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Observed Affect

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161. Factors affecting dislocation after bipolar hemiarthroplasty in patients with femoral neck fracture. (Abstract)

Factors affecting dislocation after bipolar hemiarthroplasty in patients with femoral neck fracture. This study aimed to investigate the anatomic risk factors associated with dislocation following bipolar hemiarthroplasty for the treatment of femoral neck fracture.We retrospectively reviewed 208 consecutive patients (133 women, 75 men) with femoral neck fractures who were treated with bipolar hemiarthroplasty between 2015 and 2018. A comparative analysis was performed between dislocation (n (...)  = 18) and non-dislocation (n = 190) groups in terms of patient demographics, surgical and pelvic morphologic factors, and clinical outcomes, including postoperative Harris and modified Harris hip scores. Independent risk factors affecting dislocation were also evaluated.The mean follow-up period was 30.8 ± 2.0 (range, 12-48) months. The mean age was 79.2 ± 7.4 (range, 71-94) years. The dislocation rate was 8.6% (18/208), and the mean dislocation time after operation was 2.0 ± 1.1 (range, 1-4

2020 Injury

162. Does three-dimensional surgery affect recurrence patterns in patients with gastric cancer after laparoscopic R0 gastrectomy? Results from a 3-year follow-up phase III trial. (Abstract)

patients were recruited for a phase III clinical trial (NCT02327481), which compared the short-term outcomes between the 2D and 3D groups. The long-term efficacy including recurrence patterns was compared between the 2D and 3D groups in this retrospective study. Multivariate analyses were performed to determine whether 3D-LG affects the recurrence patterns.Ultimately, 401 patients were analyzed (197 in the 2D-LG group and 204 in the 3D-LG group), and no differences were observed (...) Does three-dimensional surgery affect recurrence patterns in patients with gastric cancer after laparoscopic R0 gastrectomy? Results from a 3-year follow-up phase III trial. Numerous studies have shown that the short-term efficacy of three-dimensional (3D) laparoscopic radical gastrectomy (LG) is comparable to that of two-dimensional (2D)-LG. Whether 3D-LG affects the recurrence patterns of gastric cancer (GC) patients has not been investigated.From January 2015 to April 2016, a total of 419

2020 Surgical endoscopy

163. Superior Canal Dehiscence Similarly Affects Cochlear Pressures in Temporal Bones and Audiograms in Patients. (Abstract)

Superior Canal Dehiscence Similarly Affects Cochlear Pressures in Temporal Bones and Audiograms in Patients. The diagnosis of superior canal dehiscence (SCD) is challenging and audiograms play an important role in raising clinical suspicion of SCD. The typical audiometric finding in SCD is the combination of increased air conduction (AC) thresholds and decreased bone conduction thresholds at low frequencies. However, this pattern is not always apparent in audiograms of patients with SCD (...) confirmed). To achieve this, we used the unaffected ear to estimate the baseline hearing function for each patient, and determined the influence of SCD by referencing AC hearing thresholds of the SCD-affected ear with the unaffected contralateral ear.PDiff measured in temporal bones (n = 6) and AC thresholds in patients (n = 53) exhibited a similar pattern of SCD-related change. With decreasing frequency, SCD caused a progressive decrease in PDiff at low frequencies for all temporal bones

2020 Ear and hearing

164. Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children. (Abstract)

Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children. Osteoporosis is a major public health burden with significant economic costs. However, the correlates of bone health in Hispanic children are understudied.We aimed to identify genetic variants associated with bone mineral density (BMD) and bone mineral content (BMC) at multiple skeletal sites in Hispanic children.We conducted a cross-sectional genome-wide linkage analysis (...) , genome-wide and exome-wide association analysis of BMD and BMC. The Viva La Familia Study is a family-based cohort with a total of 1030 Hispanic children (4-19 years old at baseline) conducted in Houston, TX. BMD and BMC were measured by Dual-energy X-ray absorptiometry.Significant heritability were observed for BMC and BMD at multiple skeletal sites ranging between 44 and 68% (P < 2.8 × 10-9). Significant evidence for linkage was found for BMD of pelvis and left leg on chromosome 7p14, lumbar spine

2020 Bone

165. Chemokine signaling mediated monocyte infiltration affects anxiety-like behavior following blast injury. (Abstract)

Chemokine signaling mediated monocyte infiltration affects anxiety-like behavior following blast injury. The activation of resident microglia and infiltrated monocytes are known potent mediators of chronic neuroinflammation following traumatic brain injury (TBI). In this study, we use a mouse model of blast-induced TBI (bTBI) to investigate whether microglia and monocytes contribute to the neuroinflammatory and behavioral consequences of bTBI. Eight-ten week old mice were subject to moderate (...) TBI (180 kPa) in a shock tube. Using double transgenic CCR2RFP/+: CX3CR1GFP/+ mice, we were able to note that in addition to resident Cx3CR1+ microglia, infiltrating CCR2+ monocytes also contributed to the expanding macrophage population that was observed after bTBI. The microglia activation and monocyte infiltration occurred as early as 4 h and lasted up to 30d after blast exposure, suggesting chronic inflammation. The infiltration of monocytes may be partly mediated by chemokine CCL2-CCR2

2020 Brain, behavior, and immunity

166. Adolescent dietary manipulations differentially affect gut microbiota composition and amygdala neuroimmune gene expression in male mice in adulthood. (Abstract)

Adolescent dietary manipulations differentially affect gut microbiota composition and amygdala neuroimmune gene expression in male mice in adulthood. Adolescence is a critical developmental period that is characterised by growth spurts and specific neurobiological, neuroimmune and behavioural changes. In tandem the gut microbiota, which is a key player in the regulation of health and disease, is shaped during this time period. Diet is one of the most important regulators of microbiota (...) and the expression of genes related to neuroinflammation or neurotransmission. Interestingly, changes in myelination-related gene expression in the prefrontal cortex following high fat diet exposure were also observed. However, these effects did not translate into overt behavioural changes in adulthood. Taken together, these data highlight the importance of diet-microbiota interactions during the adolescent period in shaping specific outputs of the microbiota-gut-brain axis in later life.Copyright © 2020

2020 Brain, behavior, and immunity

167. Prolonged treatment with the synthetic glucocorticoid methylprednisolone affects adrenal steroidogenic function and response to inflammatory stress in the rat. Full Text available with Trip Pro

are restored, yet basal levels of corticosterone, as well as most of the key steroidogenic genes and their regulators, remain down regulated. We also show that, although 5-days treatment with methylprednisolone reduces the corticosterone response to LPS, an increase in intra-adrenal pro-inflammatory cytokine gene expression was observed. Our data suggests that the steroidogenic pathway is directly affected by synthetic glucocorticoid treatment in the long-term, presumably via a mechanism involving (...) Prolonged treatment with the synthetic glucocorticoid methylprednisolone affects adrenal steroidogenic function and response to inflammatory stress in the rat. Synthetic glucocorticoids are widely prescribed for the treatment of numerous inflammatory and autoimmune diseases and they can also affect the way the adrenal gland produces endogenous glucocorticoids. Indeed, patients undergoing synthetic glucocorticoid treatment can develop adrenal insufficiency, a condition characterised by reduced

2020 Brain, behavior, and immunity

168. Evaluation of factors affecting the occurrence of second atypical fracture after bone union of the first atypical fracture. (Abstract)

Evaluation of factors affecting the occurrence of second atypical fracture after bone union of the first atypical fracture. Teriparatide is sometimes used in the treatment of atypical femoral fracture (AFF). Even if bone union is achieved, orthopedic physicians must consider the risk of relapse. This study aimed to investigate the factors affecting AFF recurrence, and to determine the appropriate treatment for osteoporosis after bone union.One hundred thirty-one consecutive AFFs in 113 Japanese (...) patients were included. Eleven patients had AFF in the unaffected limb (9 patients) after the first AFF or re-fracture at the original fracture site (2 patients) after bone union of the first AFF was confirmed. We divided all patients into two groups: the second fracture group (22 AFFs in 11 patients) and non-second fracture group (109 AFFs in 102 patients). We compared clinical information between the 2 groups and investigated the factors affecting AFF recurrence using the Student t-, Welch t

2020 Bone

169. Schizotypy and psychopathic tendencies interactively improve misattribution of affect in boys with conduct problems. Full Text available with Trip Pro

measures, we observed better performance in judging neutral mental states. The preservation of affective ToM in adolescents who show elevations in psychopathic tendencies and schizotypal PD may enable them to manipulate and extort their victims for personal gain. Our results emphasize the need to consider comorbidity in clinical case formulation when working with adolescents with conduct problems and psychopathic tendencies. More broadly, our results also suggest that the pattern of social cognitive (...) Schizotypy and psychopathic tendencies interactively improve misattribution of affect in boys with conduct problems. Psychopathic tendencies are associated with difficulties in affective theory of mind (ToM), that is, in recognizing others affective mental states. In clinical and non-clinical adult samples, it has been shown that where psychopathic tendencies co-occur with schizophrenia spectrum disorders, the impairing effects of psychopathic tendencies on ToM are attenuated. These effects

2020 European child & adolescent psychiatry

170. Stressful experiences affect the course of co-occurring obsessive-compulsive and psychotic symptoms: A focus on within-subject processes. (Abstract)

Stressful experiences affect the course of co-occurring obsessive-compulsive and psychotic symptoms: A focus on within-subject processes. Obsessive-compulsive symptoms (OCS) frequently occur in patients with psychotic disorders and are associated with higher burden and poorer prognosis. This study prospectively investigated the effect of stressful experiences on the severity of OCS and co-occurring psychotic and affective symptoms, with a focus on within-subject processes.Monthly assessments (...) over 6 months in patients with a psychotic disorder (n = 56) and unaffected siblings (n = 49) resulted in 309 and 277 observations, respectively. Linear mixed-effects models investigated the disaggregated effects of within-subject changes and between-subject differences in stressful events on OCS, positive, negative and depressive symptoms. Subsequently, moderating effects of coping strategies and dysfunctional metacognitive beliefs were assessed. Mediation analyses investigated direct and indirect

2020 Schizophrenia Research

171. Molecular and clinical studies in 107 Noonan syndrome affected individuals with PTPN11 mutations. Full Text available with Trip Pro

variants in this series were in exon 8 (c.922A > G, c.923A > G), observed in 22 of the affected. Congenital cardiac anomalies were present in 84% of the mutation-positive cohort, the majority being defects in the right side of the heart. The most common facial features were downward-slanting palpebral fissures, hypertelorism and low-set posteriorly rotated ears. Other clinical features included short stature (40%), pectus excavatum (54%) and, in males, unilateral or bilateral cryptorchidism (44 (...) %).The clinical features and mutational spectrum observed in our cohort are similar to those reported in other large studies done worldwide. This is the largest case series of NS-affected individuals with PTPN11 mutations described till date from India.

2020 BMC Medical Genetics

172. Could orthodontic fixed appliances and excess weight affect gingival health in adolescents? (Abstract)

Could orthodontic fixed appliances and excess weight affect gingival health in adolescents? The aim of this study was to evaluate the impact of being overweight or obese while wearing orthodontic fixed appliances on the prevalence of gingivitis in adolescents.A total of 334 adolescents, aged between 12 and 18 years, were recruited from 3 public schools in Cuiabá, Brazil. Participants were divided in dichotomized categories of body mass index (BMI) (under and normal weight or overweight (...) . In addition, excess weight seemed to be 2 times more relevant in predicting gingivitis than orthodontic fixed appliance usage. A strong positive correlation was observed between BMI (%) variation and gingival index (ρ = 0.97, P <0.001).Orthodontic fixed appliance usage and excess weight were associated with increased gingivitis in adolescents; BMI (%) variation was the most significant predictor of gingival inflammation.Copyright © 2019 American Association of Orthodontists. Published by Elsevier Inc. All

2020 American journal of orthodontics and dentofacial orthopedics

173. Baseline Age and Mean Deviation Affect the Rate of Glaucomatous Vision Loss. (Abstract)

Baseline Age and Mean Deviation Affect the Rate of Glaucomatous Vision Loss. The purpose of this study was to assess the relationship between the rate of the glaucomatous visual field (VF) worsening and baseline age and baseline VF mean deviation (MD).This study was a retrospective, multisite cohort.A total of 84,711 reliable Swedish Interactive Thresholding Algorithm 24-2 VF tests from 8167 eyes from 5644 patients with ≥6 VF tests, ≥5 years of follow-up, baseline age 18 years or above (...) -progressing group by a factor of 1.033, and each unit increase in baseline MD (less severe visual loss) decreased the odds by a factor of 0.8821. The mean pointwise TDR ranged from -0.21 to -0.55 dB/y, with the most rapid pointwise progression observed in the nasal and paracentral regions of the field.Older age and worse MD at baseline are associated with more rapid VF progression in this large dataset. The effect of age on MDR is influenced by baseline MD severity, supporting the importance of early

2020 Journal of Glaucoma

174. Hypoalbuminemia after pancreaticoduodenectomy does not predict or affect short-term postoperative prognosis. Full Text available with Trip Pro

Hypoalbuminemia after pancreaticoduodenectomy does not predict or affect short-term postoperative prognosis. Hypoalbuminemia (HA) is a risk factor for the complications following pancreaticoduodenectomy (PD). This study aimed to explore the factors that affect HA following PD and evaluate the influence of HA on the short-term postoperative prognosis.Total 163 patients who underwent PD and met inclusion criteria were subdivided into two groups according to the status of HA. The relationships (...) grade, postoperative intraperitoneal hemorrhage and pancreatic fistula. No significant differences were observed between the complications and30-day mortality rates with and without postoperative HA.HA after PD should not be considered as an indicator but rather a result of poor prognosis. WBCs, especially neutrophils, are involved in reducing postoperative ALB level. Infusion of exogenous ALB to maintain ALB > 30 g/L could not improve clinical outcomes.

2020 BMC Surgery

175. Activation of D1 receptors affects human reactivity and flexibility to valued cues. Full Text available with Trip Pro

Activation of D1 receptors affects human reactivity and flexibility to valued cues. Reward-predicting cues motivate goal-directed behavior, but in unstable environments humans must also be able to flexibly update cue-reward associations. While the capacity of reward cues to trigger motivation ('reactivity') as well as flexibility in cue-reward associations have been linked to the neurotransmitter dopamine in humans, the specific contribution of the dopamine D1 receptor family to these behaviors (...) remained elusive. To fill this gap, we conducted a randomized, placebo-controlled, double-blind pharmacological study testing the impact of three different doses of a novel D1 agonist (relative to placebo) on reactivity to reward-predicting cues (Pavlovian-to-instrumental transfer) and flexibility of cue-outcome associations (reversal learning). We observed that the impact of the D1 agonist crucially depended on baseline working memory functioning, which has been identified as a proxy for baseline

2020 Neuropsychopharmacology

176. A prospective evaluation of factors affecting occlusal stability of Class II correction with Twin-block followed by fixed appliances. (Abstract)

A prospective evaluation of factors affecting occlusal stability of Class II correction with Twin-block followed by fixed appliances. Modified Twin-block therapy followed by fixed appliances (TBFA) is a standard treatment modality in Class II malocclusion; however, there is little information regarding the stability of this approach. We aimed to assess the stability of Class II correction with TBFA and to evaluate factors that may affect stability.A prospective evaluation involving convenience (...) discrepancy, and change in overjet during treatment.Mean overjet reduction of 6.22 mm arose during treatment, with the canine and molar relationships improving by 3.34 mm and 2.67 mm, respectively. In the 12 months posttreatment, a relapse of 0.67 mm and 0.06 mm in overjet and molar relationship, respectively, was observed, with 25% of subjects having overjet relapse of >1 mm. There is weak evidence that the treatment-induced change in overjet is linked with overjet relapse (P = 0.05; odds ratio, 0.67; 95

2020 American journal of orthodontics and dentofacial orthopedics

177. Maternal smoking during pregnancy affects adult onset of asthma in offspring: a follow up from birth to age 46 years. (Abstract)

Maternal smoking during pregnancy affects adult onset of asthma in offspring: a follow up from birth to age 46 years. Environmental tobacco smoke (ETS) exposure increases asthma risk in children. There is limited knowledge of prenatal ETS for adult-onset asthma.To determine the association between prenatal ETS and adult onset asthma.The questionnaire and clinical data of 5200 people, free of physician-diagnosed asthma by 31 years of age, who were included in the Northern Finland Birth Cohort (...) 0.10).Maternal smoking during pregnancy is associated with the cumulative incidence of asthma in offspring between the ages of 31 and 46 years. The association was accentuated in offspring who at age 31, reported having past respiratory problems and/or who had haplotype rs11702779-AA. A reduction in FEV1/FVC ratio was also observed at age 31 years in offspring with gestational smoke exposure. These results could reflect the early vulnerability of offspring's airways to ETS and its putative long

2020 European Respiratory Journal

178. Does urethral length affect continence outcomes following robot assisted laparoscopic radical prostatectomy (RALP)? Full Text available with Trip Pro

Does urethral length affect continence outcomes following robot assisted laparoscopic radical prostatectomy (RALP)? Post-operative urinary incontinence is a significant concern for patients choosing to undergo a radical prostatectomy (RP) for treatment of prostate cancer. The aim of our study was to determine the effect of pre-operative MUL on 12 month continence outcomes in men having robot-assisted laparoscopic prostatectomy (RALP).We use the South Australian Prostate Cancer Clinical Outcomes (...) ) was used to measure continence outcomes. Continence was defined as 100/100 in the EPIC-26 Urinary Continence domain score.The observed median MUL in this study was 14.6 mm. There was no association between MUL and baseline continence. MUL was associated with continence at 12 months post RALP (OR 1.13, 95% CI 1.03-1.21, p = 0.0098). In men who were continent before surgery, MUL was associated with return to continence at 12 months after RALP (OR 1.15, 1.05-1.28, p = 0.006). MUL was also associated

2020 BMC Urology

179. A deep learning image-based intrinsic molecular subtype classifier of breast tumors reveals tumor heterogeneity that may affect survival. Full Text available with Trip Pro

A deep learning image-based intrinsic molecular subtype classifier of breast tumors reveals tumor heterogeneity that may affect survival. Breast cancer intrinsic molecular subtype (IMS) as classified by the expression-based PAM50 assay is considered a strong prognostic feature, even when controlled for by standard clinicopathological features such as age, grade, and nodal status, yet the molecular testing required to elucidate these subtypes is not routinely performed. Furthermore, when (...) such bulk assays as RNA sequencing are performed, intratumoral heterogeneity that may affect prognosis and therapeutic decision-making can be missed.As a more facile and readily available method for determining IMS in breast cancer, we developed a deep learning approach for approximating PAM50 intrinsic subtyping using only whole-slide images of H&E-stained breast biopsy tissue sections. This algorithm was trained on images from 443 tumors that had previously undergone PAM50 subtyping to classify small

2020 Breast cancer research : BCR

180. Minor bleeding affects the level of knowledge in patients with atrial fibrillation on oral anticoagulant therapy. (Abstract)

Minor bleeding affects the level of knowledge in patients with atrial fibrillation on oral anticoagulant therapy. Anticoagulant therapy in patients with atrial fibrillation (AF) increases the risk of minor bleeding, which is mostly accepted by patients. We aimed to assess whether continuation of anticoagulation despite minor bleeding is associated with a higher level of knowledge on AF and anticoagulation.In 1525 patients with AF on oral anticoagulation who completed the Jessa AF Knowledge (...) Questionnaire (JAKQ) (median age: 72 years [range, 65-79 years]; men: 54.6%), persistent self-reported minor bleeding was recorded. Minor bleeding was observed in 567 patients (37.2%) including 224 patients (39.5%) on vitamin K antagonists (VKAs) and 343 (60.5%) on non-vitamin K antagonist oral anticoagulants (NOACs). The risk of minor bleeding was lower among patients on NOACs than on VKAs (33.5% vs 44.6%; P < .0001). Multiple logistic regression showed that minor bleeding was associated with the use

2020 International journal of clinical practice

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