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Obesity Risk

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1. Endoscopic placement and removal of an intra-gastric balloon (IGB) for the management of overweight and obesity in a high-risk patient

Endoscopic placement and removal of an intra-gastric balloon (IGB) for the management of overweight and obesity in a high-risk patient 1 Public Summary Document Application No. 1515 Endoscopic placement and removal of an intragastric balloon for the management of moderate obesity in patients with type 2 diabetes mellitus who have failed first-line treatments Applicant: Apollo Endosurgery Australia Date of MSAC consideration: MSAC 76 th Meeting, 1-2 August 2019 Context for decision: MSAC makes (...) its advice in accordance with its Terms of Reference, visit the MSAC website 1. Purpose of application An application requesting Medicare Benefits Schedule (MBS) listing of the endoscopic placement and removal of an intragastric balloon (IGB) for the treatment of patients aged = 18 years with moderate obesity (body mass index (BMI) of 30.0 to 34.9 kg/m 2 ), who have poorly controlled type 2 diabetes mellitus (T2DM) and who have failed first-line treatment options, was received from Apollo

2019 Medical Services Advisory Committee

2. Obese, overweight with risk factors: liraglutide (Saxenda)

Obese, overweight with risk factors: liraglutide (Saxenda) Obese, o Obese, ov verweight with risk factors: lir erweight with risk factors: liraglutide aglutide (Sax (Saxenda) enda) Evidence summary Published: 27 June 2017 nice.org.uk/guidance/es14 pathways K Ke ey points y points The content of this evidence summary was up-to-date in June 2017. See summaries of product characteristics (SPCs), British national formulary (BNF) or the MHRA or NICE websites for up- to-date information. Regulatory (...) with liraglutide 1.8 mg daily. Liraglutide has been associated with an increase in pulse rate, which the EPAR states does not appear to be dose- related. The NICE guideline on identifying, assessing and managing obesity (2014) recommends considering pharmacological treatment for people who have not reached their target weight loss or have reached a plateau on dietary, activity and behavioural changes. The guideline recommends Obese, overweight with risk factors: liraglutide (Saxenda) (ES14) © NICE 2018. All

2017 National Institute for Health and Clinical Excellence - Advice

3. During Conscious Sedation the Risk of Adverse Events Is Likely Increased in Obese Children Compared to Those of Healthy Weight

During Conscious Sedation the Risk of Adverse Events Is Likely Increased in Obese Children Compared to Those of Healthy Weight UTCAT3394, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title During Conscious Sedation the Risk of Adverse Events Is Likely Increased in Obese Children Compared to Those of Healthy Weight Clinical Question Are obese children undergoing conscious sedation at increased risk for adverse events (...) . No results were retrieved of the highest evidence level, a systematic review. This shows that more research should be done on this topic to help make guidelines for treating obese/overweight patients clearer and more definitive. Applicability This topic is more applicable to pediatric dentists and general dentists who treat children using conscious sedation. The evidence suggests that modifications and accommodations should be made for pediatric dental patients who are obese or overweight because those

2019 UTHSCSA Dental School CAT Library

4. Being overweight or obese is linked with heart disease even without other metabolic risk factors

Being overweight or obese is linked with heart disease even without other metabolic risk factors Being overweight or obese is linked with heart disease even without other metabolic risk factors Discover Portal Discover Portal Being overweight or obese is linked with heart disease even without other metabolic risk factors Published on 7 November 2017 doi: People with certain metabolic risk factors who are obese are two and a half times as likely to develop heart disease as healthy people (...) (a type of fat), low HDL “good” cholesterol levels and increased waist measurements. This large-scale observational research which tracked over 17,000 people in Europe for over 12 years gives us new insights into risk factors for heart disease. Findings suggest that prevention strategies should tackle all risk factors for people who are overweight or obese. Share your views on the research. Why was this study needed? It is estimated that over 30,000 people die in England because of obesity each year

2019 NIHR Dissemination Centre

5. Does breastfeeding affect the risk of childhood obesity?

obesity? Evidence-based answer: Yes. Even having breastfed during the first year of life is associated with a 15% lower risk of overweight or obesity over the next 2 to 14 years compared with never having breastfed. Breastfeeding exclusively for 6 months is associated with a 30% to 50% reduction in risk (strength of recommendation [SOR]: B, meta-analysis of cohort studies and subsequent cohort studies). However, interventions that increase breastfeeding rates during the first 3 to 6 months of life (...) Does breastfeeding affect the risk of childhood obesity? Does breastfeeding affect the risk of childhood obesity? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Does breastfeeding affect the risk of childhood obesity? View/ Open Date 2016-12 Format Metadata Abstract Q: Does breastfeeding affect the risk of childhood

2017 Clinical Inquiries

6. Development and validation of a population based risk algorithm for obesity: The Obesity Population Risk Tool (OPoRT). Full Text available with Trip Pro

Development and validation of a population based risk algorithm for obesity: The Obesity Population Risk Tool (OPoRT). Given the dramatic rise in the prevalence of obesity, greater focus on prevention is necessary. We sought to develop and validate a population risk tool for obesity to inform prevention efforts.We developed the Obesity Population Risk Tool (OPoRT) using the longitudinal National Population Health Survey and sex-specific Generalized Estimating Equations to predict the 10-year (...) risk of obesity among adults 18 and older. The model was validated using a bootstrap approach accounting for the survey design. Model performance was measured by the Brier statistic, discrimination was measured by the C-statistic, and calibration was assessed using the Hosmer-Lemeshow Goodness of Fit Chi Square (HL χ2).Predictive factors included baseline body mass index, age, time and their interactions, smoking status, living arrangements, education, alcohol consumption, physical activity

2018 PLoS ONE

7. Obesity and cardiovascular risk: a call for action from the European Society of Hypertension Working Group of Obesity, Diabetes and the High-risk Patient and European Association for the Study of Obesity: part B: obesity-induced cardiovascular disease, ea (Abstract)

Obesity and cardiovascular risk: a call for action from the European Society of Hypertension Working Group of Obesity, Diabetes and the High-risk Patient and European Association for the Study of Obesity: part B: obesity-induced cardiovascular disease, ea : Obesity predisposes for atrial fibrillation, heart failure, sudden cardiac death, renal disease and ischemic stroke, which are the main causes of cardiovascular hospitalization and mortality. As obesity and the cardiovascular effects (...) on the vessels and the heart start early in life, even from childhood, it is important for health policies to prevent obesity very early before the disease manifestation emerge. Key roles in the prevention are strategies to increase physical exercise, reduce body weight and to prevent or treat hypertension, lipids disorders and diabetes earlier and efficiently to prevent cardiovascular complications.

2018 Journal of Hypertension

8. Obesity and cardiovascular risk: a call for action from the European Society of Hypertension Working Group of Obesity, Diabetes and the High-risk Patient and European Association for the Study of Obesity: part A: mechanisms of obesity induced hypertension (Abstract)

Obesity and cardiovascular risk: a call for action from the European Society of Hypertension Working Group of Obesity, Diabetes and the High-risk Patient and European Association for the Study of Obesity: part A: mechanisms of obesity induced hypertension : Obesity is a key factor for cardiovascular diseases and complications. Obesity is associated with hypertension, dyslipidemia and type II diabetes, which are the major predictors of cardiovascular disease in the future. It predisposes (...) for atrial fibrillation, heart failure, sudden cardiac death, renal disease and ischemic stroke that are the main causes of cardiovascular hospitalization and mortality. As obesity and the cardiovascular effects on the vessels and the heart start early in life, even from childhood, it is important for health policies to prevent obesity very early before the disease manifestation emerge. Key roles in the prevention are strategies to increase physical exercise, reduce body weight and to prevent or treat

2018 Journal of Hypertension

9. Efficacy of Fish Oil and/or Probiotic Intervention on the Incidence of Gestational Diabetes Mellitus in an At-Risk Group of Overweight and Obese Women: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial (Abstract)

Efficacy of Fish Oil and/or Probiotic Intervention on the Incidence of Gestational Diabetes Mellitus in an At-Risk Group of Overweight and Obese Women: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial To assess whether the risk of gestational diabetes mellitus (GDM) may be lowered and glucose metabolism improved by daily administration of fish oil and/or probiotic supplements in overweight and obese pregnant women.We randomized in a double-blind manner 439 women (mean 13.9 ± 2.1 (...) ; fish oil + placebo, 23 of 96, 24.0%; probiotics + placebo, 25 of 99, 25.3%; fish oil + probiotics, 26 of 91, 28.6%; and placebo + placebo, 20 of 91, 22.0%) and the change in glucose, insulin, or HOMA2-IR (n = 364) did not differ among the intervention groups (P > 0.11 for all comparisons).An intervention with fish oil and/or probiotics during pregnancy seemed to be both safe and well tolerated but conferred no benefits in lowering the risk of GDM or improving glucose metabolism in overweight

2019 EvidenceUpdates

10. The Effect of Liquid Meal Replacements on Cardiometabolic Risk Factors in Overweight/Obese Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials (Abstract)

The Effect of Liquid Meal Replacements on Cardiometabolic Risk Factors in Overweight/Obese Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials The evidence for liquid meal replacements in diabetes has not been summarized. Our objective was to synthesize the evidence of the effect of liquid meal replacements on cardiometabolic risk factors in overweight/obese individuals with type 2 diabetes.Data sources included MEDLINE, EMBASE (...) , and the Cochrane Library through 10 December 2018. We included randomized trials of ≥2 weeks assessing the effect of liquid meal replacements in weight loss diets compared with traditional weight loss diets on cardiometabolic risk factors in overweight/obese subjects with type 2 diabetes. Two independent reviewers extracted relevant data and assessed risk of bias. Data were pooled using the inverse variance method. The overall certainty of the evidence was evaluated using GRADE (Grading of Recommendations

2019 EvidenceUpdates

11. Takeaways linked to increased cardiovascular risk factors and obesity in children

are well placed to encourage parents and children to choose healthier foods, in line with current national guidance. Share your views on the research. Why was this study needed? Childhood obesity rates are increasing in the UK, where one in five children aged 10 to 11 is now obese. Being overweight or obese increases the risk of type 2 diabetes. Both type 2 diabetes and being overweight or obese increases the risk of coronary heart disease. Other risk factors include high levels of triglycerides (...) ? Childhood obesity rates are increasing in the UK, where one in five children aged 10 to 11 is now obese. Being overweight or obese increases the risk of type 2 diabetes. Both type 2 diabetes and being overweight or obese increases the risk of coronary heart disease. Other risk factors include high levels of triglycerides and LDL cholesterol fats in the blood. Takeaways tend to have higher fat, sugar and salt levels compared with other foods. The researchers wanted to find out if eating takeaways were

2019 NIHR Dissemination Centre

12. Cohort study: Consuming meals prepared at home more frequently appears to reduce the risk of type 2 diabetes, weight gain and obesity

Cohort study: Consuming meals prepared at home more frequently appears to reduce the risk of type 2 diabetes, weight gain and obesity Consuming meals prepared at home more frequently appears to reduce the risk of type 2 diabetes, weight gain and obesity | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log (...) in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Consuming meals prepared at home more frequently appears to reduce the risk of type 2 diabetes, weight gain and obesity Article Text

2017 Evidence-Based Medicine

13. [Effect of an intervention based on child-care centers to reduce risk behaviors for obesity in preschool children]. Full Text available with Trip Pro

[Effect of an intervention based on child-care centers to reduce risk behaviors for obesity in preschool children]. Preschool age is a critical stage for health promotion and prevention of obesity, which is an emerging public health problem in children. The aim of this study was to design and evaluate the effect of a multifaceted intervention based on child-care centers to reduce risk behaviors for obesity among preschool children.A 12-month cluster-randomized community trial was conducted (...) analyzed through χ2 test.The intervention showed decrease of home availability for some non-recommended foods and increase in physical activity in the intervention group compared to the usual care group.Improvement in physical activity can be effective in the long term; innovative strategies aimed to modify family dietary risk behaviors are required.Copyright © 2016 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

2019 Boletin medico del Hospital Infantil de Mexico Controlled trial quality: uncertain

14. Interventions for supporting the initiation and continuation of breastfeeding among women who are overweight or obese. Full Text available with Trip Pro

of overweight and obesity globally and the known benefits of breastfeeding particularly in reducing the long-term risks of obesity and diabetes for infants, establishing effective ways to support and promote breastfeeding in women who are overweight or obese is paramount in achieving the goal of healthier communities.To assess the effectiveness of interventions to support the initiation or continuation of breastfeeding in women who are overweight or obese.On 23 January 2019 we searched Cochrane Pregnancy (...) . The trials were conducted in high-income countries: USA (5 trials); Denmark (1 trial) and Australia (1 trial), between 2006 and 2015. Three trials only included women who were obese prior to pregnancy and four trials included both women who were overweight and women who were obese. We judged risk of bias in the included trials to be mixed; only one trial was judged to be low risk of bias for random sequence generation, allocation concealment and attrition bias.Physical breastfeeding support (manual

2019 Cochrane

15. Effects of HIIT and MICT on cardiovascular risk factors in adults with overweight and/or obesity: A meta-analysis. Full Text available with Trip Pro

Effects of HIIT and MICT on cardiovascular risk factors in adults with overweight and/or obesity: A meta-analysis. The purpose of this study was to evaluate the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on cardiovascular disease (CVD) risk factors in adults with overweight and obesity.Twenty-two articles were included by searching six databases, the total number of subjects was 620 in these articles. Outcomes were synthesised using (...) a random-effects meta-analysis of the Standardized mean difference (SMD) in CVD risk factors.HIIT and MICT resulted in statistically significant reductions in Weight, BMI, fat%, total cholesterol(TC), and improvement in VO2max. Compared with MICT, subgroup of durations of HIIT training interval ≥2 min can significantly increase VO2max (SMD = 0.444, 95% CI:0.037~0.851,P = 0.032), subgroup of energy expenditure of HIIT equal to MICT can significantly increase VO2max (SMD = 0.399, 95% CI:0.106~0.692,P

2019 PLoS ONE

16. A behavioural intervention for obese pregnant women did not reduce risk of diabetes

A behavioural intervention for obese pregnant women did not reduce risk of diabetes A behavioural intervention for obese pregnant women did not reduce risk of diabetes Discover Portal Discover Portal A behavioural intervention for obese pregnant women did not reduce risk of diabetes Published on 4 November 2015 doi: This large NIHR-funded UK trial found that a behavioural intervention for obese pregnant women did not reduce their risk of developing diabetes during pregnancy, or having a baby (...) result does emphasise the need to follow NICE recommendations to test for diabetes in all pregnant women with obesity. Share your views on the research. Why was this study needed? Obesity rates in UK women have risen between 1993 and 2011 from 16% to 26%. Rates of gestational diabetes are also increasing. Women who are obese when they become pregnant have a higher risk of developing diabetes, high blood pressure, or having babies that are on average larger than the duration of pregnancy would predict

2018 NIHR Dissemination Centre

17. A computational framework for predicting obesity risk based on optimizing and integrating genetic risk score and gene expression profiles. Full Text available with Trip Pro

A computational framework for predicting obesity risk based on optimizing and integrating genetic risk score and gene expression profiles. Recent large-scale genome-wide association studies have identified tens of genetic loci robustly associated with Body Mass Index (BMI). Gene expression profiles were also found to be associated with BMI. However, accurate prediction of obesity risk utilizing genetic data remains challenging. In a cohort of 75 individuals, we integrated 27 BMI-associated SNPs (...) and obesity-associated gene expression profiles. Genetic risk score was computed by adding BMI-increasing alleles. The genetic risk score was significantly correlated with BMI when an optimization algorithm was used that excluded some SNPs. Linear regression and support vector machine models were built to predict obesity risk using gene expression profiles and the genetic risk score. An adjusted R2 of 0.556 and accuracy of 76% was achieved for the linear regression and support vector machine models

2018 PLoS ONE

18. Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes. Full Text available with Trip Pro

with obesity or who are overweight, acting to reduce glucose production in the liver and improve glucose uptake in smooth muscle cells, and therefore improve the overall metabolic health of women in pregnancy and reduce the risk of known adverse pregnancy outcomes.To evaluate the role of metformin in pregnant women with obesity or who are overweight, on maternal and infant outcomes, including adverse effects of treatment and costs.We searched Cochrane Pregnancy and Childbirth's Trials Register (...) Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes. There has been considerable interest in providing antenatal dietary and lifestyle advice for women with obesity or who are overweight during pregnancy, as a strategy to limit gestational weight gain and improve maternal and infant health. However, such antenatal interventions appear to have a modest effect on gestational weight gain and other clinical pregnancy and birth outcomes

2018 Cochrane

19. Physical activity, diet and other behavioural interventions for improving cognition and school achievement in children and adolescents with obesity or overweight. Full Text available with Trip Pro

Physical activity, diet and other behavioural interventions for improving cognition and school achievement in children and adolescents with obesity or overweight. The global prevalence of childhood and adolescent obesity is high. Lifestyle changes towards a healthy diet, increased physical activity and reduced sedentary activities are recommended to prevent and treat obesity. Evidence suggests that changing these health behaviours can benefit cognitive function and school achievement (...) in children and adolescents in general. There are various theoretical mechanisms that suggest that children and adolescents with excessive body fat may benefit particularly from these interventions.To assess whether lifestyle interventions (in the areas of diet, physical activity, sedentary behaviour and behavioural therapy) improve school achievement, cognitive function (e.g. executive functions) and/or future success in children and adolescents with obesity or overweight, compared with standard care

2018 Cochrane

20. Physical activity, diet and other behavioural interventions for improving cognition and school achievement in children and adolescents with obesity or overweight. Full Text available with Trip Pro

Physical activity, diet and other behavioural interventions for improving cognition and school achievement in children and adolescents with obesity or overweight. The global prevalence of childhood and adolescent obesity is high. Lifestyle changes towards a healthy diet, increased physical activity and reduced sedentary activities are recommended to prevent and treat obesity. Evidence suggests that changing these health behaviours can benefit cognitive function and school achievement (...) in children and adolescents in general. There are various theoretical mechanisms that suggest that children and adolescents with excessive body fat may benefit particularly from these interventions.To assess whether lifestyle interventions (in the areas of diet, physical activity, sedentary behaviour and behavioural therapy) improve school achievement, cognitive function (e.g. executive functions) and/or future success in children and adolescents with obesity or overweight, compared with standard care

2018 Cochrane

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