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Onychomycosis

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2. Jublia - efinaconazole - Onychomycosis

Jublia - efinaconazole - Onychomycosis efinaconazole | CADTH.ca Find the information you need efinaconazole efinaconazole Last Updated: June 18, 2019 Result type: Reports Project Number: SR0577-000 Product Line: Generic Name: efinaconazole Brand Name: Jublia Manufacturer: Bausch Health, Canada Inc. Indications: Onychomycosis Manufacturer Requested Reimbursement Criteria 1 : For the topical treatment of mild to moderate onychomycosis (tinea unguium) of toenails without lunula involvement due

2018 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

3. Putting the FUN in Fungi: Toenail onychomycosis treatments

Putting the FUN in Fungi: Toenail onychomycosis treatments Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 4,800 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care research. www.acfp.ca September (...) 3, 2019 (en français) Love Tools for Practice? Want to see it in conference format? You're in luck! Visit the ACFP website for more information. Putting the FUN in Fungi: Toenail onychomycosis treatments Clinical Question: How effective are treatments for mild- moderate adult toenail onychomycosis? Bottom Line: Up to 45-60% of patients on oral treatments (terbinafine best), 6-23% on topicals (efinaconazole best), and 3 nails), oral terbinafine for >60% involvement. 12 • Risk of terbinafine

2019 Tools for Practice

4. Oral antifungal medication for toenail onychomycosis. (PubMed)

Oral antifungal medication for toenail onychomycosis. Fungal infection of the toenails, also called onychomycosis, is a common problem that causes damage to the nail's structure and physical appearance. For those severely affected, it can interfere with normal daily activities. Treatment is taken orally or applied topically; however, traditionally topical treatments have low success rates due to the nail's physical properties. Oral treatments also appear to have shorter treatment times (...) sought to identify unpublished and ongoing trials by correspondence with authors and by contacting relevant pharmaceutical companies.RCTs comparing oral antifungal treatment to placebo or another oral antifungal treatment in participants with toenail onychomycosis, confirmed by one or more positive cultures, direct microscopy of fungal elements, or histological examination of the nail.We used standard methodological procedures expected by Cochrane.We included 48 studies involving 10,200 participants

2017 Cochrane

5. Onychomycosis

Onychomycosis Onychomycosis - medSask Home - College of Pharmacy and Nutrition - University of Saskatchewan Toggle Menu Search the U of S Search Onychomycosis Common fungal infection of the nails with toenails being primarily affected (80% of cases) but can also involve fingernails Not life-threatening, but causes discomfort and nail deformities which can affect quality of life In susceptible patients, may progress to cellulitis or diabetic foot infections Ninety percent of onychomycosis (OM (...) ) cases are caused by the dermatophyte , T. rubrum . Candida albicans is involved in up to 5% of infections, most commonly in fingernails. Risk factors: Older age Gender – 2.4 times more common in males than females Tinea pedis infection (co-infection very common) Diabetes Peripheral vascular disease Immunodeficiency Psoriasis of the skin Nail trauma Occlusive footwear Sports or other activities involving bare feet Smoking Images: Anatomy of the nail Skinsight: Nail infections, fungal (Onychomycosis

2018 medSask

6. Neodymium-doped yttrium aluminium garnet laser treatment for onychomycosis

Neodymium-doped yttrium aluminium garnet laser treatment for onychomycosis Neodymium-doped yttrium aluminium garnet laser treatment for onychomycosis Neodymium-doped yttrium aluminium garnet laser treatment for onychomycosis HAYES, Inc Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc. Neodymium-doped yttrium aluminium garnet laser treatment (...) for onychomycosis. Lansdale: HAYES, Inc. Healthcare Technology Brief Publication. 2017 Authors' conclusions Onychomycosis is a fungal infection of the nail. Onychomycosis can cause discomfort, pain, and disfigurement leading to serious physical and occupational limitations. Onychomycosis is a deepseated, recalcitrant condition with a 40% to 70% recurrence rate, which includes either relapse or reinfection. Oral antifungals are the standard of care because topical application has limited effectiveness due

2017 Health Technology Assessment (HTA) Database.

7. The efficacy and safety of pulse vs. continuous therapy for dermatophyte toenail onychomycosis

The efficacy and safety of pulse vs. continuous therapy for dermatophyte toenail onychomycosis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

8. Which oral antifungal works best for toenail onychomycosis?

Which oral antifungal works best for toenail onychomycosis? Which oral antifungal works best for toenail onychomycosis? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Which oral antifungal works best for toenail onychomycosis? View/ Open Date 2013-02 Format Metadata Abstract Terbinafine, 250 mg daily for 12 to 16

2014 Clinical Inquiries

9. Factors associated with onychomycosis in nail psoriasis: a multicenter study in Pakistan. (PubMed)

Factors associated with onychomycosis in nail psoriasis: a multicenter study in Pakistan. Treatment of psoriatic nail disease is challenging, and dystrophic psoriatic nails can get secondarily infected with fungi.This 2-year, matched case-control study was conducted at three tertiary care centers of Karachi, Pakistan. Data were collected from patients with nail psoriasis as cases with age- and gender-matched controls. A detailed questionnaire was filled for all study participants. Nail

2019 International Journal of Dermatology

10. [Effect of 0.9-ms 1064-nm Nd:YAG laser combined with itraconazole for treatment of toenail onychomycosis]. (PubMed)

[Effect of 0.9-ms 1064-nm Nd:YAG laser combined with itraconazole for treatment of toenail onychomycosis]. To evaluate the efficacy and safety of 0.9-ms 1064-nm Nd:YAG laser alone or combined with itraconazole for treatment of toenail onychomycosis.A total of 37 patients with onychomycosis (178 toenails) were randomly assigned to groups A and B, and each group was further divided into different subgroups according to the Scoring Clinical Index of Onychomycosis (SCIO) and Onychomycosis Severity (...) %, 74.72% and 70.79% toenails showed improvements in terms of clear nail growth, shape and color, respectively. The overall patients' satisfaction rate was 62.16%, and no adverse reactions related with the therapy were recorded in these patients.For treatment of toenail onychomycosis, 0.9-ms 1064-nm Nd:YAG laser can effectively improve the aesthetic appearance of the toenails, and a combined treatment with Nd:YAG laser and itraconazole can be better option in severe cases of onychomycosis.

2019 Nan fang yi ke da xue xue bao = Journal of Southern Medical University

11. Improved Methods for Assessing Therapeutic Potential of Antifungal Agents Against Dermatophytes and their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate. (PubMed)

Improved Methods for Assessing Therapeutic Potential of Antifungal Agents Against Dermatophytes and their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate. Onychomycosis is a common, difficult to treat nail infection, mainly caused by dermatophytes. Current therapies are not wholly effective and are associated with manifold side effects. The development of treatments for onychomycosis is challenging because standard in vitro tests are not predictive of antifungal (...) efficacy within the nail. We have developed a new antifungal agent, NP213, for the treatment of onychomycosis. NP213 is based on endogenous host defence peptides (HDP) produced within the nail. We compared the in vitro activity of NP213 and existing antifungal agents using conventional antimicrobial susceptibility test (AST) systems and more physiologically relevant models based on human nail. We observed that the standard in vitro AST methodologies failed to predict the efficacy of antifungal agents

2019 Antimicrobial Agents and Chemotherapy

12. Laser therapy for onychomycosis in patients with diabetes at risk for foot ulcers: A randomised, quadruple-blind, sham controlled trial (LASER-1). (PubMed)

Laser therapy for onychomycosis in patients with diabetes at risk for foot ulcers: A randomised, quadruple-blind, sham controlled trial (LASER-1). Patients with diabetes mellitus are at high risk for onychomycosis, which is related to development of foot ulcers.The aim of this study was to evaluate the safety and efficacy of the treatment of onychomycosis with local laser therapy.In a single-centre, randomised (1:1), quadruple blind, sham-controlled trial, patients with diabetes mellitus (...) , at risk for developing diabetic foot ulcers (Sims classification score 1,2) and a clinical suspicion on onychomycosis were randomised to either 4 sessions neodymium- doped yttrium aluminium garnet (Nd-YAG) 1064nM laser or sham treatment. The primary outcome was clinical and microbiological cure of onychomycosis after one-year follow-up.From March 2015 to July 2016 64 patients were randomised; 63 could be analysed. Trichophyton rubrum was the most detected pathogen. There was no difference

2019 Journal of the European Academy of Dermatology and Venereology

13. Combined long-pulsed Nd-Yag laser and itraconazole versus itraconazole alone in the treatment of onychomycosis nails. (PubMed)

Combined long-pulsed Nd-Yag laser and itraconazole versus itraconazole alone in the treatment of onychomycosis nails. Background: Oral antifungal therapies are effective for onychomycosis but it was complicated by systemic effects. Effective and safe therapy is needed to improve esthetic appearance of nails. Objective: The present study is an attempt to evaluate and compare the efficacy of of combined treatment of onychomycosis with 1,064-nm long-pulsed Nd-Yag laser and pulse itraconazole (...) therapy versus pulse itraconazole alone. Methods: Thirty onychomycosis patients were divided into two groups: Groups I and II. Patients of Group I are treated by itraconazole pulse therapy. Patients of Group II received six laser sessions with long-pulsed Nd:Yag laser and itraconazole pulse therapy. The investigators rated clearance using "Onychomycosis Severity Index (OSI)", photographs, and mycology at 6 and 9 months after treatment. Results: Group I's clinical improvement response was excellent

2019 Journal of Dermatological Treatment

14. Onychomycosis in Athletes. (PubMed)

Onychomycosis in Athletes. Onychomycosis is a common disorder that is difficult to cure. Prevalence is lower in children (0.7%), but athletes are 2.5-fold more likely to develop the disease, with infections of the toenails seven times more prevalent than those of the fingernails. This is a concern for athletes as it can interfere with their performance. The risk of developing onychomycosis is increased by the warm environment of many sports activities; the use of occlusive footwear; the warm (...) , moist environment associated with socks and sweating; shared, close quarters among athletes; and trauma to the foot and toenail. Once infected, onychomycosis treatment requires a long duration of treatment with strict compliance, a potential problem for younger patients. Treatment carries the risk of significant side effects, and recurrence rates remain high. Avoiding infection can be a potent first line of defense and may circumvent the need for treatment. Preventive recommendations such as keeping

2019 American journal of clinical dermatology

15. Monotherapy for toenail onychomycosis: a systematic review and network meta-analysis. (PubMed)

Monotherapy for toenail onychomycosis: a systematic review and network meta-analysis. Onychomycosis is a fungal infection of the nail caused by dermatophytes, yeasts and non-dermatophyte moulds that accounts for approximately 50% of all nail related disease.This study aims to assess the effectiveness and safety of monotherapy and combination treatments for toenail onychomycosis using a network meta-analysis (NMA).Quality of evidence was assessed using Cochrane-compliant rules and the Grading (...) each other. For mycological cure, evidence was of moderate or high quality while evidence ranged from very low to high quality for adverse events.Our review suggests that oral and topical treatments for toenail onychomycosis are safe and effective in producing mycological cure. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

2019 British Journal of Dermatology

16. Distal and lateral subungual onychomycosis of the finger nail in a neonate: a rare case. (PubMed)

Distal and lateral subungual onychomycosis of the finger nail in a neonate: a rare case. Onychomycosis is extremely rare in neonates, infrequently reported in children and is considered to be exclusively a disease of adults.We, herein report a case of fingernail onychomycosis in a 28-day-old, healthy, male neonate. The child presented with a history of yellowish discoloration of the fingernail of the left hand for one week. The etiological agent was demonstrated both by microscopic examination (...) candida onychomycosis of severity index score 22 (severe) and was treated with syrup fluconazole 6 mg/kg body weight/week and 5% amorolfine nail lacquer once/week for three months. After three months of therapy, the patient completely recovered with the development of a healthy nail plate.The case is presented due to its rarity in neonates which, we suppose is the first case report of onychomycosis from Nepal in a 28-day-old neonate. Oral colonization with pathogenic yeasts and finger suckling could

2019 BMC Pediatrics

17. Continuous terbinafine and pulse itraconazole for the treatment of non-dermatophyte mold toenail onychomycosis. (PubMed)

Continuous terbinafine and pulse itraconazole for the treatment of non-dermatophyte mold toenail onychomycosis. Introduction: Although dermatophytes are considered the predominant causative organisms in onychomycosis, non-dermatophyte mold (NDM) infections may be more prevalent than originally thought and may be more difficult to treat. There are limited data of oral antifungal efficacy in treating NDM onychomycosis. Method: A retrospective chart review (2009-2016) was conducted in patients (...) receiving continuous oral terbinafine or pulse itraconazole for toenail onychomycosis due to NDMs. Mycology results and percent nail affected were recorded with patient characteristics including demographics and concurrent diseases. Complete, clinical, and mycological cure were tabulated. Results: Data from 176 patients were collected. Mycological and complete cure rates for terbinafine (69.8% and 17%) and itraconazole (67.5% and 22%) were not significantly different from each other. Regardless of oral

2019 Journal of Dermatological Treatment

18. Efficacy of Two-Stage Treatment of Onychomycosis Using a Long-Pulsed Nd:YAG 1064-nm Laser. (PubMed)

Efficacy of Two-Stage Treatment of Onychomycosis Using a Long-Pulsed Nd:YAG 1064-nm Laser. Onychomycosis is a fungal infection of the nail bed, nail matrix, and nail plate. Lasers have recently been studied as future clinical options for onychomycosis. We sought to evaluate the efficacy of the long-pulsed Nd:YAG 1064-nm laser on onychomycosis using a two-stage treatment.A total of 100 affected nails (88 toenails and 12 fingernails from 22 patients) were treated using a long-pulsed Nd:YAG 1064 (...) and the clinical efficacy rate of the nails were 29% and 21% after the first stage, 69% and 35% after the second stage, and 67% and 39% during follow-up, respectively. The second stage of laser treatment significantly improved the mycological clearance and clinical efficacy.Long-pulsed Nd:YAG 1064-nm laser two-stage treatment was effective for onychomycosis, with significantly improved mycological clearance and clinical efficacy. This trial is registered with ChiCTR 1900021669.

2019 Evidence-based Complementary and Alternative Medicine (eCAM)

19. Confirmatory Testing Before Treatment of Onychomycosis?

Confirmatory Testing Before Treatment of Onychomycosis? Confirmatory Testing Before Treatment of Onychomycosis? – Less Is More Search for: Simpler & Better Medicine Menu / Summary: For patients with suspected onychomycosis, an approach of empiric terbinafine therapy without confirmatory testing may be associated with lower costs than an approach of requiring confirmatory testing prior to treatment. Strength of Recommendation = B Advertisements Like this: Like Loading... Categories: Tags: Post

2017 Less Is More Blog

20. Topical Tavaborole in the Treatment of Onychomycosis Complicated by Dermatophytoma: A Post-hoc Assessment of Phase II Subjects. (PubMed)

Topical Tavaborole in the Treatment of Onychomycosis Complicated by Dermatophytoma: A Post-hoc Assessment of Phase II Subjects. Dermatophytoma is a little-known, difficult to treat fungal infection that complicates onychomycosis. First described by Roberts and Evans in the late 1990's, dermatophytoma presents as a dense concentration of fungal hyphae within or under the nail plate and is generally white or yellow/brown in color, and linear (streaks) or round (patches) in shape; primary (...) etiologic organisms are dermatophytes. Oral antifungals have limited success in treating dermatophytoma owing to difficulties accessing and penetrating what is hypothesized to be a fungal biofilm. In this respect, dermatophytoma is generally treated with a combination therapy approach, often including both surgical and pharmacologic intervention for improved outcomes. A post-hoc assessment of Phase II tavaborole onychomycosis studies was conducted in order to assess the prevalence of dermatophytoma

2018 Journal of drugs in dermatology : JDD

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