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Observed Affect

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61. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Full Text available with Trip Pro

An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. The Bergamo province, which is extensively affected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic, is a natural observatory of virus manifestations in the general population. In the past month we recorded an outbreak of Kawasaki disease; we aimed to evaluate incidence and features of patients with Kawasaki-like disease diagnosed during

2020 Lancet

62. Vitamin D and Calcium Supplementation Along with Oral Hygiene Show Positive Affect on Periodontal Health

result in improved periodontal health? Clinical Bottom Line Evidence showed that there is only a slight positive affect on periodontal health when supplementing vitamin D and calcium along with oral hygiene. This is supported by evidence from a randomized clinical trial and an observational clinical trial that measured the periodontal health in two patient groups, one taking supplementation and one that was not. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author (...) Vitamin D and Calcium Supplementation Along with Oral Hygiene Show Positive Affect on Periodontal Health UTCAT3161, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Vitamin D and Calcium Supplementation Along with Oral Hygiene Show Positive Affect on Periodontal Health Clinical Question In patients with periodontal disease does oral supplementation of vitamin D and calcium along with recommended oral hygiene regimens

2017 UTHSCSA Dental School CAT Library

63. Cohort Study: Adverse events associated with mood stabiliser treatment should be continuously monitored in patients diagnosed with bipolar affective disorder

Cohort Study: Adverse events associated with mood stabiliser treatment should be continuously monitored in patients diagnosed with bipolar affective disorder Adverse events associated with mood stabiliser treatment should be continuously monitored in patients diagnosed with bipolar affective disorder | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more (...) in patients diagnosed with bipolar affective disorder Article Text Aetiology/Harm Cohort Study Adverse events associated with mood stabiliser treatment should be continuously monitored in patients diagnosed with bipolar affective disorder R E Nielsen 1 , 2 , R W Licht 3 Statistics from Altmetric.com Commentary on: Hayes JF , Marston L , Walters K , et al . Adverse Renal, Endocrine, Hepatic, and Metabolic Events during Maintenance Mood Stabilizer Treatment for Bipolar Disorder: A Population-Based Cohort

2017 Evidence-Based Medicine

64. Alexithymia Components Are Differentially Related to Explicit Negative Affect But Not Associated with Explicit Positive Affect or Implicit Affectivity Full Text available with Trip Pro

Alexithymia Components Are Differentially Related to Explicit Negative Affect But Not Associated with Explicit Positive Affect or Implicit Affectivity Alexithymia represents a multifaceted personality construct defined by difficulties in recognizing and verbalizing emotions and externally oriented thinking. According to clinical observations, experience of negative affects is exacerbated and experience of positive affects is decreased in alexithymia. Findings from research based on self-report (...) indicate that all alexithymia facets are negatively associated with the experience of positive affects, whereas difficulties identifying and describing feelings are related to heightened negative affect. Implicit affectivity, which can be measured using indirect assessment methods, relates to processes of the impulsive system. The aim of the present study was to examine, for the first time, the relations between alexithymia components and implicit and explicit positive and negative affectivity

2017 Frontiers in psychology

65. Gray matter differences between affective and non-affective first episode psychosis: A review of Magnetic Resonance Imaging studies. Full Text available with Trip Pro

Gray matter differences between affective and non-affective first episode psychosis: A review of Magnetic Resonance Imaging studies. Non-affective and affective psychoses are very common mental disorders. However, their neurobiological underpinnings are still poorly understood. Therefore, the goal of the present review was to evaluate structural Magnetic Resonance Imaging (MRI) studies exploring brain deficits in both non-affective (NA-FEP) and affective first episode psychosis (A-FEP (...) ).A bibliographic search on PUBMED of all MRI studies exploring gray matter (GM) differences between NA-FEP and A-FEP was conducted.Overall, the results from the available evidence showed that the two diagnostic groups share common GM alterations in fronto-temporal regions and anterior cingulate cortex. In contrast, unique GM deficits have also been observed, with reductions in amygdala for A-FEP and in hippocampus and insula for NA-FEP.Few small MRI studies with heterogeneous methodology.Although the evidences

2018 Journal of Affective Disorders

66. Delusional Themes Across Affective and Non-Affective Psychoses Full Text available with Trip Pro

Delusional Themes Across Affective and Non-Affective Psychoses The current debate about the diagnostic significance of delusion revolves around two positions. The neurocognitive position conceives delusion as a non-specific, though polymorphic, symptom. The psychopathological position views features of delusion such as content and structure as having meaningful connections with diagnostic entities. This study aims at contributing to this debate by examining the association between delusional (...) patients with manic symptoms (bipolar mania 20%; bipolar mixed states 19%; manic schizoaffective disorder 10%). They were observed significantly more often in bipolar mania than in schizophrenia (7%). Persecutory delusions were broadly distributed across diagnostic categories. However, they were significantly more frequent among patients with schizophrenia and delusional disorder compared with depressed and manic patients. Somatic delusions were also observed in all diagnostic groups, with no group

2018 Frontiers in Psychiatry

67. Is aberrant affective cognition an endophenotype for affective disorders? - A monozygotic twin study. Full Text available with Trip Pro

-risk and 36 low-risk MZ twins. Groups were demographically well-balanced and showed comparable non-affective cognitive performance. We observed no aberrant affective cognition in affected and high-risk relative to low-risk twins. However, high-risk twins displayed attentional avoidance of emotional faces (ps ⩽ 0.009) and more use of task-oriented coping strategies (p = 0.01) compared with affected twins. In contrast did affected twins show more emotion-oriented coping than high- and low-risk twins (...) Is aberrant affective cognition an endophenotype for affective disorders? - A monozygotic twin study. Identification of endophenotypes can improve prevention, detection and development of new treatments. We therefore investigated whether aberrant affective cognition constitutes an endophenotype for affective disorders by being present in monozygotic (MZ) twins with unipolar or bipolar disorder in partial remission (i.e. affected) and their unaffected co-twins (i.e. high-risk) relative to twins

2018 Psychological Medicine

68. High inter-observer agreement of observer-perceived pain assessment in the emergency department. Full Text available with Trip Pro

or severe pain) we found a 70% agreement with a mean difference in categories of 0.05 and 95% limits of agreement of +/- 1 category. Patient age, gender, localization of pain, examination room or presence of a significant other did not affect the inter-observer agreement.We found 70% agreement on pain category between the nurses and it is justified that nurse-perceived pain assessment is used for triage in the emergency department. (...) High inter-observer agreement of observer-perceived pain assessment in the emergency department. Triage is used to prioritize the patients in the emergency department. The majority of the triage systems include the patients' pain score to assess their level of acuity by using a combination of patient reported pain and observer-perceived pain; the latter therefore requires a certain degree of inter-observer agreement. The aim of the present study was to assess the inter-observer agreement

2018 BMC Emergency Medicine

69. Transient and chronic childhood immune thrombocytopenia are distinctly affected by Fc-γ receptor polymorphisms. Full Text available with Trip Pro

Transient and chronic childhood immune thrombocytopenia are distinctly affected by Fc-γ receptor polymorphisms. In childhood immune thrombocytopenia (ITP), anti-platelet autoantibodies mediate platelet clearance through Fc-γ receptor (FcγR)-bearing phagocytes. In 75% to 90% of patients, the disease has a transient, self-limiting character. Here we characterized how polymorphisms of FcγR genes affect disease susceptibility, response to intravenous immunoglobulin (IVIg) treatment, and long-term (...) recovery from childhood ITP. Genotyping of the FCGR2/3 locus was performed in 180 children with newly diagnosed ITP, 22 children with chronic ITP, and 180 healthy control children by multiplex ligation-dependent probe amplification. Children with newly diagnosed ITP were randomly assigned to a single administration of IVIg or observation, and followed for 1 year (Treatment With or Without IVIg for Kids With ITP [TIKI] trial). We defined transient ITP as a complete recovery (≥100 × 109/L) 3 months after

2019 Blood advances Controlled trial quality: uncertain

70. Medicare Spending and the Adequacy of Support With Daily Activities in Community-Living Older Adults With Disability: An Observational Study. Full Text available with Trip Pro

Medicare Spending and the Adequacy of Support With Daily Activities in Community-Living Older Adults With Disability: An Observational Study. Identifying factors that affect variation in health care spending among older adults with disability may reveal opportunities to better address their care needs while offsetting excess spending.To quantify differences in total Medicare spending among older adults with disability by whether they experience negative consequences due to inadequate support (...) ($2309 [CI, $208 to $4409]) and self-care ($3187 [CI, $432 to $5942]) disability. In the bottom-spending quartile, differences were observed for self-care only ($1460 [CI, $358 to $2561]). No differences were observed in the top quartile.This observational study could not establish causality.Inadequate support for mobility and self-care is associated with higher Medicare spending, especially in the middle and lower ends of the spending distribution. Better support for the care needs of older adults

2019 Annals of Internal Medicine

71. Steroidal contraceptives and bone fractures in women: evidence from observational studies. (Abstract)

Steroidal contraceptives and bone fractures in women: evidence from observational studies. Age-related decline in bone mass increases the risk of skeletal fractures, especially those of the hip, spine, and wrist. Steroidal contraceptives have been associated with changes in bone mineral density in women. Whether such changes affect the risk of fractures later in life is unclear. Hormonal contraceptives are among the most effective and most widely-used contraceptives. Concern about fractures may (...) limit the use of these effective contraceptives. Observational studies can collect data on premenopausal contraceptive use as well as fracture incidence later in life.We systematically reviewed the evidence from observational studies of hormonal contraceptive use for contraception and the risk of fracture in women.Through June 2015, we searched for observational studies. The databases included PubMed, POPLINE, Cochrane Central Register of Controlled Trials (CENTRAL), LILACS, EMBASE, CINAHL, and Web

2015 Cochrane

72. Clinical success of IUI cycles with donor sperm is not affected by total inseminated volume: a RCT. Full Text available with Trip Pro

Clinical success of IUI cycles with donor sperm is not affected by total inseminated volume: a RCT. What is the impact on live birth rates (LBR) when a donor IUI (dIUI) cycle is performed with an insemination volume of 0.5 mL versus the usual 0.2 mL?LBR after a dIUI cycle is no different when performed with 0.5 versus 0.2 mL.An IUI has an important role in the treatment of severe male infertility, and is often used in same-sex female couples and single parents. Different variables have been (...) (13.2 ± 6.4 versus 13.6 ± 6.0), BMI (23.5 ± 3.9 versus 23.7 ± 4.1 kg/m2), number of follicles >17 mm (1.1 ± 0.5 versus 1.1 ± 0.5), total gonadotrophin dose (553.1 ± 366.3 versus 494.6 ± 237.1 IU), and total motile sperm count (8.22 ± 7.1 versus 7.7 ± 5.7 million). Similar clinical pregnancy rates (18.9% (27/143) versus 19.8% (25/126), NS), LBRs (15.4% (22/143) versus 19.0% (24/126), NS) and miscarriage rates (18.5% (5/27) versus 4.0% (1/25), NS) were observed between groups.The study was not powered

2018 Human reproduction open Controlled trial quality: predicted high

73. Sialanar (glycopyrronium) - for treating severe drooling of saliva in children and adolescents (aged 3 years and above) with conditions affecting the nervous system, such as cerebral palsy, epilepsy and neurodegenerative diseases

Sialanar (glycopyrronium) - for treating severe drooling of saliva in children and adolescents (aged 3 years and above) with conditions affecting the nervous system, such as cerebral palsy, epilepsy and neurodegenerative diseases 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5520 Send a question via our website www.ema.europa.eu/contact 21 July 2016 EMA/555265/2016 Committee (...) apparent terminal elimination half-life TEAE treatment-emergent adverse event t.i.d three times daily T max time to maximum observed plasma concentration TSE transmissible spongiform encephalopathies UK United Kingdom ULN upper limit of the normal range USP/NF United States Pharmacopoeia/National Formulary US United States UV Ultraviolet VAS visual analogue scale V ß volume of distribution in the elimination phase V ss volume of distribution at steady state WEU Well Established Use XRD X-Ray

2016 European Medicines Agency - EPARs

74. Highly potent antioxidant Olea europaea L. leaf extract affects carotid and renal haemodynamics in experimental hypertension: The role of oleuropein Full Text available with Trip Pro

Highly potent antioxidant Olea europaea L. leaf extract affects carotid and renal haemodynamics in experimental hypertension: The role of oleuropein Haemodynamic alterations in carotid and renal arteries are associated with the severity of target organ damage in patients with hypertension. Dietary habits, such as the Mediterranean diet, regulate blood pressure and oxidative stress, thus reduce the mortality rate due to cardiovascular diseases. In this study, our aim was to evaluate the reducing (...) capacity for metal ion chelation than EDTA. All three doses of OLE, and OP, improved oxidative stress in SHR. OLE5 improved carotid and renal haemodynamics, without significant effects on systemic haemodynamics. Two different mechanisms of antihypertensive responses to OLE were observed, OLE25 was most effective in reducing cardiovascular risks by improving systemic and regional (carotid and renal) haemodynamics, peripheral and regional vascular resistance. OLE50 causes the improvement of blood

2018 EXCLI journal

75. Coastal urbanisation affects microbial communities on a dominant marine holobiont Full Text available with Trip Pro

Coastal urbanisation affects microbial communities on a dominant marine holobiont Host-associated microbial communities play a fundamental role in the life of eukaryotic hosts. It is increasingly argued that hosts and their microbiota must be studied together as 'holobionts' to better understand the effects of environmental stressors on host functioning. Disruptions of host-microbiota interactions by environmental stressors can negatively affect host performance and survival. Substantial (...) ecological impacts are likely when the affected hosts are habitat-forming species (e.g., trees, kelps) that underpin local biodiversity. In marine systems, coastal urbanisation via the addition of artificial structures is a major source of stress to habitat formers, but its effect on their associated microbial communities is unknown. We characterised kelp-associated microbial communities in two of the most common and abundant artificial structures in Sydney Harbour-pier-pilings and seawalls

2018 NPJ biofilms and microbiomes

76. Emerging implications of policies on malaria treatment: genetic changes in the Pfmdr-1 gene affecting susceptibility to artemether–lumefantrine and artesunate–amodiaquine in Africa Full Text available with Trip Pro

Emerging implications of policies on malaria treatment: genetic changes in the Pfmdr-1 gene affecting susceptibility to artemether–lumefantrine and artesunate–amodiaquine in Africa Artemether-lumefantrine (AL) and artesunate-amodiaquine (AS-AQ) are the most commonly used artemisinin-based combination therapies (ACT) for treatment of Plasmodium falciparum in Africa. Both treatments remain efficacious, but single nucleotide polymorphisms (SNPs) in the Plasmodium falciparum multidrug (...) a broad increase in sensitivity of parasites to AS-AQ, by 7-10 years after AL introduction. Observed rates of selection have implications for planning strategies to cycle drugs or use multiple first-line therapies to maintain drug efficacy.

2018 BMJ global health

77. Osteocytes Specific GSK3 Inhibition Affects In Vitro Osteogenic Differentiation Full Text available with Trip Pro

Osteocytes Specific GSK3 Inhibition Affects In Vitro Osteogenic Differentiation Osteocytes, the most important regulators of bone processes, are producers of molecules (usually proteins) that act as signals in order to communicate with nearby cells. These factors control cell division (proliferation), differentiation, and survival. Substantial evidence showed different signaling pathways activated by osteocytes and involved in osteoblast differentiation, in particular in the last decade, when (...) long bone osteocyte-Y4 cells (MLO-Y4) pre-treated with GSK3 inhibitor CHIR2201. The novel observations of this study provide knowledge about the inhibition of GSK3 in MLO-Y4 cells. This strategy could be used as a plausible target in osteocytes in order to regulate bone resorption mediated by a loss of osteoblasts activity through a paracrine loop.

2018 Biomedicines

78. Expression of ovate family protein 8 affects epicuticular waxes accumulation in Arabidopsis thaliana Full Text available with Trip Pro

Expression of ovate family protein 8 affects epicuticular waxes accumulation in Arabidopsis thaliana Transcription factors could regulate multiple aspects of plants growth and development, which is significant to plants. Ovate family proteins (OFPs) that are named due to contain OVATE domain, a 70-AA C-terminal conserved domain from the protein OVATE gene encodes, are plant-specific transcription factors family. Some members of OFPs have been shown to function as transcription factors (...) to regulate plant growth and development, but little is known about the function of AtOFP8.Here, we found AtOFP8 maybe involve in transcriptional regulation of the epicuticular waxes in Arabidopsis thaliana. First, we observed that the distribution of epicuticular waxes of wild type plants was more than that of Atofp8-1 deletion mutants, but less than that of 35S:HA-AtOFP8 transgenic overexpression lines not only on the leaves but also on the stems utilizing scanning electron microscopes. Second, we

2018 Botanical studies

79. Factors affecting the normality of channel outputs of channelized model observers: an investigation using realistic myocardial perfusion SPECT images Full Text available with Trip Pro

Factors affecting the normality of channel outputs of channelized model observers: an investigation using realistic myocardial perfusion SPECT images The channelized Hotelling observer (CHO) uses the first- and second-order statistics of channel outputs under both hypotheses to compute test statistics used in binary classification tasks. If these input data deviate from a multivariate normal (MVN) distribution, the classification performance will be suboptimal compared to an ideal observer

2016 Journal of Medical Imaging

80. Do Case Rates Affect Physicians' Clinical Practice in Radiation Oncology?: An Observational Study Full Text available with Trip Pro

Do Case Rates Affect Physicians' Clinical Practice in Radiation Oncology?: An Observational Study Case rate payments combined with utilization monitoring may have the potential to improve the quality of care by reducing over and under-treatment. Thus, a national managed care organization introduced case rate payments at one multi-site radiation oncology provider while maintaining only fee-for-service payments at others. This study examined whether the introduction of the payment method had (...) suggest that the introduction of case rate payments did not adversely affect the rate of guideline-based care at the provider examined. Additional research is needed to isolate the effect of the payment model and assess implications in other populations.

2016 PloS one

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