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Normocytic Anemia

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81. Sideroblastic Anemias

may be large, producing normocytic or macrocytic indices; if so, variation in RBC size (dimorphism) usually produces a high RBC distribution width (RDW). Congenital sideroblastic anemia The most common congenital sideroblastic anemia is an form caused by heterozygous germline mutations in ALAS2 , a gene involved in heme biosynthesis. Vitamin B 6 (pyridoxine) is an essential cofactor for the enzyme produced by ALAS2 , thus patients may respond to pyridoxine supplementation. Numerous other X-linked (...) Sideroblastic Anemias Sideroblastic Anemias - Hematology and Oncology - MSD Manual Professional Edition Brought to you by The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases / / / / IN THIS TOPIC OTHER TOPICS IN THIS CHAPTER Test your knowledge Multiple Myeloma

2013 Merck Manual (19th Edition)

82. Iron Deficiency Anemia

, for alpha-thalassemia) may help distinguish these entities. Table Differential Diagnosis of Microcytic Anemia Due to Decreased RBC Production Diagnostic Criteria Iron Deficiency Iron-Transport Deficiency Sideroblastic Iron Utilization Chronic disease/inflammation Peripheral smear Microcytosis (M) vs hypochromia (H) M > H M > H M > H, may be normocytic Frequently normocytic Polychromatophilic targeted cells Absent Absent Present Absent Stippled RBCs Absent Absent Present Absent RBCs RBC distribution (...) Iron Deficiency Anemia Iron Deficiency Anemia - Hematology and Oncology - MSD Manual Professional Edition Brought to you by The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases / / / / IN THIS TOPIC OTHER TOPICS IN THIS CHAPTER Test your knowledge Multiple

2013 Merck Manual (19th Edition)

83. Long-term mortality risks associated with mild anaemia in older persons: the Busselton Health Study. Full Text available with Trip Pro

Long-term mortality risks associated with mild anaemia in older persons: the Busselton Health Study. up to 25% of older people in the USA and other Western countries are anaemic by World Health Organization (WHO) criteria. The objective of this study was to examine the long-term relationships of haemoglobin concentration with all-cause and cause-specific mortality in a community-based sample of Australian adults surveyed in 1978.a community survey of 2,194 adults aged 40+ years in Busselton (...) , Western Australia in 1978 with mortality follow-up to 2001. Cox regression models were used to investigate the relationships of haemoglobin as a continuous measure and anaemia by WHO criteria (women <12 g/dl (7.5 mmol/l); men <13 g/dl (8.1 mmol/l)) with all-cause, cardiovascular and cancer mortality.anaemia was predominantly mild (>10 g/dl) and normocytic. There was an increased risk of death from all causes and from cancer for men with low haemoglobin. Cancers were predominantly of the prostate

2012 Age and ageing

84. Anemia of Inflammation: Investigation on Impaired Iron Regulation in Acutely Ill Patients and Their Clinical Outcome

by Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico. Recruitment status was: Recruiting First Posted : May 2, 2012 Last Update Posted : May 2, 2012 Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico Collaborator: University of Milano Bicocca Information provided by: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico Study Details Study Description Go to Brief Summary: Anemia of inflammation (AI), a normochromic, normocytic anemia, associated with abnormal iron utilization (...) Anemia of Inflammation: Investigation on Impaired Iron Regulation in Acutely Ill Patients and Their Clinical Outcome Anemia of Inflammation: Investigation on Impaired Iron Regulation in Acutely Ill Patients and Their Clinical Outcome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2012 Clinical Trials

85. Iron Deficiency – Diagnosis and Management

for IDA: microcytic anemia, hypochromia, and decreased ferritin. IDA may be normocytic if anemia is mild or in early iron deficiency. Identification of Patients at Risk for Iron Deficiency and Iron Deficiency Anemia Screening of the general population for iron deficiency is not recommended. Use a case-finding approach to identify patients at risk of iron deficiency and iron deficiency anemia (Table 1). Common risk profiles, by age, include: Infants and toddlers Adolescents and adults: endurance (...) . It may take up to 6 months to replenish iron stores. Hemoglobin will correct within 2 to 4 months if appropriate iron dosages are taken as prescribed and underlying cause of iron deficiency is corrected. Continue iron therapy an additional 4 to 6 months (adults) after correction of anemia to replenish the iron stores. Ferritin should be re-checked 3-6 months after normalization of hemoglobin in anemic patients, or after initiation of iron supplementation in non-anemic patients. Target normal ferritin

2019 Clinical Practice Guidelines and Protocols in British Columbia

86. Emergency management of adrenal insufficiency in children: advocating for treatment options in outpatient and field settings

in primary, but not secondary AI, and can be associated with hypercalcemia and metabolic acidosis. Hypoglycemia is more frequent in neonates and infants regardless of the type of AI. Other findings include normocytic anemia, lymphocytosis and eosinophilia. Hormonal measurements and provocative testing The diagnosis of primary AI is suggested by blood tests pref- erably performed at 8:00 AM that show an ACTH level greater than 100 pg/mL and a cortisol level less than 10 mcg/dL 1 or by an ACTH level

2019 Pediatric Endocrine Society

87. Multiple myeloma: When should I suspect multiple myeloma?

in about 1% of people. Occasionally, multiple myeloma can be asymptomatic (or 'smouldering') and is diagnosed due to incidental findings on blood tests, such as: Normochromic, normocytic anaemia — present in about 70% of people. Renal impairment — present in about 50% of people. Hypercalcaemia — present in about 15% of people. Raised erythrocyte sedimentation rate (ESR), plasma viscosity, serum protein, or globulin. Basis for recommendation The information on when to suspect multiple myeloma is based

2019 NICE Clinical Knowledge Summaries

88. Kawasaki and COVID-19 disease in children: a systematic review Full Text available with Trip Pro

by COVID-19 Body temperature : 38.3 °C for over 4 days Complete blood count: CRP ↑13.3mg/dl; hyponatremia; normocytic anemia; hypoalbuminemia; ↑erythrocyte sedimentation rate Hemodynamic parameters : Sinus tachycardia (200 bpm), and tachypnea Parameters of oxygenation and respiratory assessment : SpO 2 - 100%; mild subcostal retractions; small opacity in the left lung base Echocardiogram: without evidence of coronary dilation, without pericardial effusion, and with normal ventricular and valvular

2020 Revista da Associação Médica Brasileira

89. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association Full Text available with Trip Pro

and mature granulocytes. Leukopenia and lymphocyte predominance suggest an alternative diagnosis. Anemia occurs commonly, is normochromic and normocytic, and resolves with resolution of inflammation. Elevation of acute-phase reactants such as ESR and CRP is nearly universal; the degree of elevation of ESR and CRP may be discrepant. The CRP normalizes more quickly than the ESR during resolution of inflammation. Moreover, the ESR is elevated by IVIG therapy, and therefore, a decreased ESR during follow-up

2017 American Heart Association

90. Retrobulbar secondary plasmacytoma: a case report and systematic review of the literature Full Text available with Trip Pro

in the retrobulbar area of the eye. Case Presentation In January 2018, a 62-year-old man was referred to our Clinic of Hematology and oncology, with one week of back pain history, and loss of consciousness in the neurological examination. Further analysis revealed the symptom of kidney failure. In primary laboratory investigations, he had normocytic normochromic anemia with Hb: 9.6g/dL, normal WBC and a decrease in platelet count (WBC: 8,300/mm 3 ; Platelet count: 79,000/mm 3 ). Also, renal function tests (RFT

2018 Biomedical Research and Therapy

91. More Than A Medical Note

; irregularly irregular S1/S2 with a grade 4/6 harsh systolic murmur at the second right intercostal space with radiation toward the right carotid artery and a 3/6 systolic ejection murmur at the apex; and melena. Labs are significant for low hemoglobin (10.3) and hematocrit (31.3), normocytic anemia, and a positive fecal occult blood test indicating active bleeding. Transthoracic echocardiogram is consistent with severe aortic stenosis and mild aortic regurgitation as well as severe mitral annular

2016 Clinical Correlations

92. Blood Transfusions in Obstetrics

is defined as first trimester haemoglobin (Hb) less than 110 g/l, second/third trimester Hb less than 105 g/l, and postpartum Hb less than 100 g/l, in line with British Committee for Standards in Haematology (BCSH) guidance. For normocytic or microcytic anaemia, a trial of oral iron should be considered as the first step and further tests should be undertaken if there is no demonstrable rise in Hb at 2 weeks and compliance has been checked. Pregnant women should be offered screening for anaemia (...) of clinical trials. Is there a role for antifibrinolytics? For those centres not participating in clinical trials, consideration should be given to using tranexamic acid during major obstetric haemorrhage. How should intrapartum anaemia be managed? In addition to major haemorrhage guidelines, obstetric units should have guidelines on criteria for red cell transfusion in anaemic women who are not actively bleeding. If the Hb is less than 70 g/l in labour or in the immediate postpartum period, the decision

2015 Royal College of Obstetricians and Gynaecologists

93. Acquired hemophagocytic lymphohistiocytosis as initial manifestation of multiple myeloma: A case report and literature review. Full Text available with Trip Pro

for 10% of hematologic malignancies, HLH is rarely associated with multiple myeloma (MM) and other plasmacytic dyscrasias.A 64-year-old Brazilian man seeked medical care with a 3-month history of intermittent fever, weight loss, night sweats, and progressive anemic symptoms.Total blood count showed severe bicytopenia (normocytic-normochromic anemia and thrombocytopenia), biochemical exams showed elevation of creatinine, as well as monoclonal peak in serum protein electrophoresis, high IgA dosage

2020 Medicine

94. Quantitative data on red cell measures of iron status and their relation to the magnitude of the systemic inflammatory response and survival in patients with colorectal cancer. Full Text available with Trip Pro

, at a single centre between 2008 and 2017 were included (n = 824). Blood samples taken for C-reactive protein (CRP), albumin, and full blood count (FBC) allowed patients to be grouped by modified Glasgow Prognostic Score (mGPS), and anaemia subtype (haemoglobin (Hb) M < 130 mg/L and F < 120 mg/L, with microcytic anaemia being mean corpuscular volume (MCV) < 80 f/L, and normocytic anaemia with MCV 80-100 f/L). Relationships between these groupings and red cell measures iron status including Hb, MCV, mean (...) corpuscular haemoglobin (MCH) and red cell distribution width (RDW) were examined.The combination of increasing T stage and increasing mGPS was associated with lower Hb, lower MCV, lower MCH, higher RDW, and higher prevalence of both microcytic and normocytic anaemia (all p < 0.001). The combination of CRP >10 mg/L and albumin <35  g/L was associated with lower Hb, lower MCV, lower MCH, higher RDW, and higher prevalence of both microcytic and normocytic anaemia (all p < 0.010). At multivariate Cox

2019 European Journal of Surgical Oncology

95. Abnormal red blood cell morphological changes in thalassaemia associated with iron overload and oxidative stress. (Abstract)

with thalassaemia are commonly known as microcytic hypochromic anaemia with poikilocytosis. However, iron and ROS accumulation in RBCs as related to RBC morphological changes in patients with thalassaemia has not been reported.Twenty-one patients with thalassaemia, including HbH, HbH with Hb Constant Spring and β-thalassaemia/HbE (splenectomy and non-splenectomy) genotypes, and five normal subjects were recruited. RBC morphology was analysed by light and scanning electron microscopy. Systemic and RBC iron (...) status and oxidative stress were examined.Decreased normocytes were observed in the samples of patients with thalassaemia, with RBC morphological abnormality being related to the type of disease (α-thalassaemia or β-thalassaemia) and splenic status. Target cells and crenated cells were mainly found in splenectomised patients with β-thalassaemia/HbE, while target cells and teardrop cells were found in non-splenectomised patients. Patients with thalassaemia had high levels of serum ferritin, red cell

2019 Journal of Clinical Pathology

96. Transient Erythroblastopenia of Childhood: A Review for the Pediatric Emergency Medicine Physician. (Abstract)

children who present with normocytic anemia and lack of reticulocytosis without evidence of blood loss, hemolysis, or other causes of bone marrow suppression. Evaluation should be targeted at ruling out other causes of anemia. Management is mainly supportive, although some children may require blood transfusions for symptomatic anemia. Most patients demonstrate a return of hematopoiesis within two weeks of diagnosis and normalization of blood counts within two months.

2019 Pediatric Emergency Care

97. Prospective evaluation of pregnancy outcome in an Italian woman with late-onset combined homocystinuria and methylmalonic aciduria. Full Text available with Trip Pro

function and normocytic anaemia. At the age of 34, when her first pregnancy resulted in an intrauterine death of a morphologically normal growth-restricted foetus, she was diagnosed with homocystinuria and methylmalonic aciduria due to cyanocobalamin C (cblC) defect, which was confirmed by molecular investigation. Consequently, hydroxocobalamin was administered to correct homocysteine plasma levels. This treatment was efficacious in lowering homocysteine plasma levels and restored anaemia and renal (...) Prospective evaluation of pregnancy outcome in an Italian woman with late-onset combined homocystinuria and methylmalonic aciduria. Cobalamin metabolism disorders are rare, inherited diseases which cause megaloblastic anaemia and other clinical manifestations. Early diagnosis of these conditions is essential, in order to allow appropriate treatment as early as possible.Here we report the case of a patient who was apparently healthy until the age of 20, when she presented with impaired renal

2019 BMC Pregnancy and Childbirth

98. Hematological responses to iron-folate supplementation and its determinants in pregnant women attending antenatal cares in Mekelle City, Ethiopia. Full Text available with Trip Pro

, respectively). Normocytic hypochromic anemia was the commonest form of anemia found in this study followed by normocytic normochromic anemia. There was no statistically significant association between poor hemoglobin responses and all studied factors such as educational level, household size, parity, recent illness, stage of pregnancy, coffee consumption, and duration of iron treatment.Our study revealed poor hemoglobin responses in nearly half of the study participants and a high proportion of anemias (...) Hematological responses to iron-folate supplementation and its determinants in pregnant women attending antenatal cares in Mekelle City, Ethiopia. To characterize anemia and evaluate hematological responses to universal iron-folic acid (IFA) supplementation in Ethiopian pregnant women.A hospital- based prospective follow up study was done between December 2016 and June 2017. Hematological profiles were measured in pregnant women before and after a minimum of one-month IFA supplementation. Mean

2018 PLoS ONE

99. Laboratory diagnosis of non-immune hereditary red cell membrane disorders Full Text available with Trip Pro

of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, MN, USA Department of Molecular Medicine & Medical Biotechnologies, University Federico II of Naples, Naples, Italy Hématologie Biologique, Bicêtre et Faculté de Pharmacie, AP‐HP Hôpital, Université Paris‐Sud, Le Kremlin Bicêtre, France Division of Medicine, University College London, London, UK Hematology Unit, Physiopathology of Anemias Unit, Foundation IRCCS Cá Granada Ospedale Maggiore Policlinico, Milan, Italy Haematology (...) Department, St. George Hospital, SEALS Central, Sydney, NSW, Australia ICSH Representative. Hematology Unit, Physiopathology of Anemias Unit, Foundation IRCCS Cá Granada Ospedale Maggiore Policlinico, Milan, Italy for Corresponding Author Membrane Biochemistry, NHS Blood and Transplant, Bristol, UK Correspondence : May‐Jean King, Membrane Biochemistry, NHS Blood and Transplant, 500 North Bristol Park, Northway, Filton, Bristol BS34 7QH, UK. Tel.: +44 (0) 117 921 7601; Fax: +44 (0) 117 912 5782; E‐mail

2015 British Committee for Standards in Haematology

100. Spotlight Case Part 1: Oligoarticular Septic Arthritis-A Case of Disseminated Pneumococcal Disease

or cardiac exam. The white blood cell count was 21,000/mm3 with 86% neutrophils. The erythrocyte sedimentation rate and C-reactive protein were elevated to 126 mm/hr and 261 mg/L, respectively. Labs were otherwise significant for a normocytic anemia (hemoglobin 9.5 g/dL) and serum protein-albumin gap of 5. A polyclonal hypergammaglobulinemia with IgG predominance was noted. A chest radiograph showed bilateral pleural effusions, greater on the right than on the left. Arthrocentesis of the right knee

2015 Clinical Correlations

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