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Onychomycosis

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1. Early Feasibility Study to Evaluate the Efficacy and Safety of the RenewalNailâ„¢ Plasma Treatment System in Patients With Mild to Moderate Onychomycosis (Fungal Nail)

Early Feasibility Study to Evaluate the Efficacy and Safety of the RenewalNailâ„¢ Plasma Treatment System in Patients With Mild to Moderate Onychomycosis (Fungal Nail) Early Feasibility Study to Evaluate the Efficacy and Safety of the RenewalNail™ Plasma Treatment System in Patients With Mild to Moderate Onychomycosis (Fungal Nail) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms (...) x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Early Feasibility Study to Evaluate the Efficacy and Safety of the RenewalNail™ Plasma Treatment System in Patients With Mild to Moderate Onychomycosis (Fungal Nail) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been

2017 Clinical Trials

2. Early Feasibility Study to Evaluate the Efficacy of the RenewalNailâ„¢ Plasma Treatment System in Patients With Onychomycosis (Fungal Nail)

Early Feasibility Study to Evaluate the Efficacy of the RenewalNailâ„¢ Plasma Treatment System in Patients With Onychomycosis (Fungal Nail) Early Feasibility Study to Evaluate the Efficacy of the RenewalNail™ Plasma Treatment System in Patients With Onychomycosis (Fungal Nail) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study (...) Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Early Feasibility Study to Evaluate the Efficacy of the RenewalNail™ Plasma Treatment System in Patients With Onychomycosis (Fungal Nail) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier

2017 Clinical Trials

3. Efinaconazole for Fungal Nail Infections: A Review of the Clinical Effectiveness, Cost-effectiveness, and Guidelines

Efinaconazole for Fungal Nail Infections: A Review of the Clinical Effectiveness, Cost-effectiveness, and Guidelines Efinaconazole for Fungal Nail Infections: A Review of the Clinical Effectiveness, Cost-effectiveness, and Guidelines | CADTH.ca Find the information you need Efinaconazole for Fungal Nail Infections: A Review of the Clinical Effectiveness, Cost-effectiveness, and Guidelines Efinaconazole for Fungal Nail Infections: A Review of the Clinical Effectiveness, Cost-effectiveness (...) , and Guidelines Published on: January 15, 2016 Project Number: RC0737-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness and safety of efinaconazole for the treatment of fungal nail infections? What is the cost-effectiveness of efinaconazole for the treatment of fungal nail infections? What are the evidence-based guidelines regarding the treatment of fungal nail infections? Key Message Compared to vehicle alone

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

4. Fungal nail infection

Fungal nail infection Fungal nail infection - NICE CKS Share Fungal nail infection: Summary Fungal nail infection (onychomycosis) can involve any part of the nail, or the entire nail unit including the nail plate, nail bed, and root of the nail. The nail unit may discolour, the nail plate distort, and the nail bed and adjacent tissue may thicken. Toenails are seven times more likely to be affected than fingernails. Infection is caused by dermatophyte and non-dermatophyte moulds, and yeasts (...) . There is thickening of the nail; white or yellow spots; or complete destruction of the nail. There is associated paronychia, which may suggest Candida infection. Assessment of suspected fungal nail infection should include: Asking about symptoms such as pain and discomfort; difficulty wearing footwear and walking; psychosocial impact; any co-morbidities or risk factors for infection; any family or household members affected. Classifying the type of onychomycosis, if possible. Examining for fungal skin infection

2018 NICE Clinical Knowledge Summaries

5. An investigation of how fungal infection influences drug penetration through onychomycosis patient’s nail plates Full Text available with Trip Pro

An investigation of how fungal infection influences drug penetration through onychomycosis patient’s nail plates The treatment of onychomycosis remains problematic even though there are several potent antifungal agents available for patient use. The aim of this investigation was to understand whether the structural modifications that arise when a patient's nail become infected plates influences the permeation of drugs into the nail following topical application. It was hoped that through (...) improving understanding of the nail barrier in the diseased state, the development of more effective topical treatments for onychomycosis could be facilitated. The permeation of three compounds with differing hydrophobicities, caffeine, terbinafine and amorolfine (clogD at pH 7.4 of -0.55, 3.72 and 4.49 respectively), was assessed across both healthy and onychomycosis infected, full thickness, human nail plate sections. Transonychial water loss (TOWL) measurements performed on the healthy and diseased

2016 European Journal of Pharmaceutics and Biopharmaceutics

6. Evaluation of the Performance of a Fungal Nail Treatment on the Visual Signs of Onychomycosis

Evaluation of the Performance of a Fungal Nail Treatment on the Visual Signs of Onychomycosis Evaluation of the Performance of a Fungal Nail Treatment on the Visual Signs of Onychomycosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Evaluation of the Performance of a Fungal Nail Treatment on the Visual Signs of Onychomycosis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02546258 Recruitment Status : Completed First Posted : September 10, 2015 Last Update Posted : April 11, 2017 Sponsor

2015 Clinical Trials

7. Therapy of Skin, Hair and Nail Fungal Infections Full Text available with Trip Pro

Therapy of Skin, Hair and Nail Fungal Infections Treatment of superficial fungal infections has come a long way. This has, in part, been through the development and evaluation of new drugs. However, utilising new strategies, such as identifying variation between different species in responsiveness, e.g., in tinea capitis, as well as seeking better ways of ensuring adequate concentrations of drug in the skin or nail, and combining different treatment methods, have played equally important roles (...) in ensuring steady improvements in the results of treatment. Yet there are still areas where we look for improvement, such as better remission and cure rates in fungal nail disease, and the development of effective community treatment programmes to address endemic scalp ringworm.

2018 Journal of Fungi

8. Jublia - efinaconazole - Onychomycosis

Jublia - efinaconazole - Onychomycosis efinaconazole | CADTH.ca Find the information you need efinaconazole efinaconazole Last Updated: June 18, 2019 Result type: Reports Project Number: SR0577-000 Product Line: Generic Name: efinaconazole Brand Name: Jublia Manufacturer: Bausch Health, Canada Inc. Indications: Onychomycosis Manufacturer Requested Reimbursement Criteria 1 : For the topical treatment of mild to moderate onychomycosis (tinea unguium) of toenails without lunula involvement due

2018 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

10. Putting the FUN in Fungi: Toenail onychomycosis treatments

3, 2019 (en français) Love Tools for Practice? Want to see it in conference format? You're in luck! Visit the ACFP website for more information. Putting the FUN in Fungi: Toenail onychomycosis treatments Clinical Question: How effective are treatments for mild- moderate adult toenail onychomycosis? Bottom Line: Up to 45-60% of patients on oral treatments (terbinafine best), 6-23% on topicals (efinaconazole best), and 3 nails), oral terbinafine for >60% involvement. 12 • Risk of terbinafine (...) Putting the FUN in Fungi: Toenail onychomycosis treatments Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 4,800 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care research. www.acfp.ca September

2019 Tools for Practice

11. Deep neural networks show an equivalent and often superior performance to dermatologists in onychomycosis diagnosis: Automatic construction of onychomycosis datasets by region-based convolutional deep neural network. Full Text available with Trip Pro

Deep neural networks show an equivalent and often superior performance to dermatologists in onychomycosis diagnosis: Automatic construction of onychomycosis datasets by region-based convolutional deep neural network. Although there have been reports of the successful diagnosis of skin disorders using deep learning, unrealistically large clinical image datasets are required for artificial intelligence (AI) training. We created datasets of standardized nail images using a region-based (...) convolutional neural network (R-CNN) trained to distinguish the nail from the background. We used R-CNN to generate training datasets of 49,567 images, which we then used to fine-tune the ResNet-152 and VGG-19 models. The validation datasets comprised 100 and 194 images from Inje University (B1 and B2 datasets, respectively), 125 images from Hallym University (C dataset), and 939 images from Seoul National University (D dataset). The AI (ensemble model; ResNet-152 + VGG-19 + feedforward neural networks

2018 PLoS ONE

12. Onychomycosis

Onychomycosis Onychomycosis - medSask Home - College of Pharmacy and Nutrition - University of Saskatchewan Toggle Menu Search the U of S Search Onychomycosis Common fungal infection of the nails with toenails being primarily affected (80% of cases) but can also involve fingernails Not life-threatening, but causes discomfort and nail deformities which can affect quality of life In susceptible patients, may progress to cellulitis or diabetic foot infections Ninety percent of onychomycosis (OM (...) ) cases are caused by the dermatophyte , T. rubrum . Candida albicans is involved in up to 5% of infections, most commonly in fingernails. Risk factors: Older age Gender – 2.4 times more common in males than females Tinea pedis infection (co-infection very common) Diabetes Peripheral vascular disease Immunodeficiency Psoriasis of the skin Nail trauma Occlusive footwear Sports or other activities involving bare feet Smoking Images: Anatomy of the nail Skinsight: Nail infections, fungal (Onychomycosis

2018 medSask

13. Neodymium-doped yttrium aluminium garnet laser treatment for onychomycosis

for onychomycosis. Lansdale: HAYES, Inc. Healthcare Technology Brief Publication. 2017 Authors' conclusions Onychomycosis is a fungal infection of the nail. Onychomycosis can cause discomfort, pain, and disfigurement leading to serious physical and occupational limitations. Onychomycosis is a deepseated, recalcitrant condition with a 40% to 70% recurrence rate, which includes either relapse or reinfection. Oral antifungals are the standard of care because topical application has limited effectiveness due (...) , nail debridement, nail evulsion). Pharmacologic and nonpharmacologic treatments may also be used in combination. Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Humans; Lasers, Solid-State; Neodymium; Onychomycosis; Phosphatidylethanolamines Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S. Broad Street, Suite 200

2017 Health Technology Assessment (HTA) Database.

14. Opportunistic toenail onychomycosis. The fungal colonization of an available nail unit space by non-dermatophytes is produced by the trauma of the closed shoe by an asymmetric gait or other trauma. A plausible theory. Full Text available with Trip Pro

Opportunistic toenail onychomycosis. The fungal colonization of an available nail unit space by non-dermatophytes is produced by the trauma of the closed shoe by an asymmetric gait or other trauma. A plausible theory. Opportunistic onychomycosis is defined, when a non-dermatophyte mould is cultured from an abnormal nail unit in the absence of a dermatophyte. The presumption is that the mould has caused the abnormal clinical appearance of the nail unit, yet there are no data available (...) to substantiate this claim. Reports have only identified the mould being recovered from the nail unit niche. A review of the published dermatologic literature describing toenail opportunistic onychomycosis by non-dermatophyte fungi has shown toenails with onycholysis, nail bed (NB) keratosis and nail plate surface abnormalities. The appearance of these clinical changes is indistinguishable from the diagnosis of the Asymmetric Gait Nail Unit Signs (AGNUS). AGNUS is produced by the friction of the closed shoe

2014 Journal of the European Academy of Dermatology and Venereology

15. Clinico-aetiologic profile of Onychomycoses in a tertiary care centre in northeast India. (Abstract)

Clinico-aetiologic profile of Onychomycoses in a tertiary care centre in northeast India. Onychomycosis refers to fungal nail infection. Despite a clearly diseased appearance, it is often deemed a merely cosmetic problem of relatively minor importance. However, it may result in much psychological or occupational turmoil, diminished self-esteem and resulting reluctance for public interaction. A wide number of factors determine the treatment outcome and its prevalence varies greatly. Our study (...) was conducted between January 2011 and December 2014 in northeast India. Of 243 patients presenting with nail abnormalities, 158 (65%) were positively diagnosed by either direct microscopy or culture or both. A distal lateral subungual infection was the most predominant clinical pattern observed, and the most frequent aetiological agents were dermatophytes, of which Trichophyton rubrum was predominant.

2017 Tropical Doctor

16. Clinical laser treatment of toenail onychomycoses Full Text available with Trip Pro

Clinical laser treatment of toenail onychomycoses Onychomycoses are fungal infections of the fingernails or toenails having a prevalence of 3% among adults and accounts for 50% of nail infections. It is caused by dermatophytes, non-dermatophyte filamentous fungi, and yeasts. Compressions and microtraumas significantly contribute to onychomycosis. Laser and photodynamic therapies are being proposed to treat onychomycosis. Laser light (1064 nm) was used to treat onychomycosis in 156 affected (...) toenails. Patients were clinically followed up for 9 months after treatment. Microbiological detection of fungal presence in lesions was accomplished. A total of 116 samples allowed the isolation of at least a fungus. Most of nails were affected in more than two thirds surface (some of them in the full surface). In 85% of cases, after 18 months of the onset of treatment, culture turned negative. After 3 months months, only five patients were completely symptom-free with negative culture. In 25 patients

2017 Lasers in medical science

17. Kerydin (tavaborole) - For the topical treatment of onychomycosis of the toenail

Kerydin (tavaborole) - For the topical treatment of onychomycosis of the toenail Drug Approval Package: Brand Name (Generic Name) NDA # Drug Approval Package U.S. Food & Drug Administration Search FDA Drug Approval Package - Kerydin (tavaborole) Topical Solution Company: Anacor Pharmaceuticals, Inc. Application No.: 204427 Approval Date: 7/07/2014 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (PDF) (PDF

2014 FDA - Drug Approval Package

18. Which oral antifungal works best for toenail onychomycosis?

Which oral antifungal works best for toenail onychomycosis? Which oral antifungal works best for toenail onychomycosis? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Which oral antifungal works best for toenail onychomycosis? View/ Open Date 2013-02 Format Metadata Abstract Terbinafine, 250 mg daily for 12 to 16

2014 Clinical Inquiries

19. A 61 yr old woman presents requesting treatment for fungal nail infection. Clinically she has plaque psoriasis of the scalp and body with palmoplantar pustular psoriasis with nail involvement. My unde

A 61 yr old woman presents requesting treatment for fungal nail infection. Clinically she has plaque psoriasis of the scalp and body with palmoplantar pustular psoriasis with nail involvement. My unde A 61 yr old woman presents requesting treatment for fungal nail infection. Clinically she has plaque psoriasis of the scalp and body with palmoplantar pustular psoriasis with nail involvement. My understanding is that she would need systemic treatment. - Trip Database or use your Google+ account (...) questions please contact us via jon.brassey@tripdatabase.com A 61 yr old woman presents requesting treatment for fungal nail infection. Clinically she has plaque psoriasis of the scalp and body with palmoplantar pustular psoriasis with nail involvement. My understanding is that she would need systemic treatment. Prodigy has a guideline on psoriasis (1) which covers various clinical scenarios. On the management of pustular psoriasis the guideline recommends: “Generalized pustular psoriasis

2012 TRIP Answers

20. Continuous terbinafine and pulse itraconazole for the treatment of non-dermatophyte mold toenail onychomycosis. (Abstract)

receiving continuous oral terbinafine or pulse itraconazole for toenail onychomycosis due to NDMs. Mycology results and percent nail affected were recorded with patient characteristics including demographics and concurrent diseases. Complete, clinical, and mycological cure were tabulated. Results: Data from 176 patients were collected. Mycological and complete cure rates for terbinafine (69.8% and 17%) and itraconazole (67.5% and 22%) were not significantly different from each other. Regardless of oral (...) Continuous terbinafine and pulse itraconazole for the treatment of non-dermatophyte mold toenail onychomycosis. Introduction: Although dermatophytes are considered the predominant causative organisms in onychomycosis, non-dermatophyte mold (NDM) infections may be more prevalent than originally thought and may be more difficult to treat. There are limited data of oral antifungal efficacy in treating NDM onychomycosis. Method: A retrospective chart review (2009-2016) was conducted in patients

2019 Journal of Dermatological Treatment

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