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Normocytic Anemia

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101. Rare presentation of rickettsial infection as purpura fulminans: a case report Full Text available with Trip Pro

-old Sri Lankan woman who presented to Teaching Hospital Peradeniya with a febrile illness, headache, and myalgia that progressed to an erythematous rash starting over the bilateral lover limbs and hands and that became black and necrotic with a few hemorrhagic blebs. She had normocytic anemia, platelet clumps, and monocytosis as well as a deranged clotting profile. The result of immunofluorescence antibody testing for rickettsial immunoglobulin G was strongly positive for Rickettsia conorii

2018 Journal of medical case reports

102. Hematological profile of pregnant women at St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. Full Text available with Trip Pro

(1stand2nd and 1st& 3rd), HCT (1stand2nd), RDW (1stand2nd and 1stand3rd), neutrophil and lymphocyte (1stand 2nd and 1stand3rd, for both) were statistically significant (p < 0.05). The prevalence rates of anemia and thrombocytopenia were 11.62 and 7.7%, respectively and were dominantly of mild type. On the bases of blood picture, we classified anemia's of pregnancy as microcytic hypochromic (51.5%), normocytic hypochromic (27.3%), normocytic normochromic (18.2%), and dimorphic (3%).Significant changes (...) in selected hematological parameters between trimesters, and an anemia and thrombocytopenia of mild type were documented in this study. The commonest morphologic features were mostly characteristic features of iron deficiency anemia. These warrant the need for monitoring hematological parameters of pregnant women at any stage of the pregnancy to avoid adverse outcomes.

2018 BMC Hematology

103. Synchronous gastric and duodenal metastases from head and neck squamous cell carcinoma: a unique presentation of upper gastrointestinal bleeding Full Text available with Trip Pro

with melena. The patient had a percutaneous endoscopic gastrostomy tube placed 3 months prior to his presentation. Laboratory testing was significant for normocytic anemia and a digital rectal examination was positive for melena. Esophagogastroduodenoscopy revealed numerous cratered nodules with contact bleeding in the stomach as well as the duodenum that appeared malignant. Biopsies of the gastric and duodenal nodules were positive for p40 and CK 5/6, consistent with metastatic squamous cell carcinoma.

2018 Annals of Gastroenterology

104. Acquired Amegakaryocytic Thrombocytopenia and Pure Red Cell Aplasia in Thymoma Full Text available with Trip Pro

Acquired Amegakaryocytic Thrombocytopenia and Pure Red Cell Aplasia in Thymoma Association of thymoma with myasthenia gravis, pure red cell aplasia, and aplastic anemia is well documented. However, thymoma complicated by acquired amegakaryocytic thrombocytopenia (AAMT) is rarely reported. Here, we present a case of a 60-year-old male with past medical history of recurrent invasive thymoma who presented with cough and blood in sputum. He was found to have severe normocytic normochromic anemia (...) be a very early presentation of impending aplastic anemia, and treating physicians need to be aware of this entity.

2018 Case reports in hematology

105. Hematological abnormalities in HIV-antiretroviral therapy naïve clients as seen at an immune suppression syndrome clinic at Mbarara Regional Referral Hospital, southwestern Uganda Full Text available with Trip Pro

leucopenia. Of the 95 participants with anemia, 89.47% (85/95) presented with normocytic-normochromic anemia, 8.42% (8/95) with microcytic-hypochromic anemia and 2.11% (2/95) with macrocytic-hypochromic anemia. Anemia was not different across the several World Health Organization (WHO) stages of HIV infection disease progression (p>0.05). Statistically significant differences were present among participants with leucopenia (p<0.05). Also, leucopenia was more prevalent (11/38) among participants in WHO (...) at the ISS clinic of MRRH. We collected approximately 4.0 mL of EDTA anticoagulated blood samples, which were assayed for complete blood count, CD4+ cell count and thin film examination. Correlation of the hematological abnormalities with CD4+ cell counts was done using correlation coefficient (r) and analysis of variance (F), and the p-value was set at ≤0.05.A total of 141 clients were enrolled. Of these, 67.38% (95/141) were anemic, 26.24% (40/141) had thrombocytopenia while 26.95% (38/141) had

2018 Journal of blood medicine

107. Patient blood management. The GPs guide

Management Program – information for health professionals: www. health.wa.gov.au/bloodmanagement/home • BloodSafe clinician resources are available under clinical resources/anaemia management topics including chronic kidney disease management, macrocytosis, normocytic normochromic anaemia and iron deficiency anaemia: www.health.sa.gov.au/bloodsafe/ Default.aspx?tabid=77 Resources for patients • Australian Red Cross Blood Service – information on anaemia and iron deficiency, having a blood transfusion (...) deficiency anaemia. Gut 2011;60:1309–16. 12. World Health organization. united Nations Children’s Fund. united Nations university. iron deficiency anaemia: assessment, prevention, and control. A guide for programme managers. Geneva: WHo, 2001. Available at www.who.int/nutrition/publica- tions/en/ida_assessment_prevention_control.pdf [Accessed 10 September 2012]. 13. Beattie WS, Karkouti K, Wijeysundera DN, Tait G. Risk associated with preoperative anemia in noncardiac surgery: a single-center cohort

2014 Clinical Practice Guidelines Portal

108. Multiple myeloma from diagnosis to treatment

, an asymptomatic, but persistent, anaemia may be detected on routine bloods. The anaemia of multiple myeloma is typically normochromic and normocytic, but mild macrocytosis can also be seen. Routine haematinics are normal and rouleaux may be noted on the blood film. Hypercalcaemia is a less frequent manifestation of myeloma at diagnosis, occurring in approximately 13% of patients. 2 The serum calcium level should always be interpreted after correction for albumin. Symptomatic hypercalcaemia may present (...) myeloma Anaemia (normocytic or macrocytic) Vitamin B12, folate and iron studies normal No history of blood loss No haemolysis No clear alternative explanation such as renal impairment or anaemia of chronic disease Hypercalcaemia Parathyroid hormone appropriately suppressed Vitamin D normal No history of malignancy, sarcoidosis or use of medications such as thiazides Renal impairment No clear explanation including pre- renal causes, primary renal disorders or obstructive conditions Bony pain/ fractures

2014 Clinical Practice Guidelines Portal

109. Kawasaki disease. The importance of prompt recognition and early referral

], and varicella). The current recommendation is to administer varicella and annual influenza vaccines immediately and to delay MMR vaccination for 11 months after the administration of rate (eSR) and c-reactive protein (cRP) 2 • hypoalbuminaemia • anaemia (normocytic, normochromic) • mildly raised liver enzymes (predominantly alanine aminotransferase) 17 • normal platelet count that increases markedly by the second week of illness. Thrombocytosis – like periungual desquamation – is a late feature

2014 Clinical Practice Guidelines Portal

110. 2013 ACCF/AHA Guideline for the Management of Heart Failure Full Text available with Trip Pro

: Recommendations e286 8.4. Diuretics in Hospitalized Patients: Recommendations e286 8.5. Renal Replacement Therapy—Ultrafiltration: Recommendations e287 8.6. Parenteral Therapy in Hospitalized HF: Recommendation e287 8.7. Venous Thromboembolism Prophylaxis in Hospitalized Patients: Recommendation e288 8.8. Arginine Vasopressin Antagonists: Recommendation e288 8.9. Inpatient and Transitions of Care: Recommendations e288 9. Important Comorbidities in HF e290 9.1. Atrial Fibrillation e290 9.2. Anemia e293 9.3

2013 American Heart Association

111. Heart Failure: Guideline For the Management of

. Diuretics in Hospitalized Patients: Recommendations e195 8.5. Renal Replacement TherapydUltra?ltration: Recommendations e196 8.6. Parenteral Therapy in Hospitalized HF: Recommendation e196 8.7. Venous Thromboembolism Prophylaxis in Hospitalized Patients: Recommendation e197 8.8. Arginine Vasopressin Antagonists: Recommendation e198 8.9. Inpatient and Transitions of Care: Recommendations e198 9. Important Comorbidities in HF e200 9.1. Atrial Fibrillation e200 9.2. Anemia e201 9.3. Depression e203 9.4

2013 American College of Cardiology

112. Laboratory Diagnosis of Functional Iron Deficiency

. , Storniolo, A.M. , Abels, R.I. , Gordon, D.S. , Nelson, R. , Larholt, K. , Bryant, E. & Rudnick, S. ( 1995 ) Recombinant human erythropoietin therapy for anemic cancer patients receiving cisplatin therapy . Cancer Journal Scientific American , 1 , 252 – 260 . Hochberg, M.C. , Arnold, C.M. , Hogans, B.B. & Spivak, J.L. ( 1988 ) Serum immunoreactive erythropoietin in rheumatoid arthritis: impaired response to anemia . Arthritis and Rheumatism , 31 , 1318 – 1321 . Huebers, H.A. , Beguin, Y. , Pootrakul, P (...) and Conditions of Use. Shareable Link Use the link below to share a full-text version of this article with your friends and colleagues. Copy URL Share a link ). In its broadest sense this definition encompasses the partial block in iron transport to the erythroid marrow seen in subjects with infectious, inflammatory and malignant diseases, and is a major component of the anaemia of chronic disease (ACD). One form of FID, found in some subjects treated with erythropoiesis‐stimulating agents (ESAs), has been

2013 British Committee for Standards in Haematology

113. Diagnostic Dilemma-Poststreptococcal Reactive Arthritis in a Pregnant Woman

exquisite pain and decreased range of motion in her ankles, knees, hips, shoulders, elbows, wrists and finger joints. She also had mild erythema and swelling in the affected joints—most notably in the left ankle. She had a soft, systolic murmur over the right upper sternal border. Her laboratory studies were most notable for an elevated C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) of 214 mg/L and 136 mm/hr, respectively, and a normocytic anemia with a hemoglobin of 9.0 g/dl. Her EKG

2013 Clinical Correlations

114. What Is the Significance of Monoclonal Gammopathy of Undetermined Significance (MGUS)?

and/or urinary monoclonal protein Evidence of end organ damage: – hypercalcemia : serum calcium ≥11.5 mg/dL or – renal insufficiency : serum creatinine >2mg/dL or estimated creatinine clearance <40 mL/min – anemia : normochromic, normocytic with hemoglobin >2 gm/dL below lower limit of normal or <10gm/dL – bone lesions : lytic lesions, severe osteopenia, or pathological fractures Table adapted from Kyle RA, et al. Leukemia. 2010;24:1121-1127. Dr. Maryann Kwa is a 3rd year resident at NYU Langone Medical (...) , and the absence of end-organ damage that can be attributed to a (see table) [1]. End-organ damage is defined by the presence of hypercalcemia, renal insufficiency, anemia, and bony lesions (which can be remembered by the acronym CRAB). MGUS is usually discovered incidentally in the blood during routine laboratory tests. It affects approximately [2]. Prevalence is twice as high among African Americans and is lower in Asians. Older age, male sex, family history, and immunosuppression are [3]. So why do we worry

2012 Clinical Correlations

115. Tuberculosis of the Oral Cavity Misdiagnosed as Precancerous Lesion Full Text available with Trip Pro

revealed a granulomatous inflammation which was highly suspicious of sarcoidosis. During hospitalization, the patient underwent a complete physical examination, and laboratory and radiological diagnostics. Physical chest examination revealed bilaterally coarse crepitations and laboratory findings of his complete blood count revealed normocytic anemia of chronic disease. Radiographic examination of lungs showed multiple small nodules bilaterally and positive direct sputum smear.Although oral

2017 Acta Stomatologica Croatica

116. Primary hyperoxaluria detected by bone marrow biopsy: case report. Full Text available with Trip Pro

that does not show radiological bone lesions.A young 22 year old chronic hemodialysis patient with nephrocalcinosis. The patient had a personal and family history of recurrent kidney stones. He presented bone pain with worsening of his general state. On physical examination, no organomegaly was detected. Biological check-up showed only a normochromic and normocytic regenerative anemia resistant to treatment and a bone marrow biopsy was performed. It showed deposits of crystals of oxalate in the bone

2017 BMC Clinical Pathology

117. A curious case of growth failure and hypercalcemia: Questions. (Abstract)

weight was 35 kg (<3rd percentile), his height was 148 cm (≪3rd percentile), and his blood pressure was 154/116 mmHg (>99th percentile for height). Laboratory findings showed elevated creatinine (218 μmol/L), hypercalcemia (3.21 mmol/L), and normocytic anemia (hemoglobin 105 g/L). His further assessment showed a urinary concentrating defect with hypercalciuria (calcium/creatinine 1.76 mmol/mmol) and nephrocalcinosis on ultrasound. His eye examination showed uveitis with conjunctival biopsy remarkable

2017 Pediatric Nephrology

118. A curious case of growth failure and hypercalcemia: Answers. (Abstract)

weight was 35 kg (<3rd percentile), his height was 148 cm (<3rd percentile), and his blood pressure was 154/116 mmHg (>99th percentile for height). Laboratory findings showed elevated creatinine (218 umol/L), hypercalcemia (3.21 mmol/L), and normocytic anemia (hemoglobin 105 g/L). His further assessment showed a urinary concentrating defect with hypercalciuria (calcium/creatinine 1.76 mmol/mmol) and nephrocalcinosis on ultrasound. His eye examination showed uveitis with conjunctival biopsy remarkable

2017 Pediatric Nephrology

119. Immunoglobulin D Multiple Myeloma Presenting as Spontaneous Fracture Full Text available with Trip Pro

thoracic vertebrae with no sensory or motor impairment. Initial lab investigations showed normocytic anemia and hypercalcemia with low parathyroid hormone. Magnetic resonance imaging of thoracic spine with and without contrast showed acute pathological fracture of the T12 vertebral body with enhancing soft tissue which extended into the left ventral epidural space and left T11-T12 neural foramen. Serum protein electrophoresis showed abnormal protein band in the gamma globulin. Free light chain assay

2017 Case reports in oncology

120. Acute Myeloid Leukemia with Basophilic Differentiation Transformed from Myelodysplastic Syndrome Full Text available with Trip Pro

Acute Myeloid Leukemia with Basophilic Differentiation Transformed from Myelodysplastic Syndrome Myelodysplastic syndrome (MDS) terminally transforms to acute myeloid leukemia (AML) or bone marrow failure syndrome, but acute myeloid leukemia with basophilic differentiation has been rarely reported. An 81-year-old man was referred to our department for further examination of intermittent fever and normocytic anemia during immunosuppressive treatment. Chromosomal analysis showed additional (...) abnormalities involving chromosome 7. He was diagnosed as having MDS. At the time of diagnosis, basophils had not proliferated in the bone marrow. However, his anemia and thrombocytopenia rapidly worsened with the appearance of peripheral basophilia three months later. He was diagnosed as having AML with basophilic differentiation transformed from MDS. At that time, monosomy 7 was detected by chromosomal analysis. We found that basophils can be confirmed on the basis of the positivity for CD203c and CD294

2017 Case reports in hematology

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