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Normocytic Anemia

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121. Prévalence et facteurs associés à l’anémie en grossesse à l’Hôpital Général de Douala (PubMed)

. Anemia prevalence was 39,8%. The average age was 29,89±4,835 years. The mean hemoglobin level was 10.93 ± 1.23. Normochromic normocytic anemia (53,3%) was prevalent. Anaemia was severe in 2,4% of cases. Anemia in pregnancy was significantly associated with a personal history of chronic diseases (P = 0.02) and of anemia in a previous pregnancy (P = 0.003). Anemia was more frequently observed during the 3rd trimester (P = 0.04) and breastfeeding played a protective role (P = 0.02).The prevalence (...) Prévalence et facteurs associés à l’anémie en grossesse à l’Hôpital Général de Douala Anemia is a public health problem, prevalent among children and women of childbearing age. Our study aims to determine the prevalence and factors associated with anemia in pregnant women at Douala General Hospital.We conducted a cross sectional study from July 2012 to July 2013. All consenting pregnant women attending antenatal consultation and having undergone complete blood count (CBC) were

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2016 The Pan African medical journal

122. Pure red cell aplasia (PubMed)

Pure red cell aplasia Pure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. Diamond-Blackfan anemia is a congenital form of PRCA. Acquired PRCA may be either a primary disorder or secondary to some other disorder or agent. Primary acquired PRCA is an autoimmune disorder that is frequently antibody-mediated. Myelodysplastic syndromes may also present

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2016 Hematology: the American Society of Hematology Education Program

123. Etude de l’hémogramme dans la drépanocytose homozygote: à propos de 87 patients (PubMed)

) of 1.175. Biological effects of anemia were intense in 88.5% of patients; 67.8% of patients had normocytic anemia compared with 29.9% with microcytosis, and 2.3% with macrocytosis. The degree of anisocytosis was related to the degree of anemia, very evocative in patients with homozygous S/S (95.4%). Reticulocytosis was observed in 81.6% of patients; 52.9% of patients had thrombocytosis. Leukocytosis was observed in 64.4% of patients; 80.5% of patients had neutropenia. The parameters of the hemogram (...) Etude de l’hémogramme dans la drépanocytose homozygote: à propos de 87 patients Homozygous sickle cell disease is one of the most frequent haemoglobinopathies in Morocco. Sickle cell disease is characterized by a large clinical and biological expression variability which depends on modulating genetic and environmental factors. Clinical manifestation includes regenerative anemia whose severity may vary among individuals. In the absence of treatment, it results in premature death. Sickle

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2016 The Pan African medical journal

124. Rivaroxaban-Induced Hemorrhage Associated with ABCB1 Genetic Defect (PubMed)

Rivaroxaban-Induced Hemorrhage Associated with ABCB1 Genetic Defect We report a patient who presented a non-ST segment elevation myocardial infarction in the context of severe normocytic hypochromic anemia related to gastrointestinal bleeding, 3 months after switching anticoagulant from the vitamin K antagonist acenocoumarol to the direct oral anticoagulant rivaroxaban. High levels of both anti-Xa activity and rivaroxaban plasma concentrations were measured despite rivaroxaban withdrawal

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2016 Frontiers in pharmacology

125. Burkitt’s Lymphoma of the Rectosigmoid and Stomach Presenting as Hematochezia (PubMed)

showed normocytic anemia and positive fecal occult blood. Computed tomography of the abdomen revealed an asymmetric appearance of the stomach and pylorus with nodularity of the mucosa and thickening of the posterior wall, and a 10.8-cm rectal mass. Esophagogastroduodenoscopy and colonoscopy were performed and biopsies of the stomach and rectum were obtained; histopathology demonstrated involvement by Burkitt's lymphoma in the gastric body nodule and rectal mass. After 4 cycles of chemotherapy

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2016 The American journal of case reports

126. Diagnosing an atypical site of giant cell arteritis with magnetic resonance angiography: a case report (PubMed)

adjunctive method in the diagnosis of giant cell arteritis. In this case report, we describe a case of giant cell arteritis involving only the occipital artery which was revealed by magnetic resonance angiography.A 67-year-old Caucasian man was admitted to our hospital with a 4-week history of malaise, fever, and mild occipital headaches. There were no other positive findings on physical examination. Laboratory studies were remarkable for normocytic anemia, raised inflammatory markers, and mildly

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2016 Journal of medical case reports

127. Myelodysplastic/ Myeloproliferative Neoplasms Treatment (PDQ®): Health Professional Version

with an unremarkable morphology, can exhibit abnormal granulation, unusual nuclear lobation, or finely dispersed nuclear chromatin.[ ] Fewer than 20% blasts are seen in the blood or bone marrow. Neutrophilia occurs in nearly 50% of patients with neutrophil precursors (e.g., promyelocytes and myelocytes) accounting for more than 10% of the white blood cells.[ ] Mild normocytic anemia is common. (Refer to the PDQ summary on for more information on anemia.) Moderate thrombocytopenia is often present. Bone marrow (...) or complex abnormalities), and anemia.[ ][ ] The nucleoside azacitidine is an inhibitor of DNA methyltransferase that has been approved for the treatment of MDS and CMML, largely based on a Cancer and Leukemia Group B randomized trial and a randomized trial conducted in Europe.[ , ] Azacitidine may improve both the dysplastic and proliferative features of CMML. Erythropoietic growth factors may help to reduce transfusion requirements when anemia supervenes. This trial, in which patients were randomized

2015 PDQ - NCI's Comprehensive Cancer Database

128. Use of Erythropoietin-Stimulating Agents (ESA) in Patients With End-Stage Renal Failure Decided to Forego Dialysis: Palliative Perspective. (PubMed)

Use of Erythropoietin-Stimulating Agents (ESA) in Patients With End-Stage Renal Failure Decided to Forego Dialysis: Palliative Perspective. Normochromic normocytic anemia is a common complication in chronic kidney disease (CKD) and is associated with many adverse clinical consequences. Erythropoiesis-stimulating agents (ESAs) act to replace endogenous erythropoietin for patients with end-stage renal disease having anemia. Today, ESAs remain the main tool for treating anemia associated with CKD

2015 American Journal of Hospice and Palliative Medicine

129. Phase II Study of Efficacy and Safety of Lenalidomide, Subcutaneous Bortezomib and Dexamethasone Therapy for Newly Diagnosed Multiple Myeloma

) of the following (evidence of end-organ damage felt related to the plasma cell disorder related organ or tissue impairment (ROTI), commonly referred to by the acronym "CRAB"): Serum Ca ≥ 10.5 mg/dL or Renal insufficiency attributable to myeloma. Serum creatinine > 2mg/dL Anemia: Normochromic, normocytic with a hemoglobin value > 2g/dL below the lower limit of normal or a hemoglobin <10 g/dL Bone lesions (lytic lesions, severe osteopenia or pathologic fractures) or osteoporosis. *If no monoclonal protein

2015 Clinical Trials

130. Markers of inflammation and mortality in a cohort of patients with alcohol dependence. (PubMed)

(hazard ratio [HR]: 1.67, 95% confidence interval [CI]: 1.11-2.52, P < 0.01); no associations were found between mortality and high fibrinogen or high ferritin levels. A subgroup of patients with anemia was analyzed and compared to a control group of patients without anemia and a normal MCV. The mortality ratios of patients with normocytic and macrocytic anemia were 3.25 (95% CI: 1.41-7.26; P < 0.01) and 3.39 (95% CI: 1.86-6.43; P < 0.01), respectively. Patients with alcohol dependence admitted (...) Markers of inflammation and mortality in a cohort of patients with alcohol dependence. Inflammation and intestinal permeability are believed to be paramount features in the development of alcohol-related liver damage. We aimed to assess the impact of 3 surrogate markers of inflammation (anemia, fibrinogen, and ferritin levels) on mid-term mortality of patients with alcohol dependence. This longitudinal study included patients with alcohol dependence admitted for hospital detoxification between

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2015 Medicine

131. Antineutrophil Cytoplasmic Antibodies-Negative Pauci-Immune Crescentic Glomerulonephritis Associated with Multiple Myeloma (PubMed)

creatinine of 9.4 mg/dl, mild hyperkalemia and acidosis. She was noted to have normochromic, normocytic anemia with normal platelet and white cell counts, normal plasma proteins and serum protein electrophoresis. Further studies revealed increased concentrations of κ and λ light chains in a ratio of 34.89; a bone marrow biopsy found 12% plasma cells. Serum protein electrophoresis revealed no spike. ANCA, anti-glomerular basement membrane, antineutrophil antibody, hepatitis panel and serum complements

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2015 Case Reports in Nephrology and Dialysis

132. A Single Agent Study to Evaluate the Overall Response Rate, Safety and Tolerability of Orally Administered Vemurafenib

-protein Evidence of end-organ damage that can be attributed to the underlying plasma cell proliferative disorder, specifically, one or more of the following: Hypercalcemia: serum calcium >11.5 mg/100 mL Renal insufficiency: serum creatinine >2 mg/dL Anemia: normochromic, normocytic with a hemoglobin value >2 g/100 mL below the lower limit of normal or a hemoglobin value <10 g/100 mL Bone lesions: lytic lesions, severe osteopenia, or pathologic fractures Have measurable disease defined by the following

2014 Clinical Trials

133. A Phase II Open-Label, Multiple-Dose, Single Agent Study to Evaluate the Overall Response Rate of Orally Administered Trametinib

to the underlying plasma cell proliferative disorder, specifically, one or more of the following: (i) Hypercalcemia: serum calcium >11.5 mg/100 mL (ii) Renal insufficiency: serum creatinine >2 mg/dL (iii) Anemia: normochromic, normocytic with a hemoglobin value >2 g/100 mL below the lower limit of normal or a hemoglobin value <10 g/100 mL (iv)Bone lesions: lytic lesions, severe osteopenia, or pathologic fracture. Have measurable disease defined by the following: (i) Serum M-protein ≥1g/dL or urine M-protein

2014 Clinical Trials

134. Myelodysplastic/Myeloproliferative Neoplasms

than 10% of the white blood cells.[ ] Mild normocytic anemia is common. (Refer to the PDQ summary on for more information on anemia.) Moderate thrombocytopenia is often present. Bone marrow findings include the following:[ , , , ] Hypercellularity (75% of cases). Blast count less than 20%. Granulocytic proliferation (with dysgranulopoiesis). Monocytic proliferation, dyserythropoiesis (e.g., megaloblastic changes, abnormal nuclear contours, ringed sideroblasts, etc.). Micromegakaryocytes (...) arm versus 9 months in the etoposide arm ( P < .001). Main factors associated with poor survival were allocation to the etoposide arm, unfavorable karyotype (i.e., monosomy 7 or complex abnormalities), and anemia.[ ][ ] The nucleoside azacitidine is an inhibitor of DNA methyltransferase that has been approved for the treatment of MDS and CMML, largely based on a Cancer and Leukemia Group B randomized trial and a randomized trial conducted in Europe.[ , ] Azacitidine may improve both the dysplastic

2012 PDQ - NCI's Comprehensive Cancer Database

135. Fatigue

by the mean corpuscular volume (MCV). Microcytic anemias are associated with an MCV of 79 fL or lower and include iron-deficiency anemia, thalassemia, and anemia of chronic disease. Macrocytic anemias are associated with an MCV higher than 101 fL and include anemias related to vitamin B 12 or folate deficiency, myelodysplasia, and liver disease. Most anemias are normocytic, meaning that the MCV is in the normal range. This category includes the following:[ ] Myelophthisic anemia (i.e., anemia due (...) be a significant issue long into survivorship.[ , ] Fatigue is also seen as a presenting symptom in cancers that produce problems such as anemia, endocrine changes, and respiratory obstruction and is common in people with advanced cancer who are not undergoing active cancer treatment. Cancer treatment–related fatigue is reported in 14% to 96% of patients undergoing cancer treatment [ - ] and in 19% to 82% of patients posttreatment.[ , ] Several studies have documented significantly worse fatigue in cancer

2012 PDQ - NCI's Comprehensive Cancer Database

136. Myxedema Coma or Crisis (Overview)

coagulopathy may occur. [ ] Hematologic Myxedema coma is associated with a higher risk of bleeding caused by coagulopathy related to an acquired von Willebrand syndrome (type 1) and decreases in factors V, VII, VIII, IX, and X. [ , ] Patients may also have microcytic anemia secondary to hemorrhage, or macrocytic anemia caused by vitamin B12 deficiency, or normocytic normochromic anemia, which may be secondary to decreased oxygen requirement and reduced erythropoietin. [ ] Previous Next: Epidemiology United

2014 eMedicine.com

137. Uremia (Diagnosis)

to be older (mean age 71.4 years) than were the nonanemic patients with diabetes (mean age 64.4 years) and that a greater percentage were female (52.4% vs 44.4% of the nonanemic patients). In addition, 39% of the anemic patients had renal dysfunction. [ ] Anemia associated with chronic kidney disease is characteristically normocytic, normochromic, and hypoproliferative. Anemia in chronic renal failure In the setting of CKD, anemia may be due to other clinical factors or diseases, such as iron deficiency (...) . Next: Pathophysiology Normally, the kidney is the site of hormone production and secretion, acid-base homeostasis, fluid and electrolyte regulation, and waste-product elimination. In the presence of renal failure, these functions are not performed adequately and metabolic abnormalities, such as anemia, acidemia, hyperkalemia, , , and , can occur. [ ] Uremia usually develops only after the creatinine clearance falls to less than 10 mL/min, although some patients may be symptomatic at higher

2014 eMedicine.com

138. Amyloidosis, Transthyretin-Related (Overview)

deposition. See the image below. Congo Red staining of a cardiac biopsy specimen containing amyloid, viewed under polarized light. Laboratory results for different types of amyloidosis are generally nonspecific, including the following: Complete blood count: Normochromic normocytic anemia Chemistry panel: Electrolyte abnormalities (due to heart failure or malabsorption) Renal function tests: Evidence of varying degrees of proteinuria and diminished glomerular filtration rate in patients with renal

2014 eMedicine.com

139. Pyruvate Kinase Deficiency (Follow-up)

a splenectomy and cholecystectomy. In patients who had a splenectomy without simultaneous cholecystectomy, 48% later required a cholecystectomy. [ ] (See the image below.) Peripheral blood smear in a child with splenectomy and pyruvate kinase deficiency. Signs and symptoms The following are evident in pyruvate kinase deficiency: Mild to severe normochromic and normocytic anemia Reticulocytosis Symmetrical growth delay Failure to thrive Cholecystolithiasis: Usually after the first decade of life but possibly (...) Reticulocyte count Serum bilirubin level study Peripheral blood film examination Normochromic, normocytic, or macrocytic anemia, together with reticulocytosis in the absence of blood loss, is suggestive of hemolysis. A negative Coombs test result helps to exclude immune hemolysis. The enzyme activity rate in most patients with pyruvate kinase deficiency is 5-25% of normal, with measurement of the intermediates (2,3-diphosphoglycerol and glucose-6-phosphate) proximal to the enzyme defect helping to confirm

2014 eMedicine Pediatrics

140. Hepatoblastoma (Diagnosis)

abdomen: Rare; occur if the tumor ruptures Severe anemia: Occurs occasionally, as a result of tumor rupture and hemorrhage See for more detail. Diagnosis Lab studies Complete blood count (CBC) with differential: Normochromic normocytic anemia and thrombocytosis may be present Liver enzyme levels: Moderately elevated in 15-30% of patients α-fetoprotein (AFP) - levels in hepatoblastoma are often as high as 100,000-300,000 mcg/mL Imaging studies Radiography: Reveals mass in the right upper quadrant

2014 eMedicine Pediatrics

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