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Obesity Medication

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161. Characterizing the Intestinal Hormonal Secretion in Non-obese, Obese and Non-obese Patients After Bariatric Surgery

. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by Dr. Ofir Harnoy MD, Sheba Medical Center: Obesity (...) Characterizing the Intestinal Hormonal Secretion in Non-obese, Obese and Non-obese Patients After Bariatric Surgery Characterizing the Intestinal Hormonal Secretion in Non-obese, Obese and Non-obese Patients After Bariatric Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2017 Clinical Trials

162. Assessing and managing children at primary health-care facilities to prevent overweight and obesity in the context of the double burden of malnutrition

provides strong evidence that the effect is sustained at 6 months or more post-intervention (SMD = –0.30; 95% CI: –0.49 to –0.11). Referral methods: specialist medical referral, from medical records, from patients referred into an obesity clinic, from university paediatric obesity clinic; mixed referral, paediatricians from a children’s hospital or responded to a community advertisement; local professional networks in primary and secondary care, from schools and local media; media, schools, health (...) • Boland et al., 2015 (56): assessed RCTs and case-studies investigating the effect of orlistat, metformin, glucagon-like peptide-1 agonists, topiramate, and zonisamide in human subjects. Orlistat is the only Food and Drug Administration (FDA)-approved medication for paediatric obesity, and reduced BMI by 0.5–4 kg/m 2 . Gastrointestinal adverse effects are frequently reported with its use. Metformin showed BMI reductions of 0.17–1.8 kg/m 2 . Mild gastrointestinal adverse effects are usually managed

2017 World Health Organisation Guidelines

163. Being overweight or obese is linked with heart disease even without other metabolic risk factors

. In 2015, almost two-thirds of adults in England were overweight or obese. The cost of treating people who develop health problems due to obesity is around £6.1 billion a year. Obese people risk developing medical problems which themselves cause heart disease, such as high blood pressure and type 2 diabetes. Previously, it was thought that healthy obese people might not have an increased risk of heart disease unless they developed these metabolic risk factors. In this study, the researchers looked (...) conditions such as type 2 diabetes, or if the BMI is 40 or more then surgical interventions can be considered. NICE 2016 guidelines recommend healthcare professionals use the QRISK2 tool to assess cardiovascular risk. This is suitable for people up to age 84 years. Lifestyle modifications and taking statins and blood pressure lowering medication can then start as appropriate What are the implications? Having metabolic risk factors appears to be a greater risk than being overweight or obese alone. However

2019 NIHR Dissemination Centre

164. Takeaways linked to increased cardiovascular risk factors and obesity in children

Takeaways linked to increased cardiovascular risk factors and obesity in children Takeaways linked to increased cardiovascular risk factors and obesity in children Discover Portal Discover Portal Takeaways linked to increased cardiovascular risk factors and obesity in children Published on 13 February 2018 doi: Children who eat takeaways once or more each week have more body fat and higher low-density lipoprotein (LDL) “bad” cholesterol levels than those who never or hardly ever eat them (...) . Their diets were also higher in fat and lower in protein and calcium. This cross-sectional study looked in depth at eating habits and risk markers for coronary heart disease, obesity and diabetes in 2,529 children in England. Though this type of study can only show an association between takeaways and risk markers, it is one of the first of its type, and the results do give cause for concern. Increasing numbers of people are eating takeaways in the UK. Local authorities and healthcare professionals

2019 NIHR Dissemination Centre

165. Intensive lifestyle interventions can help obese young people lose weight

studies in children with obesity-related medical problems. Limitations included the small sample size of individual trials and highly variable study methods, including interventions, reported outcomes, and length of follow-up. Quality was assessed using criteria defined by the US Preventive Task Force. What did it find? Children receiving at least 52 hours of contact time in behaviour-based weight loss interventions showed greater reduction in BMI or BMI z score (how much BMI deviates from the norm (...) follow-up. Other outcomes included cardiometabolic measures, quality of life and harms. Study recruitment had to be in a healthcare setting and relevant to primary care. School-based or residential studies were excluded, as were studies in children with obesity-related medical problems. Limitations included the small sample size of individual trials and highly variable study methods, including interventions, reported outcomes, and length of follow-up. Quality was assessed using criteria defined

2019 NIHR Dissemination Centre

166. Setmelanotide for pro-opiomelanocortin deficiency obesity

Setmelanotide for pro-opiomelanocortin deficiency obesity Setmelanotide for pro-opiomelanocortin deficiency obesity | Innovation Observatory toggle menu Menu Search View All Filter by Speciality Filter by Year Filter by Category This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required (...) for our stakeholders. > > > Setmelanotide for pro-opiomelanocortin deficiency obesity Setmelanotide for pro-opiomelanocortin deficiency obesity September 2017 Body fat and food intake are regulated by signals from the brain to the gut. One of the important hormones that is responsible for this is pro-opiomelanocortin (POMC). In a very small group of people there is a lack of this hormone (due to a genetic mutation), referred to as POMC deficiency. This causes severe overeating which leads to obesity

2017 NIHR Innovation Observatory

167. Effectiveness of interventions for overweight or obesity in children and adolescents

the effects of lifestyle interventions, medical interventions and surgery in children and adolescents with overweight or obesity. Method We searched systematically for literature in nine databases (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials Register (CENTRAL), Medline (Ovid), Embase (Ovid), CINAHL via EBSCOhost, PsycINFO, ISI Web of Science, DARE (Database of abstracts of reviews of effects) and HTA). To be included the studies had to be systematic reviews (...) or RCTs, include children and adolescents with overweight or obesity, assess effectiveness of lifestyle interventions (combined lifestyle interventions (changes in diet, physical activity, behavior changes, minimum two components), physical activity interventions, and dietary interventions), medical interventions and surgery. The interventions had to be compared with standard, minimal or no treatment, and measure body mass index (BMI) and/or BMI standard deviation score (BMI z-score, indicates how

2016 Norwegian Institute of Public Health

168. Final recommendation statement: obesity in children and adolescents: screening.

Native ethnicity) or with obesity-related medical problems (e.g., type 2 diabetes, the metabolic syndrome, hypertension, lipid abnormalities). Studies were excluded if they were limited to youth who had an eating disorder, who were pregnant or postpartum, who were overweight or had obesity secondary to a medical condition, who had an intellectual or developmental disability, or who were in college. Control groups of behavior-based interventions could include usual care, no intervention, waitlist (...) Final recommendation statement: obesity in children and adolescents: screening. Final recommendation statement: obesity in children and adolescents: screening. | National Guideline Clearinghouse success fail JUN 09 2017 2018 2019 14 Apr 2018 - 12 Jul 2018 COLLECTED BY Organization: Formed in 2009, the Archive Team (not to be confused with the archive.org Archive-It Team) is a rogue archivist collective dedicated to saving copies of rapidly dying or deleted websites for the sake of history

2017 National Guideline Clearinghouse (partial archive)

169. Obesity and Metabolism

profound effects on the pulmonary immune response and appears to play a key role in the pathogenesis of lung diseases. We are in the midst of an escalating global epidemic of overweight and obesity (10). The increased prevalence of overweight and obesity conveys not only greater morbidity and mortality to the population but also substantial associated medical costs. Obesity affects multiple organ systems, including the respiratory system. Furthermore, altered metabolism (...) and mitochondrialfunctioncanleadtoprofound changes in both innate and adaptive immunity, as well as in pulmonary function. Pulmonary researchers and clinicians are just beginning to appreciate the impact of obesity on common pulmonary diseases. This transdisciplinary symposium was focused on emerging concepts and data pertaining to metabolic disease and lung health. The goals were to (1) develop research priorities and collaborations and (2) disseminate this knowledge to the wider scienti?c and medical community. Methods This symposium

2017 American Thoracic Society

170. Pediatric Obesity: Assessment, Treatment, and Prevention

2008. This guideline addresses: Preventing and treating childhood obesity with lifestyle changes Evaluating affected children for medical or psychological complications Deciding when to evaluate children for rare genetic causes of obesity Determining when medication or surgery is appropriate for severely affected adolescents Resources | Endocrine News | Endocrine Society | ENDO 2016 | Guideline Central | Hormone Health Network | Endocrine Society Pediatric Obesity - Assessment, Treatment (...) has been downgraded from a recommendation to a suggestion based on recent data. The psychological factors affecting childhood obesity are discussed, as well as the toll it takes on children. Information on the risks, contraindications, and recommendations for medication and surgery for severely affected adolescents has been added, including a discussion on bariatric surgery. Goals for future research has been updated. Summary of Recommendations 1.1 We recommend using body mass index (BMI

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2017 The Endocrine Society

171. Bariatric Surgery for the Long-Term Treatment of Obesity: A Review of the Clinical Effectiveness and Cost-Effectiveness

significant reduction in weight, waist circumference, and body mass index (BMI) as compared to medical treatment in patients with morbid obesity. Evidence from cost evaluation studies showed that bariatric surgery is more cost-effective than conventional treatment in patients with morbid obesity over a life time horizon. Despite higher inpatient costs leading to higher total healthcare costs at 15 years, there was no difference in total healthcare costs in the subgroup of patients with diabetes (...) Bariatric Surgery for the Long-Term Treatment of Obesity: A Review of the Clinical Effectiveness and Cost-Effectiveness Bariatric Surgery for the Long-Term Treatment of Obesity: A Review of the Clinical Effectiveness and Cost-Effectiveness | CADTH.ca Find the information you need Bariatric Surgery for the Long-Term Treatment of Obesity: A Review of the Clinical Effectiveness and Cost-Effectiveness Bariatric Surgery for the Long-Term Treatment of Obesity: A Review of the Clinical Effectiveness

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

172. Obesity in Children and Adolescents: Screening

medications for pediatric populations with obesity are needed. Discussion Burden of Disease Recent prevalence figures from 2011 to 2012 indicate that 17% of children and adolescents aged 2 to 18 years in the United States have obesity. Children and adolescents aged 6 to 19 years are more likely to have obesity than children aged 2 to 5 years. , . Although overt cardiovascular disease can take many years to develop, obesity is associated with poor cardiovascular and metabolic outcomes during childhood (e.g (...) children. The USPSTF added language about subgroup analyses, access, and research gaps based on comments. Update of Previous USPSTF Recommendation This recommendation updates the 2010 USPSTF recommendation statement on screening for obesity in children 6 years and older (B recommendation). Recommendations of Others In 2007, an American Medical Association expert committee recommended that clinicians’ assessments include BMI calculation as well as medical and behavioral risk factors for obesity

2017 U.S. Preventive Services Task Force

173. Obesity in Adolescents

along with the prevalence of weight-related diseases. Between the 1980s and 2014, the prevalence of obesity among adolescent females in the United States increased from approximately 10% to 21%. Although the steep increase in the prevalence of obesity in children (2–11 years) has slowed, the prevalence of obesity in adolescents (12–19 years) continues to increase. Because the obese female adolescent faces medical, psychologic, and reproductive health challenges, early intervention is imperative (...) , and psychologist or psychiatrist, should be used to select appropriate candidates for surgical intervention and provide postoperative support. Introduction Rates of obesity among adolescents in the United States have increased at a dramatic rate along with the prevalence of weight-related diseases. Because the obese female adolescent faces medical, psychologic, and reproductive health challenges, early intervention is imperative in preventing short-term and long-term morbidity. The obstetrician–gynecologist

2017 American College of Obstetricians and Gynecologists

174. A total diet replacement programme helped obese people lose weight and keep weight off

. After eight weeks of this low calorie diet, conventional meals were gradually reintroduced. This trial provides evidence that the rapid weight loss from these replacement diets can be maintained for a reasonable time and so could be considered as a treatment option for anyone who is obese and needs support to lose weight. Share your views on the research. Why was this study needed? In 2016, 26% of adults in England were obese. Obesity can lead to several medical conditions, including heart disease (...) in Applied Health Research and Care Oxford, and a research grant from Cambridge Weight Plan UK. Bibliography NHS Digital. . Leeds: NHS Digital; 2018. NHS website. . London: Department of Health and Social Care; 2016. NICE. . CG189. London: National Institute for Health and Care Excellence; 2014. Why was this study needed? In 2016, 26% of adults in England were obese. Obesity can lead to several medical conditions, including heart disease, type 2 diabetes and some cancers. Losing weight reduces the health

2019 NIHR Dissemination Centre

175. Open letter from academics, practitioners, students and members of the public to the British Medical Association, the British Medical Journal publishing group, and the British Association of Sports and Exercise Medicine regarding editorial governance of t

Open letter from academics, practitioners, students and members of the public to the British Medical Association, the British Medical Journal publishing group, and the British Association of Sports and Exercise Medicine regarding editorial governance of t Open letter from academics, practitioners, students and members of the public to the British Medical Association, the British Medical Journal publishing group, and the British Association of Sports and Exercise Medicine regarding editorial (...) : 769-774. Malhotra A, Noakes T, Phinney S. It is time to bust the myth of physical inactivity and obesity: you cannot outrun a bad diet. Br J Sports Med 2015; 49: 967-968. Original Letter Dear Ms Phipps, Dr Nagpaul, Dr Godlee, and Mr Holloway, As academics (scientists, lecturers, researchers), practitioners and students in the fields of sport and exercise science and medicine, evidence-based medicine/health care, nutrition and dietetics, public health, general practice/family medicine, as well

2018 British Journal of Sports Medicine Blog

176. Including Lifestyle Medicine in Medical Education: Rationale for American College of Preventive Medicine/American Medical Association Resolution 959. (PubMed)

and continuing medical education. Resolution 959 was passed to help address the current healthcare costs of lifestyle-related, noncommunicable chronic diseases that exert a devastating economic burden on the U.S. healthcare system. Approximately 86% of $2.9 trillion is spent annually on obesity, cardiovascular disease, type 2 diabetes, and some cancers, with very poor return on investment for health outcomes. Lifestyle medicine provides an evidence-based solution to the noncommunicable chronic disease (...) Including Lifestyle Medicine in Medical Education: Rationale for American College of Preventive Medicine/American Medical Association Resolution 959. Introduced by the American College of Preventive Medicine and released by the American Medical Association House of Delegates in 2017, Resolution 959 (I-17) supports policies and mechanisms that incentivize and/or provide funding for the inclusion of lifestyle medicine education and social determinants of health in undergraduate, graduate

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2019 American journal of preventive medicine

177. Patient-reported health outcomes for severe knee osteoarthritis after conservative treatment with an intra-articular cell-free formulation for articular cartilage regeneration combined with usual medical care vs. usual medical care alone: A randomized con (PubMed)

Patient-reported health outcomes for severe knee osteoarthritis after conservative treatment with an intra-articular cell-free formulation for articular cartilage regeneration combined with usual medical care vs. usual medical care alone: A randomized con Osteoarthritis (OA) is a major public health problem characterized by joint pain, fatigue, functional limitation and decreased quality of life of the patient, which results in increased use of healthcare services and high economical costs (...) . A promising novel bioactive cell-free formulation (BIOF2) for cartilage regeneration has recently been tested in pre-clinical and clinical trials, and has demonstrated a success rate similar to that of total joint arthroplasty for the treatment of severe knee OA. The present study evaluated the efficacy of treatment with BIOF2, by including it within a conservative regimen of 'usual medical care' of knee OA, and whether its efficacy was affected in subgroups of patients presenting with comorbidities

2019 Experimental and therapeutic medicine Controlled trial quality: uncertain

178. Weight management: lifestyle services for overweight or obese adults

are led by an appropriately qualified physical activity instructor and take into account any medical conditions people may have. Instructors should be on the Register of Exercise Professionals (or equivalent) at level 3 or above. Use a variety of behaviour-change methods. These should address: problem solving; goal setting; how to carry out a particular task or activity; planning to provide social support or Weight management: lifestyle services for overweight or obese adults (PH53) © NICE 2018. All (...) being measured and able to identify when it is practical, relevant and appropriate to measure someone. Weight management: lifestyle services for overweight or obese adults (PH53) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 20 of 65Ensure staff are aware of the common medical and psychological problems associated with being overweight or obese. Ensure staff are aware of evidence on the effect of dietary habits

2014 National Institute for Health and Clinical Excellence - Clinical Guidelines

179. Obesity: identification, assessment and management

from the Department of Health. A simulated model reported in the Lancet predicted that there would be 11 million more obese adults in the UK by 2030, with combined medical costs for treatment of associated diseases estimated to increase by up to £2 billion per year. Obesity (NICE guideline CG43) made recommendations for providing care on preventing and managing overweight and obesity. The guideline aimed to ensure that obesity became a priority at both strategic and delivery levels. In 2013 (...) responsibility for the decision. The patient (or those with authority to give consent on their behalf) should provide informed consent, which should be documented. See the General Medical Council's Prescribing guidance: prescribing unlicensed medicines for further information. Where recommendations have been made for the use of drugs outside their licensed indications ('off-label use'), these drugs are marked with a footnote in the recommendations. Obesity: identification, assessment and management (CG189) ©

2014 National Institute for Health and Clinical Excellence - Clinical Guidelines

180. [Effects of interval exercise in the improvement of glycemic control of obese adults with insulin resistance]. (PubMed)

[Effects of interval exercise in the improvement of glycemic control of obese adults with insulin resistance]. Background: physical exercise presents evidence for the treatment of insulin resistance. However, it is necessary to deepen this knowledge. Objective: to compare the effectiveness of a high intensity interval training program (HIIT) with one of resistance training (RT) to improve biochemical parameters of insulin/basal glycemia and post-load. Material and methods: twenty-eight (36 ± 13 (...) years old) non-medicated insulin-resistant individuals (age 36 ± 13 years) were studied. Two groups were randomly formed: RT group (n = 14) and HIIT group (n = 14). Each group participated in 12 weeks of intervention (three sessions/week). Both groups were homogeneous (p > 0.05) in terms of age, weight, height and BMI. Basal glycemia/insulinemia and post-load were evaluated, pre and post intervention. Results: after the intervention there were significant decreases in both groups in: fat (%) HIIT

2019 Nutricion hospitalaria Controlled trial quality: uncertain

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