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Normocytic Anemia

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81. Spotlight Case Part 2: Hypergammaglobulinemia and defective humoral immunity in HIV-infected patients

or cardiac exam. The white blood cell count was 21,000/mm3 with 86% neutrophils. The erythrocyte sedimentation rate and C-reactive protein were elevated to 126 mm/hr and 261 mg/L, respectively. Labs were otherwise significant for a normocytic anemia (hemoglobin 9.5 g/dL) and serum protein-albumin gap of 5. A polyclonal hypergammaglobulinemia with IgG predominance was noted. A chest radiograph showed bilateral pleural effusions, greater on the right than on the left. Arthrocentesis of the right knee

2015 Clinical Correlations

82. Spotlight Case Part 1: Oligoarticular Septic Arthritis-A Case of Disseminated Pneumococcal Disease

or cardiac exam. The white blood cell count was 21,000/mm3 with 86% neutrophils. The erythrocyte sedimentation rate and C-reactive protein were elevated to 126 mm/hr and 261 mg/L, respectively. Labs were otherwise significant for a normocytic anemia (hemoglobin 9.5 g/dL) and serum protein-albumin gap of 5. A polyclonal hypergammaglobulinemia with IgG predominance was noted. A chest radiograph showed bilateral pleural effusions, greater on the right than on the left. Arthrocentesis of the right knee

2015 Clinical Correlations

84. Patient blood management. The GPs guide

Management Program – information for health professionals: www. health.wa.gov.au/bloodmanagement/home • BloodSafe clinician resources are available under clinical resources/anaemia management topics including chronic kidney disease management, macrocytosis, normocytic normochromic anaemia and iron deficiency anaemia: www.health.sa.gov.au/bloodsafe/ Default.aspx?tabid=77 Resources for patients • Australian Red Cross Blood Service – information on anaemia and iron deficiency, having a blood transfusion (...) october 2012]. 6. National Blood Authority Australia. Patient blood management guidelines: Module 2 – Perioperative. Available at www.nba.gov.au/guidelines/module2/ index.html [Accessed 10 September 2012]. 7. Gombotz H, Rehak PH, Shander A, Hofmann A. Blood use in elective surgery: the Austrian Benchmark Study. Transfusion 2007;47:1468–80. 8. Guralnik JM, Ershler WB, Schrier Sl, Picozzi VJ. Anemia in the elderly: a public health crisis in hema- tology. Hematology 2005;528–32. 9. Gastroenterological

2014 Clinical Practice Guidelines Portal

85. Acute Lymphoblastic Leukemia Presenting with Liver Infiltration and Severe Lactic Acidosis (PubMed)

patient who presented with severe chest pain, dyspnea, systemic symptoms, leukopenia, normocytic anemia, and severe lactic acidosis. He was admitted with a possible diagnosis of acute pericarditis and lactic acidosis. Sodium bicarbonate replacement did not improve the lactic acidosis. Liver biopsy was performed because of persistently elevated alkaline phosphatase and gamma-glutamyl transferase; the biopsy showed atypical lymphoblasts and bone marrow biopsy confirmed the diagnosis of precursor B acute

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2018 The American journal of case reports

86. Synchronous gastric and duodenal metastases from head and neck squamous cell carcinoma: a unique presentation of upper gastrointestinal bleeding (PubMed)

with melena. The patient had a percutaneous endoscopic gastrostomy tube placed 3 months prior to his presentation. Laboratory testing was significant for normocytic anemia and a digital rectal examination was positive for melena. Esophagogastroduodenoscopy revealed numerous cratered nodules with contact bleeding in the stomach as well as the duodenum that appeared malignant. Biopsies of the gastric and duodenal nodules were positive for p40 and CK 5/6, consistent with metastatic squamous cell carcinoma.

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2018 Annals of Gastroenterology

87. Rare presentation of rickettsial infection as purpura fulminans: a case report (PubMed)

-old Sri Lankan woman who presented to Teaching Hospital Peradeniya with a febrile illness, headache, and myalgia that progressed to an erythematous rash starting over the bilateral lover limbs and hands and that became black and necrotic with a few hemorrhagic blebs. She had normocytic anemia, platelet clumps, and monocytosis as well as a deranged clotting profile. The result of immunofluorescence antibody testing for rickettsial immunoglobulin G was strongly positive for Rickettsia conorii

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2018 Journal of medical case reports

88. Hematological abnormalities in HIV-antiretroviral therapy naïve clients as seen at an immune suppression syndrome clinic at Mbarara Regional Referral Hospital, southwestern Uganda (PubMed)

leucopenia. Of the 95 participants with anemia, 89.47% (85/95) presented with normocytic-normochromic anemia, 8.42% (8/95) with microcytic-hypochromic anemia and 2.11% (2/95) with macrocytic-hypochromic anemia. Anemia was not different across the several World Health Organization (WHO) stages of HIV infection disease progression (p>0.05). Statistically significant differences were present among participants with leucopenia (p<0.05). Also, leucopenia was more prevalent (11/38) among participants in WHO

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2018 Journal of blood medicine

89. Aggressive Systemic Mastocytosis in Association with Pure Red Cell Aplasia (PubMed)

Aggressive Systemic Mastocytosis in Association with Pure Red Cell Aplasia Aggressive systemic mastocytosis (ASM) is characterized by mast cell accumulation in systemic organs. Though ASM may be associated with other hematological disorders, the association with pure red cell aplasia (PRCA) is rare and has not been reported. Pure red cell aplasia (PRCA) is a syndrome, characterized by normochromic normocytic anemia, reticulocytopenia, and severe erythroid hypoplasia. The myeloid

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2018 Case reports in hematology

90. Tacrolimus Treatment for Refractory PRCA

-effect of tacrolimus for refractory PRCA. Condition or disease Intervention/treatment Phase Pure Red Cell Aplasia Drug: tacrolimus Phase 4 Detailed Description: Pure red cell aplasia (PRCA) is a rare normocytic normochromic anemia with reticulocytopenia, characterized by a reduction of erythroid precursors from the bone marrow, could be divided into congenital and acquired PRCA according to pathogenesis. Congenital PRCA, also known as Diamond-Blackfan syndrome, has been associated with pathogenic (...) Union Medical College Hospital Study Details Study Description Go to Brief Summary: Pure red cell aplasia (PRCA) is a kind of anemia characterized by severe reticulocytopenia and obvious bone marrow erythroblastic cells decreased. Cyclosporine and /or steroids are the first line therapy but some patients were refractory or intolerance to the treatment. The effects of the second line therapy are also not satisfactory and sometimes not available. The investigators aim to explore the efficacy and side

2018 Clinical Trials

91. Rare and unusual case of anti-factor XI antibodies in patient with plasma cell leukemia. (PubMed)

by the addition of the control plasma confirming the presence of anti-factor XI autoantibodies. In addition, the blood count showed bicytopenia with non-regenerative normocytic normochromic anemia and thrombocytopenia. The blood smear demonstrated a plasma cell count of 49% (2842/mm3) evoking PCL. The bone marrow was invaded up to 90% by dystrophic plasma cells. The biochemical assessment suggested downstream renal and electrolyte disturbances from exuberant light chain production with abnormalities including (...) Rare and unusual case of anti-factor XI antibodies in patient with plasma cell leukemia. The acquired inhibitors of coagulation have been observed in very rare cases of monoclonal gammopathies. We report a very rare case of anti-factor XI antibodies in patient with plasma cell leukemia (PCL).This is a 59-year-old male patient without pathological history, admitted to the nephrology department for management of renal insufficiency and anemia syndrome. The history and physical examination

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2018 BMC Hematology

92. Hematological profile of pregnant women at St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. (PubMed)

(1stand2nd and 1st& 3rd), HCT (1stand2nd), RDW (1stand2nd and 1stand3rd), neutrophil and lymphocyte (1stand 2nd and 1stand3rd, for both) were statistically significant (p < 0.05). The prevalence rates of anemia and thrombocytopenia were 11.62 and 7.7%, respectively and were dominantly of mild type. On the bases of blood picture, we classified anemia's of pregnancy as microcytic hypochromic (51.5%), normocytic hypochromic (27.3%), normocytic normochromic (18.2%), and dimorphic (3%).Significant changes (...) in selected hematological parameters between trimesters, and an anemia and thrombocytopenia of mild type were documented in this study. The commonest morphologic features were mostly characteristic features of iron deficiency anemia. These warrant the need for monitoring hematological parameters of pregnant women at any stage of the pregnancy to avoid adverse outcomes.

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2018 BMC Hematology

93. Acquired Amegakaryocytic Thrombocytopenia and Pure Red Cell Aplasia in Thymoma (PubMed)

Acquired Amegakaryocytic Thrombocytopenia and Pure Red Cell Aplasia in Thymoma Association of thymoma with myasthenia gravis, pure red cell aplasia, and aplastic anemia is well documented. However, thymoma complicated by acquired amegakaryocytic thrombocytopenia (AAMT) is rarely reported. Here, we present a case of a 60-year-old male with past medical history of recurrent invasive thymoma who presented with cough and blood in sputum. He was found to have severe normocytic normochromic anemia (...) be a very early presentation of impending aplastic anemia, and treating physicians need to be aware of this entity.

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2018 Case reports in hematology

94. Evaluation of hepatocyte-derived microRNA-122 for diagnosis of acute and chronic hepatitis of dogs (PubMed)

hepatitis manifested anorexia, abdominal distension, weight loss, and melena. Hematological parameters showed normocytic normochromic anemia and thrombocytopenia in both acute and chronic hepatitis groups. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin were significantly higher than control values in acute hepatitis. In chronic hepatitis, total protein and albumin were significantly lower than control values with normal ALT, AST, ALP

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2018 Veterinary world

95. Primary hyperoxaluria detected by bone marrow biopsy: case report. (PubMed)

that does not show radiological bone lesions.A young 22 year old chronic hemodialysis patient with nephrocalcinosis. The patient had a personal and family history of recurrent kidney stones. He presented bone pain with worsening of his general state. On physical examination, no organomegaly was detected. Biological check-up showed only a normochromic and normocytic regenerative anemia resistant to treatment and a bone marrow biopsy was performed. It showed deposits of crystals of oxalate in the bone

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2017 BMC Clinical Pathology

96. A curious case of growth failure and hypercalcemia: Questions. (PubMed)

weight was 35 kg (<3rd percentile), his height was 148 cm (≪3rd percentile), and his blood pressure was 154/116 mmHg (>99th percentile for height). Laboratory findings showed elevated creatinine (218 μmol/L), hypercalcemia (3.21 mmol/L), and normocytic anemia (hemoglobin 105 g/L). His further assessment showed a urinary concentrating defect with hypercalciuria (calcium/creatinine 1.76 mmol/mmol) and nephrocalcinosis on ultrasound. His eye examination showed uveitis with conjunctival biopsy remarkable

2017 Pediatric Nephrology

97. A curious case of growth failure and hypercalcemia: Answers. (PubMed)

weight was 35 kg (<3rd percentile), his height was 148 cm (<3rd percentile), and his blood pressure was 154/116 mmHg (>99th percentile for height). Laboratory findings showed elevated creatinine (218 umol/L), hypercalcemia (3.21 mmol/L), and normocytic anemia (hemoglobin 105 g/L). His further assessment showed a urinary concentrating defect with hypercalciuria (calcium/creatinine 1.76 mmol/mmol) and nephrocalcinosis on ultrasound. His eye examination showed uveitis with conjunctival biopsy remarkable

2017 Pediatric Nephrology

98. Cabozantinib as a Targeted Strategy to Reverse Carfilzomib Resistance in Refractory Multiple Myeloma

(MM), with all 3 of the following IMWG criteria, except as noted: Clonal bone marrow plasma cells ≥ 10% A monoclonal protein in either serum or urine Evidence of end-organ damage that can be attributed to the underlying plasma cell proliferative disorder (to include one of the following) Hypercalcemia (corrected calcium > 2.75 mmol/L or 11.5 mg/dL); OR Renal insufficiency attributable to myeloma (serum creatinine >1.9 mg/dL); OR Anemia; normochromic, normocytic with a hemoglobin value ≥2 g/dL

2017 Clinical Trials

99. Sirolimus Treatment for Refractory PRCA

for refractory PRCA. Condition or disease Intervention/treatment Phase Pure Red Cell Aplasia Drug: Sirolimus Phase 4 Detailed Description: Pure red cell aplasia (PRCA) is a rare normocytic normochromic anemia with reticulocytopenia, characterized by a reduction of erythroid precursors from the bone marrow, could be divided into congenital and acquired PRCA according to pathogenesis. Congenital PRCA, also known as Diamond-Blackfan syndrome, has been associated with pathogenic variant in GATA1 and TSR2 (...) Hospital Study Details Study Description Go to Brief Summary: Pure red cell aplasia (PRCA) is a kind of anemia characterized by severe reticulocytopenia and obvious bone marrow erythroblastic cells decreased. Cyclosporine and /or steroids are the first line therapy but some patients were refractory or intolerance to the treatment. The effects of the second line therapy are also not satisfactory and sometimes not available. The investigators aim to explore the efficacy and side-effect of sirolimus

2017 Clinical Trials

100. Tuberculosis of the Oral Cavity Misdiagnosed as Precancerous Lesion (PubMed)

revealed a granulomatous inflammation which was highly suspicious of sarcoidosis. During hospitalization, the patient underwent a complete physical examination, and laboratory and radiological diagnostics. Physical chest examination revealed bilaterally coarse crepitations and laboratory findings of his complete blood count revealed normocytic anemia of chronic disease. Radiographic examination of lungs showed multiple small nodules bilaterally and positive direct sputum smear.Although oral

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2017 Acta Stomatologica Croatica

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