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Obsessive Compulsive Disorder

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1. Clinical effectiveness, cost-effectiveness and acceptability of low-intensity interventions in the management of obsessive compulsive disorder: the Obsessive Compulsive Treatment Efficacy randomised controlled Trial (OCTET)

Clinical effectiveness, cost-effectiveness and acceptability of low-intensity interventions in the management of obsessive compulsive disorder: the Obsessive Compulsive Treatment Efficacy randomised controlled Trial (OCTET) Clinical effectiveness, cost-effectiveness and acceptability of low-intensity interventions in the management of obsessive compulsive disorder: the Obsessive Compulsive Treatment Efficacy randomised controlled Trial (OCTET) Journals Library An error occurred retrieving

2017 NIHR HTA programme

3. Obsessive-compulsive disorder

Obsessive-compulsive disorder Obsessive-compulsive disorder - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Obsessive-compulsive disorder Last reviewed: February 2019 Last updated: December 2018 Summary Obsessions and/or compulsions that cause marked distress, are time consuming (take more than 1 hour per day), or interfere substantially with the person's normal routine, occupational or academic functioning, or usual (...) social activities or relationships. If the content of the obsessions or compulsions is limited to the scope of another psychiatric disorder, such as an obsession with food in the context of an eating disorder, then an additional diagnosis of OCD should not be made. The Yale-Brown Obsessive-Compulsive Scale is useful in grading severity initially and following trials of therapy. Patients tend to seek treatment from 3 to 4 doctors and spend on average around 9 years in treatment before a correct

2018 BMJ Best Practice

4. Obsessive-compulsive disorder

Obsessive-compulsive disorder Obsessive-compulsive disorder - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Obsessive-compulsive disorder Last reviewed: February 2019 Last updated: December 2018 Summary Obsessions and/or compulsions that cause marked distress, are time consuming (take more than 1 hour per day), or interfere substantially with the person's normal routine, occupational or academic functioning, or usual (...) social activities or relationships. If the content of the obsessions or compulsions is limited to the scope of another psychiatric disorder, such as an obsession with food in the context of an eating disorder, then an additional diagnosis of OCD should not be made. The Yale-Brown Obsessive-Compulsive Scale is useful in grading severity initially and following trials of therapy. Patients tend to seek treatment from 3 to 4 doctors and spend on average around 9 years in treatment before a correct

2017 BMJ Best Practice

5. Immune-Related Comorbidities in Childhood-Onset Obsessive Compulsive Disorder: Lifetime Prevalence in the Obsessive Compulsive Disorder Collaborative Genetics Association Study. (PubMed)

Immune-Related Comorbidities in Childhood-Onset Obsessive Compulsive Disorder: Lifetime Prevalence in the Obsessive Compulsive Disorder Collaborative Genetics Association Study. Objective: To evaluate the lifetime prevalence of infectious, inflammatory, and autoimmune disorders in a multisite study of probands with childhood-onset obsessive compulsive disorder (OCD) and their first-degree relatives. Methods: Medical questionnaires were completed by 1401 probands and 1045 first-degree relatives (...) in the OCD Collaborative Genetics Association Study. Lifetime prevalence of immune-related diseases was compared with the highest available population estimate and reported as a point estimate with 95% adjusted Wald interval. Worst-episode OCD severity and symptom dimensions were assessed with the Yale-Brown Obsessive Compulsive Scale (YBOCS) and Symptom Checklist (YBOCS-CL). Results: Probands reported higher-than-expected prevalence of scarlet fever (4.0 [3.1-5.2]% vs. 1.0%-2.0%, z = 1.491, p < 0.001, n

2019 Journal of Child and Adolescent Psychopharmacology

6. A systematic review of the clinical effectiveness and cost-effectiveness of pharmacological and psychological interventions for the management of obsessive-compulsive disorder in children/adolescents and adults

A systematic review of the clinical effectiveness and cost-effectiveness of pharmacological and psychological interventions for the management of obsessive-compulsive disorder in children/adolescents and adults A systematic review of the clinical effectiveness and cost-effectiveness of pharmacological and psychological interventions for the management of obsessive compulsive disorder in children/adolescents and adults Journals Library An error occurred retrieving content to display, please try

2016 NIHR HTA programme

7. Acute effects of aerobic exercise on negative affect and obsessions and compulsions in individuals with obsessive-compulsive disorder. (PubMed)

Acute effects of aerobic exercise on negative affect and obsessions and compulsions in individuals with obsessive-compulsive disorder. The acute effects of aerobic exercise on improved mood and anxiety reduction have been demonstrated across clinical and nonclinical populations. Limited work has evaluated the acute effects of aerobic exercise on negative affect, obsessions, and compulsions in patients with Obsessive Compulsive Disorder (OCD).Fifty-five patients (64% female) with treatment (...) -resistant OCD were randomized to either 12 weeks of aerobic exercise (AE) or health education contact (HEC) control. Participants rated negative affect (i.e., mood and anxiety), obsessions and compulsions before and after each weekly AE or HEC session. Multilevel models were constructed to evaluate the effect of intervention condition, treatment week (time), and their interaction in terms of acute change in affect, obsession, and compulsions.Results reflected a main effect of condition, such that AE

2019 Journal of Affective Disorders

8. Both psychological therapies and antidepressants are effective for obsessive compulsive disorder

Both psychological therapies and antidepressants are effective for obsessive compulsive disorder Both psychological therapies and antidepressants are effective for obsessive compulsive disorder Discover Portal Discover Portal Both psychological therapies and antidepressants are effective for obsessive compulsive disorder Published on 30 August 2016 doi: For adults with obsessive compulsive disorder (OCD), behavioural therapy, cognitive therapy and antidepressants such as clomipramine all reduce (...) by the condition equating to almost 750,000 people. OCD symptoms can range from mild to severe. Some people with OCD may spend an hour or so a day engaged in obsessive compulsive thinking but for others the condition can be more debilitating. Despite its prevalence, the disorder is under-recognised and under-treated. Several psychological therapies and drugs have been found to reduce OCD symptoms and increase quality of life but direct comparisons of these therapies is lacking. Cost-effectiveness data

2019 NIHR Dissemination Centre

9. Guided self-help therapy for people with obsessive-compulsive disorder (OCD) did not improve symptoms

Guided self-help therapy for people with obsessive-compulsive disorder (OCD) did not improve symptoms Guided self-help therapy for people with OCD did not improve symptoms Discover Portal Discover Portal Guided self-help therapy for people with obsessive-compulsive disorder (OCD) did not improve symptoms Published on 19 September 2017 doi: Offering people guided self-help whilst on a waiting list for therapist-led therapy did not improve their obsessive-compulsive symptoms when assessed after (...) three or 12 months. However, these low-intensity interventions may reduce the likelihood of people taking up therapist-led cognitive behavioural therapy (CBT). This NIHR-funded trial included 473 adults with moderate to severe obsessive-compulsive disorder (OCD) who were already waiting to receive CBT. Issues with the uptake of the low-intensity interventions and therapist-led therapy may have affected results but probably reflect the challenges of engaging people with these symptoms into therapy

2019 NIHR Dissemination Centre

10. The role of performance monitoring in neurodevelopmental disorders: a systematic review and meta-analysis of electrophysiological correlates in autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), obsessive compulsive disorder

The role of performance monitoring in neurodevelopmental disorders: a systematic review and meta-analysis of electrophysiological correlates in autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), obsessive compulsive disorder Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied

2019 PROSPERO

11. Predictors of relapse after acute-phase cognitive behavioural therapy for anxiety disorders, post-traumatic stress disorder, and obsessive-compulsive disorder: a systematic review

Predictors of relapse after acute-phase cognitive behavioural therapy for anxiety disorders, post-traumatic stress disorder, and obsessive-compulsive disorder: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility

2019 PROSPERO

12. Comparing escitaloipram with sertraline for obsessive and compulsive symptoms in patients with obsessive compulsive disorder: A comparative double blind clinical trial. (PubMed)

Comparing escitaloipram with sertraline for obsessive and compulsive symptoms in patients with obsessive compulsive disorder: A comparative double blind clinical trial. Escitalopram has some unique features among selective serotonin reuptake inhibitors. The aim of this survey is to compare the efficacy of escitalopram with sertraline on obsessive and compulsive symptoms in patients with Obsessive Compulsive Disorder (OCD).In this 12-week double blind controlled randomized clinical trial, 57 (...) patients with OCD were randomly allocated to receive escitalopram or sertraline. Yale Brown obsessive compulsive behavior scale (YBOCS) was used to assess the outcomes. Adverse effects were also recorded.41 patients (20 in the escitalopram group and 21 in the sertraline group) completed the trial. In the escitalopram group 15 (70%) patients and in the sertraline group 16 (76.19%) patients showed more than 34% decrease in mean YBOCS score at the end of the trial (P=0.531). The two groups revealed

2018 Asian Journal of Psychiatry

13. Dissecting the Yale-Brown Obsessive-Compulsive Scale severity scale to understand the routes for symptomatic improvement in obsessive-compulsive disorder. (PubMed)

Dissecting the Yale-Brown Obsessive-Compulsive Scale severity scale to understand the routes for symptomatic improvement in obsessive-compulsive disorder. We aimed to investigate which items of the Yale-Brown Obsessive-Compulsive Severity Scale best discriminate the reduction in total scores in obsessive-compulsive disorder patients after 4 and 12 weeks of pharmacological treatment. Data from 112 obsessive-compulsive disorder patients who received fluoxetine (⩽80 mg/day) for 12 weeks were (...) included. Improvement indices were built for each Yale-Brown Obsessive-Compulsive Severity Scale item at two timeframes: from baseline to week 4 and from baseline to week 12. Indices for each item were correlated with the total scores for obsessions and compulsions and then ranked by correlation coefficient. A correlation coefficient ⩾0.7 was used to identify items that contributed significantly to reducing obsessive-compulsive disorder severity. At week 4, the distress items reached the threshold

2018 Journal of psychopharmacology (Oxford, England)

14. The Relationship between Obsessive Compulsive Personality and Obsessive Compulsive Disorder Treatment Outcomes: Predictive Utility and Clinically Significant Change. (PubMed)

The Relationship between Obsessive Compulsive Personality and Obsessive Compulsive Disorder Treatment Outcomes: Predictive Utility and Clinically Significant Change. The evidence regarding whether co-morbid obsessive compulsive personality disorder (OCPD) is associated with treatment outcomes in obsessive compulsive disorder (OCD) is mixed, with some research indicating that OCPD is associated with poorer response, and some showing that it is associated with improved response.We sought (...) to explore the role of OCPD diagnosis and the personality domain of conscientiousness on treatment outcomes for exposure and response prevention for OCD.The impact of co-morbid OCPD and conscientiousness on treatment outcomes was examined in a clinical sample of 46 participants with OCD.OCPD diagnosis and scores on conscientiousness were not associated with poorer post-treatment OCD severity, as indexed by Yale-Brown Obsessive Compulsive Scale (YBOCS) scores, although the relative sample size of OCPD

2018 Behavioural and cognitive psychotherapy

15. The Effect of Atorvastatin on Obsessive-compulsive Symptoms of Refractory Obsessive-compulsive Disorder (Add-on Therapy) (PubMed)

The Effect of Atorvastatin on Obsessive-compulsive Symptoms of Refractory Obsessive-compulsive Disorder (Add-on Therapy) Considering the effect of statins on the regulation of dopamine neurotransmitters and glutamates and importance of the treatment of obsessive-compulsive disorder (OCD) due to its relatively high prevalence and disability of available drugs in treatment of many patients, we came to the point to examine effectiveness of statins in patients with OCD.This study is a double-blind (...) randomized clinical trial, which is done in OCD clinic of Isfahan Shariati in 2014 for 1 year. The target population consists of 64 patients with OCD; one group is given a daily 40 mg atorvastatin tablets and the other group receives placebo. At baseline, 4- and 8-week severities of obsessive-compulsive symptoms are measured using Yale-Brown scale and compared in the two groups.The study results show a statistically significant difference between the two groups of intervention and control (P < 0.001

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2018 Advanced biomedical research

16. Criterion Validity of the Yale-Brown Obsessive-Compulsive Scale Second Edition for Diagnosis of Obsessive-Compulsive Disorder in Adults (PubMed)

Criterion Validity of the Yale-Brown Obsessive-Compulsive Scale Second Edition for Diagnosis of Obsessive-Compulsive Disorder in Adults Background: While the Yale-Brown Obsessive-Compulsive Scale Second Edition (Y-BOCS-II) is the gold-standard for measurement of obsessive-compulsive (OC) symptom severity, its factor structure is still a matter of debate and, most importantly, criterion validity for diagnosis of OC disorder (OCD) has not been tested. This study aimed to clarify factor structure (...) patients and the 18 patients with other diagnoses, PY-BOCS-II was applied by clinicians blinded to diagnosis. Results: PY-BOCS-II had excellent internal consistency (Cronbach's α = 0.96) and very good test-retest reliability (Pearson's r = 0.94). Exploratory factor analysis revealed a two-factor structure with loadings consistent with the Obsessions and Compulsions subscales, and there was good to acceptable convergent and divergent validity. Importantly, the area under the curve (AUC) of the receiver

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2018 Frontiers in Psychiatry

17. Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group. (PubMed)

Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group. Brain imaging studies of structural abnormalities in OCD have yielded inconsistent results, partly because of limited statistical power, clinical heterogeneity, and methodological differences. The authors conducted meta- and mega-analyses comprising the largest study of cortical morphometry in OCD ever undertaken.T1-weighted MRI scans

2017 American Journal of Psychiatry

18. Efficacy and Safety of Deep Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder: A Prospective Multicenter Randomized Double-Blind Placebo-Controlled Trial

Efficacy and Safety of Deep Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder: A Prospective Multicenter Randomized Double-Blind Placebo-Controlled Trial Obsessive-compulsive disorder (OCD) is a chronic and disabling condition that often responds unsatisfactorily to pharmacological and psychological treatments. Converging evidence suggests a dysfunction of the cortical-striatal-thalamic-cortical circuit in OCD, and a previous feasibility study indicated beneficial effects (...) Obsessive Compulsive Scale (YBOCS), and the primary efficacy endpoint was the change in score from baseline to posttreatment assessment. Additional measures were response rates (defined as a reduction of ≥30% in YBOCS score) at the posttreatment assessment and after another month of follow-up.Eighty-nine percent of the active treatment group and 96% of the sham treatment group completed the study. The reduction in YBOCS score among patients who received active dTMS treatment was significantly greater

2019 EvidenceUpdates

19. Comparative effectiveness of neuroablation and deep brain stimulation for treatment-resistant obsessive-compulsive disorder: a meta-analytic study

Comparative effectiveness of neuroablation and deep brain stimulation for treatment-resistant obsessive-compulsive disorder: a meta-analytic study The safety and efficacy of neuroablation (ABL) and deep brain stimulation (DBS) for treatment refractory obsessive-compulsive disorder (OCD) has not been examined. This study sought to generate a definitive comparative effectiveness model of these therapies.A EMBASE/PubMed search of English-language, peer-reviewed articles reporting ABL and DBS (...) for OCD was performed in January 2018. Change in quality of life (QOL) was quantified based on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the impact of complications on QOL was assessed. Mean response of Y-BOCS was determined using random-effects, inverse-variance weighted meta-analysis of observational data.Across 56 studies, totalling 681 cases (367 ABL; 314 DBS), ABL exhibited greater overall utility than DBS. Pooled ability to reduce Y-BOCS scores was 50.4% (±22.7%) for ABL

2019 EvidenceUpdates

20. Comparison of the Association Between Goal-Directed Planning and Self-reported Compulsivity vs Obsessive-Compulsive Disorder Diagnosis. (PubMed)

Comparison of the Association Between Goal-Directed Planning and Self-reported Compulsivity vs Obsessive-Compulsive Disorder Diagnosis. Dimensional definitions of transdiagnostic mental health problems have been suggested as an alternative to categorical diagnoses, having the advantage of capturing heterogeneity within diagnostic categories and similarity across them and bridging more naturally psychological and neural substrates.To examine whether a self-reported compulsivity dimension has (...) a stronger association with goal-directed and related higher-order cognitive deficits compared with a diagnosis of obsessive-compulsive disorder (OCD).In this cross-sectional study, patients with OCD and/or generalized anxiety disorder (GAD) from across the United States completed a telephone-based diagnostic interview by a trained rater, internet-based cognitive testing, and self-reported clinical assessments from October 8, 2015, to October 1, 2017. Follow-up data were collected to test

2019 JAMA psychiatry (Chicago, Ill.)

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