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Notalgia Paresthetica

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1. Notalgia paresthetica: treatment review and algorithmic approach. (PubMed)

Notalgia paresthetica: treatment review and algorithmic approach. Notalgia paresthetica (NP) is a sensory neuropathy of the back characterized by a well demarcated, hyperpigmented macule or patch located medial or inferior to the scapulae. Symptoms include localized pruritus and pain, and the clinical course consists of remissions and relapses. It can be an underrecognized and difficult disease to treat since conventional treatments for pruritus in inflammatory dermatosis have variable efficacy (...) . There are a variety of treatment modalities, but strong evidence to suggest the superiority of any one treatment is lacking.This review describes the treatments that have been used for NP in the literature and evaluates their level of evidence with respect to their efficacy. We also present a treatment algorithm based on our analysis.MEDLINE search was performed using the terms 'notalgia,' 'paresthetica,' and 'treatment.' All resulting articles have been included in this review.Treatment options include topical

2019 Journal of Dermatological Treatment

2. Notalgia paresthetica: a review for dermatologists. (PubMed)

Notalgia paresthetica: a review for dermatologists. Notalgia paresthetica (NP) is an underdiagnosed condition that presents with unilateral pruritus medial to the scapula on the midback with or without an associated hyperpigmented or hypopigmented macule. There is a paucity of recent reviews on this chronic cutaneous neuropathy in peer-reviewed journals. Current theories propose the condition is likely multifactorial, including spinal entrapment and muscular compressive neuropathy. An extensive (...) literature review was performed by searching the MEDLINE database to review all published works on notalgia paresthetica. This review will provide a useful update for clinicians on the pathogenesis, clinical features, biopsy features, risk factors, and management options for this condition including pharmacological and nonpharmacological methods detailing published treatment options to date for this difficult to treat condition.© 2017 The International Society of Dermatology.

2017 International Journal of Dermatology

3. Notalgia paresthetica: factors associated with its perceived severity, duration, side, and localization. (PubMed)

Notalgia paresthetica: factors associated with its perceived severity, duration, side, and localization. Notalgia paresthetica (NP) is a disorder characterized by pruritus localized to the patient's back. Little is known about predictors of severity, duration, side, and localization.To identify factors associated with perceived severity, duration, side, and localization of NP.In a cross-sectional study, disease severity, duration, side, and localization were compared among the considered

2017 International Journal of Dermatology

4. Notalgia Paresthetica: A Novel Approach to Treatment with Cryolipolysis (PubMed)

Notalgia Paresthetica: A Novel Approach to Treatment with Cryolipolysis Notalgia paresthetica, a neurosensory syndrome that typically occurs on the upper back, has multiple clinical symptoms with variable degrees of expression in each individual afflicted with the condition. The involved site is usually hyperpigmented and is associated with burning, coldness, hypoesthesia, increased pain, pruritus and/or tingling. In the affected area, the number of nerve fibers may be increased (...) and the cutaneous sensory nerves are altered secondary to localized impingement, central injury, or both. Although multiple therapeutic approaches for notalgia paresthetica have been described, none specifically address the essential pathogenesis of the condition-the altered cutaneous nerves. Cryolipolysis is a well-tolerated nonsurgical technique to reduce the subcutaneous fat layer. Selective apoptosis of adipocytes occurs since the lipid-rich fat cells are more susceptible to cold injury than the surrounding

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2017 Cureus

5. A Case Report of Refractory Notalgia Paresthetica Treated with Lidocaine Infusions (PubMed)

A Case Report of Refractory Notalgia Paresthetica Treated with Lidocaine Infusions BACKGROUND Notalgia paresthetica is a neuropathic condition that manifests as a chronic itch in the thoraco-dorsal region. It is often resistant to treatment, and specific guidelines for its management are lacking. As such, we present a treatment approach with intravenous lidocaine infusions. CASE REPORT The case involves a 50-year-old woman with spinal cord injury caused by an epidural abscess. The patient (...) developed notalgia paresthetica and sublesional neuropathic pain following its drainage. In the course of her pain management, she was treated with intravenous lidocaine which resulted in profound relief of notalgia paresthetica. CONCLUSIONS Intravenous lidocaine was effective in relieving neuropathic itch in the patient case presented.

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2017 The American journal of case reports

6. A Rare Cause of Neuropathic Pain in the Back: Notalgia Paresthetica (PubMed)

A Rare Cause of Neuropathic Pain in the Back: Notalgia Paresthetica 28360775 2018 11 13 1300-0667 53 1 2016 Mar Noro psikiyatri arsivi Noro Psikiyatr Ars A Rare Cause of Neuropathic Pain in the Back: Notalgia Paresthetica. 89-90 10.5152/npa.2015.10029 Terzi Rabia R Clinic of Physical Medicine and Rehabilitation, Derince Training and Research Hospital, Kocaeli, Turkey. Bekdik Şirinocak Pınar P Clinic of Neurology, Derince Training and Research Hospital, Kocaeli, Turkey. eng Journal Article 2016

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2016 Nöro Psikiyatri Arşivi

7. Considerable Variability in the Efficacy of 8% Capsaicin Topical Patches in the Treatment of Chronic Pruritus in 3 Patients with Notalgia Paresthetica (PubMed)

Considerable Variability in the Efficacy of 8% Capsaicin Topical Patches in the Treatment of Chronic Pruritus in 3 Patients with Notalgia Paresthetica Notalgia paresthetica (NP) is a focal neuropathic itch condition manifesting in intense chronic or recurrent episodic itch in a hyperpigmented, macular, uni- or bilateral skin area located below and/or medially to the scapulae. Achieving satisfactory relieve in NP patients is challenging. In this case-series three female NP patients were treated

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2016 Annals of dermatology

8. Notalgia Paresthetica

Notalgia Paresthetica Notalgia Paresthetica Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Notalgia Paresthetica Notalgia (...) Paresthetica Aka: Notalgia Paresthetica , Paresthetic Notalgia From Related Chapters II. Pathophysiology Sensory involving dorsal spinal nerves Considered subset of III. Symptoms on the back Associated other sensations involving back Pain Hyperesthesia IV. Signs Circumscribed hyperpigmented patch on back Associated with chronic rubbing and scratching V. Associated Conditions A VI. Management No known effective therapy 300 mg bid and titrate to effect Found possibly effective in small trials Images: Related

2018 FP Notebook

9. Treatment of notalgia paresthetica with botulinum toxin A: a double-blind randomized controlled trial. (PubMed)

Treatment of notalgia paresthetica with botulinum toxin A: a double-blind randomized controlled trial. 24831319 2014 06 30 2014 05 16 1097-6787 70 6 2014 Jun Journal of the American Academy of Dermatology J. Am. Acad. Dermatol. Treatment of notalgia paresthetica with botulinum toxin A: a double-blind randomized controlled trial. 1139-41 10.1016/j.jaad.2013.12.006 S0190-9622(13)01336-4 Maari Catherine C Innovaderm Research, Montreal, Canada. Electronic address: cmaari@hotmail.com. Marchessault

2014 Journal of the American Academy of Dermatology

10. Notalgia Paresthetica

Notalgia Paresthetica Notalgia Paresthetica Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Notalgia Paresthetica Notalgia (...) Paresthetica Aka: Notalgia Paresthetica , Paresthetic Notalgia From Related Chapters II. Pathophysiology Sensory involving dorsal spinal nerves Considered subset of III. Symptoms on the back Associated other sensations involving back Pain Hyperesthesia IV. Signs Circumscribed hyperpigmented patch on back Associated with chronic rubbing and scratching V. Associated Conditions A VI. Management No known effective therapy 300 mg bid and titrate to effect Found possibly effective in small trials Images: Related

2015 FP Notebook

11. Treatment of Notalgia Paresthetica With Xeomin

Treatment of Notalgia Paresthetica With Xeomin Treatment of Notalgia Paresthetica With Xeomin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment of Notalgia Paresthetica With Xeomin The safety (...) on the back. Safety will be evaluated with adverse events. Condition or disease Intervention/treatment Phase Notalgia Paresthetica Drug: Xeomin Drug: Placebo / Xeomin Phase 3 Detailed Description: Notalgia paresthetica is a common sensory neuropathy, affecting mainly the interscapular area especially the T2-T6 dermatomes. The characteristic symptom is pruritus on the upper back. It is occasionally accompanied by pain, paresthesia, hyperesthesia and a well circumscribed hyperpigmentation of the affected

2010 Clinical Trials

12. Notalgia paresthesica successfully treated with narrow-band UVB: report of five cases. (PubMed)

phototherapy in five patients. Phototherapy contributed substantially to improve pruritus in all of them.Given the benefits achieved, we stress the interest of UVB narrow-band as a safe and well tolerated alternative treatment for notalgia paresthetica. (...) Notalgia paresthesica successfully treated with narrow-band UVB: report of five cases. Notalgia paresthesica is a disorder of unknown origin characterized by pruritus localized to the patients' back. Local pain, burning or paresthesias have also been described. No definite treatments have been found for this disorder and most of those reported to date are anecdotal. Topical capsaicin is the option most widely used among dermatologists. Transcutaneous electrical nerve stimulation, gabapentin

2010 Journal of the European Academy of Dermatology and Venereology

13. Serratus muscle stimulation effectively treats notalgia paresthetica caused by long thoracic nerve dysfunction: a case series (PubMed)

Serratus muscle stimulation effectively treats notalgia paresthetica caused by long thoracic nerve dysfunction: a case series Currently, notalgia paresthetica (NP) is a poorly-understood condition diagnosed on the basis of pruritus, pain, or both, in the area medial to the scapula and lateral to the thoracic spine. It has been proposed that NP is caused by degenerative changes to the T2-T6 vertebrae, genetic disposition, or nerve entrapment of the posterior rami of spinal nerves arising at T2 (...) EMS to the serratus anterior in an area far lateral to the site of pain and pruritus, resulting in significant and rapid pain relief. These findings are the first to identify long thoracic nerve injury as a cause for notalgia paresthetica and electrical muscle stimulation of the serratus anterior as a possible treatment, and we discuss the implications of these findings on better diagnosing and treating notalgia paresthetica.

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2009 Journal of brachial plexus and peripheral nerve injury

14. Laser treatment of medical skin disease in women (PubMed)

Laser treatment of medical skin disease in women Laser treatment is a relatively new and increasingly popular modality for the treatment of many dermatologic conditions. A number of conditions that predominantly occur in women and that have a paucity of effective treatments include rosacea, connective tissue disease, melasma, nevus of Ota, lichen sclerosus (LS), notalgia paresthetica and macular amyloidosis, and syringomas. Laser therapy is an important option for the treatment of patients

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2017 International journal of women's dermatology

15. Revised ATA guidelines for the management of medullary thyroid carcinoma

of stress. Hyperpigmented lesions develop later, apparently secondary to scratching. The in- citing lesion appears to be notalgia paresthetica, a sensory neuropathyinvolvingthedorsalspinalnerves(66).TheCLA may be present at a young age and prior to the onset of clinically evident MTC, thus serving as a precursor for the syndrome(43,67).TheCLAinpatientswithMEN2Aoccurs almost exclusively in patients with the RET codon 634 mu- tation,althoughithasbeenreportedinapatientwithacodon 804mutation(68,69

2015 Pediatric Endocrine Society

16. Pruritus (PDQ®): Health Professional Version

for Treatment of Opioid-induced Pruritus: A Systematic Review of Literature. Clin J Pain 32 (1): 87-93, 2016. [ ] Wallengren J, Klinker M: Successful treatment of notalgia paresthetica with topical capsaicin: vehicle-controlled, double-blind, crossover study. J Am Acad Dermatol 32 (2 Pt 1): 287-9, 1995. [ ] Weisshaar E, Szepietowski JC, Darsow U, et al.: European guideline on chronic pruritus. Acta Derm Venereol 92 (5): 563-81, 2012. [ ] Kaufmann R, Bieber T, Helgesen AL, et al.: Onset of pruritus relief

2016 PDQ - NCI's Comprehensive Cancer Database

17. Dorsal scapular nerve neuropathy: a narrative review of the literature (PubMed)

Dorsal scapular nerve neuropathy: a narrative review of the literature The purpose of this paper is to elucidate this little known cause of upper back pain through a narrative review of the literature and to discuss the possible role of the dorsal scapular nerve (DSN) in the etiopathology of other similar diagnoses in this area including cervicogenic dorsalgia (CD), notalgia paresthetica (NP), SICK scapula and a posterolateral arm pain pattern.Dorsal scapular nerve (DSN) neuropathy has been

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2017 The Journal of the Canadian Chiropractic Association

18. A Randomized Placebo-Controlled Study of the Neurokinin-1 (NK1) Receptor Antagonist VPD-737 Prurigo Nodularis (PN)

) and clinical laboratory tests (including urinalysis). Agreeing to confidential use and storage of all data and use of all anonymized data for publication including scientific publication. Exclusion Criteria: Subjects not eligible for the study are those who: Have chronic pruritus due conditions other than PN, such as the following conditions: Lichen simplex chronicus Lichen amyloidosus Localized pruritus (e.g., only one arm affected) Neuropathic and psychogenic pruritus (notalgia paresthetica

2014 Clinical Trials

19. Pruritus

Acad Dermatol 54 (3): 527-31, 2006. Jannuzzi RG: Nalbuphine for Treatment of Opioid-induced Pruritus: A Systematic Review of Literature. Clin J Pain 32 (1): 87-93, 2016. Wallengren J, Klinker M: Successful treatment of notalgia paresthetica with topical capsaicin: vehicle-controlled, double-blind, crossover study. J Am Acad Dermatol 32 (2 Pt 1): 287-9, 1995. Weisshaar E, Szepietowski JC, Darsow U, et al.: European guideline on chronic pruritus. Acta Derm Venereol 92 (5): 563-81, 2012. Kaufmann R

2012 PDQ - NCI's Comprehensive Cancer Database

20. Brachioradial Pruritus (Diagnosis)

. Brachioradial pruritus: a case report and review of the literature. Cutis . January 2008. 81(1):37-40. . Cohen AD, Masalha R, Medvedovsky E, Vardy DA. Brachioradial pruritus: a symptom of neuropathy. J Am Acad Dermatol . 2003 Jun. 48(6):825-8. . Gore DR, Sepic SB, Gardner GM. Roentgenographic findings of the cervical spine in asymptomatic people. Spine . 1986 Jul-Aug. 11(6):521-4. . Savk E, Savk SO. On brachioradial pruritus and notalgia paresthetica. J Am Acad Dermatol . 2004 May. 50(5):800-1. . Mirzoyev (...) , Steinke S, et al. Capsaicin 8% cutaneous patch: a promising treatment for brachioradial pruritus?. Br J Dermatol . 2015 Jun. 172 (6):1669-71. . Steinke S, Gutknecht M, Zeidler C, Dieckhöfer AM, Herrlein O, Lüling H, et al. Cost-effectiveness of an 8% Capsaicin Patch in the Treatment of Brachioradial Pruritus and Notalgia Paraesthetica, Two Forms of Neuropathic Pruritus. Acta Derm Venereol . 2017 Jan 4. 97 (1):71-76. . Pereira MP, Lüling H, Dieckhöfer A, Steinke S, Zeidler C, Agelopoulos K, et al

2014 eMedicine.com

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