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Observed Affect

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101. A prospective, longitudinal, observational cohort study examining how glaucoma affects quality of life and visually-related function over 4 years: design and methodology. (Full text)

A prospective, longitudinal, observational cohort study examining how glaucoma affects quality of life and visually-related function over 4 years: design and methodology. The aim of this study is to summarize the design and methodology of a prospective, longitudinal, observational cohort study to investigate how glaucoma affects patients' quality of life and visually-related function over a 4-year period.One hundred sixty-one (161) subjects were enrolled in this ongoing study. Patients between

2015 BMC Ophthalmology PubMed abstract

102. Observational Longitudinal Study in Children Affected by Idiopathic Growth Hormone Deficiency (GHD)

Observational Longitudinal Study in Children Affected by Idiopathic Growth Hormone Deficiency (GHD) Observational Longitudinal Study in Children Affected by Idiopathic Growth Hormone Deficiency (GHD) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Observational Longitudinal Study in Children Affected by Idiopathic Growth Hormone Deficiency (GHD) (GHD) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02507245 Recruitment Status : Completed First Posted : July 23, 2015 Last Update Posted : July 23

2015 Clinical Trials

103. Abdominal circumference but not the degree of lumbar flexion affects the accuracy of lumbar interspace identification by Tuffier's line palpation method: an observational study. (Full text)

Abdominal circumference but not the degree of lumbar flexion affects the accuracy of lumbar interspace identification by Tuffier's line palpation method: an observational study. Lumbar puncture for spinal or epidural anesthesia is commonly performed by palpating bony landmarks, but identification of the desired intervertebral level is often inaccurate. It is unclear whether such inaccuracy is related to patient factors, such as body mass index and degree of lumbar flexion. We hypothesized (...) markings.Patients with larger abdominal circumferences (mean (SD), 94.0(12.1) cm), higher body mass indices (25.9(3.9) kg/m(2)), and aged between 50 and 70 years old had lumbar interspaces that were higher than the presumed level; patients with smaller abdominal circumferences (82.8(13.5) cm) and lower body mass indices (21.6(4.1) kg/m(2)) had intervertebral levels that were lower than the presumed level. Cobb's angle, indicating the degree of lumbar flexion, did not affect the accuracy obtained.Patients

2015 BMC Anesthesiology PubMed abstract

104. Factors affecting response to proton pump inhibitor therapy in patients with gastroesophageal reflux disease: a multicenter prospective observational study. (Abstract)

Factors affecting response to proton pump inhibitor therapy in patients with gastroesophageal reflux disease: a multicenter prospective observational study. Proton pump inhibitor (PPI) therapy, the first-line treatment for gastroesophageal reflux disease (GERD), is not always effective. This study aimed to examine the effect of pretreatment patient characteristics on response to PPI therapy.Japanese outpatients with symptomatic GERD scheduled to receive endoscopy and PPI therapy were enrolled (...) in this multicenter prospective observational study. The patients' characteristics, including GERD and dyspeptic symptoms, anxiety, depression, and quality of life, were assessed using questionnaires before and 2 and 4 weeks after the start of PPI therapy. Factors affecting therapeutic response were examined by simple and multiple regression analyses using three patient-reported outcome measures as objective variables.Data from 182 patients were analyzed. In multiple regression analysis using the residual symptom

2015 Journal of gastroenterology

105. Statin withdrawal beyond acute phase affected outcome of thrombolytic stroke patients: an observational retrospective study. (Full text)

Statin withdrawal beyond acute phase affected outcome of thrombolytic stroke patients: an observational retrospective study. Statin withdrawal is associated with deleterious outcome on stroke patients. Whether risk changes over time, depends on concomitant treatment of intravenous thrombolysis, or both remains to be clarified. We assessed the influence of statin withdrawal within 3 weeks while initiated in acute phase (72 hours) among patients receiving intravenous thrombolysis.This (...) was a monocentered retrospective observational study enrolling intravenous thrombolytic stroke patients from June 2009 to May 2014. Consecutive patients were distinguished into 3 groups according to the initiation and withdrawal of statin: the reference group (not received statin in 72 hours after stroke onset); the continued group (initiated statin therapy in 72 hours and continued for at least 3 weeks); the withdrawal group (initiated statin in 72 hours and discontinued within 3 weeks). All reasons

2015 Medicine PubMed abstract

106. Factors that Affect Nonurgent Emergency Department Visits in a Publicly Insured Pediatric Population: An Observational Study. (Abstract)

Factors that Affect Nonurgent Emergency Department Visits in a Publicly Insured Pediatric Population: An Observational Study. Publicly insured children have high rates of nonurgent emergency department visits (LAVs). The factors that drive consumption of these services are unknown.Demographics, emergency department visits, hospitalizations, missed preventative care appointments, zip code, and asthma status as factors for LAVs were determined by univariate, multivariate, and classification

2015 Journal for Healthcare Quality

107. SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing (Full text)

SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing SIRT1 is likely to play a role in the extension in healthspan induced by dietary restriction. Actions of SIRT1 are pleiotropic, and effects on healthspan may include effects on DNA methylation. Polycomb group protein target genes (PCGTs) are suppressed by epigenetic mechanisms in stem cells, partly through the actions of the polycomb repressive complexes (PRCs), and have (...) been shown previously to correspond with loci particularly susceptible to age-related changes in DNA methylation. We hypothesised that SIRT1 would affect DNA methylation particularly at PCGTs. To map the sites in the genome where SIRT1 affects DNA methylation, we altered SIRT1 expression in human intestinal (Caco-2) and vascular endothelial (HuVEC) cells by transient transfection with an expression construct or with siRNA. DNA was enriched for the methylated fraction then sequenced (HuVEC

2015 Human Genomics PubMed abstract

108. The role of low-level image features in the affective categorization of rapidly presented scenes. (Full text)

are also exploited by the human visual system. Subsequently, we tested observers' rapid classification of affective and neutral naturalistic scenes, presented briefly (~33.3 ms) and backward masked with synthetic textures. We tested categorization accuracy across three distinct experimental conditions, using: (i) original images, (ii) images having their amplitude spectra swapped within a single affective image category (e.g., an aversive image whose amplitude spectrum has been swapped with another (...) The role of low-level image features in the affective categorization of rapidly presented scenes. It remains unclear how the visual system is able to extract affective content from complex scenes even with extremely brief (< 100 millisecond) exposures. One possibility, suggested by findings in machine vision, is that low-level features such as unlocalized, two-dimensional (2-D) Fourier spectra can be diagnostic of scene content. To determine whether Fourier image amplitude carries any

2019 PLoS ONE PubMed abstract

109. Participation-performance tension and gender affect recreational sports clubs' engagement with children and young people with diverse backgrounds and abilities. (Full text)

is understood, experienced and managed in junior sport. The study combined in-depth interviews (n = 101), surveys (n = 450) and observations over a three-year period. The results revealed that a focus on performance and competitiveness negatively affected junior sports clubs' commitment to diversity and inclusive participation. Gender and a range of attitudes about diversity were also strongly related. On average, we found that those who identified as men were more likely to support a pro-performance stance (...) Participation-performance tension and gender affect recreational sports clubs' engagement with children and young people with diverse backgrounds and abilities. Sport participation has been shown to be associated with health and social benefits. However, there are persisting inequities and barriers to sport participation that can prevent children and young people with diverse backgrounds and abilities from accessing these benefits. This mixed methods study investigated how diversity

2019 PLoS ONE PubMed abstract

110. Maternal protein restriction during perinatal life affects lung mechanics and the surfactant system during early postnatal life in female rats. (Full text)

Maternal protein restriction during perinatal life affects lung mechanics and the surfactant system during early postnatal life in female rats. Limited information is available on how fetal growth retardation (FGR) affects the lung in the neonatal period in males and females. This led us to test the hypothesis that FGR alters lung mechanics and the surfactant system during the neonatal period. To test this hypothesis a model of FGR was utilized in which pregnant rat dams were fed a low protein (...) and higher tissue elastance which was observed in FGR female offspring at day 21 compared to control offspring. In addition, female LP offspring exhibited lower surfactant pool sizes at postnatal day 1compared to controls. These changes were not observed in the male offspring. It is concluded that FGR has a different impact on pulmonary function and on surfactant in female, as compared to male, offspring.

2019 PLoS ONE PubMed abstract

111. Transgenic Cry1Ac cotton does not affect the development and fecundity of Chrysoperla carnea. (Full text)

Transgenic Cry1Ac cotton does not affect the development and fecundity of Chrysoperla carnea. The development and fecundity of the predator Chrysoperla carnea Stephens (Neuroptera: Chrysopidae) were assessed by feeding Aphis gossypii Glover (Hemiptera: Aphididae) that had been reared on transgenic Bacillus thuringiensis (Bt) cotton SGK321 and a non-Bt cotton control (SY321) for two successive generations. We found no significant differences in the developmental stage duration, stage survival (...) , or egg hatch rate between C. carnea fed A. gossypii reared on the Bt and non-Bt cotton. The fecundity per female over a 25-day observation period was very similar between treatments; for C. carnea fed A. gossypii reared on SGK321 vs. SY321, the amount of eggs laid was not significantly different in both generations. Furthermore, a population dynamics of A. gossypii and lacewing (mainly C. carnea) were highly similar in the SGK321 and SY321 treatments during 2016-2017. These results suggest that Bt

2019 PLoS ONE PubMed abstract

112. Feather colour affects the aggressive behaviour of chickens with the same genotype on the dominant white (I) locus. (Full text)

Feather colour affects the aggressive behaviour of chickens with the same genotype on the dominant white (I) locus. Aggression in chickens is a serious economic and animal welfare issue in poultry farming. Pigmentation traits have been documented to be associated with animal behaviour. Chicken pecking behaviour has been found to be related to feather colour, with premelanosome protein 17 (PMEL17) being one of the candidate genes. In the present study, we performed a genotypic and phenotypic (...) to determine whether the feather colour alone affected the behaviour, given that the genetic background should be the same except for feather colour. The aggressiveness was recorded 5 days after sexual maturity at 26 weeks. Generally, white plumage hens showed significantly higher aggressiveness compared to the red ones in chasing, attacking, pecking, and threatening behaviour traits. We assessed three candidate feather colour genes-PMEL17, solute carrier family 45 member 2 (SLC45A2), and SRY-box 10 (SOX10

2019 PLoS ONE PubMed abstract

113. Evaluation of heart rate variability and behavior of electrocardiographic parameters in dogs affected by chronic Monocytic Ehrlichiosis. (Full text)

Evaluation of heart rate variability and behavior of electrocardiographic parameters in dogs affected by chronic Monocytic Ehrlichiosis. Canine Monocytic Ehrlichiosis (CME) is a systemic disease prevalent in the entire world caused by the obligate intracellular bacteria Ehrlichia canis. The occurrence of myocarditis with a high prevalence of arrhythmias in dogs affected by this disease in the cytopenic phase has already been proven. This study aims to evaluate the concentrations of CK MB, cTnI (...) and NT-proBNP in dogs affected by Ehrlichia canis in the chronic phase since the intense stimulation of the immune system can lead to myocarditis; to evaluate if the condition can lead to arrhythmic events and, if so, define their frequency and classification through conventional and ambulatory electrocardiogram tests (Holter method) for a period of 24 hours; to analyze heart rate variability in the time domain and whether the condition can lead to autonomic imbalance; and to determine the survival

2019 PLoS ONE PubMed abstract

114. Climate change has likely already affected global food production. (Full text)

Climate change has likely already affected global food production. Crop yields are projected to decrease under future climate conditions, and recent research suggests that yields have already been impacted. However, current impacts on a diversity of crops subnationally and implications for food security remains unclear. Here, we constructed linear regression relationships using weather and reported crop data to assess the potential impact of observed climate change on the yields of the top ten (...) reduction (-3.5 X 1013 kcal/year) in consumable food calories in these ten crops. In nearly half of food insecure countries, estimated caloric availability decreased. Our results suggest that climate change has already affected global food production.

2019 PLoS ONE PubMed abstract

115. Autumn temperatures at African wintering grounds affect body condition of two passerine species during spring migration. (Full text)

Autumn temperatures at African wintering grounds affect body condition of two passerine species during spring migration. Most papers on the physical condition of birds during spring migration focused on food availability preceding migratory take-off. Only a few studies examined the effect of climate conditions at the wintering grounds upon autumn arrival on bird physical condition later on. Here, we hypothesized that environmental conditions upon arrival at the wintering grounds (...) , and not necessarily upon departure, have a crucial carry-over effect on bird spring migration. Using 29,000 observations of the lesser whitethroat, Sylvia curruca, and the eastern Bonelli's warbler, Phylloscopus orientalis, we found temperatures upon arrival at the African wintering grounds to be the only climatic variable correlated with birds' body state upon spring stopover in Israel, six months later. Two different mechanisms could explain these results. One possibility is that high temperatures create

2019 PLoS ONE PubMed abstract

116. Microbiota data from low biomass milk samples is markedly affected by laboratory and reagent contamination. (Full text)

Microbiota data from low biomass milk samples is markedly affected by laboratory and reagent contamination. Discoveries of bacterial communities in environments that previously have been described as sterile have in recent years radically challenged the view of these environments. In this study we aimed to use 16S rRNA sequencing to describe the composition and temporal stability of the bacterial microbiota in bovine milk from healthy udder quarters, an environment previously believed (...) . Sequencing of no template control samples, positive control samples, with defined levels of bacteria, and 288 milk samples with various levels of bacterial growth, revealed that the data was influenced by contaminating taxa, primarily Methylobacterium. We observed an increasing impact of contamination with decreasing microbial biomass where the contaminating taxa became dominant in samples with less than 104 bacterial cells per mL. By applying a contamination filtration on the sequence data, the amount

2019 PLoS ONE PubMed abstract

117. Helicobacter pylori eradication rate of standard triple therapy and factors affecting eradication rate at Bahir Dar city administration, Northwest Ethiopia: A prospective follow up study. (Full text)

Helicobacter pylori eradication rate of standard triple therapy and factors affecting eradication rate at Bahir Dar city administration, Northwest Ethiopia: A prospective follow up study. Eradication of Helicobacter pylori infection with standard triple therapy has been accepted to curb associated risks of chronic gastritis andpeptic ulcer disease.To assess H. pylori eradication rate of standard triple therapy and patient related factors affecting eradication rate.A facility based prospective (...) . Bivariate and backward stepwise multivariate logistic regression was used to analyze data. P-value < 0.05 at 95%CI was considered as significant.The overall H. pylori eradication rate was 90.3% (379/421). Almost 80% of the patients were urban residents. Mean (±SD) age and body weight of patients were 30.63 (± 10.74) years and 56.79 (± 10.17) kg, respectively. Self-reported adverse drug effects and area of residence of patients were factors affecting eradication rate significantly. Patients with no self

2019 PLoS ONE PubMed abstract

118. Contact with adult hen affects development of caecal microbiota in newly hatched chicks. (Full text)

Contact with adult hen affects development of caecal microbiota in newly hatched chicks. Chickens in commercial production are hatched in a clean hatchery environment in the absence of any contact with adult hens. However, Gallus gallus evolved to be hatched in a nest in contact with an adult hen which may act as a donor of gut microbiota. In this study, we therefore addressed the issue of microbiota development in newly hatched chickens with or without contact with an adult hen. We found (...) and Ruminococcaceae therefore originated from environmental sources instead of from the hens. These observation may have considerable consequences for the evidence-based design of the new generation of probiotics for poultry.

2019 PLoS ONE PubMed abstract

119. Effects of radial extracorporeal shockwave therapy on spasticity of upper-limb agonist/antagonist muscles in patients affected by stroke: a randomized, single-blind clinical trial (Full text)

Effects of radial extracorporeal shockwave therapy on spasticity of upper-limb agonist/antagonist muscles in patients affected by stroke: a randomized, single-blind clinical trial Effects of Radial Extracorporeal Shockwave Therapy on Spasticity of Upper-Limb Agonist/Antagonist Muscles in Patients Affected by Stroke: A Randomized, Single-Blind Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome (...) collection Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation Age Ageing Actions 2019 Dec 17 [Online ahead of print] Effects of Radial Extracorporeal Shockwave Therapy on Spasticity of Upper-Limb Agonist/Antagonist Muscles in Patients Affected

2018 EvidenceUpdates PubMed abstract

120. Hypoglycemia does not affect the progression of preclinical atherosclerosis in subjects with type 2 diabetes. (Full text)

Hypoglycemia does not affect the progression of preclinical atherosclerosis in subjects with type 2 diabetes. Intensive treatment aimed at achieving optimal metabolic control to prevent the development of chronic diabetic complications is often associated with an increased rate of hypoglycemic events. Hypoglycemia is believed to be responsible for acute fatal and nonfatal cardiovascular events likely as a consequence of the activation of pro-inflammatory and pro-atherothrombotic pathways (...) control. At the end of the observation time, subjects were divided in two groups: with hypoglycemia (H-group) or without hypoglycemia (C-group).Baseline characteristic were comparable between groups. HbA1c significantly decreased in both groups, and fasting plasma glucose was only significant in the H-group. Subjects with hypoglycemia showed a significant reduction of carotid wall thickness after one-year of treatment (H-groups: right baseline 834±141 vs. 1-year 770±132 μ p<0.05; C-group: 757±162 vs

2019 PLoS ONE Controlled trial quality: uncertain PubMed abstract

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