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Normocytic Anemia

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121. Abnormal amyloid β42 expression and increased oxidative stress in plasma of CKD patients with cognitive dysfunction: A small scale case control study comparison with Alzheimer's disease Full Text available with Trip Pro

by spectrophotometrically. Aβ level was determined by immunoblotting method. The parameters were statistically compared with healthy, normocytic normochromic anemia and AD subjects.Like AD subjects, significantly increased Aβ and LPO level while decreased SOD, CAT, GPx and GSH levels were observed in plasma of CKD patients with cognitive dysfunction when compared to healthy, CKD without cognitive dysfunction and normocytic normochromic anemic subjects.Results suggest that elevated plasma oxidative stress and Aβ were (...) without cognitive dysfunction and 30 CKD with cognitive dysfunction based on neuropsychological assessment tests. To compare antioxidant status and Aβ42 levels in plasma, the following groups such as healthy subjects (n = 30), normocytic normochromic anemia (n = 30) and Alzheimer's disease (AD, n = 10) patients were also maintained. Plasma Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), Reduced glutathione (GSH) and lipid peroxidation (LPO) were determined

2017 Bba Clinical

122. Paraganglioma of the organ of Zuckerkandl associated with a somatic HIF2α mutation: A case report Full Text available with Trip Pro

presented with uncontrolled hypertension during the first trimester of pregnancy. A diagnostic hysteroscopy was performed 3 months after delivery, precipitating a hypertensive crisis. Thereafter, the patient was diagnosed with noradrenaline-secreting OZ-PGL. A complete blood count identified mild normocytic anemia of an inflammatory origin. Surgical removal of the tumor resulted in normalization of plasma and urinary normetanephrine levels. Genetic testing for germline mutations (including large

2017 Oncology letters

123. Métastase costale révélant un carcinome épidermoïde de l’œsophage Full Text available with Trip Pro

with weight loss. The patient also reported mechanical dysphagia evolving during 4 months which had not motivated consultation. Clinical examination showed a poor general condition, a hard, sensitive swelling measuring 3 cm along its longer axis, located on the anterolateral surface of the right hemithorax at the level of the 5thrib. Biological examinations showed normocytic normochromic anemia with hemoglobin level of 9.4 g/dl, non-specific biological inflammatory syndrome, and hypercalcemia (corrected

2017 The Pan African medical journal

124. Sirolimus Treatment for Refractory PRCA

for refractory PRCA. Condition or disease Intervention/treatment Phase Pure Red Cell Aplasia Drug: Sirolimus Phase 4 Detailed Description: Pure red cell aplasia (PRCA) is a rare normocytic normochromic anemia with reticulocytopenia, characterized by a reduction of erythroid precursors from the bone marrow, could be divided into congenital and acquired PRCA according to pathogenesis. Congenital PRCA, also known as Diamond-Blackfan syndrome, has been associated with pathogenic variant in GATA1 and TSR2 (...) Hospital Study Details Study Description Go to Brief Summary: Pure red cell aplasia (PRCA) is a kind of anemia characterized by severe reticulocytopenia and obvious bone marrow erythroblastic cells decreased. Cyclosporine and /or steroids are the first line therapy but some patients were refractory or intolerance to the treatment. The effects of the second line therapy are also not satisfactory and sometimes not available. The investigators aim to explore the efficacy and side-effect of sirolimus

2017 Clinical Trials

125. Cabozantinib as a Targeted Strategy to Reverse Carfilzomib Resistance in Refractory Multiple Myeloma

(MM), with all 3 of the following IMWG criteria, except as noted: Clonal bone marrow plasma cells ≥ 10% A monoclonal protein in either serum or urine Evidence of end-organ damage that can be attributed to the underlying plasma cell proliferative disorder (to include one of the following) Hypercalcemia (corrected calcium > 2.75 mmol/L or 11.5 mg/dL); OR Renal insufficiency attributable to myeloma (serum creatinine >1.9 mg/dL); OR Anemia; normochromic, normocytic with a hemoglobin value ≥2 g/dL

2017 Clinical Trials

126. Safety and Efficacy Study for AKB-6548 in Subjects With Chronic Kidney Disease and Anemia

Safety and Efficacy Study for AKB-6548 in Subjects With Chronic Kidney Disease and Anemia Safety and Efficacy Study for AKB-6548 in Subjects With Chronic Kidney Disease and Anemia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Safety and Efficacy Study for AKB-6548 in Subjects With Chronic Kidney Disease and Anemia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01235936 Recruitment Status : Completed First Posted : November 8, 2010 Last Update Posted : November 14, 2018 Sponsor: Akebia

2010 Clinical Trials

127. The prevalence of nutritional anemia in pregnancy in an east Anatolian province, Turkey. Full Text available with Trip Pro

at the third trimester (OR = 2.3) and having a low family income (OR = 1.6) were determined as the independent predictors of anemia in pregnancy. Anemia was also associated with soil eating (PICA) in the univariate analysis (p < 0.05). Of anaemic women, 50.0% had a transferrin saturation less than 10% indicating iron deficiency, 34.5% were deficient in B12 vitamin and 71.7% were deficient in folate. Most of the anemias were normocytic-normochromic (56.5%) indicating mixed anemia.In Malatya, for pregnant (...) The prevalence of nutritional anemia in pregnancy in an east Anatolian province, Turkey. Anemia is considered a severe public health problem by World Health Organization when anemia prevalence is equal to or greater than 40% in the population. The purpose of this study was to determine the anemia prevalence with the associated factors in pregnant women and to determine the serum iron, folate and B12 vitamin status in anaemic pregnants in Malatya province.This is a cross-sectional survey

2010 BMC Public Health

128. Chronic Renal Failure

and granular casts present Hypertensive Nephropathy Protein to ratio 200-1000 mg/g Noninflammatory Glomerular Disease Protein to ratio >1000 mg/g Proliferative Protein to ratio >500 mg/g s, casts, s, casts present Tubulointerstitial Nephritis Protein to ratio 200-1000 mg/g s, s, casts present IgA Nephropathy or ( ) Dysmorphic urinary s or casts XIV. Labs: Findings in Chronic Kidney Disease Stages 3-4 (Normochromic, Normocytic) decreases > 2-3 <20-30 Results from decreased synthesis Decreased Serum (...) management options Non- with care Delayed until <5 ml/min (similar morbidity and mortality) XXII. Management: Anemia (EPO) Efficacy Initial studies showed benefit for Recent studies show no benefit and higher risk of Outcomes are the same with and without normalized via erythropoetin Morbidity and patient sense of well-being is not improved on erythropoetin Indications for Erythropoeitin <9 mg/dl Adverse effects Increased risk of Often indicated in patients Parenteral replacement is often needed

2018 FP Notebook

129. Macroglobulinemia

. Signs Pallor Peripheral l lesions l l Exudate Venous congestion Pulmonary Disease Infiltrates or VI. Labs Normocytic normochromic Rouleau formation markedly elevated Hypocellular Extensive Infiltrations by lymphoid and plasma cells Increased Mast Cell numbers Immunoelectrophoresis Monoclonal IgM Protein >3 g/dl VII. Differential Diagnosis (CLL) VIII. Management Suppression of and Plasma Cell proliferation Chlorambucil Cyclophosphamide Combination chemotherapeutic regimens Hyperviscosity (...) other tissues, also known as lymphoplasmacytic lymphoma. Clinical features include ANEMIA; HEMORRHAGES; and hyperviscosity. Concepts Neoplastic Process ( T191 ) MSH ICD9 273.3 ICD10 , SnomedCT 190818004 , 35562000 , 154750002 , 190014001 , 109981009 , 190821002 , 267503004 , 190817009 English Macroglobulinemia , Macroglobulinemia, Waldenstrom's , Waldenstrom's Macroglobulinemia , Waldenstroms Macroglobulinemia , Macroglobulinaemia NOS , Waldenstrom's macroglobulinaem , Macroglobulinemia NOS

2018 FP Notebook

130. Vitamin C Deficiency

Aminoaciduria Normocytic Normochromic is typically normal increased X. Management ( ) Replacement (preferred) Doses in excess of 1000 mg are not absorbed Adults: 200 mg orally daily Children: 100 to 200 mg orally daily Dietary Orange Juice or Tomato Juice >4 ounces per day XI. Complications Risk of sudden death in late disease XII. Prevention See for recommended daily needs XIII. References Behrman (2000) Nelson Pediatrics, p. 182-4 Cotran (1999) Robbins Pathologic Basis, p. 449-50 Rees in Lee (1999 (...) ascorbique , Déficit en acide ascorbique Derived from the NIH UMLS ( ) Ontology: Scurvy (C0036474) Definition (MSH) An acquired blood vessel disorder caused by severe deficiency of vitamin C (ASCORBIC ACID) in the diet leading to defective collagen formation in small blood vessels. Scurvy is characterized by bleeding in any tissue, weakness, ANEMIA, spongy gums, and a brawny induration of the muscles of the calves and legs. Concepts Disease or Syndrome ( T047 ) MSH ICD10 SnomedCT 267493006 , 190638001

2018 FP Notebook

131. Multiple myeloma

') and is diagnosed due to incidental findings on blood tests, such as: Normochromic, normocytic anaemia — present in about 70% of people. Renal impairment — present in about 50% of people. Hypercalcaemia — present in about 15% of people. Raised erythrocyte sedimentation rate (ESR), plasma viscosity, serum protein, or globulin. Basis for recommendation Basis for recommendation The information on when to suspect multiple myeloma is based on expert opinion in the British Committee for Standards in Haematology (...) include: Pathological bone fractures. Spinal cord compression. Renal damage. Impaired resistance to infection. Anaemia. Bleeding disorders. Hyperviscosity of the blood. Symptoms of multiple myeloma include: Bone pain, often in the lower back. Fatigue. Confusion, muscle weakness, constipation, thirst, and polyuria (due to hypercalcaemia). Weight loss. Recurrent infection. Headache, visual disturbance, cognitive impairment, mucosal bleeding, and breathlessness (due to hyperviscosity of the blood

2016 NICE Clinical Knowledge Summaries

132. Myelodysplastic/ Myeloproliferative Neoplasms Treatment (PDQ®): Health Professional Version

with an unremarkable morphology, can exhibit abnormal granulation, unusual nuclear lobation, or finely dispersed nuclear chromatin.[ ] Fewer than 20% blasts are seen in the blood or bone marrow. Neutrophilia occurs in nearly 50% of patients with neutrophil precursors (e.g., promyelocytes and myelocytes) accounting for more than 10% of the white blood cells.[ ] Mild normocytic anemia is common. (Refer to the PDQ summary on for more information on anemia.) Moderate thrombocytopenia is often present. Bone marrow (...) or complex abnormalities), and anemia.[ ][ ] The nucleoside azacitidine is an inhibitor of DNA methyltransferase that has been approved for the treatment of MDS and CMML, largely based on a Cancer and Leukemia Group B randomized trial and a randomized trial conducted in Europe.[ , ] Azacitidine may improve both the dysplastic and proliferative features of CMML. Erythropoietic growth factors may help to reduce transfusion requirements when anemia supervenes. This trial, in which patients were randomized

2015 PDQ - NCI's Comprehensive Cancer Database

133. Supportive care in multiple myeloma

concentration <120 g/l) is common in myeloma and is present in approximately 75% of patients at diagnosis ( ). In most patients the anaemia will be normochromic and normocytic and attributed to the myeloma itself and/or the myelosuppressive effect of the chemotherapy. Other causes, such as haematinic deficiency or bleeding, should be excluded. Fatigue is also reported by many patients and may be caused by both physical and psychological factors related to the disease and its treatment but anaemia has been (...) be observed and some will become less anaemic as the myeloma is controlled with chemotherapy. ESA treatment is recommended for anaemic patients with myeloma with associated renal impairment ( ). ESA doses of <20 000 iu/week may be adequate in patients where renal disease is the main cause of the anaemia. In the UK, it may be necessary to refer the patient to a renal physician to access NHS funding for ESAs. Data from randomized trials, which have included patients with myeloma, suggest that ESAs increase

2011 British Committee for Standards in Haematology

134. Case of the Month: Vertebral Osteomyelitis and Psoas Abscess with Acinetobacter Baumanii: Report of an Unusual Case

was afebrile, and other vital signs were unremarkable except for mild hypertension. There was no external sign of trauma. Gait and neurological examination of his lower extremities were normal, as was his rectal sphincter tone. The remainder of physical examination was within normal limits. A normochromic, normocytic anemia was present. Erythrocyte sedimentation rate was 40 mm/h. Urine analysis was unremarkable. Plain films of the lumbar spine showed destruction of L1-3 vertebral bodies. CT imaging

2011 Clinical Correlations

135. 2011 update to NHFA and CSANZ guidelines for the prevention, detection and management of chronic heart failure in Australia

11.4 Restrictive cardiomyopathy 47 11.5 Treatment of HFPSF 47 12. Treatment of associated disorders 50 12.1 Cardiac arrhythmia 50 12.2 Valvular heart disease 51 12.3 CHD 51 12.4 Arthritis 51 12.5 Chronic renal failure 51 12.6 Anaemia 52 12.7 Cancer 52 12.8 Diabetes 52 12.9 Thromboembolism 52 12.10 Gout 53 13. P o s t - d i s c h ar ge m an a ge m e nt programs 54 14. Palliative support 56 14.1 Clarifying goals of treatment 56 14.2 ICDs 56 14.3 Symptom control 56 14.4 Community palliative support 58 (...) such as sunitinib, tricyclic antidepressants, non-steroidal anti-inflammatory drugs and cyclo-oxygenase-2 enzyme (COX-2) inhibitors, thiazolidinediones and tumour necrosis factor antagonists. CHF is often accompanied by important comorbid conditions that require specific intervention. These include concomitant ischaemic heart disease, valvular disease, arrhythmia, arthritis, gout, renal dysfunction, anaemia, diabetes and sleep apnoea. Heart failure with preserved systolic function (HFPSF), or diastolic heart

2011 Clinical Practice Guidelines Portal

136. Guidelines for the prevention, detection and management of chronic heart failure (updated October 2011)

Treatment of HFPSF 47 12. Treatment of associated disorders 50 12.1 Cardiac arrhythmia 50 12.2 Valvular heart disease 51 12.3 CHD 51 12.4 Arthritis 51 12.5 Chronic renal failure 51 12.6 Anaemia 52 12.7 Cancer 52 12.8 Diabetes 52 12.9 Thromboembolism 52 12.10 Gout 53 13. P o s t - d i s c h ar ge m an a ge m e nt programs 54 14. Palliative support 56 14.1 Clarifying goals of treatment 56 14.2 ICDs 56 14.3 Symptom control 56 14.4 Community palliative support 58 14.5 Support agencies and services 58 15 (...) , non-steroidal anti-inflammatory drugs and cyclo-oxygenase-2 enzyme (COX-2) inhibitors, thiazolidinediones and tumour necrosis factor antagonists. CHF is often accompanied by important comorbid conditions that require specific intervention. These include concomitant ischaemic heart disease, valvular disease, arrhythmia, arthritis, gout, renal dysfunction, anaemia, diabetes and sleep apnoea. Heart failure with preserved systolic function (HFPSF), or diastolic heart failure, is common and may account

2011 Clinical Practice Guidelines Portal

137. Pure red cell aplasia. Full Text available with Trip Pro

Pure red cell aplasia. Pure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. Diamond-Blackfan anemia is a congenital form of PRCA. Acquired PRCA may be either a primary disorder or secondary to some other disorder or agent. Primary acquired PRCA is an autoimmune disorder that is frequently antibody-mediated. Myelodysplastic syndromes may also present

2016 Blood

138. Monoclonal gammopathy-associated pure red cell aplasia. Full Text available with Trip Pro

Monoclonal gammopathy-associated pure red cell aplasia. Pure red cell aplasia (PRCA) is a rare disorder characterized by inhibition of erythroid precursors in the bone marrow and normochromic, normocytic anaemia with reticulocytopenia. Among 51 PRCA patients, we identified 12 (24%) patients having monoclonal gammopathy, monoclonal gammopathy of undetermined significance or smouldering multiple myeloma, with presence of monoclonal protein or abnormal serum free light chains and atypical bone

2016 British journal of haematology

139. Elevated Low-Shear Blood Viscosity is Associated with Decreased Pulmonary Blood Flow in Children with Univentricular Heart Defects. Full Text available with Trip Pro

measured. PVR and PBF were calculated using the Fick equation. Group differences were analyzed by ANOVA and correlations by linear regression. Blood viscosity at all shear rates was higher in Glenn and Fontan, partially due to normocytic anemia in ASD. RBC aggregation and deformability were similar between all groups. Low-shear viscosity negatively correlated with PBF in Glenn and Fontan only (R (2) = 0.27, p < 0.001); it also negatively correlated with pulmonary artery pressure in Glenn (R (2) = 0.15

2016 Pediatric Cardiology

140. Haematological and biochemical indicators of tropical theileriosis diseased cattle in wilaya of Sétif (North East Algeria) Full Text available with Trip Pro

, the erythrocytes, hemoglobin, hematocrit means decreased significantly (p = 0.027; 0.003 and <0.001, respectively). Two types of anemia were detected: a microcytic hypochromic anemia in Montbéliard breed clinically infected cattle and normocytic normochromic anemia in local and cross breed cattle. Tropical theileriosis induces severe biochemical and haematological alterations that should be taken into consideration by field veterinarians for both the diagnosis of the disease and its treatment.

2016 Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology

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