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Ocular Orbit

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1. Influence of orbital morphology on proptosis reduction and ocular motility after decompression surgery in patients with Graves' orbitopathy. (PubMed)

Influence of orbital morphology on proptosis reduction and ocular motility after decompression surgery in patients with Graves' orbitopathy. Orbital decompression surgery is performed in patients with Graves' orbitopathy to treat dysthyroid optical neuropathy (DON) and reduce disfiguring proptosis. The intended proptosis reduction can deviate from the postoperative result and changes of motility with consecutive diplopia can occur. We performed a retrospective study to identify anatomical (...) factors in computed tomography (CT), which influence the surgical effect and postoperative ocular motility and diplopia.Pre- and postoperative CT-scans of 125 eyes of 68 patients, who mainly underwent a balanced orbital decompression for disfiguring proptosis (≥18mm Hertel Index), have been analyzed. Proptosis, ductions, misalignment and diplopia were assessed before and after surgery. Medial and lateral orbital wall length, conus angle, depth of ethmoidal sinus, orbital surface, length of medial

2019 PLoS ONE

2. Orbital radiotherapy plus three-wall orbital decompression in a patient with rare ocular manifestations of thyroid eye disease: case report. (PubMed)

Orbital radiotherapy plus three-wall orbital decompression in a patient with rare ocular manifestations of thyroid eye disease: case report. Thyroid eye disease (TED) is a debilitating autoimmune orbital disease that is often a result of Graves' disease. Dysthyroid optic neuropathy (DON) is a rare but sight-threatening manifestation of TED with therapeutic challenges that can potentially lead to visual loss.A 74-year-old man experienced active TED with extremely severe redness and swelling (...) and severe case of DON with therapeutic challenges. To date, no cases has been reported of a patient with such severe and unusual ocular manifestations. Early awareness of the occurrence of optic nerve compression and prompt treatment are important to prevent irreversible outcomes. Orbital radiotherapy should be considered as a useful surgery-delaying alternative for DON, especially in patients who have contraindications to steroids.

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2018 BMC Endocrine Disorders

3. Peri-orbital and orbital cellulitis

. Complications include sub-periosteal abscess, cavernous sinus thrombosis, intracranial abscess, and subsequent loss of vision and/or death. Definition Peri-orbital (also known as pre-septal) cellulitis is inflammation and infection of the superficial eyelid, usually from a superficial source. The inflammation remains confined to the soft tissue layers superficial to the orbital septum and ocular function remains intact. Orbital cellulitis is an infection within the orbital soft tissues with associated (...) ocular dysfunction and is usually due to underlying bacterial sinusitis. Orbital cellulitis is a far more serious condition and warrants hospital admission. It has much higher morbidity than peri-orbital cellulitis, and warrants urgent imaging and surgical evaluation by oculoplastic as well as a head-and-neck consultant. History and exam presence of risk factors recent sinus infection recent eyelid injury redness and swelling of eye ocular pain decreased vision proptosis eyelid oedema insect bite

2018 BMJ Best Practice

4. Prospective study on ocular motility limitation due to orbital muscle entrapment or impingement associated with orbital wall fracture. (PubMed)

Prospective study on ocular motility limitation due to orbital muscle entrapment or impingement associated with orbital wall fracture. The recommended urgent surgical management of ocular motility restriction due to orbital muscle entrapment or impingement associated with orbital wall fracture needs to be elucidated.To evaluate the importance of the time from injury to surgery for the outcome in ocular motility and diplopia, the time lapse of ocular motility, diplopia and hypesthesia (...) recovery.Patients with entrapment or impingement of orbital contents due to orbital wall fracture were followed up prospectively over 1year regarding ocular motility, diplopia, hypesthesia and cosmetic deformity.21 patients (10 entrapments and 11 impingements) were included and treated surgically. The median time from injury to surgery was 36 (8-413)h for the entrapment group and 168 (48-326)h for the impingement group. The median time from study inclusion to surgery was 0 (0-1) days for the entrapment group

2017 Injury

5. Aminobisphosphonate-associated orbital and ocular inflammatory disease. (PubMed)

Aminobisphosphonate-associated orbital and ocular inflammatory disease. Aminobisphosphonates may cause orbital/ocular inflammation. Awareness of the clinical presentation and disease course is crucial. The purpose of this study was to analyse demographics, clinical presentation, disease course and treatment of aminobisphosphonate-associated orbital/ocular inflammation in a large series of patients.A retrospective study of patients with aminobisphosphonate-associated orbital/ocular inflammation (...) . The aminobisphosphonate was halted in all patients, and some patients had anti-inflammatory treatment. Literature review included 68 patients (83 eyes), of them the most abundant drugs causing orbital/ocular inflammation were pamidronate (38 eyes) and zoledronate (35 eyes). Overall, among 76 patients, all drugs induced orbital disease, while uveitis was induced mostly by zoledronate and pamidronate, less by alendronate and not found among risedronate users. Time interval from drug administration to symptoms was hours

2019 Acta ophthalmologica

6. Treatment of Ocular Neuralgia After Refractive Surgery With Bilateral Orbital Steroid and Anesthetic Injections. (PubMed)

Treatment of Ocular Neuralgia After Refractive Surgery With Bilateral Orbital Steroid and Anesthetic Injections. To describe a patient with chronic periocular pain after bilateral photorefractive keratectomy (PRK) and ocular neuralgia that was controlled with regular orbital steroid and anesthetic injections.Case report.A 21-year-old man presented 3 months following bilateral PRK surgery in severe bilateral orbital pain. Previous treatments included topical (artificial tears, corticosteroids (...) , and nonsteroidal anti-inflammatory drugs [NSAIDs) and oral (NSAIDs, opioids, and pregabalin) therapies with minimal pain relief. A bilateral orbital triamcinolone acetonide 40 mg/cc and 0.25% bupivacaine injection was done after a successful, diagnostic unilateral 0.25% bupivacaine injection. Following bilateral bupivacaine and triamcinolone acetonide injections, pain intensity improved from 7 of 9 to 1 of 3 out of 10. Repeat injections have been regularly performed over the past 3 years, allowing the patient

2019 Journal of Refractive Surgery

7. Temporal Expression of Genes in Biofilm-Forming Ocular Candida albicans Isolated From Patients With Keratitis and Orbital Cellulitis. (PubMed)

Temporal Expression of Genes in Biofilm-Forming Ocular Candida albicans Isolated From Patients With Keratitis and Orbital Cellulitis. To study antibiotic susceptibility and biofilm-forming potential of ocular isolates of Candida albicans along with gene expression.Seven clinical isolates of C. albicans (keratitis-6 and orbital cellulitis-1) were evaluated. Biofilm formation in one isolate was monitored by scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM (...) ). Expression of 27 genes (real-time PCR) associated with biofilm formation and virulence was compared between biofilm-positive and biofilm-negative ocular C. albicans isolates. The temporal expression (4 to 72 hours) of the 27 overexpressed genes was also determined. Similar studies were also done with biofilm-positive and biofilm-negative nonocular C. albicans.Four of seven ocular C. albicans isolates exhibited the potential to form biofilm, one of which was resistant to three antifungals, whereas three

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2018 Investigative Ophthalmology & Visual Science

8. Ultrasonographic Prenatal Imaging of Fetal Ocular and Orbital Abnormalities. (PubMed)

Ultrasonographic Prenatal Imaging of Fetal Ocular and Orbital Abnormalities. Technological progress in medicine has provided earlier diagnosis, even into the prenatal period. We address ultrasonographic imaging of the prenatal eye and orbit. During development of these structures, multiple pathologies and diseases can arise. Orbital anomalies can be detected prenatally using ultrasound or magnetic resonance imaging. Some of these include congenital cataracts, hypertelorism, hypotelorism (...) , dacryocystocele, microphthalmia, anophthalmia, orbital tumors/masses, and septo-optic dysplasia. We describe characteristic ultrasound findings of these diseases. Prenatal ocular and orbital diagnosis is best facilitated by a team approach between ophthalmology, radiology, obstetrics, neonatology, and genetic counselors to optimize diagnostic accuracy, familial expectations, and early treatment.Copyright © 2018 Elsevier Inc. All rights reserved.

2018 Survey of Ophthalmology

9. Interventions for orbital lymphangioma. (PubMed)

Interventions for orbital lymphangioma. Orbital lymphangiomas are a subset of localized vascular and lymphatic malformations, which most commonly occur in the head and neck region. Orbital lymphangiomas typically present in the first decade of life with signs of ptosis, proptosis, restriction of ocular motility, compressive optic neuropathy, and disfigurement. Therefore, early and effective treatment is crucial to preserving vision. Due to proximity to vital structures, such as the globe, optic (...) nerve, and extraocular muscles, treatment for these lesions is complicated and includes a large array of approaches including observation, sclerotherapy, systemic therapy, and surgical excision. Of these options, there is no clear gold standard of treatment.To assess the evidence supporting medical and surgical interventions for the reduction/treatment of orbital lymphangiomas in children and young adults.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains

2019 Cochrane

10. Extra-ocular movement restriction and diplopia following orbital fracture repair. (PubMed)

Extra-ocular movement restriction and diplopia following orbital fracture repair. To report a series of patients with extra-ocular movement restriction and diplopia after orbital fracture repair, and determine the effect of timing of repair and the type of implant used.A chart review was conducted identifying all patients >18years of age at our institution between June 2005 and June 2008 who underwent orbital fracture repair, and presented with clinically significant diplopia and extra-ocular (...) without revision of primary fracture repair. Titanium mesh was the intra-orbital implant found in all patients requiring revision of orbital fracture repair. All revisions resulted in resolution of clinically significant diplopia.Clinically significant diplopia and extra-ocular movement restriction is not an uncommon complication after orbital fracture repair. In our series, there was a strong association between these complications and the use of porous titanium mesh implants. Revision of fractures

2017 American Journal of Otolaryngology

11. Impact of surgical timing of postoperative ocular motility in orbital blowout fractures. (PubMed)

Impact of surgical timing of postoperative ocular motility in orbital blowout fractures. To investigate the surgical timing postinjury in regard to ocular motility in patients with orbital-floor blowout fractures.This study involved 197 eyes (92 right eyes and 105 left eyes) of 197 patients (154 males and 43 females, mean age: 29.0 years, range: 7-85 years) with pure orbital blowout fractures. All patients underwent surgical repair within 30 days postinjury and were followed up for 3 months (...) or more postoperative (mean follow-up period: 8.4 months, range: 3-59 months). Orbital blowout fractures were classified into one of three shapes: (1) trap-door fracture with muscle entrapment, (2) trap-door fracture with incarcerated tissue and (3) depressed fragment fracture. Ocular motility was estimated by percentage of Hess area ratio (HAR%) on the Hess chart at the final follow-up examination. In addition, correlations between postinjury surgical timing and HAR% were analysed.The mean postinjury

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2017 British Journal of Ophthalmology

12. Ocular Morbidity in the Correction of Orbital Hypertelorism and Dystopia: A 15-Year Experience. (PubMed)

Ocular Morbidity in the Correction of Orbital Hypertelorism and Dystopia: A 15-Year Experience. Complex surgery for appearance change is controversial. Correction of orbital hypertelorism risks diplopia and loss of stereopsis for aesthetic gain. The risk-to-benefit ratio remains ill-defined. The aim of this study was to define specific ocular morbidity following orbital translocation.The authors compared stable preoperative and postoperative orthoptic indices (i.e., angle of strabismus, ocular (...) years (range, 5 to 17 years). Nontransient change (favorable or unfavorable) in angle of strabismus was noted in 14 patients. Ocular motility was altered in 12. Six patients had stereopsis preoperatively that was disrupted in two cases because of changes in ocular alignment and/or motility. There was one perioperative ophthalmic emergency (superior orbital fissure syndrome) and three acute reexplorations for external ocular muscle entrapment. Corrective surgery for strabismus was performed for four

2017 Plastic and reconstructive surgery

13. Diffuse ocular and orbital inflammation after zoledronate infusion—case report and review of the literature (PubMed)

Diffuse ocular and orbital inflammation after zoledronate infusion—case report and review of the literature Bisphosphonates have become a commonly used class of medications to treat osteoporosis and other bone diseases. Zoledronate (zoledronic acid) can be dosed annually via intravenous infusion, making it an appealing option for patients and physicians. We report the case of a 68-year-old woman who developed severe, unilateral, ocular inflammation, including corneal endotheliitis, anterior (...) uveitis with hyphema, scleritis, and orbital inflammation beginning 12 hours after receiving her first zoledronate infusion. Symptoms escalated but ultimately resolved with topical steroids and high-dose systemic corticosteroids. To our knowledge, this is the first report of unilateral diffuse inflammation of the eye and orbit, including corneal inflammation developing within 12 hours of a first zoledronate infusion.

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2017 Digital Journal of Ophthalmology : DJO

14. Incipient Ocular Mucosa-associated Lymphoid Tissue Lymphoma in IgG4-related Orbital Disease (PubMed)

Incipient Ocular Mucosa-associated Lymphoid Tissue Lymphoma in IgG4-related Orbital Disease 28367047 2017 11 02 2018 11 13 2092-9382 31 2 2017 04 Korean journal of ophthalmology : KJO Korean J Ophthalmol Incipient Ocular Mucosa-associated Lymphoid Tissue Lymphoma in IgG4-related Orbital Disease. 172-174 10.3341/kjo.2017.31.2.172 Kim Ji Won JW Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. Han Sol Ah SA Kyung Hee University College (...) Immunoglobulin G immunology Lymphoma, B-Cell, Marginal Zone complications diagnosis Male Middle Aged Orbital Diseases diagnosis etiology immunology Orbital Neoplasms complications diagnosis Tomography, X-Ray Computed Conflict of Interest: No potential conflict of interest relevant to this article was reported. 2017 4 4 6 0 2017 4 4 6 0 2017 11 3 6 0 ppublish 28367047 10.3341/kjo.2017.31.2.172 PMC5368092 PLoS One. 2015 Jun 25;10(6):e0131458 26111022 Mod Rheumatol. 2012 Jun;22(3):414-8 21894525 Med Mol Morphol

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2017 Korean journal of ophthalmology : KJO

15. A case report of the orbit, ocular association and the lung in granulomatosis with polyangiitis: A diagnostic challenge (PubMed)

A case report of the orbit, ocular association and the lung in granulomatosis with polyangiitis: A diagnostic challenge Granulomatosis with polyangiitis (GPA) is a systemic form of vasculitis that involves small to medium sized vessels and is associated with high morbidity and mortality. GPA presents a continuous and difficult clinical diagnostic concern, due to the rarity of the disease and the diversity of the manifestations. This case report discusses the unusual symptoms presented (...) of an orbital mass, resulted in the identification of an asymptomatic space-occupying lesion in the right middle lung, which was surgically removed in March 2015. A total of four weeks later, surgery was then applied to remove a left orbital mass, in the same hospital. A total of three months later, the patient was diagnosed with peripheral ulcerative keratitis associated with GPA, at the present institution. The corneal lesions were then treated bilaterally with cryotherapy and oral prednisone

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2017 Experimental and therapeutic medicine

16. Primary Ocular Adnexal Extranodal Marginal Zone Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Presenting as Orbital Apex Syndrome (PubMed)

Primary Ocular Adnexal Extranodal Marginal Zone Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Presenting as Orbital Apex Syndrome A 75-year-old female with a past medical history significant for prior stroke and atrial fibrillation presented with acute onset of orbital apex syndrome with chemosis and periorbital ecchymosis. Following initial treatment to relieve intraocular pressure, she began spontaneously haemorrhaging retro-orbitally. Preliminary investigation with neuroimaging (...) demonstrated a left orbital mass with extension into the orbital apex. A provisional diagnosis of cavernous haemangioma was made. She was treated with transorbital resection of the orbital mass. Subsequent histopathology revealed a diagnosis of ocular adnexal non-Hodgkin lymphoma of histologic type extranodal marginal zone of mucosa-associated lymphoid tissue (MALT lymphoma). MALT lymphoma should be considered in cases of orbital apex syndrome.

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2017 Neuro-Ophthalmology

17. Orbital fractures

, or cranial bones. The most common presentation of orbital fractures is associated with zygomatic complex fractures (i.e., involving the cheek bone and thus the lateral orbital wall). The most common intraorbital fracture is the medial wall 'blow-out' fracture. al-Qurainy IA, Stassen LF, Dutton GN, et al. The characteristics of midfacial fractures and the association with ocular injury: a prospective study. Br J Oral Maxillofac Surg. 1991 Jan;29(1):291-301. http://www.ncbi.nlm.nih.gov/pubmed/1742258?tool (...) Orbital fractures Orbital fractures - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Orbital fractures Last reviewed: February 2019 Last updated: March 2018 Summary Traumatic injuries usually caused by sports and interpersonal violence. In children, play and accidents are the most common causes. A careful assessment of the orbit injury may include examination of the facial bones, eyelids, and surrounding soft tissue

2018 BMJ Best Practice

18. Comprehensive Genomic Profiling of Orbital and Ocular Adnexal Lymphomas Identifies Frequent Alterations in MYD88 and Chromatin Modifiers: New Routes to Targeted Therapies (PubMed)

Comprehensive Genomic Profiling of Orbital and Ocular Adnexal Lymphomas Identifies Frequent Alterations in MYD88 and Chromatin Modifiers: New Routes to Targeted Therapies Non-Hodgkin lymphoma of the orbit and ocular adnexa is the most common primary orbital malignancy. Treatments for low- (extra-nodal marginal zone and follicular lymphomas) and high-grade (diffuse large B-cell lymphoma) are associated with local and vision-threatening toxicities. High-grade lymphomas relapse frequently (...) and exhibit poor survival rates. Despite advances in genomic profiling and precision medicine, orbital and ocular adnexal lymphomas remain poorly characterized molecularly. We performed targeted next-generation sequencing (NGS) profiling of 38 formalin-fixed, paraffin-embedded orbital and ocular adnexal lymphomas obtained from a single-center using a panel targeting near-term, clinically relevant genes. Potentially actionable mutations and copy number alterations were prioritized based on gain- and loss

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2016 Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

19. Postoperative Pain in Orbital Disease and Ocular Tumor

Postoperative Pain in Orbital Disease and Ocular Tumor Postoperative Pain in Orbital Disease and Ocular Tumor - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Postoperative Pain in Orbital Disease and Ocular (...) provided by (Responsible Party): Huijing Ye, Sun Yat-sen University Study Details Study Description Go to Brief Summary: The purpose of this study is to evaluate the postoperative pain after general anesthesia of orbital diseases and ocular tumor patients. Condition or disease Intervention/treatment Phase Postoperative Pain Procedure: general anesthesia,orbital operation Not Applicable Detailed Description: The purpose of this study is to evaluate patients diagnosed of orbital diseases or ocular tumor

2016 Clinical Trials

20. Lymphoid Hyperplasia of the Orbit and Ocular Adnexa: A Clinico-Pathological Review. (PubMed)

Lymphoid Hyperplasia of the Orbit and Ocular Adnexa: A Clinico-Pathological Review. Lymphoid hyperplasia (LH) is a benign lymphoproliferative disorder that, in a minority of cases, may be associated with concurrent or metachronous non-Hodgkin lymphoma. LH cases are further subdivided into "reactive" and "atypical" categories based on the presence or absence of unequivocal malignant features. With improving molecular diagnostic technologies, "reactive" LH is by far the most common category of LH (...) of lymphoproliferative disorders of the orbit and ocular adnexa. Reactive LH and low-grade malignant lymphoproliferative disorders in the orbit and ocular adnexa are clinically and radiologically indistinguishable from each other, requiring tissue biopsy in all cases. The prognosis of ocular adnexal LH is generally favorable, but the small risk of non-Hodgkin lymphoma mandates follow-up for at least 5 years. We summarize the current state of knowledge on LH occurring in the orbit and ocular adnexa.Copyright © 2016

2016 Survey of Ophthalmology

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