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Normocytic Anemia

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41. New Treatment Approaches for the Anemia of CKD. Full Text available with Trip Pro

New Treatment Approaches for the Anemia of CKD. Normocytic normochromic anemia is a common complication in chronic kidney disease and is associated with many adverse clinical consequences. Erythropoiesis-stimulating agents (ESAs) and adjuvant iron therapy represent the primary treatment for anemia in chronic kidney disease. The introduction of ESAs into clinical practice was a success story, mediating an increase in hemoglobin concentrations without the risk for recurrent blood transfusions

2016 American Journal of Kidney Diseases

42. Anemia and low-grade inflammation in pediatric kidney transplant recipients. Full Text available with Trip Pro

protein (CRP) (hsCRP) and interleukin-6 (IL-6) were analyzed by enzyme-linked immunosorbent assays, and GFR was analyzed by 51Cr-EDTA clearance.The median levels of Hb (115 g/L), hsCRP (0.4 mg/L) and IL-6 (1.4 pg/mL) and the median erythrocyte sedimentation rate (ESR; 19 mm/h) remained stable after the first post-operative year. However, approximately half of the patients had a normocytic, normochromic anemia, and one-third had elevated levels of hsCRP (>1 mg/L) and ESR (>25 mm/h), indicating (...) Anemia and low-grade inflammation in pediatric kidney transplant recipients. Anemia and low-grade inflammation are reported to be associated with impaired long-term graft outcome in renal transplant (RTx) recipients. In this study, hemoglobin (Hb) and inflammation marker levels were correlated with measured glomerular filtration rate (GFR) in 128 pediatric RTx recipients over a median follow-up period of 10 years.Serum levels of erythropoietin (EPO), hepcidin-25, high-sensitivity C-reactive

2016 Pediatric Nephrology

43. Diamond Blackfan Anemia: A Nonclassical Patient With Diagnosis Assisted by Genomic Analysis Full Text available with Trip Pro

Diamond Blackfan Anemia: A Nonclassical Patient With Diagnosis Assisted by Genomic Analysis Diamond Blackfan anemia (DBA) is an inherited syndrome usually presenting with severe macrocytic anemia in infancy, paucity of erythroid precursors in the bone marrow, and congenital anomalies. We describe a child with mild, transfusion independent normocytic anemia whose diagnosis of DBA was established by identification of a novel de novo mutation disrupting normal splicing of the ribosomal protein

2016 Journal of pediatric hematology/oncology

44. A 2-month-old boy with hemolytic anemia and reticulocytopenia following intravenous immunoglobulin therapy for Kawasaki disease: a case report and literature review Full Text available with Trip Pro

suggestive of incomplete Kawasaki disease. His fever resolved 8 days after treatment with aspirin and high dose infusion of intravenous immunoglobulin. The hemoglobin and hematocrit decreased from 9.7 g/dL and 27.1% to 7.4 g/dL and 21.3%, respectively. The patient had normocytic hypochromic anemia with anisocytosis, poikilocytosis, immature neutrophils, and nucleated red blood cells. The direct antiglobulin test result was positive, and the reticulocyte count was 1.39%. The patient had an uneventful (...) A 2-month-old boy with hemolytic anemia and reticulocytopenia following intravenous immunoglobulin therapy for Kawasaki disease: a case report and literature review Herein, we report a rare case of hemolytic anemia with reticulocytopenia following intravenous immunoglobulin therapy in a young infant treated for Kawasaki disease. A 2-month-old boy presented with fever lasting 3 days, conjunctival injection, strawberry tongue, erythematous edema of the hands, and macular rash, symptoms and signs

2016 Korean journal of pediatrics

45. A recurring mutation in the respiratory complex 1 protein NDUFB11 is responsible for a novel form of X-linked sideroblastic anemia. Full Text available with Trip Pro

A recurring mutation in the respiratory complex 1 protein NDUFB11 is responsible for a novel form of X-linked sideroblastic anemia. The congenital sideroblastic anemias (CSAs) are a heterogeneous group of inherited blood disorders characterized by pathological mitochondrial iron deposition in erythroid precursors. Each known cause has been attributed to a mutation in a protein associated with heme biosynthesis, iron-sulfur cluster biogenesis, mitochondrial translation, or a component (...) of the mitochondrial respiratory chain. Here, we describe a recurring mutation, c.276_278del, p.F93del, in NDUFB11, a mitochondrial respiratory complex I-associated protein encoded on the X chromosome, in 5 males with a variably syndromic, normocytic CSA. The p.F93del mutation results in respiratory insufficiency and loss of complex I stability and activity in patient-derived fibroblasts. Targeted introduction of this allele into K562 erythroleukemia cells results in a proliferation defect with minimal effect

2016 Blood

46. Is hidradenitis suppurativa associated with anaemia?: a population-based and hospital-based cross-sectional study from Denmark. (Abstract)

normocytic anaemia and 40% microcytic anaemia, in concordance with anaemia of inflammation.In contrast to our hypothesis, this study showed that HS is not associated with anaemia. Thus, anaemia may not be the cause of the described fatigue in HS patients. Furthermore, the results indicate that if an HS patient does suffer from anaemia it is most likely to be normocytic or microcytic and thus compatible with anaemia seen in other chronic inflammatory disorders.© 2015 European Academy of Dermatology (...) Is hidradenitis suppurativa associated with anaemia?: a population-based and hospital-based cross-sectional study from Denmark. Chronic inflammatory diseases may be associated with anaemia of inflammation. Hidradenitis suppurativa is a chronic inflammatory dermatological disease associated with metabolic comorbidities, low quality of life and fatigue. Anaemia may cause fatigue, and it has been hypothesized that HS-related fatigue may be partly due to anaemia.Our objective was to investigate

2015 Journal of the European Academy of Dermatology and Venereology

47. Prevalence and associated risk factors of anemia among HIV infected children attending Gondar university hospital, Northwest Ethiopia: a cross sectional study. Full Text available with Trip Pro

in 16.2 % (43 /265) of children, 60.5 % of them had mild anemia, 37.2 % had moderate anemia and 2.3 % had severe anemia. About 46.5 % of anemic children had normocytic-normochromic anemia followed by macrocytic-normochromic anemia (39.5 %). In this study, anemia was associated with eating green leafy vegetables (OR = 0.43, 95 % CI (0.188-0.981) and being on cotrimoxazole treatment (OR = 2.169, 95 % CI (1.047-4.49). But there was no significant association with age, sex, WHO clinical stage (...) Prevalence and associated risk factors of anemia among HIV infected children attending Gondar university hospital, Northwest Ethiopia: a cross sectional study. Anemia is the most common hematological abnormalities in HIV patients and it is a wide spread public health problem. The World Health Organization estimates that over 2 billion people are anemic worldwide with more than 100 million of these anemic children living in Africa. In Ethiopia, there is limited information about the prevalence

2015 BMC Hematology

48. Hemoglobin, Anemia, and Cognitive Function: The Atherosclerosis Risk in Communities Study. Full Text available with Trip Pro

Hemoglobin, Anemia, and Cognitive Function: The Atherosclerosis Risk in Communities Study. Our objective was to characterize the relationship of low and high hemoglobin concentrations and normocytic, microcytic, and macrocytic anemia with cross-sectional cognition and change in cognition over a median of 6 years.Cross-sectional and prospective analyses of 13,133 participants (mean age 57 years, 56% women, 24% black, 10% anemia) in the Atherosclerosis Risk in Communities (ARIC) study (baseline (...) 1990-1992) were carried out. Anemia was defined as hemoglobin concentrations lower than 13g/dl for men and lower than 12g/dl for women and was subclassified as normocytic (mean corpuscular volume [MCV] 80-100 fL), microcytic (MCV < 80 fL), and macrocytic (MCV > 100 fL). Cognition was assessed by delayed word recall test (DWRT), digit symbol substitution test (DSST), word fluency test (WFT), and global Z-score at Visit 2 (1990-1992) and Visit 4 (1996-1998). Adjusted linear regression models

2015 Biological Sciences and Medical Sciences

49. Anemia in prospective blood donors deferred by the copper sulphate technique of hemoglobin estimation. Full Text available with Trip Pro

were collected from the study subjects into EDTA anticoagulant tubes. The hemoglobin levels and red cell indices were measured using Sysmex hematology analyser. A thin blood film was prepared and stained using Leishman stain and then observed under the light microscope.The prevalence of anemia among the total deferred patients (538) was 17.1 %. Four different types of anemia were found among the subjects. These were normocytic normochromic (46.74 %), microcytic hypochromic (42.39 %) normocytic (...) Anemia in prospective blood donors deferred by the copper sulphate technique of hemoglobin estimation. Patients who require transfusion as part of their clinical management have the right to expect sufficient blood to be available to meet their needs and to receive the safest blood possible. Donor deferrals (disqualification) lead to loss of precious blood donors and blood units available for transfusion purposes. It is believed that a large majority of donor deferrals are due to temporal

2015 BMC Hematology

50. Anemia in elderly hospitalized patients: prevalence and clinical impact. (Abstract)

elderly patients admitted to the Internal Medicine Ward of Ca'Granda Policlinico Hospital along 6 months, and its relationship to comorbidities and to the length of hospitalization. Anemia was classified according to the WHO criteria. The majority of patients (48 %) had a mildmoderate, normocytic anemia; severe anemia was found in 8 out of 92 anemic patients. In a subgroup of patients erythropoietin was tested and resulted statistically higher if compared to non-anemic controls (p = 0.003 (...) Anemia in elderly hospitalized patients: prevalence and clinical impact. Anemia is a common finding in elderly individuals. Several studies have shown a strong relationship between anemia, morbidity and mortality, suggesting anemia as a significant independent predictor of adverse outcome in elderly hospitalized patients. The pathophisiology of anemia in the elderly is not yet completely understood. Several mechanisms are involved. We investigated the prevalence of anemia in a cohort of 193

2015 Internal and emergency medicine

51. Erythroblast apoptosis and microenvironmental iron restriction trigger anemia in the VK*MYC model multiple myeloma. Full Text available with Trip Pro

using the Vk*MYC mouse, which spontaneously develops an indolent bone marrow localized disease with aging. Affected Vk*MYC mice develop a mild normochromic normocytic anemia. We excluded the possibility that anemia results from defective erythropoietin production, inflammation or increased hepcidin expression. Mature erythroid precursors are reduced in Vk*MYC bone marrow compared with wild-type. Malignant plasma cells express the apoptogenic receptor Fas ligand and, accordingly, active caspase 8 (...) Erythroblast apoptosis and microenvironmental iron restriction trigger anemia in the VK*MYC model multiple myeloma. Multiple myeloma is a malignant disorder characterized by bone marrow proliferation of plasma cells and by overproduction of monoclonal immunoglobulin detectable in the sera (M-spike). Anemia is a common complication of multiple myeloma, but the underlying pathophysiological mechanisms have not been completely elucidated. We aimed to identify the different determinants of anemia

2015 Haematologica

52. Protease inhibitors-based therapy induces acquired spherocytic-like anaemia and ineffective erythropoiesis in chronic hepatitis C virus patients. Full Text available with Trip Pro

spectrometry analysis, quantification of erythroid microparticles release. IL28B and ITPA polymorphisms were also evaluated.We found early acute normochromic normocytic haemolytic anaemia (4-8 weeks) followed by a late macrocytic hypo-regenerative anaemia with inappropriate low reticulocyte count (12-24 weeks). Studies on red cells revealed: (i) presence of spherocytes; (ii) increased osmotic fragility; (iii) abnormalities in red cell membrane protein composition; (iv) reduced membrane-cytoskeleton (...) Protease inhibitors-based therapy induces acquired spherocytic-like anaemia and ineffective erythropoiesis in chronic hepatitis C virus patients. The addition of protease inhibitors, boceprevir (BOC) or telaprevir (TRV), to peg-interferon and ribavirin (PR) increases the incidence of anaemia in patients with chronic hepatitis C virus (HCV) infection. Although genetic variants in inosine triphosphatase (ITPA) gene have been linked to the haemolytic anaemia induced by PR, the mechanism sustaining

2015 Liver International

53. Prevalence and prognostic implications of anaemia and iron deficiency in Tanzanian patients with heart failure. Full Text available with Trip Pro

outcome was anaemia and the secondary outcome was a composite of hospitalisation for HF or all-cause mortality.A total of 401 HF patients (median age 56 years, IQR 41-67 years; women 51%) were included. The prevalence of anaemia was 57%. The overall prevalence of ID was 49% distributed as 69% versus 21% in subjects with and without anaemia (p < 0.001). Normocytic anaemia was seen in 18% of the patients while none had macrocytic anaemia. The risk of having anaemia was positively associated (...) Prevalence and prognostic implications of anaemia and iron deficiency in Tanzanian patients with heart failure. To determine the prevalence, correlates and prognostic implications of anaemia and iron deficiency (ID) in patients with heart failure (HF) in Tanzania.This was a cross-sectional and prospective observational study conducted at Muhimbili National Hospital in Dar es Salaam, Tanzania. Patients were ≥ 18 years of age, with HF defined according to the Framingham criteria. The primary

2014 Heart

54. Markers of inflammation and activation of coagulation are associated with anaemia in antiretroviral-treated HIV disease. Full Text available with Trip Pro

trial with haemoglobin and mean corpuscular volume (MCV) measurements at entry were categorized by presence of anaemia (haemoglobin ≤14 g/dl in men and ≤12 g/dl in women) and, for those with anaemia, by type [microcytic (MCV < 80 fl), normocytic (80-100 fl), macrocytic (>100 fl)]. We analysed the association between inflammation (IL-6 and hsCRP) and coagulation (D-dimer) and haemoglobin, controlling for demographics (age, race and sex), BMI, HIV plasma RNA levels, CD4⁺ T-cell counts (nadir (...) and baseline), Karnofsky score, previous AIDS diagnosis, hepatitis B/C coinfection and use of zidovudine.Among 1410 participants, 313 (22.2%) had anaemia. Of these, 4.1, 27.2 and 68.7% had microcytic, normocytic and macrocytic anaemia, respectively. When compared with participants with normal haemoglobin values, those with anaemia were more likely to be older, black, male and on zidovudine. They also had lower baseline CD4⁺ T-cell counts and lower Karnofsky scores. Adjusted relative odds of anaemia per two

2014 AIDS

55. Hepcidin-dependent and hepcidin-independent regulation of erythropoiesis in a mouse model of anemia of chronic inflammation. Full Text available with Trip Pro

Hepcidin-dependent and hepcidin-independent regulation of erythropoiesis in a mouse model of anemia of chronic inflammation. Increased hepcidin antimicrobial peptide correlates with hypoferremia and anemia in various disease states, but its requirement for anemia of inflammation has not been adequately demonstrated. Anemia of inflammation is usually described as normocytic and normochromic, while diseases associated with over expression of hepcidin, alone, are often microcytic and hypochromic (...) . These differences in erythrocyte parameters suggest anemia in many inflammatory states may not be fully explained by hepcidin-mediated iron sequestration. We used turpentine-induced sterile abscesses to model chronic inflammation in mice with targeted disruption of Hepcidin 1 [Hepc1 (-/-)] or its positive regulator, Interleukin-6 [IL-6 (-/-)], to determine whether these genes are required for features characteristic of anemia of inflammation. Although hemoglobin levels did not decline in Hepc1 (-/-) mice

2014 American journal of hematology

56. Association of renal tubular damage with cardio-renal anemia syndrome in patients with heart failure. (Abstract)

with normocytic anemia, accompanying iron deficiency and inflammation. RTD added prognostic information to conventional CRAS, suggesting the importance of RTD in cardio-renal anemia interaction.Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. (...) Association of renal tubular damage with cardio-renal anemia syndrome in patients with heart failure. Cardio-renal anemia syndrome (CRAS) has begun to gather attention as a vicious circle since chronic heart failure (CHF), chronic kidney disease (CKD), and anemia are all able to be caused and exacerbated by each other. However, it remains unclear whether renal tubular damage (RTD), another type of kidney dysfunction, is associated with this vicious circle. The aim of the present study

2014 International journal of cardiology

57. Iron Deficiency Anemia (Overview)

that is normocytic. The bone marrow is stimulated to increase production of hemoglobin, thereby depleting iron in body stores. Once they are depleted, hemoglobin synthesis is impaired and microcytic hypochromic erythrocytes are produced. Sequential changes in laboratory values following blood loss are depicted. A healthy human was bled 5 L in 500-mL increments over 45 days. A moderate anemia ensued, initially with normal cellular indices and serum iron. Subsequently, the mean corpuscular volume (MCV) increased (...) population of erythrocytes, normocytic cells produced before bleeding, and microcytic cells produced after bleeding. This is reflected in the red blood cell distribution width (RDW); thus, the earliest evidence of the development of an iron-deficient erythropoiesis is seen in the peripheral smear, in the form of increased RDW. Hemosiderinuria, hemoglobinuria, and pulmonary hemosiderosis Iron deficiency anemia can occur from loss of body iron in the urine. If a freshly obtained urine specimen appears

2014 eMedicine.com

58. Anemia, Chronic (Overview)

, , and lead poisoning. Anemia of chronic disease commonly is manifested by normocytic normochromic indices; however, microcytic hypochromic indices also can be associated with anemia of chronic disease. Macrocytic anemia Possible causes of macrocytic anemia include vitamin B-12 deficiency, folate deficiency, liver disease, and hypothyroidism. Normocytic anemia Normocytic anemia is further divided into 2 broad categories: anemia with primary bone marrow involvement and anemia secondary to underlying (...) Anemia, Chronic (Overview) Chronic Anemia: Practice Essentials, Etiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzgwMTc2LW92ZXJ2aWV3 processing > Chronic Anemia Updated: Sep 09, 2016 Author

2014 eMedicine Emergency Medicine

59. Anemia, Acute (Overview)

because of an expanded plasma volume. An acutely bleeding patient may have a normal initial hematocrit level; therefore, in this clinical setting, serial hematocrit levels must be measured. The studies listed below may or may not be useful, depending on the clinical presentation. Peripheral indices The most important index is the mean corpuscular volume (MCV), on the basis of which anemias can be classified as microcytic, normocytic, or macrocytic: Microcytic anemias (usually defined as MCV < 80 fL (...) ) include anemias of chronic disease, iron deficiency, lead poisoning, and the hemoglobinopathies (ie, sickle cell disease, sideroblastic anemia, thalassemias). Normocytic anemias (MCV 80-100 fL) include anemias of acute blood loss, hemolysis, uremia, and cancer. Patients with early forms of microcytic anemia and multifactorial anemia may have normocytic MCVs. Macrocytic anemias (usually defined as MCV >100 fL) include anemias related to alcoholism, folate and vitamin B-12 deficiencies (pernicious

2014 eMedicine Emergency Medicine

60. Anemia, Acute (Treatment)

because of an expanded plasma volume. An acutely bleeding patient may have a normal initial hematocrit level; therefore, in this clinical setting, serial hematocrit levels must be measured. The studies listed below may or may not be useful, depending on the clinical presentation. Peripheral indices The most important index is the mean corpuscular volume (MCV), on the basis of which anemias can be classified as microcytic, normocytic, or macrocytic: Microcytic anemias (usually defined as MCV < 80 fL (...) ) include anemias of chronic disease, iron deficiency, lead poisoning, and the hemoglobinopathies (ie, sickle cell disease, sideroblastic anemia, thalassemias). Normocytic anemias (MCV 80-100 fL) include anemias of acute blood loss, hemolysis, uremia, and cancer. Patients with early forms of microcytic anemia and multifactorial anemia may have normocytic MCVs. Macrocytic anemias (usually defined as MCV >100 fL) include anemias related to alcoholism, folate and vitamin B-12 deficiencies (pernicious

2014 eMedicine Emergency Medicine

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