive features and recognize benign versus malignant disease and when a biopsy is warranted. 1 In this continuing medical (...) education series, we review oral anatomy and the clinical attributes of several benign lesions of the oral cavity along with the appropriate management and therapeutic modalities.Copyright © 2018. Published by Elsevier Inc.

2018 Journal of American Academy of Dermatology

4. The use of biological agents in the treatment of oral lesions due to pemphigus, mucous membrane pemphigoid (MMP), oral lichen planus (OLP), recurrent aphthous ulcers and Beh‡et's disease: a systematic review

The use of biological agents in the treatment of oral lesions due to pemphigus, mucous membrane pemphigoid (MMP), oral lichen planus (OLP), recurrent aphthous ulcers and Beh‡et's disease: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears

2019 PROSPERO

5. Malignant transformation of oral lichen planus/oral lichenoid lesions: a systematic review and meta-analysis protocol

Malignant transformation of oral lichen planus/oral lichenoid lesions: a systematic review and meta-analysis protocol Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated

2019 PROSPERO

6. Comparison of Er:YAG and Er,Cr:YSGG Laser in the Treatment of Oral Leukoplakia Lesions Refractory to the Local Retinoid Therapy. (PubMed)

Comparison of Er:YAG and Er,Cr:YSGG Laser in the Treatment of Oral Leukoplakia Lesions Refractory to the Local Retinoid Therapy. Objective: The aim of this study was to compare the efficacy of Er:YAG and Er,Cr:YSGG laser in the treatment of oral leukoplakia refractory to conventional retinoid therapy. Materials and methods: The study sample consisted of 54 patients (16 men and 38 women) who were histopathologically diagnosed with oral leukoplakia that was refractory to conventional retinoid (...) therapy. Patients were randomly allocated into two groups according to the type of the laser used for treatment of oral leukoplakia: Group 1. Er:YAG laser; Group 2. Er,Cr:YSGG laser. Patients were recalled at 6 months and 1 year after treatment to evaluate possible recurrence and assess the patients' postoperative quality of life. Results: After initial ablation, the degree of residual lesion was significantly greater in the Er:YAG laser group (74.1%), compared with the Er,Cr:YSGG group (18.5%) (p

2019 Publication 4890922 Controlled trial quality: uncertain

7. Increase in detection of oral cancer and precursor lesions by dentists: Evidence from an oral and maxillofacial pathology service. (PubMed)

Increase in detection of oral cancer and precursor lesions by dentists: Evidence from an oral and maxillofacial pathology service. Dentists play an important role in the detection and diagnosis of oral diseases, including oral cancer and its precursor lesions. There are few comprehensive reviews in the recent literature that examine the scope and trends of oral disease diagnoses by dentists.The authors analyzed all accessions to the Toronto Oral Pathology Service at the Faculty of Dentistry (...) increase in mucosal carcinomas over the study period. The rate of increase of OED and OSCC was significantly higher than the rate of increase of total oral carcinomas diagnosed in the region, the population changes, and the number of dentists in the region.Within the limitations of a study of a single large oral pathology biopsy service, the analysis of diagnoses shows that dentists are increasingly involved in the detection of oral mucosal carcinoma and precursor lesions. The dental community plays

2019 Journal of the American Dental Association

8. Oral lichen planus and oral lichenoid lesions - an analysis of clinical and histopathological features. (PubMed)

Oral lichen planus and oral lichenoid lesions - an analysis of clinical and histopathological features. In the oral mucosa, a precise classification of inflammatory lesions with a histopathological lichenoid inflammation represents a diagnostic challenge. Oral lichen planus (OLP) and oral lichenoid lesions (OLL) share several clinical and histopathological characteristics, therefore it is often difficult to distinguish between them. However, considering that the pathophysiologic mechanisms

2019 Journal of the European Academy of Dermatology and Venereology

9. Human papillomavirus in premalignant oral lesions: No evidence of association in a Spanish cohort. (PubMed)

Human papillomavirus in premalignant oral lesions: No evidence of association in a Spanish cohort. Human papillomavirus (HPV) is the cause of a fraction of head and neck squamous cell carcinoma. Although this relation is well-known, it is still not clear the role of HPV in premalignant oral lesions such as oral lichen planus (OLP) and dysplasia. We aimed to evaluate the HPV-DNA prevalence and type distribution in a set of oral biopsies obtained from patients diagnosed with OLP and dysplasia (...) , as well as the role of HPV in these lesions.A retrospective cohort of all premalignant oral lesions consecutively diagnosed from March 30th 1995 to May 21st 2014 at Hospital of Bellvitge and Odontological University Hospital of Bellvitge was identified and classified in four groups: OLP (groups 1 and 2) and dysplasias (groups 3 and 4) that progressed or not to invasive cancer during follow-up. A random selection targeting 25 cases was aimed to be performed for each group. All selected cases were

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2019 PLoS ONE

10. Betel nut chewing, oral premalignant lesions, and the oral microbiome. (PubMed)

Betel nut chewing, oral premalignant lesions, and the oral microbiome. Oral cancers are attributed to a number of causal agents including tobacco, alcohol, human papillomavirus (HPV), and areca (betel) nut. Although betel nut chewing has been established as an independent cause of oral cancer, the mechanisms of carcinogenesis are poorly understood. An investigation was undertaken to evaluate the influence of betel nut chewing on the oral microbiome and oral premalignant lesions. Study (...) participants were recruited from a dental clinic in Guam. Structured interviews and oral examinations were performed. Oral swabbing and saliva samples were evaluated by 454 pyrosequencing of the V3- V5 region of the 16S rRNA bacterial gene and genotyped for HPV. One hundred twenty-two adults were enrolled including 64 current betel nut chewers, 37 former chewers, and 21 with no history of betel nut use. Oral premalignant lesions, including leukoplakia and submucous fibrosis, were observed in 10 chewers

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2017 PLoS ONE

11. Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions. (PubMed)

Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions. Oral squamous cell carcinoma is the most common form of malignancy of the lip and oral cavity, often being proceeded by potentially malignant disorders (PMD). Early detection can reduce the malignant transformation of PMD and can improve the survival rate for oral cancer. The current standard of scalpel biopsy with histology is painful for patients and involves a delay (...) whilst histology is completed; other tests are available that are unobtrusive and provide immediate results.To estimate the diagnostic accuracy of index tests for the detection of oral cancer and PMD of the lip and oral cavity, in people presenting with clinically evident lesions.To estimate the relative accuracy of the different index tests.The electronic databases were searched on 30 April 2013. We searched MEDLINE (OVID) (1946 to April 2013) and four other electronic databases (the Cochrane

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2015 Cochrane

12. Oral symptoms and salivary findings in oral lichen planus, oral lichenoid lesions and stomatitis. (PubMed)

Oral symptoms and salivary findings in oral lichen planus, oral lichenoid lesions and stomatitis. To examine if patients with oral lichen planus, oral lichenoid lesions and generalised stomatitis and concomitant contact allergy have more frequent and severe xerostomia, lower unstimulated and chewing-stimulated saliva and citric-acid-stimulated parotid saliva flow rates, and higher salivary concentration of total protein and sIgA than cases without contact allergy and healthy controls.Forty-nine (...) patients (42 women, aged 61.0 ± 10.3 years) and 29 healthy age- and gender-matched subjects underwent a standardised questionnaire on general and oral health, assessment of xerostomia, clinical examination, sialometry, mucosal biopsy and contact allergy testing.Nineteen patients had oral lichen planus, 19 patients had oral lichenoid lesions and 11 patients had generalised stomatitis. 38.8% had contact allergy. Xerostomia was significantly more common and severe in patients (46.9%) than in healthy

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2017 BMC Oral Health

13. The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw

The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning (...) You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider

2018 Clinical Trials

14. Differential metallothionein expression in oral lichen planus and amalgam-associated oral lichenoid lesions (PubMed)

Differential metallothionein expression in oral lichen planus and amalgam-associated oral lichenoid lesions Oral lichen planus (OLP) is a chronic inflammatory disease mediated by T cells, which manifests as reticular (white) or erosive (red) lesions, that are eventually painful. Oral lichenoid lesion (OLL) are distinguished from OLP by the presence of precipitating factors. The aim of this study was to evaluate whether the presence of metallothionein, which is involved in anti-apoptotic

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2018 Medicina oral, patología oral y cirugía bucal

15. Immunohistochemically Detection of Angiogenesis in Oral Pre-Cancerous Lesions Compared with Oral Invasive Carcinomas (PubMed)

Immunohistochemically Detection of Angiogenesis in Oral Pre-Cancerous Lesions Compared with Oral Invasive Carcinomas Background: Angiogenic activity is an important event in oral carcinogenesis. During transition of normal oral mucosa to different grades of dysplasia and to invasive carcinoma, significant increase of vascularity occurs. Angiogenesis can be determined by immunohistochemical assessment of several endothelial cell markers like Endogelin (CD 105), expressed in activated endothelial (...) cells and associated with neovasculature, and the vascular endothelial growth factor (VEGF). This study was conducted to evaluate angiogenic activity in oral precancerous lesions compared with oral invasive carcinomas by immunohistochemical staining of VEGF and CD 105 proteins. Methods: In the present cross-sectional study, 20 normal, 20 pre-cancerous mucosa and 20 oral invasive carcinoma samples were immunohistochemically stained. Positive cells were counted in each section and micro vessel density

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2018 Asian Pacific journal of cancer prevention : APJCP

16. Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions.

Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions. Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03509675 Recruitment Status : Not yet recruiting First Posted : April 26

2018 Clinical Trials

17. The use of tools to support oral lesion description in oral medicine referrals. (PubMed)

The use of tools to support oral lesion description in oral medicine referrals. The use of response prompts improves the quality of referral letters.

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2018 British Dental Journal

18. Knowledge of Oral Precancerous Lesions Considering Years Since Graduation Among Dentists in the Capital City of Iran: a Pathway to Early Oral Cancer Diagnosis and Referral? (PubMed)

Knowledge of Oral Precancerous Lesions Considering Years Since Graduation Among Dentists in the Capital City of Iran: a Pathway to Early Oral Cancer Diagnosis and Referral? Background: Late diagnosis and improper treatment lead to many avoidable deaths in patients suffering from oral cancer. This study evaluated the knowledge and perceptions of general dentists regarding oral precancerous lesions and oral cancer risk factors with reference to early diagnosis and referral. Materials and Methods (...) : In this descriptive study, 200 private general dental practitioners were randomly selected in Tehran, Iran. Demographic information and years since graduation were recorded; knowledge levels were evaluated with a standardized questionnaire consisting of 15 closed-response item questions about precancerous lesions and oral cavity cancer. Each correct answer got one point. Results: Out of 200 selected dentists, 153 returned completed questionnaires. The average age of participants was 36 and the average achieved

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2018 Asian Pacific journal of cancer prevention : APJCP Controlled trial quality: uncertain

19. The role of DNA image cytometry in screening high risk oral potentially malignant lesions using brushing: a systematic review

The role of DNA image cytometry in screening high risk oral potentially malignant lesions using brushing: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

20. Genomic analysis of oral precancerous verrucous lesions: a systematic review

Genomic analysis of oral precancerous verrucous lesions: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO

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