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Normogonadotropic Hypogonadism

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1. Normogonadotropic Hypogonadism

Normogonadotropic Hypogonadism Normogonadotropic Hypogonadism Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Normogonadotropic (...) Hypogonadism Normogonadotropic Hypogonadism Aka: Normogonadotropic Hypogonadism , Eugonadotropic Causes of Delayed Puberty , Normogonadropic Causes of Delayed Puberty From Related Chapters II. Definition: Normogonadotropic Hypogonadism Delayed and growth delay Occurs despite normal pituitary gonadotropin secretion III. See Also IV. Causes: Delayed Menarche Gonadal dysgenesis variants Residually functioning ovarian tissue Abnormalities Mullerian duct development Absence of and possibly Vagina Polycystic

2018 FP Notebook

2. Normogonadotropic Hypogonadism

Normogonadotropic Hypogonadism Normogonadotropic Hypogonadism Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Normogonadotropic (...) Hypogonadism Normogonadotropic Hypogonadism Aka: Normogonadotropic Hypogonadism , Eugonadotropic Causes of Delayed Puberty , Normogonadropic Causes of Delayed Puberty From Related Chapters II. Definition: Normogonadotropic Hypogonadism Delayed and growth delay Occurs despite normal pituitary gonadotropin secretion III. See Also IV. Causes: Delayed Menarche Gonadal dysgenesis variants Residually functioning ovarian tissue Abnormalities Mullerian duct development Absence of and possibly Vagina Polycystic

2015 FP Notebook

3. International evidence-based guideline for the assessment and management of polycystic ovary syndrome (PCOS)

with amenorrhea and more severe clinical features including consideration of hypogonadotropic hypogonadism, Cushing’s disease, or androgen producing tumours. We acknowledge the challenges in defining specific diagnostic features, including around menarche and menopause, where diagnostic features naturally evolve. The guideline aims to facilitate timely and appropriate diagnosis for women with PCOS, whilst avoiding over diagnosis, especially in adolescents. Specific recommendations of relevance here include

2018 European Society of Human Reproduction and Embryology

4. Ovaleap - follitropin alfa

stimulation during assisted reproduction treatment: a comparison of recombinant and highly purified urinary human FSH. Hum Reprod 2000; 15(8):1691-7. 14 Westergaard LG, Erb K, Laursen SB, Rex S, Rasmussen P. Human menopausal gonadotropin versus recombinant follicle-stimulating homrone in normogonadotropic women downregulated with a gonadotropin- releasing hormone agonist who were undergoing in vitro fertilization and intracytoplasmic sperm injection: a prospective randomized study. Fertil Steril 2001; 76 (...) of biosimilarity. The observed dose differences in the pivotal Phase III study are only small. The total Ovaleap dose was only 4.8% lower than the total Gonal-f dose. This difference is not clinically relevant, and consequently the data of the pivotal Phase III study can be extrapolated to all other indications, including the indication ‘hypogonadotropic hypogonadism’. The major objection on the potentially increased immunogenicity risk as a consequence of the presence of a higher content of non-human sialic

2013 European Medicines Agency - EPARs

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