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Obesity Medication

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81. Undisclosed financial ties between guideline writers and pharmaceutical companies: a cross-sectional study across 10 disease categories. Full Text available with Trip Pro

Undisclosed financial ties between guideline writers and pharmaceutical companies: a cross-sectional study across 10 disease categories. To investigate the proportion of potentially relevant undisclosed financial ties between clinical practice guideline writers and pharmaceutical companies.Cross-sectional study of a stratified random sample of Australian guidelines and writers.Guidelines available from Australia's National Health and Medical Research Council guideline database, 2012-2014 (...) , stratified across 10 health priority areas.402 authors of 33 guidelines, including up to four from each area, dependent on availability: arthritis/musculoskeletal (3); asthma (4); cancer (4); cardiovascular (4); diabetes (4); injury (3); kidney/urogenital (4); mental health (4); neurological (1); obesity (1). For guideline writers with no disclosures, or who disclosed no ties, a search of disclosures in the medical literature in the 5 years prior to guideline publication identified potentially relevant

2019 BMJ open

82. [Comparison of health education and drug therapy monitoring interventions in patients with cardiovascular risk factors attending a community pharmacy (FISFTES-PM Study).] Full Text available with Trip Pro

[Comparison of health education and drug therapy monitoring interventions in patients with cardiovascular risk factors attending a community pharmacy (FISFTES-PM Study).] To compare health education (HE) and drug therapy monitoring (DTM) interventions in patients with cardiovascular risk factors (CVRF).Randomised experimental studys: 100 patients per group.Playa-Miramar pharmacy (Valencia, Spain). March 2010-November 2011.Patients with one or more CVRF detected based on medication they were (...) taking or questions they asked when drugs were dispensed. Patients were assigned to one of the two groups (HE or DTM) using a random number table. 100 patients by group were included.Six months of DTM (DTMG) or health education (HEG) per patient.The primary variables were modifiable CVRF: hypertension, dyslipidaemia, diabetes, smoking, obesity and low physical activity. Secondary variables were non modifiable CVRF (age, sex, cardiovascular disease), heart rate, body mass index, waist measurement

2014 Atencion primaria / Sociedad Española de Medicina de Familia y Comunitaria Controlled trial quality: uncertain

83. Dietary Management of Blood Glucose in Medical Critically Ill Overweight and Obese Patients: An Open-Label Randomized Trial. Full Text available with Trip Pro

Dietary Management of Blood Glucose in Medical Critically Ill Overweight and Obese Patients: An Open-Label Randomized Trial. Enteral nutrition (EN) increases hyperglycemia due to high carbohydrate concentrations while providing insufficient protein. The study tested whether an EN formula with very high-protein- and low-carbohydrate-facilitated glucose control delivered higher protein concentrations within a hypocaloric protocol.This was a multicenter, randomized, open-label clinical trial (...) with parallel design in overweight/obese mechanically ventilated critically ill patients prescribed 1.5 g protein/kg ideal body weight/day. Patients received either an experimental very high-protein (37%) and low-carbohydrate (29%) or control high-protein (25%) and conventional-carbohydrate (45%) EN formula.A prespecified interim analysis was performed after enrollment of 105 patients (52 experimental, 53 control). Protein and energy delivery for controls and experimental groups on days 1-5 were 1.2 ± 0.4

2018 JPEN. Journal of parenteral and enteral nutrition Controlled trial quality: uncertain

84. Safety and Efficacy of High Versus Standard Starting Doses of Insulin Glargine in Overweight and Obese Chinese Individuals with Type 2 Diabetes Mellitus Inadequately Controlled on Oral Antidiabetic Medications (Beyond VII): Study Protocol for a Randomized Full Text available with Trip Pro

Safety and Efficacy of High Versus Standard Starting Doses of Insulin Glargine in Overweight and Obese Chinese Individuals with Type 2 Diabetes Mellitus Inadequately Controlled on Oral Antidiabetic Medications (Beyond VII): Study Protocol for a Randomized Treatment with basal insulin in Chinese populations is currently sub-optimal, with delayed initiation of insulin treatment and inadequate dose titration. Increasing the initial dose of insulin may be a practicable and effective solution (...) dose treatment. The aim of this study is to assess the safety and efficacy of higher (0.3 U/kg) compared with standard (0.2 U/kg) starting doses of basal insulin in overweight and obese Chinese patients with type 2 diabetes who have failed to achieve glycaemic control using oral antidiabetic drugs (OADs).This is a phase IV, randomized, non-inferiority, open-label trial that will be conducted at approximately 50 centers in China. Eight hundred eighty overweight and obese adult Chinese patients

2018 Advances in therapy Controlled trial quality: uncertain

85. Brief strategic therapy and cognitive behavioral therapy for women with binge eating disorder and comorbid obesity: A randomized clinical trial one-year follow-up. (Abstract)

Brief strategic therapy and cognitive behavioral therapy for women with binge eating disorder and comorbid obesity: A randomized clinical trial one-year follow-up. Binge eating disorder (BED) is frequently linked with obesity and related health risks like cardiovascular disease and diabetes. The purpose of this randomized clinical trial (RCT) was to determine the effectiveness of brief strategic therapy (BST) compared with cognitive-behavioral therapy (CBT) 1 year after a two-phase inpatient (...) and outpatient-telemedicine treatment for BED.Italian women with BED and comorbid obesity were recruited from a self-referred inpatient treatment program for weight loss (N = 60) and randomly assigned to either the BST treatment condition (n = 30) or CBT treatment condition (n = 30). Inpatient psychotherapy sessions were conducted in person and outpatient telemedicine psychotherapy sessions were conducted over the telephone. Multilevel growth curve modeling was used to estimate average growth trajectories

2018 Journal of Consulting and Clinical Psychology Controlled trial quality: uncertain

86. Comparison of Mask Oxygen Therapy and High-Flow Oxygen Therapy after Cardiopulmonary Bypass in Obese Patients Full Text available with Trip Pro

Comparison of Mask Oxygen Therapy and High-Flow Oxygen Therapy after Cardiopulmonary Bypass in Obese Patients To clarify the efficiency of mask O2 and high-flow O2 (HFO) treatments following cardiopulmonary bypass (CPB) in obese patients.During follow-up, oxygenization parameters including arterial pressure of oxygen (PaO2), peripheral oxygen saturation (SpO2), and arterial partial pressure of carbon dioxide (PaCO2) and physical examination parameters including respiratory rate, heart rate (...) , HFO leads patients to achieve better postoperative FVC (p < 0.001). Also, dyspnea scores and comfort scores were significantly better in patients who received HFO in both postoperative day 1 and day 2 (p < 0.001, p < 0.001 and p=0.002, p=0.001, resp.).Our study demonstrated that HFO following CPB in obese patients improved postoperative PaO2, SpO2, and PaCO2 values and decreased the atelectasis score, reintubation, and mortality rates when compared with mask O2.

2018 Canadian respiratory journal Controlled trial quality: uncertain

87. Metabolic phenotype of male obesity-related secondary hypogonadism pre-replacement and post-replacement therapy with intra-muscular testosterone undecanoate therapy Full Text available with Trip Pro

Metabolic phenotype of male obesity-related secondary hypogonadism pre-replacement and post-replacement therapy with intra-muscular testosterone undecanoate therapy To explore the metabolic phenotype of obesity-related secondary hypogonadism (SH) in men pre-replacement and post-replacement therapy with long-acting intramuscular (IM) testosterone undecanoate (TU).A prospective observational pilot study on metabolic effects of TU IM in male obesity-related SH (hypogonadal [HG] group, n = 13 (...) , P = 0.03). Lipid profiles and energy expenditure were unchanged following TU IM therapy. Comparisons between baseline data for HG and EG groups were equivalent apart from differences in testosterone, SHBG and basal metabolic rate (BMR).In men with obesity-related SH (including a subgroup with T2D), TU IM therapy improved glycaemic control, beta cell function, and body composition.

2018 Endocrine

88. Mechanisms of Acupuncture Therapy for Simple Obesity: An Evidence-Based Review of Clinical and Animal Studies on Simple Obesity. Full Text available with Trip Pro

Mechanisms of Acupuncture Therapy for Simple Obesity: An Evidence-Based Review of Clinical and Animal Studies on Simple Obesity. Simple obesity is a worldwide epidemic associated with rapidly growing morbidity and mortality which imposes an enormous burden on individual and public health. As a part of Traditional Chinese Medicine (TCM), acupuncture has shown the positive efficacy in the management of simple obesity. In this article, we comprehensively review the clinical and animal studies (...) that demonstrated the potential mechanisms of acupuncture treatment for simple obesity. Clinical studies suggested that acupuncture regulates endocrine system, promotes digestion, attenuates oxidative stress, and modulates relevant molecules of metabolism in patients of simple obesity. Evidence from laboratory indicated that acupuncture regulates lipid metabolism, modulates inflammatory responses, and promotes white adipose tissue browning. Acupuncture also suppresses appetite through regulating appetite

2019 Evidence-based Complementary and Alternative Medicine (eCAM)

89. Longer-term liraglutide administration at the highest dose approved for obesity increases reward-related orbitofrontal cortex activation in response to food cues: Implications for plateauing weight loss in response to anti-obesity therapies. Full Text available with Trip Pro

Longer-term liraglutide administration at the highest dose approved for obesity increases reward-related orbitofrontal cortex activation in response to food cues: Implications for plateauing weight loss in response to anti-obesity therapies. GLP-1 analogs have recently risen to the forefront as effective medications for lowering weight through actions in the central nervous system (CNS). However, their actions in the CNS have not yet been studied in the human brain after longer-term (...) administration at the highest dose approved for obesity (liraglutide 3.0 mg).A total of 20 participants with obesity were treated with placebo and liraglutide (3.0 mg) in the context of a randomized, placebo-controlled, double-blind, cross-over trial after 5 weeks of dose escalation. Neurocognitive and neuroimaging (fMRI) responses to food cues were examined at the clinical research center of Beth Israel Deaconess Medical Center.While using liraglutide, patients lost more weight (placebo-subtracted -2.7%; P

2019 obesity & metabolism Controlled trial quality: uncertain

90. Prophylactic incisional negative pressure wound therapy reduces the risk of surgical site infection after caesarean section in obese women: a pragmatic randomised clinical trial Full Text available with Trip Pro

Prophylactic incisional negative pressure wound therapy reduces the risk of surgical site infection after caesarean section in obese women: a pragmatic randomised clinical trial To evaluate the reduction of surgical site infections by prophylactic incisional negative pressure wound therapy compared with standard postoperative dressings in obese women giving birth by caesarean section.Multicentre randomised controlled trial.Five hospitals in Denmark.Obese women (prepregnancy body mass index (BMI (...) negative pressure wound therapy significantly reduced wound exudate whereas no difference was found for dehiscence and quality of life between the two groups.Prophylactic use of incisional negative pressure wound therapy reduced the risk of surgical site infection in obese women giving birth by caesarean section.RCT: prophylactic incisional NPWT versus standard dressings postcaesarean in 876 women significantly reduces the risk of SSI.© 2018 The Authors. BJOG: An International Journal of Obstetrics

2018 EvidenceUpdates

91. Prophylactic Negative Pressure Wound Therapy and Wound Complication After Cesarean Delivery in Women With Class II or III Obesity: A Randomized Controlled Trial Full Text available with Trip Pro

Prophylactic Negative Pressure Wound Therapy and Wound Complication After Cesarean Delivery in Women With Class II or III Obesity: A Randomized Controlled Trial To compare the occurrence of superficial surgical site infections in obese women using prophylactic negative pressure therapy with standard dressings after cesarean delivery.We conducted a randomized controlled, nonblinded, two-center study of prophylactic negative pressure therapy compared with standard surgical dressings placed (...) in the occurrence of composite wound complications between women using prophylactic negative pressure wound therapy (25/80 [31%]) compared with women who received the standard dressing (24/81 [30%], P=.87).In this randomized controlled trial that did not achieve full anticipated enrollment, we did not observe a decrease in superficial surgical site infections after cesarean delivery in obese women with the use of prophylactic negative pressure wound therapy.ClinicalTrials.gov, NCT02390401.

2018 EvidenceUpdates

92. Obesity influences the outcomes of anti-IgE (omalizumab) therapy of asthma. (Abstract)

Obesity influences the outcomes of anti-IgE (omalizumab) therapy of asthma. Asthma is a chronic lung disease characterized by airflow obstruction, bronchial hyper-reactivity and inflammation of the airways. Immunoglobulin E (IgE) plays an important role in the pathogenesis of asthma. Blocking IgE binding to its high affinity FcεR1 with anti-IgE (omalizumab, Xolair®) can provide moderate-to-severe asthma patients with certain levels of clinical benefit by reducing asthma exacerbations, symptoms

2020 Clinical and Experimental Allergy

93. INCREASED BONE TURNOVER IN TYPE 2 DIABETES PATIENTS RANDOMIZED TO BARIATRIC SURGERY VERSUS MEDICAL THERAPY AT 5 YEARS. (Abstract)

INCREASED BONE TURNOVER IN TYPE 2 DIABETES PATIENTS RANDOMIZED TO BARIATRIC SURGERY VERSUS MEDICAL THERAPY AT 5 YEARS. The aim of our study was to determine the 5-year outcomes of bariatric surgery versus intensive medical therapy on bone turnover in patients with type 2 diabetes mellitus (T2DM) from the STAMPEDE trial.This was an ancillary investigation of a 5-year randomized control trial at a single tertiary care center involving 95 patients aged 48.5 ± 8 years with obesity (body mass index (...) [BMI], 36.5 ± 3.6 kg/m2) and uncontrolled T2DM (glycated hemoglobin 9.3 ± 1.6% [78 mmol/mol]). Patients were randomized to intensive medical therapy (IMT; n = 25), Roux-en-Y gastric bypass (RYGB; n = 37), or sleeve gastrectomy (SG; n = 33) for diabetes treatment. Bone formation marker osteocalcin (OC), bone resorption marker serum C-telopeptide of type 1 collagen (CTX), and intact parathyroid hormone (PTH) were assessed at baseline and 5 years postintervention. Analysis with key clinical parameters

2018 Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Controlled trial quality: uncertain

94. Obesity medications reduce total body weight by 3-9% compared with placebo, when combined with lifestyle changes. Full Text available with Trip Pro

Carolina, USA Veterans Affairs Medical Center, Durham, North Carolina, USA. eng Journal Article Comment 2014 05 19 England Evid Based Nurs 9815947 1367-6539 0 Anti-Obesity Agents IM N JAMA. 2014 Jan 1;311(1):74-86 24231879 Anti-Obesity Agents therapeutic use Humans Life Style Obesity drug therapy Clinical Pharmacology Nutrition & Dietetics 2014 5 21 6 0 2014 5 21 6 0 2015 5 23 6 0 ppublish 24842056 eb-2014-101785 10.1136/eb-2014-101785 (...) Obesity medications reduce total body weight by 3-9% compared with placebo, when combined with lifestyle changes. 24842056 2015 05 21 2018 12 02 1468-9618 18 1 2015 Jan Evidence-based nursing Evid Based Nurs Obesity medications reduce total body weight by 3-9% compared with placebo, when combined with lifestyle changes. 29-30 10.1136/eb-2014-101785 Gadde Kishore M KM Duke University Medical Center, Durham, North Carolina, USA. Yancy William S WS Jr Duke University Medical Center, Durham, North

2015 Evidence-Based Nursing Controlled trial quality: predicted high

95. What is the clinical effectiveness and cost-effectiveness of using drugs in treating obese patients in primary care? A systematic review

What is the clinical effectiveness and cost-effectiveness of using drugs in treating obese patients in primary care? A systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

96. Cognitive Training Therapy Improves the Effect of Hypocaloric Treatment on Subjects with Overweight/Obesity: A Randomised Clinical Trial. Full Text available with Trip Pro

Cognitive Training Therapy Improves the Effect of Hypocaloric Treatment on Subjects with Overweight/Obesity: A Randomised Clinical Trial. Obesity has been associated with impaired cognitive performance. This study aimed to determine whether improvements in cognitive function may contribute to higher weight loss in patients with obesity. In this randomised, 12-week trial, participants with overweight/obesity were randomised into a cognitive training intervention (Cognitive) group or a cognitive (...) with obesity.

2019 Nutrients Controlled trial quality: uncertain

97. Randomized Controlled Trial of Home-Based Lifestyle Therapy on Postpartum Weight in Underserved Women with Overweight or Obesity. (Abstract)

Randomized Controlled Trial of Home-Based Lifestyle Therapy on Postpartum Weight in Underserved Women with Overweight or Obesity. This study aimed to assess the efficacy of a home-based lifestyle intervention delivered through Parents as Teachers (PAT), a national home-visiting organization, designed to minimize excessive weight gain through 12 months post partum in socioeconomically disadvantaged (SED) African American women with overweight or obesity.This randomized controlled trial (...) ) and were more likely to return to their baseline weight (38.0% vs. 21.5%; P = 0.01) from baseline to 12 months post partum. There were no differences between groups in cardiometabolic outcomes, indices of glycemic control and insulin sensitivity, and plasma lipid profile. The estimated cost of PAT+Lifestyle was $81 more to deliver per family than standard PAT.PAT+Lifestyle decreases weight gain during pregnancy through 12 months post partum in SED African American women with overweight or obesity

2019 Obesity Controlled trial quality: uncertain

98. Long term effect of spa therapy combined with patient education program on subjects with overweight and obesity - A controlled study. (Abstract)

Long term effect of spa therapy combined with patient education program on subjects with overweight and obesity - A controlled study. The aim of this single center prospective controlled study in volunteers with obesity and overweight was to evaluate the effect of a patient therapeutic education program (PTE group) combined with spa therapy on weight, physical activity, eating habits and quality of life versus spa therapy alone (control group). The main endpoint was weight change at 5 months (...) after the end of the program. The PTE group of 151 subjects with obesity or overweight followed a 3-week program combining patient education with spa therapy and 189 attended a course of spa therapy alone. At 5 months significant loss was observed in the PTE group compared to controls (-2.69kg vs -1.24kg, p=0.008), a relative weight loss of -2.8% vs -1.3%. At 11 months after spa therapy, only the PTE group maintained a weight loss in addition to the weight loss obtained during spa therapy

2019 Obesity research & clinical practice Controlled trial quality: uncertain

99. Effectiveness of cognitive-behavioral therapy on nutrition improvement and weight of overweight and obese adolescents: A randomized controlled trial. Full Text available with Trip Pro

Effectiveness of cognitive-behavioral therapy on nutrition improvement and weight of overweight and obese adolescents: A randomized controlled trial. To assess the effectiveness of a cognitive-behavioral treatment (CBT) program on weight reduction among Iranian adolescents who are overweight.Using a randomized controlled trial design, 55 adolescents who were overweight (mean [SD] age = 14.64 [1.69] years; zBMI = 2.18 [0.65]) were recruited in the CBT program and 55 in the treatment as usual (...) their psychosocial health, physical activity, and health-related quality of life (p-values<0.001).The CBT program showed its effectiveness in reducing weight among Iranian adolescents who were overweight. Healthcare providers may want to adopt this program to treat excess weight problems among adolescents.Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.

2019 Diabetes & metabolic syndrome Controlled trial quality: uncertain

100. Open letter from academics, practitioners, students and members of the public to the British Medical Association, the British Medical Journal publishing group, and the British Association of Sports and Exercise Medicine regarding editorial governance of t

Open letter from academics, practitioners, students and members of the public to the British Medical Association, the British Medical Journal publishing group, and the British Association of Sports and Exercise Medicine regarding editorial governance of t Open letter from academics, practitioners, students and members of the public to the British Medical Association, the British Medical Journal publishing group, and the British Association of Sports and Exercise Medicine regarding editorial (...) : 769-774. Malhotra A, Noakes T, Phinney S. It is time to bust the myth of physical inactivity and obesity: you cannot outrun a bad diet. Br J Sports Med 2015; 49: 967-968. Original Letter Dear Ms Phipps, Dr Nagpaul, Dr Godlee, and Mr Holloway, As academics (scientists, lecturers, researchers), practitioners and students in the fields of sport and exercise science and medicine, evidence-based medicine/health care, nutrition and dietetics, public health, general practice/family medicine, as well

2018 British Journal of Sports Medicine Blog

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