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Normocytic Anemia

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21. KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease

concentration, other reported results of the CBC may convey important clinical information. The anemia of CKD is hypoproliferative, and in general, normochromic and normocytic. In this regard it is morphologically indistinguishable from the anemia of chronic disease. 10 Folate or vitamin B 12 de?ciencies may lead to macrocytosis, whereas iron de?ciency or inherited disorders of Hb formation (e.g., a-or b-thalassemia) may produce microcytosis. Iron de?ciency, especially if long- standing, is associated (...) KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease VOLUME 2 | ISSUE 4 | AUGUST ?2? 2012 http://www.kidney-international.org OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY OF NEPHROLOGY KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease KI_SuppCover_2.4.indd 1 KI_SuppCover_2.4.indd 1 7/11/12 12:00 PM 7/11/12 12:00 PMKDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease KDIGO gratefully acknowledges the following consortium of sponsors

2012 National Kidney Foundation

22. Diamond Blackfan Anemia: A Nonclassical Patient With Diagnosis Assisted by Genomic Analysis (PubMed)

Diamond Blackfan Anemia: A Nonclassical Patient With Diagnosis Assisted by Genomic Analysis Diamond Blackfan anemia (DBA) is an inherited syndrome usually presenting with severe macrocytic anemia in infancy, paucity of erythroid precursors in the bone marrow, and congenital anomalies. We describe a child with mild, transfusion independent normocytic anemia whose diagnosis of DBA was established by identification of a novel de novo mutation disrupting normal splicing of the ribosomal protein

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2016 Journal of pediatric hematology/oncology

23. Investigation of the Etiology of Anemia in Thromboangiitis Obliterans (PubMed)

Investigation of the Etiology of Anemia in Thromboangiitis Obliterans During a review of patients admitted with thromboangiitis obliterans (TAO), there was evidence of normochromic normocytic anemia and abrupt changes in hemoglobin (Hgb) levels in patients with several hospital admissions. Therefore, the evidence of hemolytic anemia was evaluated based on 37 banked plasma samples taken from Caucasian male TAO patients during disease exacerbation between 2012 and 2014. The patients' hospital (...) was 12.9 ± 2.6 g/dL. CRP and IAT were positive in 75.6 and 70.2% of the samples, respectively. The tests and corresponding results were as follows: hsCRP, 14.07 ± 2.37 µg/mL; LDH, 2,552 ± 315 u/L; haptoglobin, 2.27 ± 1.1 g/L; indirect bilirubin, 0.09 ± 0.04 mg/dL; AST, 67 ± 7 u/L; and ALT, 26 ± 3 u/L. There was a significant inverse correlation between hsCRP and hospital-documented Hgb level (p = 0.03). Anemia with the positive IAT in most of the samples, high LDH and AST, and normal ALT are suggestive

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2016 The International journal of angiology : official publication of the International College of Angiology, Inc

24. Incidence of anemia in patients diagnosed with solid tumors receiving chemotherapy, 2010–2013 (PubMed)

from the health plan's electronic medical records. Incidence proportions of patients developing anemia and 95% confidence intervals were calculated overall and by anemia severity and type, as well as by stage at cancer diagnosis, and by chemotherapy regimen and cycle.A total of 4,426 patients who received chemotherapy were included. Across cancers, 3,962 (89.5%) patients developed anemia during the course of chemotherapy (normocytic 85%, macrocytic 10%, microcytic 5%; normochromic 47%, hyperchromic (...) Incidence of anemia in patients diagnosed with solid tumors receiving chemotherapy, 2010–2013 The purpose of this study was to evaluate and characterize the risk of anemia during the course of chemotherapy among patients with five common types of solid tumors.Patients diagnosed with incident cancers of breast, lung, colon/rectum, stomach, and ovary who received chemotherapy were identified from Kaiser Permanente Southern California Health Plan (2010-2012). All clinical data were collected

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2016 Clinical epidemiology

25. Iron Deficiency Anemia

condition history or (e.g. ) Colon cancer Medication usage predisposing to ing s s V. Associated Conditions ralized in children VI. Labs (CBC) See See (MCV) ral See MCV cutoff varies by age and per reference MCV usually <75 in Iron Deficiency Anemia MCV >95 fl virtually excludes Iron Deficiency ( >97%) (MCV 80 to 100 fl) Normocytic early in course of Normocytic erythrocytes are found in 40% of Iron Deficiency patients (MCV <80 fl) Microcytosis follows drop of 2 g/dl (RDW) Precedes change in to ratio See (...) Iron Deficiency Anemia Iron Deficiency Anemia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Iron Deficiency Anemia Iron Deficiency

2018 FP Notebook

26. Anemia in Older Adults

See See See VIII. Evaluation: Microcytic or Normocytic Anemia Low (<46 ng/ml or <103 pmol/L) Treat as Evaluate for causes including gastrointestinal (e.g. endoscopy) Intermediate (46 to 100 ng/ml or 103 to 225 pmol/L) Serum receptor (sTfR) to index <1.5 (GFR) <60 (GFR) >60 Consider other causes of , Serum receptor (sTfR) to index >1.5 Treat as Evaluate for causes including gastrointestinal (e.g. endoscopy) High (>100 ng/ml or >225 pmol/L) Consider congenital Consider other causes of elevation (...) Anemia in Older Adults Anemia in Older Adults Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Anemia in Older Adults Anemia in Older

2018 FP Notebook

27. Anemia and low-grade inflammation in pediatric kidney transplant recipients. (PubMed)

protein (CRP) (hsCRP) and interleukin-6 (IL-6) were analyzed by enzyme-linked immunosorbent assays, and GFR was analyzed by 51Cr-EDTA clearance.The median levels of Hb (115 g/L), hsCRP (0.4 mg/L) and IL-6 (1.4 pg/mL) and the median erythrocyte sedimentation rate (ESR; 19 mm/h) remained stable after the first post-operative year. However, approximately half of the patients had a normocytic, normochromic anemia, and one-third had elevated levels of hsCRP (>1 mg/L) and ESR (>25 mm/h), indicating (...) Anemia and low-grade inflammation in pediatric kidney transplant recipients. Anemia and low-grade inflammation are reported to be associated with impaired long-term graft outcome in renal transplant (RTx) recipients. In this study, hemoglobin (Hb) and inflammation marker levels were correlated with measured glomerular filtration rate (GFR) in 128 pediatric RTx recipients over a median follow-up period of 10 years.Serum levels of erythropoietin (EPO), hepcidin-25, high-sensitivity C-reactive

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2016 Pediatric Nephrology

28. A 2-month-old boy with hemolytic anemia and reticulocytopenia following intravenous immunoglobulin therapy for Kawasaki disease: a case report and literature review (PubMed)

suggestive of incomplete Kawasaki disease. His fever resolved 8 days after treatment with aspirin and high dose infusion of intravenous immunoglobulin. The hemoglobin and hematocrit decreased from 9.7 g/dL and 27.1% to 7.4 g/dL and 21.3%, respectively. The patient had normocytic hypochromic anemia with anisocytosis, poikilocytosis, immature neutrophils, and nucleated red blood cells. The direct antiglobulin test result was positive, and the reticulocyte count was 1.39%. The patient had an uneventful (...) A 2-month-old boy with hemolytic anemia and reticulocytopenia following intravenous immunoglobulin therapy for Kawasaki disease: a case report and literature review Herein, we report a rare case of hemolytic anemia with reticulocytopenia following intravenous immunoglobulin therapy in a young infant treated for Kawasaki disease. A 2-month-old boy presented with fever lasting 3 days, conjunctival injection, strawberry tongue, erythematous edema of the hands, and macular rash, symptoms and signs

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2016 Korean journal of pediatrics

29. A recurring mutation in the respiratory complex 1 protein NDUFB11 is responsible for a novel form of X-linked sideroblastic anemia. (PubMed)

A recurring mutation in the respiratory complex 1 protein NDUFB11 is responsible for a novel form of X-linked sideroblastic anemia. The congenital sideroblastic anemias (CSAs) are a heterogeneous group of inherited blood disorders characterized by pathological mitochondrial iron deposition in erythroid precursors. Each known cause has been attributed to a mutation in a protein associated with heme biosynthesis, iron-sulfur cluster biogenesis, mitochondrial translation, or a component (...) of the mitochondrial respiratory chain. Here, we describe a recurring mutation, c.276_278del, p.F93del, in NDUFB11, a mitochondrial respiratory complex I-associated protein encoded on the X chromosome, in 5 males with a variably syndromic, normocytic CSA. The p.F93del mutation results in respiratory insufficiency and loss of complex I stability and activity in patient-derived fibroblasts. Targeted introduction of this allele into K562 erythroleukemia cells results in a proliferation defect with minimal effect

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2016 Blood

30. Hemoglobin, Anemia, and Cognitive Function: The Atherosclerosis Risk in Communities Study. (PubMed)

Hemoglobin, Anemia, and Cognitive Function: The Atherosclerosis Risk in Communities Study. Our objective was to characterize the relationship of low and high hemoglobin concentrations and normocytic, microcytic, and macrocytic anemia with cross-sectional cognition and change in cognition over a median of 6 years.Cross-sectional and prospective analyses of 13,133 participants (mean age 57 years, 56% women, 24% black, 10% anemia) in the Atherosclerosis Risk in Communities (ARIC) study (baseline (...) 1990-1992) were carried out. Anemia was defined as hemoglobin concentrations lower than 13g/dl for men and lower than 12g/dl for women and was subclassified as normocytic (mean corpuscular volume [MCV] 80-100 fL), microcytic (MCV < 80 fL), and macrocytic (MCV > 100 fL). Cognition was assessed by delayed word recall test (DWRT), digit symbol substitution test (DSST), word fluency test (WFT), and global Z-score at Visit 2 (1990-1992) and Visit 4 (1996-1998). Adjusted linear regression models

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2015 Biological Sciences and Medical Sciences

31. Anemia in prospective blood donors deferred by the copper sulphate technique of hemoglobin estimation. (PubMed)

were collected from the study subjects into EDTA anticoagulant tubes. The hemoglobin levels and red cell indices were measured using Sysmex hematology analyser. A thin blood film was prepared and stained using Leishman stain and then observed under the light microscope.The prevalence of anemia among the total deferred patients (538) was 17.1 %. Four different types of anemia were found among the subjects. These were normocytic normochromic (46.74 %), microcytic hypochromic (42.39 %) normocytic (...) Anemia in prospective blood donors deferred by the copper sulphate technique of hemoglobin estimation. Patients who require transfusion as part of their clinical management have the right to expect sufficient blood to be available to meet their needs and to receive the safest blood possible. Donor deferrals (disqualification) lead to loss of precious blood donors and blood units available for transfusion purposes. It is believed that a large majority of donor deferrals are due to temporal

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2015 BMC Hematology

32. Prevalence and associated risk factors of anemia among HIV infected children attending Gondar university hospital, Northwest Ethiopia: a cross sectional study. (PubMed)

in 16.2 % (43 /265) of children, 60.5 % of them had mild anemia, 37.2 % had moderate anemia and 2.3 % had severe anemia. About 46.5 % of anemic children had normocytic-normochromic anemia followed by macrocytic-normochromic anemia (39.5 %). In this study, anemia was associated with eating green leafy vegetables (OR = 0.43, 95 % CI (0.188-0.981) and being on cotrimoxazole treatment (OR = 2.169, 95 % CI (1.047-4.49). But there was no significant association with age, sex, WHO clinical stage (...) Prevalence and associated risk factors of anemia among HIV infected children attending Gondar university hospital, Northwest Ethiopia: a cross sectional study. Anemia is the most common hematological abnormalities in HIV patients and it is a wide spread public health problem. The World Health Organization estimates that over 2 billion people are anemic worldwide with more than 100 million of these anemic children living in Africa. In Ethiopia, there is limited information about the prevalence

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2015 BMC Hematology

33. Anemia in elderly hospitalized patients: prevalence and clinical impact. (PubMed)

elderly patients admitted to the Internal Medicine Ward of Ca'Granda Policlinico Hospital along 6 months, and its relationship to comorbidities and to the length of hospitalization. Anemia was classified according to the WHO criteria. The majority of patients (48 %) had a mildmoderate, normocytic anemia; severe anemia was found in 8 out of 92 anemic patients. In a subgroup of patients erythropoietin was tested and resulted statistically higher if compared to non-anemic controls (p = 0.003 (...) Anemia in elderly hospitalized patients: prevalence and clinical impact. Anemia is a common finding in elderly individuals. Several studies have shown a strong relationship between anemia, morbidity and mortality, suggesting anemia as a significant independent predictor of adverse outcome in elderly hospitalized patients. The pathophisiology of anemia in the elderly is not yet completely understood. Several mechanisms are involved. We investigated the prevalence of anemia in a cohort of 193

2015 Internal and emergency medicine

34. Erythroblast apoptosis and microenvironmental iron restriction trigger anemia in the VK*MYC model multiple myeloma. (PubMed)

using the Vk*MYC mouse, which spontaneously develops an indolent bone marrow localized disease with aging. Affected Vk*MYC mice develop a mild normochromic normocytic anemia. We excluded the possibility that anemia results from defective erythropoietin production, inflammation or increased hepcidin expression. Mature erythroid precursors are reduced in Vk*MYC bone marrow compared with wild-type. Malignant plasma cells express the apoptogenic receptor Fas ligand and, accordingly, active caspase 8 (...) Erythroblast apoptosis and microenvironmental iron restriction trigger anemia in the VK*MYC model multiple myeloma. Multiple myeloma is a malignant disorder characterized by bone marrow proliferation of plasma cells and by overproduction of monoclonal immunoglobulin detectable in the sera (M-spike). Anemia is a common complication of multiple myeloma, but the underlying pathophysiological mechanisms have not been completely elucidated. We aimed to identify the different determinants of anemia

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2015 Haematologica

35. Hepcidin-dependent and hepcidin-independent regulation of erythropoiesis in a mouse model of anemia of chronic inflammation. (PubMed)

Hepcidin-dependent and hepcidin-independent regulation of erythropoiesis in a mouse model of anemia of chronic inflammation. Increased hepcidin antimicrobial peptide correlates with hypoferremia and anemia in various disease states, but its requirement for anemia of inflammation has not been adequately demonstrated. Anemia of inflammation is usually described as normocytic and normochromic, while diseases associated with over expression of hepcidin, alone, are often microcytic and hypochromic (...) . These differences in erythrocyte parameters suggest anemia in many inflammatory states may not be fully explained by hepcidin-mediated iron sequestration. We used turpentine-induced sterile abscesses to model chronic inflammation in mice with targeted disruption of Hepcidin 1 [Hepc1 (-/-)] or its positive regulator, Interleukin-6 [IL-6 (-/-)], to determine whether these genes are required for features characteristic of anemia of inflammation. Although hemoglobin levels did not decline in Hepc1 (-/-) mice

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2014 American journal of hematology

36. Association of renal tubular damage with cardio-renal anemia syndrome in patients with heart failure. (PubMed)

with normocytic anemia, accompanying iron deficiency and inflammation. RTD added prognostic information to conventional CRAS, suggesting the importance of RTD in cardio-renal anemia interaction.Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. (...) Association of renal tubular damage with cardio-renal anemia syndrome in patients with heart failure. Cardio-renal anemia syndrome (CRAS) has begun to gather attention as a vicious circle since chronic heart failure (CHF), chronic kidney disease (CKD), and anemia are all able to be caused and exacerbated by each other. However, it remains unclear whether renal tubular damage (RTD), another type of kidney dysfunction, is associated with this vicious circle. The aim of the present study

2014 International journal of cardiology

37. Aplastic Anemia (Overview)

: Sameer Bakhshi, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Aplastic Anemia Overview Practice Essentials Aplastic anemia is a syndrome of bone marrow failure characterized by peripheral pancytopenia and marrow hypoplasia (see the image below). Although the anemia is often normocytic, mild macrocytosis can also be observed in association with stress erythropoiesis and elevated fetal hemoglobin levels. Low power, H and E showing a hypocellular bone marrow (...) Aplastic Anemia (Overview) Aplastic Anemia: Practice Essentials, Background, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTk4NzU5LW92ZXJ2aWV3 processing > Aplastic Anemia Updated: Dec 05, 2018 Author

2014 eMedicine.com

38. Aplastic Anemia (Diagnosis)

: Sameer Bakhshi, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Aplastic Anemia Overview Practice Essentials Aplastic anemia is a syndrome of bone marrow failure characterized by peripheral pancytopenia and marrow hypoplasia (see the image below). Although the anemia is often normocytic, mild macrocytosis can also be observed in association with stress erythropoiesis and elevated fetal hemoglobin levels. Low power, H and E showing a hypocellular bone marrow (...) Aplastic Anemia (Diagnosis) Aplastic Anemia: Practice Essentials, Background, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTk4NzU5LW92ZXJ2aWV3 processing > Aplastic Anemia Updated: Dec 05, 2018 Author

2014 eMedicine.com

39. Iron Deficiency Anemia (Overview)

that is normocytic. The bone marrow is stimulated to increase production of hemoglobin, thereby depleting iron in body stores. Once they are depleted, hemoglobin synthesis is impaired and microcytic hypochromic erythrocytes are produced. Sequential changes in laboratory values following blood loss are depicted. A healthy human was bled 5 L in 500-mL increments over 45 days. A moderate anemia ensued, initially with normal cellular indices and serum iron. Subsequently, the mean corpuscular volume (MCV) increased (...) population of erythrocytes, normocytic cells produced before bleeding, and microcytic cells produced after bleeding. This is reflected in the red blood cell distribution width (RDW); thus, the earliest evidence of the development of an iron-deficient erythropoiesis is seen in the peripheral smear, in the form of increased RDW. Hemosiderinuria, hemoglobinuria, and pulmonary hemosiderosis Iron deficiency anemia can occur from loss of body iron in the urine. If a freshly obtained urine specimen appears

2014 eMedicine.com

40. Anemia of Prematurity (Overview)

is observed 8-12 weeks after birth. Anemia of prematurity (AOP) is an exaggerated, pathologic response of the preterm infant to this transition. AOP is a normocytic, normochromic, hyporegenerative anemia characterized by a low serum EPO level, often despite a remarkably reduced hemoglobin concentration. Nutritional deficiencies of iron, vitamin E, vitamin B-12, and folate may exaggerate the degree of anemia, as may blood loss and/or a reduced red cell life span. AOP spontaneously resolves in many (...) Anemia of Prematurity (Overview) Anemia of Prematurity: Background, Etiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTc4MjM4LW92ZXJ2aWV3 processing > Anemia of Prematurity Updated: Jan 08

2014 eMedicine Pediatrics

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