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OralAllergySyndrome in Birch Pollen-Sensitized Patients from a Korean University Hospital Oralallergysyndrome (OAS) is a type of allergic reaction that mainly occurs on oral contact with raw fruit, vegetables, or nuts. The most common type of OAS is birch pollen-related food allergy. Although OAS is a common food allergy in adults, only few epidemiologic studies have been reported in Korea. Here we investigate the prevalence and triggers of birch pollen-related food allergy.We conducted (...) a retrospective chart review of 1,427 patients who underwent a skin prick test for inhalant allergens at the Asthma and Allergy Clinic in Seoul National University Bundang Hospital from January 2011 to December 2016.Of 1,427 patients, 125 (8.7%) were sensitized to birch pollen. Among them, 20.0% developed OAS, which was the most common food allergy (96.2%). The prevalence of OAS was higher in females, and was 18.2% in birch pollen-sensitized allergic rhinoconjunctivitis patients. Further, 72.0% OAS patients
Shellfish/crustacean oralallergysyndrome among national service pre-enlistees in Singapore All Singaporean males undergo medical screening prior to compulsory military service. A history of possible food allergy may require referral to a specialist Allergy clinic to ensure that special dietary needs can be taken into account during field training and deployment.To study the pattern of food allergy among pre-enlistees who were referred to a specialist allergy clinic to work up suspected food (...) %). The most commonly reported foods were shellfish/crustaceans (78%), peanut (15.6%), and egg (6.5%). Self-limiting oralallergysyndrome, OAS (itchy lips and throat with/without lip angioedema) was the most common manifestation (n = 33, 42.9%) followed by anaphylaxis (n = 23, 29.9%). Majority of OAS was from shellfish/crustacean (90.6%); of which shrimp (30.3%), crab (15.2%), and lobster (3.0%) were the most common. Mild childhood asthma (69.7%), allergic rhinitis (6.3%), and eczema (6.1%) were the most
Oralallergysyndrome. To review oralallergysyndrome (OAS).We searched several medical literature data bases with the following key words: "oralallergysyndrome," "OAS," "pollen-food allergysyndrome," "PFAS," "allergy," "diagnosis," "treatment."Oralallergysyndrome (OAS), also called "pollen-food allergysyndrome," is a type of food allergy brought about by flavors, nuts, raw fruit, and vegetables. The most well-known symptoms are mouth and throat itching, which starts rapidly after a food (...) is placed in the mouth, and that, as a rule, continues for just a couple of minutes after the food has been swallowed. The frequency of OAS with pollen allergy has been reported as 5-8%; 1-2% of patients with OAS with pollen allergy show extreme responses, e.g., anaphylaxis. Birch tree pollen, ragweed pollen, and grass pollen hypersensitivity cause the symptoms. The diagnosis of OAS is confirmed by a positive history and positive skin-prick test result triggered by the food's fresh extract. Oral
Galectin-1 inhibits oral-intestinal allergysyndrome The pathogenesis of oral-intestinal allergysyndrome (OIAS) has not been well understood. Published data indicate that galectin (Gal) 1 has immune regulatory functions. This study tests a hypothesis that Gal1 inhibits oral-intestinal allergy syndrome.Mice were sensitized to peanut extracts (PE) via the buccal mucosa with or without using Gal1 together.Upon re-exposure to specific antigen, the OIAS mice showed the systemic allergic response (...) , the oral allergic reactions, and intestinal allergic inflammation, including increases in serum histamine, drop of the core temperature, higher levels of PE-specific IgE and interleukin (IL)-4. Increases in mast cell and eosinophil in the oral mucosa and intestinal mucosa were also observed. The OIAS was inhibited by co-administration with Gal1 via a mechanism of suppressing micro RNA (miR)-98 and reversing the expression of IL-10 in CD14+ cells in the intestine.The OIAS can be induced by applying
Birch allergy and oralallergysyndrome: The practical relevance of serum immunoglobulin E to Bet v 1. Birch allergy (BA) may frequently be associated with fruit-vegetables oralallergysyndrome (OAS). Bet v 1 is the major birch allergen. Previously, it was reported that serum-specific immunoglobulin E (IgE) level could differentiate allergy from sensitization. Thus, this study aimed to investigate the practical role of Bet v 1 IgE.A total of 245 subjects (128 women, 117 men; mean age, 41 years
Allergy to apple cultivars among patients with birch pollinosis and oralallergysyndrome. Oralallergysyndrome (OAS) is caused by cross-reacting allergens found in pollen, raw fruits, vegetables, and some tree nuts. The major apple allergen, Mal d 1, is a cause of food allergic reactions in birch pollen sensitized patients.To explore the allergenicity of the most popular and commonly consumed apple cultivars in Poland in patients with birch pollen allergy with or without OAS.Data were (...) obtained from 46 adults with clinical symptoms of birch allergy and allergic rhinitis or rhinoconjunctivitis. Patients were divided into 2 groups according to the occurrence of OAS to apple. Skin prick tests (SPTs) were performed with pulp from the 11 most popular apple cultivars in Poland. Specific IgE (sIgE) to Bet v 1 was measured by radioallergosorbent test.Patients with OAS had more positive responses to apple SPT vs patients without OAS (odds ratios, 4.8-11.96). Patients with OAS had distinctive
Pollen food allergysyndrome (PFAS): A review of current available literature. Pollen food allergysyndrome (PFAS) is a complex syndrome posing a diagnostic and therapeutic challenge. Our objective was to summarize the available literature regarding its prevalence, pathogenesis, diagnosis, and treatment.A PubMed search was performed to include English language articles with the following search terms: pollen food syndrome, pollen food allergysyndrome, PFAS, oralallergysyndrome, OAS, food (...) the reaction. As multiple families of proteins with varying stability cause PFAS, severe systemic reactions are also possible, as anaphylactic shock has been documented in up to 1.7% of reactions.Pollen food allergysyndrome therefore cannot be dismissed as a benign food allergy, but it needs to be approached individually based on known risk factors.Published by Elsevier Inc.
Oral and Sublingual Immunotherapy for Treatment of IgE-Mediated Food Allergy. Development of active therapies for IgE-mediated food allergy is a critical action step toward alleviating the adverse medical, psychosocial, and economic burdens on affected patients and families. Significant progress has been observed specifically in the application of single-allergen oral and sublingual immunotherapy for treatment of IgE-mediated food allergy, with emphasis on milk, egg, and peanut as the primary (...) (SLIT) has been utilized for the treatment of food allergy and pollen-food allergysyndrome, demonstrating moderate efficacy, a favorable safety profile and variable tolerability, with oropharyngeal symptoms most commonly observed. Although studies directly comparing OIT and SLIT are limited, in general, the favorable safety profile associated with SLIT comes at the expense of reduced efficacy, while the more robust clinical effects observed with OIT come at the risk of potentially intolerable
. 2002 Aug 31;360(9334):701-10. http://www.ncbi.nlm.nih.gov/pubmed/12241890?tool=bestpractice.com IgE-mediated food disorders include anaphylaxis and oralallergysyndrome. Cell-mediated reactions involve T cells, and may occur several hours to days after ingesting the offending food. Sicherer SH. Food allergy. Lancet. 2002 Aug 31;360(9334):701-10. http://www.ncbi.nlm.nih.gov/pubmed/12241890?tool=bestpractice.com Food protein-induced enterocolitis, enteropathy, proctocolitis, and coeliac disease (...) been confirmed as a trigger of bronchospasm in sulphite-sensitive asthmatic patients. Simon RA. Update on sulfite sensitivity. Allergy. 1998;53(46 Suppl):78-9. http://www.ncbi.nlm.nih.gov/pubmed/9826006?tool=bestpractice.com Differentials Oralallergysyndrome Atopic dermatitis Food protein-induced proctocolitis Coeliac disease Lactose intolerance Food-induced anaphylaxis Food-dependent exercise-induced anaphylaxis Eosinophilic oesophagitis Food protein-induced enterocolitis Congenital sucrase
provided by (Responsible Party): Eleonora Nucera, Catholic University of the Sacred Heart Study Details Study Description Go to Brief Summary: This study evaluates the effects of Nickel oral hyposensitization treatment (NiOHT) on health-related quality of life (HRQoL) of patients suffered from Systemic Nickel AllergySyndrome (SNAS). Condition or disease Intervention/treatment Systemic Nickel AllergySyndrome Quality of Life Biological: Nickel oral hyposensitization treatment Detailed Description (...) rhinitis, we hypothesized similar positive results even after oral Ni desensitization. Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 40 participants Observational Model: Cohort Time Perspective: Prospective Official Title: Quality of Life Assessment Before and After Hyposensitization Treatment in Systemic Nickel AllergySyndrome Actual Study Start Date : March 2015 Estimated Primary Completion Date : April 30, 2019 Estimated Study Completion
2012 and December 2016. All patients were investigated according to the European Network for Drug Allergy (ENDA) recommendations through skin testing (major and minor penicillin determinants, penicillin, amoxicillin, cefazolin, cefuroxime and ceftriaxone) and oral challenges tests.We included 7 patients (median age 40 years) with perioperative anaphylactic reactions immediately after cefazolin injection, 4 with hypotension and 1 with Kounis syndrome (KS) type I. The presence of a selective IgE (...) Perioperative Anaphylaxis Including Kounis Syndrome due to Selective Cefazolin Allergy. Perioperative use of cefazolin has been associated with severe allergic reactions, and patients are usually labelled as allergic to penicillin afterwards. The aim of our study was to describe a group of patients with immediate reactions to cefazolin, with proven selective hypersensitivity reactions.Systematic review of all patients followed at our drug centre with cefazolin-related reactions, between January
, premenstrual syndrome, fatigue or depression are due to “hidden allergies”, a claim for which there is no evidence. Instead of relating allergy to IgE, or an inflammatory response mediated by the immune system, disease is attributed to either (a) a disturbance of vital life force or energy (“Qi”, yin-yang), or (b) are secondary to noxious external triggers such as environmental toxins and chemicals, food allergens / additives, or chronic infection with organisms like Candida albicans. It is stated (...) assisted analysis of the patient’s voice. There is no scientific rationale for this technique, and no evidence that results are useful for diagnosing any disorder, including allergies. Other techniques Other techniques such as pulse testing, stool or hair analysis or oral provocation/neutralisation have no scientific basis and no proven role in the diagnosis or management of any medical condition. Unorthodox therapies are unproven Claims of “breakthrough treatments” continue to appear at regular
Characterization of oral immune cells in birch pollen-allergic patients: impact of the OralAllergySyndrome and sublingual allergen immunotherapy on antigen presenting cells. A detailed characterization of human oral immune cells is needed to better understand local mechanisms associated with allergen capture following oral exposure.Oral immune cells were characterized by immunohistology and immunofluorescence in biopsies obtained from three healthy individuals and 23 birch pollen-allergic (...) patients with/without oralallergysyndrome (OAS), at baseline and after 5 months of sublingual allergen immunotherapy (AIT).Similar cell subsets (i.e., dendritic cells, mast cells, and T lymphocytes) were detected in oral tissues from healthy and birch pollen-allergic individuals. CD207+ Langerhans cells (LCs) and CD11c+ myeloid dendritic cells (DCs) were found in both the epithelium and the papillary layer of the Lamina propria (LP), whereas CD68+ macrophages, CD117+ mast cells, and CD4+ /CD8+ T
Safety and Efficacy Study of Oral Fosfomycin Versus Oral Levofloxacin to Treat Complicated Urinary Syndromes (FOCUS) Safety and Efficacy Study of Oral Fosfomycin Versus Oral Levofloxacin to Treat Complicated Urinary Syndromes (FOCUS) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Safety and Efficacy Study of Oral Fosfomycin Versus Oral Levofloxacin to Treat Complicated Urinary Syndromes (FOCUS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details
Anaphylactic shock with methylprednisolone sodium succinate in a child with short bowel syndrome and cowâ€™s milk allergy Medications with methyl-prednisolone sodium succinate containing lactose, which potentially contains traces of cow's milk proteins (CMP), could cause allergic reactions or compromise treatment of acute allergic reactions in sensitized patients.We describe the unusual case of a one-year-old child affected by short bowel syndrome and history of severe cow's milk allergy (CMA (...) and symptom resolution occurred.Children who are highly sensitive to milk may have severe allergic reactions also after exposure to CMP through a different administration route than the oral one. Patients who have food allergies need to pay particular attention to the prescription of drugs and their formulation.
CRACKCast E119 – Allergy, Hypersensitivity, Angioedema, and Anaphylaxis CRACKCast E119 – Allergy, Hypersensitivity, Angioedema, and Anaphylaxis - CanadiEM CRACKCast E119 – Allergy, Hypersensitivity, Angioedema, and Anaphylaxis In , by Chris Lipp October 19, 2017 This episode of CRACKCast covers Rosen’s Chapter 119 (109 in 9th), Allergy, Hypersensitivity, Angioedema, and Anaphylaxis. Patients suffering from acute allergic reactions, anaphylaxis, and angioedema are amongst the most unstable (...) patients presenting to the ED. With proper management, however, these patients can be efficiently managed and discharged with relative ease. Shownotes – Also check out EMCases Rapid Review video on Rosen’s in Perspective This chapter covers disease states in which the immune system overreacts against typically harmless agents. These hypersensitivity reactions are manifested in clinical symptoms ranging from mildly inconvenient to fatal. For practical purposes, let’s define some terms: Allergy Used
Aripiprazole Oral Solution in the Treatment of Children and Adolescents With Tourette's Syndrome Aripiprazole Oral Solution in the Treatment of Children and Adolescents With Tourette's Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Aripiprazole Oral Solution in the Treatment of Children and Adolescents With Tourette's Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03487783 Recruitment Status : Recruiting
and penicillin as first-line treatments, amoxicillin is preferred over penicillin because it is more effective against various gram-negative anaerobes and its lower incidence of gastrointestinal side effects. As an alternative for patients with a history of a penicillin allergy, but without a history of anaphylaxis, angioedema, or hives with penicillin, ampicillin, or amoxicillin, the panel suggests dentists prescribe oral cephalexin (500 mg, 4 times per d, 3-7d). Of note, the anaerobic activity (...) of cephalexin is not well described for some oral pathogens. Clinicians should have a low threshold to add metronidazole to cephalexin therapy in patients with a delayed response to antibiotics. As an alternative for patients with a history of a penicillin allergy and with a history of anaphylaxis, angioedema, or hives with penicillin, ampicillin, or amoxicillin, the panel suggests dentists prescribe oral azithromycin (loading dose of 500 mg on day 1, followed by 250 mg for an additional 4 d) or oral