How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

100,392 results for

Observed Affect

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

100221. Coadministration of orally inhaled zanamivir with inactivated trivalent influenza vaccine does not adversely affect the production of antihaemagglutinin antibodies in the serum of healthy volunteers. (Abstract)

Coadministration of orally inhaled zanamivir with inactivated trivalent influenza vaccine does not adversely affect the production of antihaemagglutinin antibodies in the serum of healthy volunteers. Zanamivir, a clinically proven potent and specific inhibitor of influenza A and B neuraminidase, has been approved in some countries for the treatment of influenza and is in late-stage development for the prophylaxis of influenza. This study investigated whether the coadministration of zanamivir (...) and influenza vaccine affected the development of antibody responses to injected influenza haemagglutinin.This double-blind randomised placebo-controlled study compared the antihaemagglutinin antibody production [haemagglutination inhibition (HAI) titre] after administration of inactivated trivalent influenza vaccine in healthy volunteers receiving zanamivir or placebo once daily for 28 days.138 healthy volunteers (52 men and 86 nonpregnant women, mean age 32.7 years) were randomised to the zanamivir (70

1999 Clinical pharmacokinetics Controlled trial quality: predicted high

100222. Does the inhalation device affect the bronchodilatory dose response curve of salbutamol in asthma and chronic obstructive pulmonary disease patients? (Abstract)

Does the inhalation device affect the bronchodilatory dose response curve of salbutamol in asthma and chronic obstructive pulmonary disease patients? This open randomized study examined differences between the effects of an equal dose of salbutamol administered via the Diskus, Turbuhaler, and pMDI plus Volumatic. Measurements included dose response curves, dynamic and static lung volumes, respiratory muscle strength, and systemic effects.The cumulative dose-response study compared (...) is of marginal clinical relevance since the additional bronchodilation was a maximum of 140 ml FEV(1) and did not exceed the minimal patient-perceivable improvement. In the asthma group a more evident plasma K(+) decrease was found after salbutamol delivered via pMDI and pMDI plus Volumatic. Furthermore, especially in the COPD patients a significant decrease was observed in hyperinflation and consequently an improvement in maximal inspiratory pressure as a result of salbutamol via all devices.Bronchodilation

2003 European journal of clinical pharmacology Controlled trial quality: uncertain

100223. Is coronary stent deployment and remodeling affected by predilatation? An intravascular ultrasound randomized study Stenting with or without predilation: an IVUS study. (Abstract)

Is coronary stent deployment and remodeling affected by predilatation? An intravascular ultrasound randomized study Stenting with or without predilation: an IVUS study. In this intravascular ultrasound (IVUS) randomized trial we compared a strategy of direct stenting (DS) without predilation (n = 30) vs. conventional stenting with predilation (SWP) (n = 30) in patients with suitable type A or B non-calcified lesions in native vessels > or = 3 mm. Optimal deployment was achieved using (...) elastic membrane (EEM)-cross sectional area (CSA) (delta = 3.7 +/- 2.1 mm2 and delta = 2.4 +/- 6.8 mm2, respectively, p < 0.49) and 34% was due to a reduced P + M-CSA (delta = 0.02 +/- 6.9 mm2 and delta = 1.2 +/- 6.3 mm2, respectively, p < 0.50). We conclude that at the same maximal pressure inflation the mechanisms of stent expansion are similar in both DS and SWP groups. In this observational study, the IVUS data showed clearly under-expansion of stents in both groups in comparison with previously

2002 The international journal of cardiovascular imaging Controlled trial quality: uncertain

100224. A comparison of a waterpik dual-motor powered toothbrush and a manual toothbrush in affecting interproximal bleeding reduction and dental biofilm accumulation. (Abstract)

A comparison of a waterpik dual-motor powered toothbrush and a manual toothbrush in affecting interproximal bleeding reduction and dental biofilm accumulation. This single-blind, 21-day clinical study was designed to compare the effectiveness of a dual-motor powered toothbrush (SynchroSonic) and a manual toothbrush in affecting interproximal bleeding reduction and dental biofilm accumulation in a cohort of 70 subjects.After baseline evaluations of soft tissue trauma, dental biofilm (...) %, p = 0.02).The results demonstrated that both the manual toothbrush and the SynchroSonic powered toothbrush were safe, with no evidence of clinically significant hard or soft tissue abrasion observed. Additionally, the powered toothbrush was more effective in reducing biofilm and gingival bleeding than the manual toothbrush.

2003 The Journal of clinical dentistry Controlled trial quality: uncertain

100225. Red and white wine differently affect collagen-induced platelet aggregation. (Abstract)

Red and white wine differently affect collagen-induced platelet aggregation. Moderate consumption of wine is associated with reduced cardiovascular events, but the mechanism is not fully elucidated. Aim of the study was to seek if consumption of red or white wine, that are known to have different amount of polyphenols, differently influenced platelet aggregation. 20 healthy subjects were randomly allocated to consume for two weeks 300 ml of red or white wine; both wines had the same (...) concentration of alcohol. At baseline and 12 hours after last drink collagen-induced platelet aggregation was performed. At baseline no difference of laboratory values was observed between the two groups. At the end of treatment subjects given red wine had lower response to platelet agonist than those given white wine (<0.005). No ethanol could be found in plasma 12 hours after last drink. This study shows that red and white wine have different effect on platelet activation likely because of the different

2003 Pathophysiology of haemostasis and thrombosis Controlled trial quality: uncertain

100226. [Steady car engine noise does not affect the cognitive abilities of sleep apnea syndrome patients]. (Abstract)

[Steady car engine noise does not affect the cognitive abilities of sleep apnea syndrome patients]. Traffic accidents are more frequent for sleep apnea syndrome (SAS) patients than in the population at large. The mechanisms that underlie this observation are poorly defined. Our working hypothesis was that in SAS patients the steady noise of a car engine might alter cognitive capacities that may be involved in driving, thus increasing the risk of traffic accidents. To test this hypothesis we

2003 Archivos de bronconeumologia Controlled trial quality: uncertain

100227. Factors that affect the variability in heart rate during endoscopic retrograde cholangiopancreatography. (Abstract)

Factors that affect the variability in heart rate during endoscopic retrograde cholangiopancreatography. To find out if drugs, position, and endoscopic manipulation during endoscopic retrograde cholangiopancreatography (ERCP) influence the changes in the variability of heart rate.Single-blind randomised trial.10 volunteers given butyscopolamine, glucagon, or saline intravenously on three different study days, and 10 patients who had ERCP without butylscopolamine or glucagon.Holter tape analysis (...) vagal tone. The previously observed reduced vagal tone during ERCP may therefore be primarily the result of giving butylscopolamine.

2002 The European journal of surgery = Acta chirurgica Controlled trial quality: uncertain

100228. Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tension. Full Text available with Trip Pro

, but does not affect fatigability or specific tension. The changes in leg strength and power are dependent on testosterone dose and circulating testosterone concentrations and exhibit a log-linear relationship with serum total and free testosterone. Failure to observe a significant testosterone dose relationship with fatigability suggests that testosterone does not affect this component of muscle performance and that different components of muscle performance are regulated by different mechanisms. (...) Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tension. Testosterone supplementation in men increases fat-free mass, but whether measures of muscle performance, such as maximal voluntary strength, power, fatigability, or specific tension, are improved has not been determined. Furthermore, the extent to which these measures of muscle performance are related to testosterone dose or circulating concentration is unknown

2003 The Journal of clinical endocrinology and metabolism Controlled trial quality: uncertain

100229. The effects of EDTA gel conditioning exposure time on periodontitis-affected human root surfaces: surface topography and PDL cell adhesion. (Abstract)

The effects of EDTA gel conditioning exposure time on periodontitis-affected human root surfaces: surface topography and PDL cell adhesion. The purpose of this investigation was to study the surface topography of periodontally-affected human roots following EDTA gel application at different time periods with and without scaling and root planing. In addition, to assess any correlations between root surface changes following EDTA gel conditioning and periodontal ligament fibroblast adhesion.Forty (...) -eight teeth that had a labial probing depth and clinical attachment loss of more than 7mm were used in this study. Periodontally-affected teeth were randomly divided into 4 groups of 12 teeth in each. Furthermore, a sample group of 6 teeth, which had a healthy periodontium, were used to serve as the healthy control (G1). The second group (G2) served as a diseased treated control in which sample teeth were only scaled and root planed prior to immediate extraction. Teeth in the third group (G3) were

2003 Journal of the International Academy of Periodontology Controlled trial quality: uncertain

100230. Factors affecting use of permethrin-treated bed nets during a randomized controlled trial in western Kenya. (Abstract)

Factors affecting use of permethrin-treated bed nets during a randomized controlled trial in western Kenya. Adherence with permethrin-treated bed net (ITN) use and their proper deployment was directly observed in 2,178 individuals (784 households) participating in a large-scale trial of ITNs on child mortality in western Kenya. The ITNs were distributed free of charge to ensure high coverage, resulting in a ratio of 1.46 persons per ITN. Approximately 30% of ITNs present were unused (...) . The overall percentage adherence was 72.3%. The probability of adherence by individuals depended strongly on age (relative risk [RR] = 0.86, 95% confidence limit [CL] = 0.78-0.94), in which children less than five years of age were less likely to use ITNs than older individuals, and temperature, in which ITNs were more likely to be used in periods of cooler weather. A marginally significant diminution in adherence during the second year of the project was also observed (RR = 0.83, 95% CL = 0.68-1.01

2003 The American journal of tropical medicine and hygiene Controlled trial quality: uncertain

100231. PROP sensitivity affects macronutrient selection. (Abstract)

PROP sensitivity affects macronutrient selection. The objective was to study the effect of 6-n-propylthiouracyl (PROP) taster status on macronutrient selection. Thirteen PROP nontasters (PNT) and 23 PROP tasters (PT) were offered three ad libitum lunches in a random order: a high-fat (HF; CHO/P/F: 30/10/60), a high-carbohydrate (HCHO; 80/10/10), and a mixed (MIX) lunch consisting of products of the HF and HCHO lunch. PT compared to PNT ate relatively more fat (47+/-9 vs. 38+/-10%, P<.05 (...) ) and less carbohydrate (45+/-9 vs. 53+/-10%, P<.05) from the MIX lunch. When dividing PT into supertasters (PST) and medium tasters (PMT), the same relation between PT status and macronutrient selection was observed (P<.05). The energy density of the food consumed was higher for PT than for PNT (P<.05). Protein, food (g) and energy (kJ) intake, appetite, and hedonic value were not different between PT and PNT. At the HCHO as well as HF lunch, no differences with respect to macronutrient selection, food

2003 Physiology & behavior Controlled trial quality: uncertain

100232. A single dose of Ginkgo biloba does not affect soleus motoneuron pool excitability. (Abstract)

A single dose of Ginkgo biloba does not affect soleus motoneuron pool excitability. EGb 761 has been shown to increase acetylcholine synthesis and release and increase cholinergic receptors leading to an increase in cholinergic neurotransmission. These effects may be observed in the neuromuscular system, manifested by changes in motoneuron pool excitability as measured by the Hoffmann reflex to motor response (H/M) ratio. The objective was to determine whether a single dose of EGb 761 affects (...) motoneuron pool excitability of the soleus muscle as measured by the H/M ratio. Following initial soleus H/M measurements, 20 healthy volunteers were randomly assigned to 1 of 3 treatment groups (control, 180 g cellulose placebo, and 180 g EGb 761). H/M ratios were recorded 1, 2, and 3 hours post treatment. A 3 x 4 repeated-measures analysis of variance was used to analyze differences in H/M ratio between treatments. No differences were observed between treatments (p = 0.75) or over time (p = 0.17

2003 Journal of strength and conditioning research / National Strength & Conditioning Association Controlled trial quality: uncertain

100233. Interfacial micromorphology of three adhesive systems created in caries-affected dentin. (Abstract)

down to 0.25-microm particle size, immersed in 10% orthophosphoric acid for 3-5 s and 5% sodium hypochlorite for 10 min. All specimens were gold sputter-coated and observed using FE-SEM.All groups showed hybrid layer formation. However, the thickness varied depending on the adhesive system and the carious dentin removal technique used. One Coat Bond (a "one-bottle" system) showed the thickest hybrid layer (approximately 2 microm) in acid/base treated specimens when bonded to caries-affected dentin (...) Interfacial micromorphology of three adhesive systems created in caries-affected dentin. To investigate the morphology of the resin-dentin interface of three dentin adhesive systems (One Coat Bond, Clearfil SE Bond and One-Up Bond F) bonded to caries-affected dentin, exposed using either rotary instrumentation in conjunction with a caries detector dye or a chemo-mechanical caries removal system (Carisolv).60 extracted human molars with occlusal caries were used. 30 teeth had carious dentin

2003 American journal of dentistry Controlled trial quality: uncertain

100234. Placement of the vaginal 17beta-estradiol tablets in the inner or outer one third of the vagina affects the preferential delivery of 17beta-estradiol toward the uterus or periurethral areas, thereby modifying efficacy and endometrial safety. (Abstract)

Placement of the vaginal 17beta-estradiol tablets in the inner or outer one third of the vagina affects the preferential delivery of 17beta-estradiol toward the uterus or periurethral areas, thereby modifying efficacy and endometrial safety. The purpose of this study was to investigate whether the effects of 17beta-estradiol tablets that are designed for the treatment of postmenopausal urovaginal atrophy are influenced by the site of placement into the vagina.In this controlled crossover trial (...) , 10 postmenopausal women received a single 17beta-estradiol tablet in the outer or inner one third of the vagina. Before and 3 hours after treatment, the pulsatility index, resistance index, and blood flow were evaluated in the uterine and periurethral vessels by Doppler examination. Parallel 17beta-estradiol serum evaluations were performed.Comparable and significant increases in 17beta-estradiol were observed. After inner administration, the pulsatility index and resistance index of both uterine

2003 American journal of obstetrics and gynecology Controlled trial quality: uncertain

100235. Megestrol acetate-induced weight gain does not negatively affect blood lipids in elderly men: effects of resistance training and testosterone replacement. (Abstract)

Megestrol acetate-induced weight gain does not negatively affect blood lipids in elderly men: effects of resistance training and testosterone replacement. Megestrol acetate (MA) has been used to stimulate weight gain in elderly populations, with the majority of the weight gain being adipose tissue. Because of the increased energy intake and adipose tissue accrual with MA, it may have a negative effect on circulating lipids. Thus, in this study we examined the effects of MA--alone (...) and in combination with resistance training and/or testosterone replacement--on blood lipids.All subjects (n = 28) received MA and were randomly assigned to one of four groups: 1) placebo (P) injections, 2) resistance training and P (RT+P), 3) weekly injections of testosterone (T; 100 mg/week), or 4) RT and T (RT+T).A significant time effect was observed for total cholesterol (p = 0.0006) and high density lipoprotein (HDL) cholesterol (p = .0003) with the mid and post time points being significantly lower than

2003 The journals of gerontology. Series A, Biological sciences and medical sciences Controlled trial quality: uncertain

100236. The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers. (Abstract)

deficits similar to those observed previously in cases of clinical depression. In particular, TRP depletion increased response times for happy but not sad targets in an affective go/no-go task and slowed responding in a visual discrimination and reversal learning task. These deficits were not due to a global sedative effect, as planning ability was unimpaired.The present data indicate that serotonergic factors may be more involved in the disrupted inhibitory and emotional processing characteristic (...) The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers. Cognitive impairment is a common feature of depressive illness. While accumulating evidence suggests that brain serotonin (5-HT) pathways play an important role in the neurobiology of depression, the extent to which altered 5-HT function is responsible for the associated changes in cognition and emotion remains unclear.The present study examined the effects of acute dietary depletion of tryptophan

2002 Psychopharmacology Controlled trial quality: uncertain

100237. Calcium affects biomarkers of colon carcinogenesis after right hemicolectomy. (Abstract)

Calcium affects biomarkers of colon carcinogenesis after right hemicolectomy. In Western societies colonic cancer most frequently develops in the distal colon, largely as a result of the composition of the diet. Modulation of dietary factors is therefore an attractive modality to reduce colorectal cancer risk. This study aims to evaluate the potentially protective effects of calcium in right hemicolectomy patients.A randomized controlled cross-over intervention trial was performed with 1000 mg (...) -third of the crypt was observed. Alkaline phosphatase activity was reduced from 6.2 +/- 2.6 U mL-1 in the placebo period to 4.6 +/- 2.2 in the calcium period (P = 0.02), and a trend toward a lower cytotoxicity of faecal water was observed. No effect on total bile acids in faeces was observed, but calcium increased the percentage of deoxycholic acid (from 49.6 +/- 7.0% to 56.5 +/- 6.2%, P = 0.03) and decreased the percentages of cholic acid (from 10.3 +/- 4.7% to 5.8 +/- 2.7%, P = 0.05

2002 European journal of clinical investigation Controlled trial quality: uncertain

100238. Decreased carotenoid concentrations due to dietary sucrose polyesters do not affect possible markers of disease risk in humans. Full Text available with Trip Pro

) in all SPE groups. No negative effects were observed on markers of oxidation, eye health, cardiovascular health or immune status. This study shows that decreases in serum carotenoid concentrations do not affect possible markers of disease risk. (...) Decreased carotenoid concentrations due to dietary sucrose polyesters do not affect possible markers of disease risk in humans. Excessive consumption of energy and fat increases the risk for obesity. Snacks containing sucrose polyesters (SPE) as a dietary fat replacer are on the market in the United States. SPE products have been shown to lower concentrations of serum carotenoids in short-term studies. Experimental studies on the longer-term effects on health of decreased carotenoid

2003 The Journal of nutrition Controlled trial quality: uncertain

100239. Green tea extract only affects markers of oxidative status postprandially: lasting antioxidant effect of flavonoid-free diet. (Abstract)

Green tea extract only affects markers of oxidative status postprandially: lasting antioxidant effect of flavonoid-free diet. Epidemiological studies suggest that foods rich in flavonoids might reduce the risk of cardiovascular disease and cancer. The objective of the present study was to investigate the effect of green tea extract (GTE) used as a food antioxidant on markers of oxidative status after dietary depletion of flavonoids and catechins. The study was designed as a 2 x 3 weeks blinded (...) human cross-over intervention study (eight smokers, eight non-smokers) with GTE corresponding to a daily intake of 18.6 mg catechins/d. The GTE was incorporated into meat patties and consumed with a strictly controlled diet otherwise low in flavonoids. GTE intervention increased plasma antioxidant capacity from 1.35 to 1.56 (P<0.02) in postprandially collected plasma, most prominently in smokers. The intervention did not significantly affect markers in fasting blood samples, including plasma

2002 The British journal of nutrition Controlled trial quality: uncertain

100240. What really affects the incidence of central venous catheter-related infections for short-term catheterization? (Abstract)

What really affects the incidence of central venous catheter-related infections for short-term catheterization? Central venous catheterization is one of the important sepsis reasons in surgical patients. In this randomized controlled study, the effect of the frequency and type of catheter site care, as well as age, coexisting malignancy or diabetes mellitus, total parenteral nutrition administration and antibiotics use, on central venous catheter infection was investigated. Seventy-two single (...) and antibiotics use did not have any significant effect on the rate of central venous catheter infections (p > 0.05). In conclusion, we observed that the frequency of insertion site care and the type of dressing applied to the site had no significant effect on the rate of CVC infection. Insertion site infection was the most significant factor increasing the incidence of catheter tip infection. The use of the CVC for total parenteral nutrition facilitated tip infection as well.

2002 Acta chirurgica Belgica Controlled trial quality: uncertain

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>