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Obesity Medication

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26461. The Use of a Silver Containing Dressing (Acticoat) on Wound Complication Rates Post Elective Cesarean Section

will have a standard dressing (OpSite PostOp) applied at the time of elective cesarean section. Device: OpSite PostOp Outcome Measures Go to Primary Outcome Measures : Wound complication [ Time Frame: 6 weeks post-op ] Composite of: wound infection treated with antibiotics, incision and drainage, wound requiring packing, or patient requiring medical attention for concerns about wound healing. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study (...) at the pre-op visit consent to participate Exclusion Criteria: allergy to silver immunocompromised (HIV/AIDS, on immunosuppressive medications) Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02288884 Locations Layout table for location information

2014 Clinical Trials

26462. The Effect of Sugar Sweetened and Diet Beverages Consumed as Part of a Weight-Maintenance Diet on Fat Storage

: None (Open Label) Primary Purpose: Basic Science Official Title: A Comparison of the Effects of Sugar Sweetened Beverages (SSBs), Diet Beverages and Water on Weight, Body Composition, Liver and Muscle Fat Infiltration, Visceral Fat, Neurocognitive Function, Blood Lipids, Insulin Resistance and Hydration Status in Healthy Weight and Overweight, Premenopausal Females Aged 20-50 Study Start Date : February 2013 Estimated Primary Completion Date : March 2015 Arms and Interventions Go to Arm (...) Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 20 Years to 50 Years (Adult) Sexes Eligible for Study: All

2014 Clinical Trials

26463. Assess Measurements of Wireless Cardiac Output Device

electrode patches as required Patient has skin sensitivity to adhesive or hydrogel materials used in electrode patches Patient is considered by the PI to be medically unsuitable for study participation Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number (...) on the health care system Condition or disease Intervention/treatment Congestive Heart Failure Device: CoVa Detailed Description: Heart failure patients should be in a position to provide readings of their weight, blood pressure, fluid intake, thoracic fluid, heart rate, heart rate variability, respiration rate, stroke volume, cardiac output, medications and other important parameters and communicate this data to care providers using wireless technology. This data should be made available to medical

2014 Clinical Trials

26464. Propofol and Sevoflurane for Catheter-Related Bladder Discomfort

by (Responsible Party): Seoul National University Hospital Study Details Study Description Go to Brief Summary: The investigators want to evaluate the efficacy of the propofol and sevoflurane for the prevention of catheter-related bladder discomfort. Condition or disease Intervention/treatment Phase Catheter Site Discomfort Complications Anesthesia Urinary Bladder Neoplasms Drug: Propofol Drug: Sevoflurane Not Applicable Detailed Description: The mechanism of catheter-related bladder discomfort is thought (...) : Parallel Assignment Masking: Triple (Participant, Investigator, Outcomes Assessor) Primary Purpose: Prevention Official Title: Effect of Propofol and Sevoflurane on Postoperative Catheter-Related Bladder Discomfort Study Start Date : November 2014 Actual Primary Completion Date : January 2015 Actual Study Completion Date : January 2015 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator

2014 Clinical Trials

26465. The Effects of Ketamine and Methadone on Postoperative Pain for Laminectomy

30, 2019 See Sponsor: Cedars-Sinai Medical Center Information provided by (Responsible Party): Roya Yumul, M.D.,PhD., Cedars-Sinai Medical Center Study Details Study Description Go to Brief Summary: The purpose of this research is to determine the pain-reducing effects of ketamine (Ketalar, an FDA-approved drug for anesthesia) and methadone (Dolophine, a long-acting narcotic) after lumbar laminectomy. The investigators would like to evaluate whether intraoperative use of both drugs may be able (...) pain control and reduce the use of narcotic painkiller medications (analgesics) after lumbar surgery as compared to either drug (ketamine or methadone) alone. Ketamine is used to help to reduce the amount of the commonly used intravenous anesthetic drugs, minimize heart rate and blood pressure instability during surgery, and to improve outcomes after surgery (e.g. less pain, less constipation, less nausea and vomiting after surgery, faster return of bowel function and shortened length of hospital

2014 Clinical Trials

26466. A Clinical Study of a Spine Fusion System in Vertebral Body Fusion Surgery

and requires fusion at 3 or more levels. Has been previously diagnosed with osteopenia, osteoporosis, or osteomalacia to a degree that spinal instrumentation would be contraindicated Has presence of active malignancy Has a medical condition with less than 1 year of life expectancy. Pregnancy or women in lactation period. Is grossly obese, i.e. Body Mass Index≥40. Has a diagnosis, which requires postoperative medication or treatment that interferes with fusion, such as steroids, chemotherapy, radiotherapy (...) , growth factor (for more than 3 months), Nonsteroidal Antiinflammatory Drugs(for more than 3 months), and etc. Has history of endocrine or metabolic disorder known to affect osteogenesis (e.g. uncontrolled Diabetes with medication, renal osteodystrophy, or osteogenesis imperfect) Alcoholic (taking more than 40g/day, equals to 100ml 50°Chinese liquor), smoking more than 40 cigarettes/day, or Drug abuser; Is currently participating in another investigational drug or device study. Contacts and Locations

2014 Clinical Trials

26467. Metformin in Kidney Disease

: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Age 18 years old; Ability to give informed consent; Life expectancy greater than 6 months; Estimated GFR 30-59 ml/min/1.73m^2; Overweight (BMI >=25 to < 30 kg/m^2) or obese (BMI >=30 kg/m^2); or normal (BMI >=18.5 to <25 kg/m^2) if pre-diabetic or insulin resistant. Exclusion Criteria: Pregnancy or breast feeding; Presence or history of Diabetes Mellitus type I or II History of metformin use or any insulin sensitizer or any drug (...) : October 1, 2014 Estimated Primary Completion Date : December 31, 2019 Estimated Study Completion Date : December 31, 2019 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: metformin 500 to 1500 mg orally per day for 16 weeks if eGFR > 45 ml/min; 500 to 1000 mg orally per day for 16 weeks if eGFR =< 45 ml/min Drug: metformin 500 to 1500 mg orally per day for 16 weeks if eGFR > 45 ml/min

2014 Clinical Trials

26468. The $Ensible Weight Program: An Intervention Tailored for Low Income Women

): Jeannine Goetz, PhD, University of Kansas Medical Center Study Details Study Description Go to Brief Summary: The purpose of this study is to learn if a weight loss program especially designed to address food insecurity is more effective compared to a standard weight loss program. Condition or disease Intervention/treatment Phase Weight Loss Other: Standard Weight Management Program Other: Sensible Weigh Program Not Applicable Detailed Description: Low income women are at greater risk of both obesity (...) : December 2015 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Standard Weight Management Program Participants will be given information on diet and exercise. Participants will attend meetings to discuss barriers to exercise and nutrition and ways to solve these problems. Participants will be given healthy snack ideas and planning tools. Other: Standard Weight Management Program Standard Diet program

2014 Clinical Trials

26469. Adaptated Physical Activity in Cancerology

patients) Patient with a local recurrence of breast cancer Patient with a second non-metastatic breast cancer Breast cancer treated, regardless of the surgery, at least by radiotherapy, chemotherapy (neoadjuvant or adjuvant) +/- targeted therapy A mandatory social security affiliation. Obtaining informed consent in writing, signed and dated. Medical certificate of fitness to practice physical (issued by the medical oncologist) Exclusion Criteria: Cancer other than breast cancer and / or associated (...) of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment Arm A with physical activity during the treatment In the arm A, patients will realise physical activity during the treatment. Blood samples will be realised. Questionnaries will be given to the patients. Other: physical activity Patients will realise physical activity either during their treatment, either after their treatment. They will have practise a physical activity three times per week. Arm B

2014 Clinical Trials

26470. The STRENGTH Study: Shapely Sisters Targeting Realistic Exercise and Nutrition Goals Through Healthy Habits

will be required to obtain medical clearance from their medical provider Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02253641 Locations Layout table for location information United States, North Carolina UNC Center for Health Promotion and Disease (...) Posted : September 22, 2015 Sponsor: University of North Carolina, Chapel Hill Collaborator: Academy of Nutrition and Dietetics Information provided by (Responsible Party): Danielle Braxton, MPH, RD, University of North Carolina, Chapel Hill Study Details Study Description Go to Brief Summary: This study evaluates the efficacy of a stress-focused tailored weight loss intervention compared to a standard weight loss intervention on weight loss in severely obese (BMI > 40.0) African American women

2014 Clinical Trials

26471. Home Sleep and Metabolism

will not be allowed, as these medications are known to affect insulin sensitivity. Women will be required to not be on hormone replacement therapy. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02253368 Contacts Layout table for location contacts Contact: Eva (...) apnea or history of any other sleep disorder night or rotating shift work (current or in the past 2 years) habitual daytime naps recent (< 4 week) travel across time zones extreme chronotypes any acute or chronic medical condition diabetes prior or current eating or psychiatric disorders claustrophobia irregular menstrual periods, menopause, pregnancy, alcohol abuse, excessive caffeine intake, smoking, illegal drug use subjects who are currently following a weight loss regimen or any other special

2014 Clinical Trials

26472. Impact of Life-Style Modification On Ablation Outcome in Atrial Fibrillation

Posted : October 19, 2017 See Sponsor: Texas Cardiac Arrhythmia Research Foundation Information provided by (Responsible Party): Texas Cardiac Arrhythmia Research Foundation Study Details Study Description Go to Brief Summary: This prospective randomized pilot study aims to evaluate the impact of aggressive life style modification in terms of calorie-controlled diet and supervised exercise on outcome of catheter ablation in overweight and obese patients with atrial fibrillation. Hypothesis: Weight (...) recurrence in overweight and obese patients with atrial fibrillation. Endpoints: Primary: AF recurrence following index ablation procedure It will be assessed at 3, 6 and 12 months after the procedure by event recorders, 12-lead ECG and Holter monitoring Any episode of AF/AFL/AT > 30 sec will be considered as a recurrence. Episodes that occur during the first 3 months after the procedure (blanking period) will not be considered as recurrence. Secondary: Change in QoL It will be evaluated by a validated

2014 Clinical Trials

26473. The Effects of a Weight Management Program on Body Weight and Quality of Life

Update Posted : August 19, 2014 Sponsor: Massachusetts General Hospital Information provided by (Responsible Party): Goedkoop, Sonja, Massachusetts General Hospital Study Details Study Description Go to Brief Summary: Evaluate the impact of a 12-week behavioral weight management program on body weight and quality of life. We hypothesize that participants will lose body weight and see improved quality of life after program completion. Condition or disease Overweight Obesity Detailed Description (...) and Quality of Life Study Start Date : June 2014 Estimated Primary Completion Date : February 2015 Estimated Study Completion Date : February 2015 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Outcome Measures Go to Primary Outcome Measures : Weight Change [ Time Frame: Approximately 4 months after enrollment ] The primary outcomes will be change in body weight comparing body weight at the start of the behavior change program and at the end

2014 Clinical Trials

26474. Continuous Adductor Canal Nerve Blocks: Relative Effects of a Basal Infusion v. Hourly Bolus Doses

Sponsor: University of California, San Diego Information provided by (Responsible Party): Brian M. Ilfeld, MD, MS, University of California, San Diego Study Details Study Description Go to Brief Summary: Patients usually experience moderate-to-severe pain following the knee replacement that is often treated with a femoral nerve block (injection of numbing medicine placed around the main nerve of the knee joint). To make the nerve block last longer, a tiny tube is often placed next to the nerve (...) and numbing medicine is infused for multiple days. However, while the numbing medicine takes away pain, it also decreases sensations, muscle strength, and proprioception (knowing where the leg is in space without looking at it) which greatly increases the risk of falling. Since falling can be catastrophic following major surgery, a femoral nerve blocks are being phased out by surgeons and anesthesiologists. The most-promising replacement is called an adductor canal nerve block. For this new type of block

2014 Clinical Trials

26475. Geriatric Patients and Laryngeal Mask Unique

pulmonary compliance or high airway resistance (morbid obesity, lung disease) Throat pain, dysphagia and dysphonia Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02219282 Locations Layout table for location information Turkey Dokuz Eylül University (...) Study Description Go to Brief Summary: As a result of rises in living standards quality of life is progressively increasing. Combined with developments in anesthesia, surgical techniques and medication allowing more difficult and complicated interventions to be carried out, elderly patients are encountered more often in daily anesthetic practice.Reduced tone in the upper airway of geriatric patients increases the possibility of airway obstruction. In old patients with no teeth, sunken cheeks may

2014 Clinical Trials

26476. Mommio: Training in Vegetable Parenting

a 3-5 year old child with a medical condition that influences diet; or a parent with an illness that impairs the ability to complete questionnaires Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02215421 Locations Layout table for location (...) episodes targeting barriers identified by parents across five levels of difficulty influences vegetable parenting practices and children's dietary intake. We had to discontinue the study since changes in commercial availability of game development software required reprogramming and available funding did not allow for completion of game programming. Thus, no game evaluation was possible. Condition or disease Intervention/treatment Phase Obesity Behavioral: Mommio Not Applicable Detailed Description

2014 Clinical Trials

26477. Effect of Prebiotic and PUFA on the Gut Microbiota and Metabolic Risk Markers

, dietary fibre or fish oil supplement Lactation, pregnancy or planning of pregnancy during the study Gastro intestinal and liver disorders Chronic inflammatory disorders Diagnosed psychiatric disorder including treatment required depression Surgical treatment of obesity and abdominal surgery Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided (...) to induce beneficial changes in the gut microbiota composition and to affect markers for insulin sensitivity, lipid metabolism and inflammation. The investigators hypothesize that the effect of both interventions on the metabolic risk markers will be partly mediated by the diet-induced changes in the gut microbiota composition. Condition or disease Intervention/treatment Phase Overweight Dietary Supplement: Wheat bran extract Dietary Supplement: Fish oil Not Applicable Study Design Go to Layout table

2014 Clinical Trials

26478. Rosuvastatin Interethnic PK Study

in Caucasian and Asian Morbid Obese Patients Study Start Date : February 2015 Estimated Primary Completion Date : December 2016 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Asians Drug: Rosuvastatin Rosuvastatin 20mg po x1 Other Name: Crestor Drug: Rosuvastatin Rosuvastatin 20mg po x1 Other Name: Crestor Experimental: Caucasians Drug: Rosuvastatin Rosuvastatin 20mg po x1 Other Name: Crestor Drug (...) alcohol or illegal drug use. Subjects who are pregnant, lactating, or trying to conceive during the study period. Subjects allergic to rosuvastatin or any known component of the medications. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02215174

2014 Clinical Trials

26479. Dexmedetomidine for Postoperative Analgesia After Bariatric Surgery

University of Beirut Medical Center Study Details Study Description Go to Brief Summary: The purpose of this study is to determine if Dexmedetomidine given at the end of surgery will reduce postoperative morphine consumption and improve postoperative quality of recovery as compared to morphine in patients undergoing laparoscopic bariatric surgery. Condition or disease Intervention/treatment Phase Obesity Sleep Apnea Diabetes Hypertension Drug: Dexmedetomidine Drug: Morphine Phase 2 Phase 3 Detailed (...) of uncontrolled hypertension heart block greater than first degree prolonged QT interval clinically significant neurologic, cardiovascular, renal, hepatic, or gastrointestinal diseases received an opioid analgesic medication within a 24 h period prior to surgery history of alcohol, drug abuse or chronic opioid intake history of psychiatric disorder pregnant or breastfeeding. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may

2014 Clinical Trials

26480. Evaluation of Treatment Efficacy and Comfort of a Modified Positive Airway Pressure Device to Treat Obstructive Sleep Apnea.

according to the AASM (American Academy of Sleep Medicine) Clinical Guidelines for the Manual Titration of Positive Airway Pressure in Patients with OSA. The participant will be randomized to either the modified PAP or market released device group. They will be issued with a PAP device and a pressure-flow logger to be used at home in the usual manner of their PAP therapy for 3 weeks (+/- 4 days), after which participants will return to the FPH sleep laboratory to participate in a overnight PSG study (...) ) (e.g. periodic leg movements, insomnia, central sleep apnea) Previous use of a bi-level device with-in the last 2 years (from enrolment date). Patients with respiratory failure, bullous lung disease or COPD (Chronic Obstructive Pulmonary Disease). Patients with obesity hypoventilation syndrome or congestive heart failure Patients that require supplemental oxygen with their CPAP (Continuous Positive Airway Pressure) device Patients with implanted or life-supporting electronic medical devices (e.g

2014 Clinical Trials

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