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Obesity Medication

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141. Erratum: Endoscopic Medical Devices for Primary Obesity Treatment in Patients With Diabetes. Diabetes Spectrum 2017;30;258–264 (DOI:10.2337/ds017-0046) Full Text available with Trip Pro

Erratum: Endoscopic Medical Devices for Primary Obesity Treatment in Patients With Diabetes. Diabetes Spectrum 2017;30;258–264 (DOI:10.2337/ds017-0046) [This corrects the article on p. 258 in vol. 30, PMID: 29151716.].

2018 Diabetes spectrum : a publication of the American Diabetes Association

142. New Evidence on the Effect of Medical Insurance on the Obesity Risk of Rural Residents: Findings from the China Health and Nutrition Survey (CHNS, 2004–2011) Full Text available with Trip Pro

New Evidence on the Effect of Medical Insurance on the Obesity Risk of Rural Residents: Findings from the China Health and Nutrition Survey (CHNS, 2004–2011) The obesity rate in China has risen significantly in the past few decades. While a number of causes for the rise in obesity have been explored, little attention has been paid to the role of health insurance per se. This study aims to investigate the impact of health insurance on the risk of obesity in rural China using longitudinal data (...) from the China Health and Nutrition Survey (CHNS). We employed pooled ordinary least squares (OLS), probit estimation, and pooled two-stage least squares (2SLS) for an instrumental variable (IV). The IV model revealed that New rural cooperative medical insurance (NRCMS) participation had a significant positive impact on people's tendency towards unhealthy lifestyles, for instances, high-fat food (8.01% for female and 7.35% for male), cigarette smoking (25% for male), heavy drinking (25% for female

2018 International journal of environmental research and public health

143. The Association between Antihypertensive Medication Use and Blood Pressure Is Influenced by Obesity Full Text available with Trip Pro

The Association between Antihypertensive Medication Use and Blood Pressure Is Influenced by Obesity One in three US adults is living with obesity or hypertension, and more than 75% of hypertensive individuals are using antihypertensive medications. Therefore, it is important to examine blood pressure (BP) differences in populations that are using these medications with differing obesity status.We examined whether BP attained when using various antihypertensive medications varies amongst (...) medications (NoBPMed) (P < 0.05), whereby in women, the differences in systolic BP between angiotensin-converting-enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) users and NoBPMed were greater in those with obesity (ACE inhibitors: -14 ± 1 mmHg; ARB: -16 ± 1 mmHg) compared to normal weight individuals (ACE inhibitors: -9 ± 1 mmHg; ARB: -11 ± 1 mmHg) (P < 0.05). Diastolic BP differences between women ARB users and NoBPMed were also greatest in obesity (-5 ± 1 mmHg) (P < 0.05) whilst there were

2018 Journal of obesity

144. Establishment of a Database of Patients Suffering From Obesity With a Medical Treatment

Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by University Hospital, Montpellier: Obesity Nutrition Disorders Additional relevant MeSH terms: Layout table for MeSH terms Obesity Overnutrition Nutrition Disorders Overweight Body Weight Signs and Symptoms (...) Establishment of a Database of Patients Suffering From Obesity With a Medical Treatment Establishment of a Database of Patients Suffering From Obesity With a Medical Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2018 Clinical Trials

145. Beyond lifestyle interventions: exploring the potential of anti‐obesity medications in the UK Full Text available with Trip Pro

Beyond lifestyle interventions: exploring the potential of anti‐obesity medications in the UK In the UK, over one-quarter of the adult population have obesity (body mass index ≥30 kg m-2 ). This has major implications for patients' health and the National Health Service. Despite published studies showing that significant weight loss can be achieved and maintained in primary care, and guidance from the National Institute for Health and Care Excellence, weight management services (...) are inconsistently implemented. This may be due primarily to workload and financial constraints. There is also a lack of belief that specialist weight management services and anti-obesity medications (AOMs) are a viable alternative to bariatric surgery for long-term maintenance of weight loss. This article discusses the challenges facing obesity management and explores the reasons for the lack of investment in AOMs in the UK to date. The aim of this article is to identify whether the newer AOMs

2018 Clinical Obesity

146. Who pays for the medical costs of obesity? New evidence from the employer mandate. (Abstract)

Who pays for the medical costs of obesity? New evidence from the employer mandate. Theory suggests that the medical costs of obesity should be passed on to obese workers, in the form of lower wages, whenever health coverage is a part of employee compensation. In contrast to existing work on this topic, this paper illustrates that the medical expenditures caused by obesity among working adults are relatively small and that wage offsets should therefore be difficult to detect. The paper supports (...) this claim by exploiting the variation provided by the Affordable Care Act's employer mandate. Findings suggest that obese workers tend to bear the approximate cost of their medical expenditures via lower wages. However, the observed effects are often insignificantly different from zero.© 2018 John Wiley & Sons, Ltd.

2018 Health economics

147. Laparoscopic Conversion of a Vertical Banded Gastroplasty to a Sleeve Gastrectomy in a Morbidly Obese Patient with a Complicated Medical History. Full Text available with Trip Pro

Laparoscopic Conversion of a Vertical Banded Gastroplasty to a Sleeve Gastrectomy in a Morbidly Obese Patient with a Complicated Medical History. We present our technique for performing a laparoscopic conversion of vertical banded gastroplasty (VBG) to sleeve gastrectomy (SG) in a morbidly obese patient.A 58-year-old female with history of hypertension, diabetes, and morbid obesity (BMI 41). She had initially undergone an open VBG (BMI 58) and cholecystectomy (2002) and subsequently underwent

2018 Obesity Surgery

148. Antibiotic and acid-suppression medications during early childhood are associated with obesity. (Abstract)

Antibiotic and acid-suppression medications during early childhood are associated with obesity. Gut microbiota alterations are associated with obesity. Early exposure to medications, including acid suppressants and antibiotics, can alter gut biota and may increase the likelihood of developing obesity. We investigated the association of antibiotic, histamine-2 receptor antagonist (H2RA) and proton pump inhibitor (PPI) prescriptions during early childhood with a diagnosis of obesity.We performed (...) a cohort study of US Department of Defense TRICARE beneficiaries born from October 2006 to September 2013. Exposures were defined as having any dispensed prescription for antibiotic, H2RA or PPI medications in the first 2 years of life. A single event analysis of obesity was performed using Cox proportional hazards regression.333 353 children met inclusion criteria, with 241 502 (72.4%) children prescribed an antibiotic, 39 488 (11.8%) an H2RA and 11 089 (3.3%) a PPI. Antibiotic prescriptions were

2018 Gut

149. Ileal interposition coupled with duodenal diverted sleeve gastrectomy versus standard medical treatment in type 2 diabetes mellitus obese patients: long-term results of a case-control study. (Abstract)

Ileal interposition coupled with duodenal diverted sleeve gastrectomy versus standard medical treatment in type 2 diabetes mellitus obese patients: long-term results of a case-control study. Randomized controlled trials have demonstrated that bariatric surgery is effective in obtaining remission of type 2 diabetes mellitus (T2DM) in obese patients, yet no data exist in the literature from prospective studies with ileal interposition with duodenal diversion sleeve gastrectomy (II-DD-SG). The aim (...) of this case-control study is to investigate if II-DD-SG is superior to medical treatment in T2DM obese patients.Thirty obese patients (BMI > 30) affected by T2DM were recruited for surgery (II-DD-SG) between 2008 and 2011 and were matched with an equal control group which received standard medical treatment. Anthropometric measures, glucose metabolism, cardiovascular risk factors were determined baseline and during follow-up. The primary end point was T2DM remission; reduction of body weight, BMI

2018 Surgical endoscopy

150. Vagal Nerve Blockade for Obesity: VBLOC Therapy Using the Maestro RC2 Device

to bring about sustained and clinically significant weight loss in patients for whom drug therapy or bariatric surgery are not indicated, or who do not want to undergo bariatric procedures that are invasive, irreversible, and bring a higher risk of short- and long-term adverse events. The Maestro RC2 device, a vagal nerve blocker positioned laparoscopically, could satisfy the need for such an alternative approach to inducing weight loss in obese patients. Compared with evidence concerning available (...) daily battery checks and undertake recharging as needed. The device can be removed if necessary. Regulatory Status Toward the end of 2015, EnteroMedics will submit an application to Health Canada for regulatory approval of VBLOC therapy for adult obesity using the Maestro RC2 device (Dan Cohen, EnteroMedics Inc., St. Paul, MN: personal communication, 2015 March). The US Food and Drug Administration (FDA) recently approved this first-of-kind device to induce weight loss via vagal nerve blockade

2015 CADTH - Issues in Emerging Health Technologies

151. Vagal Nerve Blockade for Obesity: VBLOC Therapy Using the Maestro RC2 Device

to bring about sustained and clinically significant weight loss in patients for whom drug therapy or bariatric surgery are not indicated, or who do not want to undergo bariatric procedures that are invasive, irreversible, and bring a higher risk of short- and long-term adverse events. The Maestro RC2 device, a vagal nerve blocker positioned laparoscopically, could satisfy the need for such an alternative approach to inducing weight loss in obese patients. Compared with evidence concerning available (...) daily battery checks and undertake recharging as needed. The device can be removed if necessary. Regulatory Status Toward the end of 2015, EnteroMedics will submit an application to Health Canada for regulatory approval of VBLOC therapy for adult obesity using the Maestro RC2 device (Dan Cohen, EnteroMedics Inc., St. Paul, MN: personal communication, 2015 March). The US Food and Drug Administration (FDA) recently approved this first-of-kind device to induce weight loss via vagal nerve blockade

2015 CADTH - Issues in Emerging Health Technologies

152. Knocking out or Pharmaceutical Inhibition of Fatty Acid Binding Protein 4 (FABP4) Alleviates Osteoarthritis Induced by High-Fat Diet in Mice. Full Text available with Trip Pro

Knocking out or Pharmaceutical Inhibition of Fatty Acid Binding Protein 4 (FABP4) Alleviates Osteoarthritis Induced by High-Fat Diet in Mice. Adipokines play roles in the pathogenesis of osteoarthritis (OA). Fatty acid binding protein 4 (FABP4) is a novel adipokine that is closely associated with obesity and metabolic diseases. The aim of this study was to discover the potential role of FABP4 in OA.Seventy-two FABP4 knockout mice (KO) in C57BL/6N background and wild-type littermates (WT) (male (...) of knee OA and micro-CT analysis of subchondral bone were performed.HFD induced obesity in mice. After 3 months and 6 months of HFD, KO mice showed alleviated cartilage degradation and synovitis, with significantly lower COMP, modified Mankin OA score, and MMP-13/ADAMTS4 expression. After 6 months and 9 months of HFD, KO mice showed less osteophyte formation and subchondral bone sclerosis. Chronic treatment of BMS309403 for 4 months and 6 months significantly alleviated cartilage degradation, but had

2018 Osteoarthritis and Cartilage

153. Pharmaceutical significance of Leuconostoc mesenteroides KS-TN11 isolated from Nile Tilapia, Oreochromis niloticus Full Text available with Trip Pro

Pharmaceutical significance of Leuconostoc mesenteroides KS-TN11 isolated from Nile Tilapia, Oreochromis niloticus Aquatic animals are known for their myriad of beneficial bacteria with diverse biologically active compounds. The current study was aimed to isolate and characterize potentially beneficial lactic acid bacteria from Nile Tilapia and evaluate their pharmaceutical applications. The fish samples were dissected and stomach, intestine, and gills were collected and serially diluted (...) Red O staining. The isolate showed strong antibacterial activity against a number of pathogenic bacteria in vitro. In addition, L. mesenteroides KS-TN11 KS-TN11 (50 mg/ml and 100 mg/ml) tends to inhibit adipogenesis in 3T3-L1 adipocytes and thus may have possible anti-obesity effects. Moreover, L. mesenteroides KS-TN11 exhibited substantial α-glucosidase inhibitory activities by 41.33% at 50 mg/ml and 64% at 100 mg/ml, respectively. The bacterium showed potent antibacterial activity against

2018 Saudi Pharmaceutical Journal : SPJ

154. A Study to Assess the Long-Term Safety of Pharmaceutical Grade Synthetic Cannabidiol Oral Solution in Patients With Prader-Willi Syndrome

. Condition or disease Intervention/treatment Phase Prader-Willi Syndrome Drug: Cannabidiol Oral Solution Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 66 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Multicenter, Open-Label Study to Assess the Long-Term Safety of Pharmaceutical Grade Synthetic Cannabidiol Oral Solution in Patients (...) . The two equivalent doses will be administered twice a day with a standard meal approximately every 12 hours. Drug: Cannabidiol Oral Solution An oral solution containing pharmaceutical grade cannabidiol (nonplant-based). Outcome Measures Go to Primary Outcome Measures : Incidence of Adverse Events (AEs) and Serious Adverse Events (SAEs) Associated with Cannabidiol Oral Solution [ Time Frame: Baseline (Visit 10 of INS011-16-085) up to Visit 9 (approximately Week 52) ] Number of Participants with Change

2018 Clinical Trials

155. A precision medicine approach to develop and internally validate optimal exercise and weight loss treatments for overweight and obese adults with knee osteoarthritis. (Abstract)

A precision medicine approach to develop and internally validate optimal exercise and weight loss treatments for overweight and obese adults with knee osteoarthritis. Apply a precision medicine approach to determine the optimal treatment regime for participants in an exercise (E), dietary weight loss (D), and D+E trial for knee osteoarthritis (KOA) that would have maximized their expected outcomes.Using data from 343 participants of the Intensive Diet and Exercise for Arthritis (IDEA) trial, we (...) with 9.8 kg if all received D+E (p = 0.01).The precision medicine models supported the overall findings from IDEA that the D+E intervention was optimal for most participants, but there was evidence that a subgroup of participants would likely benefit more from diet alone for two outcomes.This article is protected by copyright. All rights reserved.

2020 Arthritis care & research

156. Differential representation of liver proteins in obese human subjects suggests novel biomarkers and promising targets for drug development in obesity Full Text available with Trip Pro

Differential representation of liver proteins in obese human subjects suggests novel biomarkers and promising targets for drug development in obesity The proteome of liver biopsies from human obese (O) subjects has been compared to those of nonobese (NO) subjects using two-dimensional gel electrophoresis (2-DE). Differentially represented proteins were identified by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS)-based peptide mass fingerprinting (...) identified as putative diagnostic markers of liver dysfunction in animal models of steatosis or obesity, suggesting additional investigations on their role in these syndromes. Their differential representation in human liver was suggestive of their consideration as obesity human biomarkers and for the development of novel antiobesity drugs.

2017 Journal of enzyme inhibition and medicinal chemistry

157. Systematic review and meta-analysis: Bariatric surgery produces greater weight loss and improvements in medical conditions than non-surgical treatment of obesity

Systematic review and meta-analysis: Bariatric surgery produces greater weight loss and improvements in medical conditions than non-surgical treatment of obesity Bariatric surgery produces greater weight loss and improvements in medical conditions than non-surgical treatment of obesity | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we (...) -surgical treatment of obesity Article Text Therapeutics Systematic review and meta-analysis Bariatric surgery produces greater weight loss and improvements in medical conditions than non-surgical treatment of obesity Kristoffel Dumon , Goda Savulionyte Statistics from Altmetric.com Commentary on: Gloy VL , Briel M , Bhatt DL , et al . Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials . Request Permissions If you wish

2014 Evidence-Based Medicine

158. Carpal tunnel syndrome: sometimes drug-related

caused by certain drugs, and disappears when the medication is stopped. Carpal tunnel syndrome is a set of sensory and sometimes motor disorders caused by compression of the median nerve at the wrist in the carpal tunnel. Its symptoms are pain, tingling, numbness in the sensory area of the median nerve: thumb, index finger, middle finger and the side of the ring finger facing the middle finger. In some patients, these symptoms extend to the entire hand or sometimes spread to the forearm and even (...) medication-related. The drugs now known to expose patients to carpal tunnel syndrome chiefly include: aromatase inhibiting antiestrogens such as anastrozole, exemestane and letrozole, used to treat some breast cancers; disphosphonates used in osteoporosis; oral anticoagulants; and some antiretrovirals. When a drug is likely to be the cause of carpal tunnel syndrome, discontinuation should be considered, since this often allows symptoms to regress and sometimes avoids the need for surgery. ©Prescrire 1

2019 Prescrire

159. Drug-Induced Liver Injury

synergistically with other risk factors, contributing to pathogenesis and progression of liver disease. In a multicentre trial involving more than 5,000 women, tamoxifen therapy was associated with 2-fold risk of developing fatty liver over a 5-year period with an incidence of 0.4% per year in the treated group compared with 0.2% in the placebo group. 99 This associa- tion was restricted to overweight and obese women and the increased risk manifested within the ?rst 2years of treatment. Other factors (...) andpathologicalphenotypesandthecurrentabsenceofspeci?c biomarkers. This makes the diagnosis of drug-induced liver injury an uncertain process, requiring a high degree of aware- ness of the condition and the careful exclusion of alternative aetiologies of liver disease. Idiosyncratic hepatotoxicity can be severe, leading to a particularly serious variety of acute liver failure for which no effective therapy has yet been developed. These Clinical Practice Guidelines summarize the available evi- dence on risk factors, diagnosis, management and risk

2019 European Association for the Study of the Liver

160. Drug and alcohol psychosocial interventions

and different types of mental health conditions. Thus, there is still a lack of evidence on the effectiveness of interventions within specific combinations of comorbidities Sax Institute | Drug and alcohol psychosocial interventions 5 – Evidence for family-based therapy was limited by its evaluation among adolescents only; more evidence is needed to support its use in other population groups – There was no evidence found for psychosocial interventions for many special population groups, including Lesbian (...) were used: 1. Alcohol and other drug/substance use-related terms (e.g., alcohol abuse, drug abuse, substance abuse) 2. Psychosocial intervention-related terms (therapy, psychotherapy, cognitive behavioural therapy) 3. Systematic and literature review-related terms (review, synthesis, meta-analysis). Adjacency terms were also used to enhance the flexibility and comprehensiveness of the search and accommodate variations in the wording of relevant terms and phrases. The full search strategy for each

2020 Sax Institute Evidence Check

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