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Obesity Medication

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141. Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized trial. (PubMed)

Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized trial. To determine if (poly)phenols alter cardiovascular risk factors, we assessed the potential of a high (poly)phenol beverage drink, rich in hydroxycinnamates and flavonoids, to modify vascular function in middle aged, overweight or obese subjects without medical co-morbidity in a randomized placebo controlled (...) increased in active versus placebo recipients (0.32 vs - 0.18 pg/ml; p=0.010).There was no evidence for a short-term beneficial effect of (poly)phenol intervention on microcutaneous vascular response or pulse wave velocity, and no evidence for a benefit on established or novel risk factors in overweight or obese subjects. Our results do not support a short-term benefit of (poly)phenol supplementation on cardiometabolic risk.Clinical Trials.gov (NCT00795834).Copyright © 2016. Published by Elsevier

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2016 Atherosclerosis Controlled trial quality: predicted high

142. Clinical Considerations Regarding the Use of Obesity Pharmacotherapy in Adolescents with Obesity. (PubMed)

through four stages of intervention. Although a recent surge in the number of Food and Drug Administration-approved medications for obesity treatment has emerged in adults, pharmacotherapy options for youth remain limited. Recognizing treatment and knowledge gaps related to pharmacological agents and the urgent need for more effective treatment strategies in this population, discussed here are the efficacy, safety, and clinical application of obesity pharmacotherapy in youth with obesity based (...) on current literature. Legal ramifications, informed consent regulations, and appropriate off-label use of these medications in pediatrics are included, focusing on prescribing practices and prescriber limits.© 2019 The Obesity Society.

2019 Obesity

143. The anti-obesity effects of Tongbi-san in a high-fat diet-induced obese mouse model. (PubMed)

The anti-obesity effects of Tongbi-san in a high-fat diet-induced obese mouse model. Recently, it has been noted that natural herbal medications may be effective in treating obesity. Tongbi-san (TBS) is a traditional medicine usually used for dysuria (i.e., painful urination), containing three herbs, Cyperus rotundus L., Citrus unshiu Markovich, and Poria cocos. In this study, we aimed to examine whether TBS can inhibit high-fat diet (HFD)-induced adipogenesis in the liver and epididymal (...) adipose tissue of obese mice.Male C57BL/6 N mice were fed a normal diet, an HFD, an HFD plus orlistat 10 or 20 mg/kg, or an HFD plus TBS 50 or 100 mg/kg for 11 weeks. Body weight was checked weekly and histological tissue examinations were investigated. An expression of genes involved in adipogenesis was also assessed.Oral administration of TBS significantly reduced body weight and decreased epididymal and visceral white adipose tissue (WAT) weight. In addition, we found that TBS enhanced

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2019 BMC Complementary and Alternative Medicine

144. Genomics and Obesity: We Need Both Population and Individualized Approaches in the Prevention and Management of Obesity

and local organizations can create a supportive environment to promote healthy living behaviors that prevent obesity. The Journal of the American Medical Association recently revisited old approaches and reimagined new solutions to obesity in a . Ultimately, the use of individualized and population level interventions are needed, and not merely the search for Identifying additional genetic, metabolic, behavioral, and environmental factors that make people susceptible to obesity and better clarifying (...) Genomics and Obesity: We Need Both Population and Individualized Approaches in the Prevention and Management of Obesity Genomics and Obesity: We Need Both Population and Individualized Approaches in the Prevention and Management of Obesity | | Blogs | CDC Search Form Controls TOPIC ONLY Search The CDC cancel submit Search Form Controls TOPIC ONLY Search The CDC cancel submit Note: Javascript is disabled or is not supported by your browser. For this reason, some items on this page

2018 CDC Genomics and Health Impact Blog

145. Association between central obesity and tooth loss in the non-obese people: results from the continuous national health and nutrition examination survey (NHANES) 1999-2012. (PubMed)

was measured by the number of teeth missing. Central obesity was defined by a categorized 3-level waist circumference according to the WHO recommendation. A zero-inflated negative binomial model was used to investigate the association between tooth loss and central obesity. All models were adjusted for demographic, socioeconomic status, lifestyles, medical conditions and inflammatory biomarkers.For an overweight person with central obesity, the prevalence of tooth loss increased by 31% (Prevalence ratio (...) Association between central obesity and tooth loss in the non-obese people: results from the continuous national health and nutrition examination survey (NHANES) 1999-2012. This study was to investigate the association between central obesity and tooth loss in non-obese population.This national cross-sectional study included 19436 participants, aged 19-74 years with body mass index(BMI) 18.5-29.9 kg/m2 , from the National Health and Nutrition Examination Survey(NHANES) 1999-2012. Tooth loss

2019 Journal of Clinical Periodontology

146. Longer-term liraglutide administration at the highest dose approved for obesity increases reward-related orbitofrontal cortex activation in response to food cues: Implications for plateauing weight loss in response to anti-obesity therapies. (PubMed)

Longer-term liraglutide administration at the highest dose approved for obesity increases reward-related orbitofrontal cortex activation in response to food cues: Implications for plateauing weight loss in response to anti-obesity therapies. GLP-1 analogs have recently risen to the forefront as effective medications for lowering weight through actions in the central nervous system (CNS). However, their actions in the CNS have not yet been studied in the human brain after longer-term (...) administration at the highest dose approved for obesity (liraglutide 3.0 mg).A total of 20 participants with obesity were treated with placebo and liraglutide (3.0 mg) in the context of a randomized, placebo-controlled, double-blind, cross-over trial after 5 weeks of dose escalation. Neurocognitive and neuroimaging (fMRI) responses to food cues were examined at the clinical research center of Beth Israel Deaconess Medical Center.While using liraglutide, patients lost more weight (placebo-subtracted -2.7%; P

2019 obesity & metabolism Controlled trial quality: uncertain

147. Is social exposure to obesity associated with weight status misperception? Assessing Australians ability to identify overweight and obesity. (PubMed)

Is social exposure to obesity associated with weight status misperception? Assessing Australians ability to identify overweight and obesity. Overweight and obesity prevalence has increased significantly over the past two decades, currently impacting greater than 60% of Australians. It is unclear if a social perception of a healthy weight has been obscured by the increase in prevalence and thus has become inconsistent with the medical definitions.An electronic questionnaire was distributed via (...) email and social media using the authors' informal networks. Australian adults were eligible to participate. Participants were asked to categorise their own body size using medically accepted words and previously published silhouettes, before identifying underweight, healthy weight, overweight or obesity in a series ofsilhouettes.Eight hundred six questionnaires were completed, a majority of participants had attained a high level of education and were employed female health professionals. Under half

2019 BMC Public Health

148. Effects of Bariatric Surgery in Obese Patients With Hypertension: The GATEWAY Randomized Trial (Gastric Bypass to Treat Obese Patients With Steady Hypertension)

Effects of Bariatric Surgery in Obese Patients With Hypertension: The GATEWAY Randomized Trial (Gastric Bypass to Treat Obese Patients With Steady Hypertension) Recent research efforts on bariatric surgery have focused on metabolic and diabetes mellitus resolution. Randomized trials designed to assess the impact of bariatric surgery in patients with obesity and hypertension are needed.In this randomized, single-center, nonblinded trial, we included patients with hypertension (using ≥2 (...) medications at maximum doses or >2 at moderate doses) and a body mass index between 30.0 and 39.9 kg/m2. Patients were randomized to Roux-en-Y gastric bypass plus medical therapy or medical therapy alone. The primary end point was reduction of ≥30% of the total number of antihypertensive medications while maintaining systolic and diastolic blood pressure <140 mm Hg and 90 mm Hg, respectively, at 12 months.We included 100 patients (70% female, mean age 43.8±9.2 years, mean body mass index 36.9±2.7 kg/m2

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2017 EvidenceUpdates

149. [Characteristics of exercise ventilation and gas exchange in obese and extremely obese patients]. (PubMed)

[Characteristics of exercise ventilation and gas exchange in obese and extremely obese patients]. Objective: To evaluate the characteristics of exercise ventilation and gas exchange in obese and extremely obese patients by Cardiopulmonary exercise test (CPX). Methods: Restrospective anal-ysis of subjects who underwent CPET in Shengjing Hospital of China Medical University from June 2014 to June 2017. A total of 74 subjects were enrolled. According to the body mass index (BMI), 74 subjects were (...) divided into control group(18.5 kg/m(2)≤BMI<23.9 kg/m(2)) (n=21), obese group (28.0 kg/m(2)≤BMI<40.0 kg/m(2)) (n=30) and extremely obese group(BMI≥40.0 kg/m(2))(n=23), respectively. V(O2max), V(O2max)/kg, anaerobic thresh-old(AT), oxygen pulse(V(O2)/HR), breath reserve(BR), inhale time (VTin), expiratory time(VTex) and ventilato-ry equivalent for CO(2)(EqCO(2))were measured by CPX and compared by using one-way ANOVA. Results: Compared to the control group (1 620±400) L/min, the maximal oxygen uptake(V

2019 Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

150. After the STAMPEDE: Surgical versus Medical Treatment for Obese Patients with Diabetes

After the STAMPEDE: Surgical versus Medical Treatment for Obese Patients with Diabetes Rotation Prep | NEJM Resident 360 Social Login Email Login Log in via Email Create Your Account We will not share your email with anyone. Password must be at least 8 characters. Show or Hide the password you are typing. Request to Join has invited you to join this group Your browser does not support video tags Welcome! NEJM Resident 360 helps you prepare for your next rotation quickly and efficiently (...) institution's subscription, or you may connect with an individual subscription to NEJM, NEJM Journal Watch, or NEJM Knowledge+. Choose your current rotation below to get started. Ongoing and Upcoming Discussions Featured Articles NEJM Resident 360 is a product of NEJM Group, a division of the Massachusetts Medical Society. Copyright ©2018 Massachusetts Medical Society. All rights reserved.

2014 Now@NEJM

151. What are the estimated costs of childhood overweight and obesity on the island of Ireland?

What are the estimated costs of childhood overweight and obesity on the island of Ireland? What are the estimated costs of childhood overweight and obesity on the island of Ireland?What are the estimated costs of childhood overweight and obesity on the island of Ireland? To be cited as Ivan J. Perry, Seán R. Millar, Kevin P. Balanda, Anne Dee, David Bergin, Laura Carter, Edel Doherty, Lorraine Fahy, Douglas Hamilton, Abbygail Jaccard, André Knuchel-Takano, Laura McCarthy, Adam McCune, Grace (...) O’Malley, Laura Pimpin, Michelle Queally and Laura Webber ISBN: 978-1-905767-75-5 Publication date: November 2017 What are the estimated costs of childhood overweight and obesity on the island of Ireland? Table of contents Table of contents 1 List of tables 3 List of figures 1 List of abbreviations 1 Acknowledgements 3 Executive summary 4 Introduction 4 Aims and objectives 5 Link with EU Joint Action on Nutrition and Physical Activity (JANPA) project 6 Literature review 6 Methods 11 Results 20

2018 Institute of Public Health in Ireland

152. Perioperative Management of Obstructive Sleep Apnea and Obesity Hypoventilation Syndrome: A Workshop Report

Perioperative Management of Obstructive Sleep Apnea and Obesity Hypoventilation Syndrome: A Workshop Report AMERICANTHORACICSOCIETY DOCUMENTS KnowledgeGapsinthePerioperativeManagementofAdultswith ObstructiveSleepApneaandObesityHypoventilationSyndrome An Of?cial American Thoracic Society Workshop Report Najib T. Ayas, Cheryl R. Laratta, John M. Coleman, Anthony G. Doufas, Matthias Eikermann, Peter C. Gay, Daniel J. Gottlieb, Indira Gurubhagavatula, David R. Hillman, Roop Kaw, Atul Malhotra (...) ?cientevidencetoguidescreeningandoptimizationofOSAand OHSintheperioperativesettingtoachievetheseobjectives.Patients whoareatgreatestriskofrespiratoryorcardiaccomplicationsrelated toOSAandOHSarenotwellde?ned,andtheeffectivenessof monitoringandotherinterventionsremainstobedetermined. Centersinvolvedinsleepresearchneedtodevelopcollaborative networkstoallowmulticenterstudiestoaddresstheknowledgegaps identi?edbelow. Keywords: obstructive sleep apnea; perioperative care; obesity hypoventilation syndrome; risk assessment; postoperative complications Ann

2018 American Thoracic Society

153. Weight Loss to Prevent Obesity-Related Morbidity and Mortality in Adults: Behavioral Interventions

and dissemination of interventions in primary care settings are needed. Future research is needed on factors (eg, genetics or untreated medical or psychological conditions) that may be barriers to weight loss during behavioral interventions. Trials are needed that examine whether interventions that focus on both weight loss and support of persons living with obesity improve patient-centered outcomes. Comparative effectiveness trials would provide more evidence about the components of effective interventions (...) enrolled as study participants. Meta-analyses could not be conducted because of the few number of trials for each drug or variability in outcome reporting. The rate of trial completion in the medication and placebo groups ranged from 10% to 93% (most ranged from 50% to 70%). Ten trials of pharmacotherapy-based interventions (n = 13,145) examined quality of life outcomes. Many trials showed improvement in obesity-specific quality of life measures among participants receiving pharmacotherapy compared

2018 U.S. Preventive Services Task Force

154. Obesity

or contribute to obesity: Elevated BMIs associated with increased muscle mass rather than obesity, as seen in body builders and athletes Medication-induced weight gain, for example: insulin, antipsychotics, corticosteroids Anxiey, depression - may alter eating habits Type 2 diabetes mellitus Excess fluid retention Endocrine diseases such as hypothyroidism, polycystic ovarian syndrome, Cushing's disease, antipsychotics syndrome, central hypothyroidism and hypothalamic disorders – may cause or worsen obesity (...) activities eg watching TV, playing computer games Behaviour modification Bariatric surgery should be considered for patients with BMIs of 35 kg/m 2 and comorbidity or BMI over 40 kg/m 2 in addition to lifestyle modification Over-The Counter medications: There is insufficient evidence to recommend for or against the use of herbal remedies, dietary supplements or homeopathy for weight management in the obese person Many OTC and herbal products are marketed for weight loss. Many contain vitamins and may

2018 medSask

155. The Patient Centred Medical Home: barriers and enablers to implementation

The Patient Centred Medical Home: barriers and enablers to implementation The Patient Centred Medical Home: barriers and enablers to implementation An Evidence Check rapid review brokered by the Sax Institute for COORDINARE. January 2018 An Evidence Check rapid review brokered by the Sax Institute for COORDINARE. January 2018. This report was prepared by: Jim Pearse and Deniza Mazevska – Health Policy Analysis Pty Ltd. January 2018 © Sax Institute 2018 This work is copyright. It may (...) : Pearse J, Mazevska D. The Patient Centered Medical Home: barriers and enablers: an Evidence Check rapid review brokered by the Sax Institute (www.saxinstitute.org.au) for COORDINARE, 2018. Disclaimer: This Evidence Check Review was produced using the Evidence Check methodology in response to specific questions from the commissioning agency. It is not necessarily a comprehensive review of all literature relating to the topic area. It was current at the time of production (but not necessarily

2018 Sax Institute Evidence Check

156. MASCC/ISOO/ASCO Clinical Practice Guideline: Medication-Related Osteonecrosis of the Jaw (MRONJ)

MASCC/ISOO/ASCO Clinical Practice Guideline: Medication-Related Osteonecrosis of the Jaw (MRONJ) Medication-Related Osteonecrosis of the Jaw: MASCC/ISOO/ASCO Clinical Practice Guideline | Journal of Clinical Oncology Search in: Menu Article Tools ASCO SPECIAL ARTICLE Article Tools OPTIONS & TOOLS COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.19.01186 Journal of Clinical Oncology - published online before print July 22, 2019 PMID: Medication-Related Osteonecrosis (...) Michelle Beadle ; , DDS, PhD 19 x Siri Beier Jensen ; and , DMD 20 x Deborah P. Saunders 1 Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel 2 Tel Aviv University, Tel Aviv, Israel 3 Icahn School of Medicine at Mt Sinai, New York, NY 4 UConn Health: Neag Comprehensive Cancer Center, Farmington, CT 5 University of Michigan, Ann Arbor, MI 6 American Society of Clinical Oncology, Alexandria, VA 7 Hofstra North Shore-LIJ School of Medicine, Hempstead, NY 8 Stony Brook School of Dental Medicine, Stony

2019 International Society for Oral Oncology

157. Immediate postpartum long-acting reversible contraception for women at high risk for medical complications

Immediate postpartum long-acting reversible contraception for women at high risk for medical complications SocietyforMaternal-FetalMedicine(SMFM) ConsultSeries#48:Immediatepostpartum long-actingreversiblecontraceptionforwomen athighriskformedicalcomplications Society for Maternal-Fetal Medicine (SMFM); Laura K. Vricella, MD; Lori M. Gawron, MD, MPH; Judette M. Louis, MD, MPH The Society of Family Planning (SFP) endorses this document. The American College of Obstetricians and Gynecologists (...) (ACOG) supports the value of this clinical document as an educational tool; February 2019. Reproductive planning is essential for all women and most important for those with complex health conditions or at high risk for complications. Pregnancy planning can allow these high-risk women the opportunity toreceive preconception counseling, medication adjustment,andriskassessmentrelated tohealthconditionsthathaveadirectimpactonmaternalmorbidityandmortalityrisk.Despitetheneed for pregnancy planning

2019 Society for Maternal-Fetal Medicine

158. Bariatric surgery to treat obesity in individuals under 21 years old

coverage policies of bariatric surgery in patients under 21. Overweight and obesity are among the main death risk and disease burden factors worldwide. In Argentina, according to the 2012 Global School-Based Student Health Survey, 28.5% and 5.9% of adolescents 13-15 years old have overweight and obesity, respectively. In our country, since 2009, our Mandatory Medical Plan covers surgical treatment for obesity starting at the age of 21. It is estimated that bariatric surgery might have a role (...) Bariatric surgery to treat obesity in individuals under 21 years old Bariatric surgery to treat obesity in individuals under 21 years old Bariatric surgery to treat obesity in individuals under 21 years old Rodríguez B, Augustovski F, Pichon-Riviere A, García Martí S, Alcaraz A, Bardach A, Ciapponi A, López A, Rey-Ares L Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made

2017 Health Technology Assessment (HTA) Database.

159. Roux-en-Y gastric bypass for diabetes in obese or severely obese patients

, Inc.. Directory Publication. 2014 Authors' objectives Roux-en-Y gastric bypass (RYGB) is a complex surgical procedure that reduces the size of the stomach and reroutes portions of the small intestine. The RYGB procedure helps patients with severe obesity who have been unable to achieve significant weight loss through medical therapy and lifestyle changes to lose a significant amount of weight and maintain that weight loss in the long term. RYGB is also associated with significant improvements (...) Roux-en-Y gastric bypass for diabetes in obese or severely obese patients Roux-en-Y gastric bypass for diabetes in obese or severely obese patients Roux-en-Y gastric bypass for diabetes in obese or severely obese patients Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Roux-en-Y gastric bypass for diabetes in obese or severely obese patients. Lansdale: HAYES

2014 Health Technology Assessment (HTA) Database.

160. Surgical Versus Medical Treatment of Type 2 Diabetes Mellitus in Nonseverely Obese Patients: A Systematic Review and Meta-Analysis (PubMed)

Surgical Versus Medical Treatment of Type 2 Diabetes Mellitus in Nonseverely Obese Patients: A Systematic Review and Meta-Analysis To compare surgical versus medical treatment of type 2 diabetes mellitus (T2DM) remission and comorbidities in patients with a body mass index (BMI) less than 35 kg/m2.Obesity surgery can achieve remission of T2DM and its comorbidities. Metabolic surgery has been proposed as a treatment option for diabetic patients with BMI less than 35 kg/m2 but the efficacy (...) of metabolic surgery has not been conclusively determined.A systematic literature search identified randomized (RCT) and nonrandomized comparative observational clinical studies (OCS) evaluating surgical versus medical T2DM treatment in patients with BMI less than 35 kg/m2. The primary outcome was T2DM remission. Additional analyses comprised glycemic control, BMI, HbA1c level, remission of comorbidities, and safety. Random effects meta-analyses were calculated and presented as weighted odds ratio

2015 EvidenceUpdates

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