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Observed Affect

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41. International prospective observational study of upper gastrointestinal haemorrhage: Does weekend admission affect outcome? Full Text available with Trip Pro

International prospective observational study of upper gastrointestinal haemorrhage: Does weekend admission affect outcome? Out of hours admissions have higher mortality for many conditions but upper gastrointestinal haemorrhage studies have produced variable outcomes.Prospective study of 12 months consecutive admissions of upper gastrointestinal haemorrhage from four international high volume centres. Admission period (weekdays, weeknights or weekends), demographics, haemodynamic parameters

2017 United European gastroenterology journal

42. Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions? Observations and introspection of the bioanalysis Full Text available with Trip Pro

Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions? Observations and introspection of the bioanalysis 28461740 2018 07 17 2018 12 02 1177-8881 11 2017 Drug design, development and therapy Drug Des Devel Ther Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug (...) interactions? Observations and introspection of the bioanalysis. 1263-1265 10.2147/DDDT.S137116 Thakkar Disha D Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research-Ahmedabad, Gandhinagar, Gujarat, India. Dash Ranjeet Prasad RP Drug Metabolism and Pharmacokinetics, Johns Hopkins Drug Discovery Program, Johns Hopkins University. Department of Neurology, Johns Hopkins University, Baltimore, MD, USA. eng Journal Article 2017 04 20 New Zealand Drug Des Devel Ther

2017 Drug design, development and therapy

43. Workload even affects hand hygiene in a highly trained and well-staffed setting: a prospective 365/7/24 observational study. (Abstract)

Workload even affects hand hygiene in a highly trained and well-staffed setting: a prospective 365/7/24 observational study. Compliance with hand hygiene (HH) has often not proved satisfactory; high workload is a commonly self-reported reason. Previous studies comparing workload and compliance have not measured workload precisely and have focused on certain times of day. This study aimed to investigate the association between HH compliance and workload, both electronically defined 365/7/24 (...) (primary endpoint). In addition, the quality of commonly used compliance defining methods (hand disinfectant usage, direct observation) was investigated (secondary endpoint).Correlation of electronically measured HH compliance (hand-rub activities (HRA)/HH opportunities) with electronically determined workload (nursing time output/nursing time input) was undertaken over one year at a stem cell transplant unit at University Hospital Basel, Switzerland. HRA and procedures requiring HRA according

2017 Journal of Hospital Infection

44. What is the effect of the COVID-19 pandemic on substance use, overdoses, and substance-related deaths? How have rates of overdoses and substance-related deaths been affected during the COVID-19 pandemic? What strategies have been used to mitigate substanc

is the effect of the COVID-19 pandemic on substance use, overdoses, and substance-related deaths? The very limited research evidence on this question points to certain observed or anticipated effects of the COVID-19 pandemic: ? People who use substances have reduced access to harm-reduction and treatment services ? There has been a disruption to the supply of illicit drugs in Canada, affecting the availability and cost, and increasing the risk of drug adulteration ? People who use substances may be at risk (...) What is the effect of the COVID-19 pandemic on substance use, overdoses, and substance-related deaths? How have rates of overdoses and substance-related deaths been affected during the COVID-19 pandemic? What strategies have been used to mitigate substanc Version 1: June 19, 2020 Rapid Review: What is the effect of the COVID-19 pandemic on opioid and substance use and related harms? Prepared by: The National Collaborating Centre for Methods and Tools Date: June 19, 2020 Suggested Citation

2020 COVID-19 Rapid Evidence Service

45. Seasonal affective disorder

Seasonal affective disorder Seasonal affective disorder - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Seasonal affective disorder Last reviewed: February 2019 Last updated: June 2018 Summary Not considered to be a unique diagnostic entity in itself, but rather a sub-type specifier used to describe temporal variations in recurrent major depressive or bipolar disorders over at least a 2-year period. Most commonly (...) presents with onset of depression in the autumn or winter, and full remission of symptoms in the spring or summer. Atypical vegetative symptoms of depression are common, such as hypersomnia, hyperphagia, and weight gain. Assessment is based on self-report, clinical interview, and behavioural observation. Light therapy, selective serotonin-reuptake inhibitors, and serotonin-noradrenaline reuptake inhibitors, either alone or in combination, are considered the initial treatment options. Longer-term

2018 BMJ Best Practice

46. What helps to support people affected by Adverse Childhood Experiences? A Review of Evidence

What helps to support people affected by Adverse Childhood Experiences? A Review of Evidence What helps to support people aected by Adverse Childhood Experiences? A review of evidence Sarah Lester, Theo Lorenc, Katy Sutcliffe, Meena Khatwa Claire Stans?eld, Amanda Sowden, James Thomas ––––––––––––––– November 2019 Department of Health & Social Care eviews Facility To support national policy development and implementation The Department of Health & Social Care Reviews Facility is a collaboration (...) between the following centres of excellence:What helps to support people affected by Adverse Childhood Experiences? A review of evidence The authors of this report are: Sarah Lester 1 , Theo Lorenc 2 , Katy Sutcliffe 1 , Meena Khatwa 1 , Claire Stansfield 1 , Amanda Sowden 2 , James Thomas 1 (1 - EPPI-Centre, 2 – Centre for Reviews and Dissemination). Editorial and cover design by: Lionel Openshaw 1 Acknowledgements: We would like to thank Dr Louca-Mai Brady for her valuable contribution to organising

2019 EPPI Centre

47. Paternal 132 bp deletion affecting <i>KCNQ1OT1</i> in 11p15.5 is associated with growth retardation but does not affect imprinting. (Abstract)

. It does not affect the IC2 methylation in general and the coding sequence of the KCNQ1 gene. Thus, the deletion is only associated with a growth retardation phenotype when paternally transmitted but not with other clinical features in case of maternal inheritance as observed for larger deletions.© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. (...) Paternal 132 bp deletion affecting KCNQ1OT1 in 11p15.5 is associated with growth retardation but does not affect imprinting. The chromosomal region 11p15.5 harbours two imprinting centres (H19/IGF2:IG-DMR/IC1, KCNQ1OT1:TSS-DMR/IC2). Molecular alterations of the IC2 are associated with Beckwith-Wiedemann syndrome (BWS), whereas only single patients with growth retardation and Silver-Russell syndrome (SRS) features have been reported. CNVs in 11p15.5 account for less than 1% of patients

2020 Journal of Medical Genetics

48. Observed Affect

Observed Affect Observed Affect Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Observed Affect Observed Affect Aka: Observed Affect (...) , Affect Examination , Affect Exam , Stated Mood , Emotional Mood II. Definition Observed Affect Clinician's objective observation of a patient's emotional state Stated Mood Constant emotional state (depression, euphoria, anxiousness, anger, irritability) the patient can describe III. Exam: Affect Characteristics Emotional Range: Broad or Restricted Intensity: Expansive, Blunted/Flat or Normal Stability IV. Exam: Consistency Appropriate for situation? Congruence with Stated Mood Is Observed Affect

2018 FP Notebook

49. Urban traffic air pollution could affect children attention at school

Urban traffic air pollution could affect children attention at school Urban traffic air pollution could affect children attention at school - Evidencias en pediatría Searching, please wait Show menu Library Management You did not add any article to your library yet. | Search Evidence-Based decision making Evidence-Based decision making Show menu Library Management You did not add any article to your library yet. × User Password Log in × Reset password If you need to reset your password please (...) enter your email and click the Send button. You will receive an email to complete the process. Email Send × Library Management × September 2017. Volume 13. Number 3 Urban traffic air pollution could affect children attention at school Rating: 0 (0 Votes) Reviewers: , . | Newsletter Free Subscription Regularly recieve most recent articles by e-mail Subscribe × Newsletter subscription: Email Confirm email I accept the journal’s privacy policy. Subscribe × Warnings and privacy policy To whom

2017 Evidencias en Pediatría

50. Does the exposure to general anaesthesia in children affect long-term academic and cognitive performance?

Does the exposure to general anaesthesia in children affect long-term academic and cognitive performance? Does the exposure to general anaesthesia in children affect long-term academic and cognitive performance? - Evidencias en pediatría Searching, please wait Show menu Library Management You did not add any article to your library yet. | Search Evidence-Based decision making Evidence-Based decision making Show menu Library Management You did not add any article to your library yet. × User (...) Password Log in × Reset password If you need to reset your password please enter your email and click the Send button. You will receive an email to complete the process. Email Send × Library Management × March 2017. Volume 13. Number 1 Does the exposure to general anaesthesia in children affect long-term academic and cognitive performance? Rating: 0 (0 Votes) Reviewers: , . | Newsletter Free Subscription Regularly recieve most recent articles by e-mail Subscribe × Newsletter subscription: Email Confirm

2017 Evidencias en Pediatría

51. Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. Full Text available with Trip Pro

Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. To describe the characteristics of children and adolescents affected by an outbreak of Kawasaki-like multisystem inflammatory syndrome and to evaluate a potential temporal association with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Prospective observational study.General paediatric department of a university hospital in Paris (...) in the Paris area might be related to SARS-CoV-2. In this study an unusually high proportion of the affected children and adolescents had gastrointestinal symptoms, Kawasaki disease shock syndrome, and were of African ancestry.© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

2020 BMJ

52. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Full Text available with Trip Pro

An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. The Bergamo province, which is extensively affected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic, is a natural observatory of virus manifestations in the general population. In the past month we recorded an outbreak of Kawasaki disease; we aimed to evaluate incidence and features of patients with Kawasaki-like disease diagnosed during

2020 Lancet

53. Cohort Study: Adverse events associated with mood stabiliser treatment should be continuously monitored in patients diagnosed with bipolar affective disorder

Cohort Study: Adverse events associated with mood stabiliser treatment should be continuously monitored in patients diagnosed with bipolar affective disorder Adverse events associated with mood stabiliser treatment should be continuously monitored in patients diagnosed with bipolar affective disorder | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more (...) in patients diagnosed with bipolar affective disorder Article Text Aetiology/Harm Cohort Study Adverse events associated with mood stabiliser treatment should be continuously monitored in patients diagnosed with bipolar affective disorder R E Nielsen 1 , 2 , R W Licht 3 Statistics from Altmetric.com Commentary on: Hayes JF , Marston L , Walters K , et al . Adverse Renal, Endocrine, Hepatic, and Metabolic Events during Maintenance Mood Stabilizer Treatment for Bipolar Disorder: A Population-Based Cohort

2017 Evidence-Based Medicine

54. Vitamin D and Calcium Supplementation Along with Oral Hygiene Show Positive Affect on Periodontal Health

result in improved periodontal health? Clinical Bottom Line Evidence showed that there is only a slight positive affect on periodontal health when supplementing vitamin D and calcium along with oral hygiene. This is supported by evidence from a randomized clinical trial and an observational clinical trial that measured the periodontal health in two patient groups, one taking supplementation and one that was not. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author (...) Vitamin D and Calcium Supplementation Along with Oral Hygiene Show Positive Affect on Periodontal Health UTCAT3161, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Vitamin D and Calcium Supplementation Along with Oral Hygiene Show Positive Affect on Periodontal Health Clinical Question In patients with periodontal disease does oral supplementation of vitamin D and calcium along with recommended oral hygiene regimens

2017 UTHSCSA Dental School CAT Library

55. Alexithymia Components Are Differentially Related to Explicit Negative Affect But Not Associated with Explicit Positive Affect or Implicit Affectivity Full Text available with Trip Pro

Alexithymia Components Are Differentially Related to Explicit Negative Affect But Not Associated with Explicit Positive Affect or Implicit Affectivity Alexithymia represents a multifaceted personality construct defined by difficulties in recognizing and verbalizing emotions and externally oriented thinking. According to clinical observations, experience of negative affects is exacerbated and experience of positive affects is decreased in alexithymia. Findings from research based on self-report (...) indicate that all alexithymia facets are negatively associated with the experience of positive affects, whereas difficulties identifying and describing feelings are related to heightened negative affect. Implicit affectivity, which can be measured using indirect assessment methods, relates to processes of the impulsive system. The aim of the present study was to examine, for the first time, the relations between alexithymia components and implicit and explicit positive and negative affectivity

2017 Frontiers in psychology

56. Is aberrant affective cognition an endophenotype for affective disorders? - A monozygotic twin study. (Abstract)

-risk and 36 low-risk MZ twins. Groups were demographically well-balanced and showed comparable non-affective cognitive performance. We observed no aberrant affective cognition in affected and high-risk relative to low-risk twins. However, high-risk twins displayed attentional avoidance of emotional faces (ps ⩽ 0.009) and more use of task-oriented coping strategies (p = 0.01) compared with affected twins. In contrast did affected twins show more emotion-oriented coping than high- and low-risk twins (...) Is aberrant affective cognition an endophenotype for affective disorders? - A monozygotic twin study. Identification of endophenotypes can improve prevention, detection and development of new treatments. We therefore investigated whether aberrant affective cognition constitutes an endophenotype for affective disorders by being present in monozygotic (MZ) twins with unipolar or bipolar disorder in partial remission (i.e. affected) and their unaffected co-twins (i.e. high-risk) relative to twins

2018 Psychological Medicine

57. Gray matter differences between affective and non-affective first episode psychosis: A review of Magnetic Resonance Imaging studies. Full Text available with Trip Pro

Gray matter differences between affective and non-affective first episode psychosis: A review of Magnetic Resonance Imaging studies. Non-affective and affective psychoses are very common mental disorders. However, their neurobiological underpinnings are still poorly understood. Therefore, the goal of the present review was to evaluate structural Magnetic Resonance Imaging (MRI) studies exploring brain deficits in both non-affective (NA-FEP) and affective first episode psychosis (A-FEP (...) ).A bibliographic search on PUBMED of all MRI studies exploring gray matter (GM) differences between NA-FEP and A-FEP was conducted.Overall, the results from the available evidence showed that the two diagnostic groups share common GM alterations in fronto-temporal regions and anterior cingulate cortex. In contrast, unique GM deficits have also been observed, with reductions in amygdala for A-FEP and in hippocampus and insula for NA-FEP.Few small MRI studies with heterogeneous methodology.Although the evidences

2018 Journal of Affective Disorders

58. Delusional Themes Across Affective and Non-Affective Psychoses Full Text available with Trip Pro

Delusional Themes Across Affective and Non-Affective Psychoses The current debate about the diagnostic significance of delusion revolves around two positions. The neurocognitive position conceives delusion as a non-specific, though polymorphic, symptom. The psychopathological position views features of delusion such as content and structure as having meaningful connections with diagnostic entities. This study aims at contributing to this debate by examining the association between delusional (...) patients with manic symptoms (bipolar mania 20%; bipolar mixed states 19%; manic schizoaffective disorder 10%). They were observed significantly more often in bipolar mania than in schizophrenia (7%). Persecutory delusions were broadly distributed across diagnostic categories. However, they were significantly more frequent among patients with schizophrenia and delusional disorder compared with depressed and manic patients. Somatic delusions were also observed in all diagnostic groups, with no group

2018 Frontiers in Psychiatry

59. High inter-observer agreement of observer-perceived pain assessment in the emergency department. Full Text available with Trip Pro

or severe pain) we found a 70% agreement with a mean difference in categories of 0.05 and 95% limits of agreement of +/- 1 category. Patient age, gender, localization of pain, examination room or presence of a significant other did not affect the inter-observer agreement.We found 70% agreement on pain category between the nurses and it is justified that nurse-perceived pain assessment is used for triage in the emergency department. (...) High inter-observer agreement of observer-perceived pain assessment in the emergency department. Triage is used to prioritize the patients in the emergency department. The majority of the triage systems include the patients' pain score to assess their level of acuity by using a combination of patient reported pain and observer-perceived pain; the latter therefore requires a certain degree of inter-observer agreement. The aim of the present study was to assess the inter-observer agreement

2018 BMC Emergency Medicine

60. Transient and chronic childhood immune thrombocytopenia are distinctly affected by Fc-γ receptor polymorphisms. Full Text available with Trip Pro

Transient and chronic childhood immune thrombocytopenia are distinctly affected by Fc-γ receptor polymorphisms. In childhood immune thrombocytopenia (ITP), anti-platelet autoantibodies mediate platelet clearance through Fc-γ receptor (FcγR)-bearing phagocytes. In 75% to 90% of patients, the disease has a transient, self-limiting character. Here we characterized how polymorphisms of FcγR genes affect disease susceptibility, response to intravenous immunoglobulin (IVIg) treatment, and long-term (...) recovery from childhood ITP. Genotyping of the FCGR2/3 locus was performed in 180 children with newly diagnosed ITP, 22 children with chronic ITP, and 180 healthy control children by multiplex ligation-dependent probe amplification. Children with newly diagnosed ITP were randomly assigned to a single administration of IVIg or observation, and followed for 1 year (Treatment With or Without IVIg for Kids With ITP [TIKI] trial). We defined transient ITP as a complete recovery (≥100 × 109/L) 3 months after

2019 Blood advances Controlled trial quality: uncertain

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