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Occupational Skin Neoplasm

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1. Niraparib (Zejula) - Fallopian Tube Neoplasms, Ovarian Neoplasms, Peritoneal Neoplasms

first detected in advanced stages when prognosis is poor. Assessment report EMA/648982/2017 Page 10/122 The 5-year overall survival rate of ovarian cancer patients is 46% across all stages and only 29% in patients diagnosed with distant metastatic disease. Most patients will die within 3 to 4 years of diagnosis [Coleman et al 2013]. 2.1.5. Management The majority of patients with ovarian cancer receive surgery to remove or debulk the tumour. The primary treatment of advanced-stage ovarian cancer (...) Resonance Non-gBRCAmut without a germline BRCA mutation NOR Normal Operating Range OAT organic anion transporter OATP organic anion transport polypeptide OCT organic cation transporter OCT Pool ovarian cancer treatment pool OS overall survival OVAT One variable at a time PAR Proven Acceptable Range PARP-1, -2 poly (ADP-ribose) polymerase 1, 2 PBMC peripheral blood mononuclear cells PD progressive disease PDX patient-derived xenograft PFS progression-free survival PFS2 progression-free survival 2 PGI

2017 European Medicines Agency - EPARs

2. Neratinib (Nerlynx) - Breast cancer, breast neoplasms

disease-free survival DFS-DCIS disease-free survival including ductal carcinoma in situ ECG electrocardiogram ECOG Eastern Cooperative Oncology Group EGFR epidermal growth factor receptor EQ-5D EuroQol 5-Dimension Questionnaire ER estrogen receptor ERBB erythroblastic leukemia viral oncogene homolog; also termed HER ExteNET Extended Adjuvant Treatment of Breast Cancer with Neratinib FACT-B Functional Assessment of Cancer Therapy-Breast FMO flavin-containing monooxygenase GI gastrointestinal HER human (...) Neratinib (Nerlynx) - Breast cancer, breast neoplasms 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2018. Reproduction is authorised provided the source is acknowledged. 13 July 2018 EMA/CHMP/525204/2018 Committee for Medicinal Products for Human Use (CHMP) Assessment report Nerlynx International

2018 European Medicines Agency - EPARs

3. Investigating potential exogenous tumor initiating and promoting factors for Cutaneous T-Cell Lymphomas (CTCL), a rare skin malignancy Full Text available with Trip Pro

Investigating potential exogenous tumor initiating and promoting factors for Cutaneous T-Cell Lymphomas (CTCL), a rare skin malignancy Most skin malignancies are caused by external and often preventable environmental agents. Multiple reports demonstrated that cutaneous T-cell lymphomas (CTCL) can occur in married couples and cluster in families. Furthermore, recent studies document geographic clustering of this malignancy in Texas as well as in other areas of the United States. Multiple (...) infectious, occupational, and medication causes have been proposed as triggers or promoters of this malignancy including hydrochlorothiazide diuretics, Staphylococcus aureus, dermatophytes, Mycobacterium leprae, Chlamydia pneumoniae, human T-Cell lymphotropic virus type 1 (HTLV1), Epstein-Barr virus (EBV), and herpes simplex virus (HSV). In this report, we review recent evidence evaluating the involvement of these agents in cancer initiation/progression. Most importantly, recent molecular experimental

2016 Oncoimmunology

4. Occupational Skin Neoplasm

Occupational Skin Neoplasm Occupational Skin Neoplasm Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Occupational Skin Neoplasm (...) Occupational Skin Neoplasm Aka: Occupational Skin Neoplasm , Occupational Skin Cancer II. Causes Ionizing radiation exposure (most significant risk) Polycyclic hydrocarbons Inorganic metals als s Nitrosamines Tar exposure (with direct sunlight exposure) Ultraviolet light exposure or III. Risk Factors: Occupations Carbonated drink production Chimney sweep Coal or tar workers Metal manufacturing Mining Industry Outdoor workers (e.g. farmers) Road construction Roofing IV. Prevention See Limit direct chemical

2018 FP Notebook

5. Palliative care - malignant skin ulcer

onwards. This CKS topic covers the assessment and management of malignant skin ulcers (also known as fungating wounds, ulcerating tumours, or neoplastic skin lesions) and the management of complications. Guidance is incorporated from the National Institute for Health and Care Excellence on Care of dying adults in the last days of life [ ]. This CKS topic does not cover the management of the underlying cancer. It is assumed that the person has been assessed for local control of the tumour (...) , malignant ulcer.tw, skin ulcer/, wound healing/, wounds and injuries/, wound$.tw, exudates and transudates/, odors/, pruritus/, itch$.tw, pruritus.tw palliative care/, exp terminal care/, terminally ill/, palliative.tw, terminal$.tw., cancer.tw., neoplasm$.tw, tumor$.tw tumour$.tw, metronidazole/, metronidazole.tw bandages, hydrocolloid/, biological dressings/, dressing$.tw, gauze.tw, hydrocolloid$.tw, alginat$.tw, hydrogel.tw, charcoal.tw, foam$.tw sulfadiazine silver/, silver sulfadiazine.tw. exp

2018 NICE Clinical Knowledge Summaries

6. Atezolizumab (Tecentriq) - Non-Small-Cell Lung Carcinoma or Transitional Cell Carcinoma

for approximately 85% of all cases (Howlader et al. 2014; Molina et al. 2008). UC Urothelial carcinoma presents the highest recurrence rate among solid tumors and is the second leading cause of death in genitourinary cancers. Despite recent advances in the understanding of the pathophysiology of the disease, the management of UC patients remains a clinically challenging problem (Siegel et al. 2014). Approximately 10%-15% of patients present with metastatic UC at the time of diagnosis. Despite the low frequency (...) -free survival PK pharmacokinetic Assessment report EMA/153102/2018 Page 6/205 PS performance status PR partial response q3w every 3 weeks QA quality attribute QbD Quality by Design RECIST Response Evaluation Criteria in Solid Tumors SAE serious adverse event SAT severe acute toxicity SD stable disease SOC system organ class TCC transitional cell carcinoma TIR time in response TTOR time to onset of response UC urothelial carcinoma Vss volume of distribution at steady state Assessment report EMA

2017 European Medicines Agency - EPARs

7. A Comparison Between England and Wales and Sweden in the Incidence and Mortality of Malignant Skin Tumours Full Text available with Trip Pro

melanoma are higher in Sweden than in England and Wales.These differences do not appear likely to be due to differences in the statistical or medical care systems, and suggest important genetic and occupational effects.Total skin cancer rates and rates summarizing all ages may be poor indicators of the real variations between populations in the epidemiology of malignant skin tumours. (...) A Comparison Between England and Wales and Sweden in the Incidence and Mortality of Malignant Skin Tumours Although the population lives in a higher latitude, the incidence of and death rate from skin cancer is approximately the same in Sweden as it is in England and Wales. The proportion of malignant melanoma is higher in the Swedish deaths and the death rate from malignant melanoma is higher in Sweden than in England and Wales.The ratios of male to female cases and deaths from malignant

1972 British journal of cancer

8. Skin cancer in outdoor workers exposed to solar radiation: a largely underreported occupational disease in Italy. Full Text available with Trip Pro

Skin cancer in outdoor workers exposed to solar radiation: a largely underreported occupational disease in Italy. Solar UV radiation (sUVR) is one of the main carcinogen exposures in occupational settings, and UV induced skin cancers are the most frequent tumors in fair skinned individuals worldwide.According to this premise, we should expect a high number of occupational skin cancers reported to the national workers' compensation authorities each year, also considering that the incidence (...) of skin cancers has been constantly increased in recent years.We examined the data on reported Non Melanoma Skin Cancers (NMSC) and Actinic Keratoses (AK) to the Italian National Workers Compensation Authority (INAIL) from 2012 to 2017, and we compared the number of reported skin cancers for outdoor workers with the expected numbers, obtained from currently available NMSC incidence rates for the Italian population applied to the occupational sUVR exposed workers estimated with the CAREX methodology

2019 Journal of the European Academy of Dermatology and Venereology

9. Association of atopy and tentative diagnosis of skin cancer - results from occupational skin cancer screenings. (Abstract)

Association of atopy and tentative diagnosis of skin cancer - results from occupational skin cancer screenings. The relationship between atopic conditions and carcinoma of the skin has been described inconsistently. Population-based data providing information on atopic diseases as well as on skin cancer are sparse.To determine the correlation between atopy and prevalence of precanceroses, non-melanoma skin cancer and malignant melanoma (MM), while taking into account known risk factors for skin (...) keratosis, basal cell carcinoma and malignant melanoma.The study cohort comprised 90 265 employees (mean age 43 ± 11 years, 58.5% male), 30.7% of whom were ever diagnosed with an atopic disease. Persons with atopic conditions recorded in their medical history and at the time of screening had a significantly lower prevalence of actinic keratosis (AK), basal cell carcinoma (BCC) and MM. After controlling for age, sex and relevant risk factors (skin type, childhood sun burns), atopy remained significantly

2017 Journal of the European Academy of Dermatology and Venereology

10. Myelodysplastic/ Myeloproliferative Neoplasms Treatment (PDQ®): Health Professional Version

of tumor cell growth.[ , ] Current Clinical Trials Use our to find NCI-supported cancer clinical trials that are now enrolling patients. The search can be narrowed by location of the trial, type of treatment, name of the drug, and other criteria. about clinical trials is also available. References Orazi A, Germing U: The myelodysplastic/myeloproliferative neoplasms: myeloproliferative diseases with dysplastic features. Leukemia 22 (7): 1308-19, 2008. [ ] Emanuel PD: Myelodysplasia (...) incidence data are available for CMML.[ ] Although the specific etiology of CMML is unknown, exposure to occupational and environmental carcinogens, ionizing radiation, and cytotoxic agents has been associated in some cases.[ ] Morphologically, the disease is characterized by a persistent peripheral blood monocytosis (always >1 × 10 9 /L) that may exceed 80 × 10 9 /L with monocytes typically accounting for more than 10% of the white blood cells.[ , ] Monocytes, though typically mature

2017 PDQ - NCI's Comprehensive Cancer Database

11. Malignant Tumors of the Mobile Tongue

erythroplakia the earliest sign of asymptomatic cancer. [ ] Squamous cell carcinoma Squamous cell carcinoma is by far the most common malignancy of the tongue, typically having 3 gross morphologic growth patterns: exophytic, ulcerative, and infiltrative. The infiltrative and ulcerative types are observed most commonly on the tongue. Early carcinomas smaller than 1 cm may be detected only during a routine clinical examination. In the case of symptomatic tumors, the most common finding is an indurated (...) . Previous Next: Presentation Malignancies of the tongue may grow to significant size before they cause symptoms. Approximately three fourths of the cancer occurs in the mobile tongue and is most often well differentiated. Because of the relative laxity of the tissue planes separating the intrinsic tongue musculature, cancer cells may spread easily and become symptomatic only when tumor size interferes with tongue mobility. Squamous cell carcinoma of the tongue may arise in apparently normal epithelium

2014 eMedicine Surgery

12. Parameters for estimating the national and global burden of melanoma and non-melanoma skin cancer attributable to occupational exposure to solar ultraviolet radiation: protocol for a systematic review of occupational exposure to solar ultraviolet radiatio

Parameters for estimating the national and global burden of melanoma and non-melanoma skin cancer attributable to occupational exposure to solar ultraviolet radiation: protocol for a systematic review of occupational exposure to solar ultraviolet radiatio Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content (...) . Not an in vivo animal study 3. No metastases/ only primary tumor 4. No control group 5. Combination therapy or contamination 6. Not about analgesics used in the clinic Full text-screening: As above, with the addition of: 7. No relevant outcome measure reported ">Prioritise the exclusion criteria Example: Two reviewers will independently extract data from each article. We first try to extract numerical data from tables, text or figures. If these are not reported, we will extract data from graphs using digital

2018 PROSPERO

13. Management of hepatocellular carcinoma

Management of hepatocellular carcinoma EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma q European Association for the Study of the Liver ? Summary Liver cancer is the ?fth most common cancer and the second most frequent cause of cancer-related death globally. Hepato- cellular carcinoma represents about 90% of primary liver can- cers and constitutes a major global health problem. The following Clinical Practice Guidelines will give up-to-date advice for the clinical (...) the leading causes of cancer death globally (evidence high). Vaccination against hepatitis B reduces the risk of HCC and is recommended for all new-borns and high-risk groups (evidence high; recommendation strong). Governmental health agencies should implement poli- cies to prevent HCV/HBV transmission, counteract chronicalcoholabuse,andencouragelifestylesthatpre- ventobesityandmetabolicsyndrome(evidencemoder- ate; recommendation strong). In general, chronic liver disease should be treated to avoid

2018 European Association for the Study of the Liver

14. The economic evaluation of early intervention with Anti-Tumor Necrosis Factor-alpha treatments in pediatric Crohn's disease

The economic evaluation of early intervention with Anti-Tumor Necrosis Factor-alpha treatments in pediatric Crohn's disease The Hospital for Sick Children Technology Assessment at SickKids (TASK) FULL REPORT THE ECONOMIC EVALUATION OF EARLY INTERVENTION WITH ANTI-TUMOR NECROSIS FACTOR-a TREATMENTS IN PEDIATRIC CROHN’S DISEASE Authors: Naazish S. Bashir, MSc, MBA, PhD Research Fellow, Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada Thomas D. Walters, MD, MSc (...) RCT Randomized controlled trial SD Standard Deviation SOC Standard of Care TNF Tumor necrosis factor UC Ulcerative colitis UK United Kingdom USA or US United States of America wPCDAI Weighted Pediatric Crohn’s Disease Activity Index WTP Willingness to pay Table of Contents Executive Summary xx Acknowledgements ii Table of Contents v List of Tables x List of Figures xv List of Appendices xviii List of Abbreviations iii Introduction 1 1.1 Overview 1 1.2 Background Information 6 1.2.1 Crohn’s Disease

2019 SickKids Reports

15. A Study to Evaluate Safety/Tolerability of Immunotherapy Combinations in Participants With Triple-Negative Breast Cancer and Gynecologic Malignancies

in combination with PLD. Any active autoimmune disease or a documented history of autoimmune disease or syndrome that required systemic treatment in past 2 years Prior malignancy active within the previous 2 years except for locally curable cancers that have been apparently cured, such as basal or squamous cell skin cancer, superficial bladder cancer or carcinoma in situ of the cervix, breast, or prostate cancer. Prior chemotherapy, targeted small-molecule therapy, or radiation therapy within 4 weeks prior (...) Last Verified: March 2019 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No Layout table for additional information Studies a U.S. FDA-regulated Drug Product: Yes Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Breast Neoplasms Triple Negative Breast Neoplasms Neoplasms by Site Neoplasms Breast Diseases Skin Diseases Doxorubicin Liposomal doxorubicin Antibiotics, Antineoplastic Antineoplastic Agents Topoisomerase

2018 Clinical Trials

16. Shift in Occupational Risk for Basal Cell Carcinoma from Outdoor to Indoor Workers: A Large Population-based Case-control Register Study from Sweden. Full Text available with Trip Pro

Shift in Occupational Risk for Basal Cell Carcinoma from Outdoor to Indoor Workers: A Large Population-based Case-control Register Study from Sweden. Basal cell carcinoma (BCC) is the most common form of cancer worldwide. Exposure of the skin to ultraviolet (UV) radiation, from sunlight and other sources, is the most important risk factor. The aim of this large-scale case-control study was to determine which occupations are associated with increased risk of BCC in Sweden. The case cohort (...) comprised 74,247 patients with BCC and the control cohort comprised 574,055 subjects linked to population-based registers. Compared with the occupational category of farmers, foresters and gardeners we observed elevated risks of BCC for almost all occupational categories studied. Legal workers with odds ratio (OR) 2.69 (95% confidence interval (CI) 2.36-3.06), dentists OR 2.69 (95% CI 2.35-3.08) and physicians OR 2.47 (95% CI 2.24-2.74) had the highest risk for both sexes taken together. In conclusion

2017 Acta Dermato-Venereologica

17. Avelumab (Bavencio) - Neuroendocrine Tumors

for granting a marketing authorisation to Bavencio on 20 July 2017. 2. Scientific discussion 2.1. Problem statement 2.1.1. Disease or condition MCC is a very rare cutaneous neoplasm belonging to the group of neuroendocrine tumours. MCC is an aggressive disease with frequent locoregional recurrences, visceral metastatic evolution, and a high mortality rate. 1, 2 2.1.2. Epidemiology and risk factors Incidence rates for Merkel cell carcinoma from the European Union (EU) are in the range of 0.1 to 0.4 per (...) Acad Dermatol 2003;49(5):832-841. 4 Miller RW, Rabkin CS. Merkel cell carcinoma and melanoma: Etiological similarities and differences. Cancer Epidemiol Biomarkers Prev 1999;8:153-158. 5 Asgari MM, Sokil MM, Warton EM, et al. Effect of host, tumor, diagnostic, and treatment variables on outcomes in a large cohort with Merkel cell carcinoma. JAMA Dermatol 2014;150(7):716-723. 6 Penn I and First MR. Merkel’s cell carcinoma in organ recipients: report of 41 cases. Transplantation 1999;68:1717-1721

2017 European Medicines Agency - EPARs

18. Targeted programs for skin cancer prevention

to our health system, is significant. Despite this, it is estimated nearly 95% of skin cancers can be prevented through reduced exposure to ultraviolet radiation. Which skin cancer prevention programs were effective? Behavioural change interventions for skin cancer prevention were beneficial in education, health and outdoor settings. This included primary schools, secondary schools, early childhood settings, outdoor occupational settings, outdoor recreational settings, and health care settings (...) Targeted programs for skin cancer prevention Targeted programs for skin cancer prevention - Cancer Institute NSW Cancer Institute NSW Careers, news, media and the Institute's role Recent NSW cancer related data NSW Pop. & Health Services Research Ethics Committee Cervical cancer is one of the most preventable cancers—having a Pap test every two years is currently the best way to prevent it. Find out more about NSW Cervical Screening Program. Search for: > next level > next level Targeted

2018 Sax Institute Evidence Check

19. TP53 Gene Polymorphisms and Occupational Skin Cancer Risks for Workers of Glass Fiber Manufacture Full Text available with Trip Pro

TP53 Gene Polymorphisms and Occupational Skin Cancer Risks for Workers of Glass Fiber Manufacture Determining the role of genetic markers in individual sensitivity to chemical exposures raises a possibility of risk assessment of occupational diseases and their prevention. This paper focuses on the results of the identification of molecular-genetic markers associated with occupational skin cancer susceptibility. This study aimed to explore an association between polymorphisms of the TP53 tumor (...) risks of occupational skin cancer. This study suggests the potential use of molecular-genetic data to assess increased individual risks of the development and prognosis of occupational skin neoplasms.

2017 Iranian journal of public health

20. Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

, bleeding, splenomegaly) PS (distinguish cancer-related symptoms of recent onset with long-standing symptoms associated with cirrhosis) and nutritional state Laboratoryanalysis Aetiology of liver disease: HBV (at least HBsAg and anti-HBc), HCV (at least anti-HCV), iron status, autoimmune disease Liver function: prothrombin, albumin, bilirubin Complete blood cell count including platelets Tumour marker: serum AFP Assessmentofportalhypertension Upper endoscopy: varices and/or hypertensive gastropathy (...) b Pembrolizumab b [III, B] Ablation a [III, A] TACE [I, B] TACE a [I, A] Nivolumab b [I, B] BSC [III, A] Systemic therapy [I, A] SIRT [III, C] TACE failure/ refractoriness Figure 1. HCC treatment options depending on BCLC stage. a See Table 4 for indication constraints based on tumour burden and liver function. b Not EMA-approved as of August 2018. BCLC, Barcelona Clinic Liver Cancer; BSC, best supportive care; EMA, European Medicines Agency; HCC, hepatocellular carcinoma; LTX, liver

2018 British Society of Gastroenterology

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