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336 results for

Normocytic Anemia

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321. Prevalence of anemia in clinic patients with heart failure and cost analysis of epoetin treatment. (Abstract)

, and published hospitalization and drug-use data.We evaluated 170 adults with chronic heart failure who were enrolled in the clinic and for whom at least one complete blood count was recorded between January 1, 2003, and April 15, 2006.In part 1, demographic and clinical data were extracted from electronic medical records. The overall prevalence of anemia was 47.6% or 47.1%, as based on World Health Organization or National Kidney Foundation definitions, respectively. Normocytic anemia was characterized (...) Prevalence of anemia in clinic patients with heart failure and cost analysis of epoetin treatment. To determine the prevalence of anemia in an outpatient heart failure clinic, describe the type of anemia in patients treated there, and evaluate the potential costs associated with epoetin therapy in this cohort.Single-center, retrospective cohort analysis (part 1) and a literature-based economic decision analysis (part 2).Medical records from a multidisciplinary, outpatient, heart failure clinic

2007 Pharmacotherapy

322. Prevalence of anaemia before major joint arthroplasty and the potential impact of preoperative investigation and correction on perioperative blood transfusions. Full Text available with Trip Pro

revision knee). About 19.6% were anaemic [7.1% haemoglobin (Hb) <110 g litre(-1); 1.6% Hb<100 g litre(-1)]. Overall, 21.3% of admissions were transfused (mean 0.58 units per case: 95% CI 0.50-0.61). For anaemic admissions, 42.0% were transfused (mean 1.11 units per case: 95% CI 0.90-1.32). Mean red cell use for admissions with normocytic normochromic anaemia (12.7% of admissions) and hypochromic anaemia (4.6%) was 1.04 (95% CI 0.78-1.31) and 1.14 (95% CI 0.71-1.57) units per admission, respectively (...) Prevalence of anaemia before major joint arthroplasty and the potential impact of preoperative investigation and correction on perioperative blood transfusions. Preoperative investigation and treatment of anaemia is recommended before orthopaedic surgery. We measured the prevalence of anaemia among admissions presenting for elective major joint arthroplasty (MJA), assessed their transfusion requirements, and investigated factors associated with perioperative blood transfusion.All admissions

2007 British Journal of Anaesthesia

323. The prevalence and characteristics of anaemia at discharge home after intensive care. (Abstract)

The prevalence and characteristics of anaemia at discharge home after intensive care. To document the prevalence of anaemia among ICU survivors at the time of discharge home and to document red cell morphology among anaemic patients.Observational cohort study in a single-centre teaching hospital.Three cohorts of ICU admissions over a 3-year period managed with restrictive ICU transfusion practice. The study group comprised the 283 patients who survived and were discharged directly home from our (...) 100 g/l was Hb at the time of ICU discharge. Multivariate regression analysis showed patient age, gender, APACHE II score, and ICU length of stay not to be independent predictors after including the ICU discharge Hb. Among anaemic patients 82% had normochromic normocytic red cell indices, but 12% had red cell hypochromasia and/or microcytosis, which may indicate iron deficiency.Anaemia is highly prevalent among survivors of critical illness and persists until hospital discharge. Most patients have

2006 Intensive Care Medicine

324. Anaemia in advanced chronic fasciolosis. (Abstract)

. Bacteriological bile cultures revealed viable bacteria in 53.8% of specimens at 60 weeks p.i. The results show that the type of anaemia in fasciolosis might be considered a biomarker of the chronicity period of the disease, changing from normocytic to macrocytic in the early chronic period (20 weeks p.i.) and to microcytic in the advanced chronic period (60 weeks p.i.). Likewise, changing from normochromic in the early chronic period to hypochromic in the advanced chronic period. Multivariate analysis (...) Anaemia in advanced chronic fasciolosis. The association between fasciolosis-induced anaemia and related factors has been quantified in a rodent model. Haematological parameters were analysed in Wistar rats at 20 and 60 weeks post-infection (p.i.). Pigment stones and bile specimens were collected. Serum IgG1, IgG2a and IgE were determined in rat serum samples. Cytokine levels have been correlated with haematological parameters. The screening for gastrointestinal bleeding was carried out

2008 Acta Tropica

325. Risk factors for anemia in patients with ileal pouch-anal anastomosis. (Abstract)

microcytic, and 49 (74 percent) had normocytic anemia. Sixteen patients (24 percent) had unidentified causes for anemia. Multivariable analysis showed that the presence of malignancy or desmoid tumor and the J-pouch configuration were the only independent risk factors associated with anemia.Anemia is common in ileal-pouch patients. Malignancy or desmoid tumor and J-pouch configuration are independent risk factors for anemia. One-fourth of the patients with anemia have unclear etiology. (...) Risk factors for anemia in patients with ileal pouch-anal anastomosis. Anemia is frequently observed in patients with ileal pouch-anal anastomosis. The identification of the underlying causes can be challenging. This study was designed to define the prevalence and to identify etiologic factors for anemia in this patient population.A prospectively maintained database and medical records of patients who had restorative proctocolectomy between 1998 and 2005 were reviewed. All patients

2007 Diseases of the Colon & Rectum

326. Anaemia in Pregnancy

in women with haemoglobinopathy or where the cause is in doubt. Management [ ] Routine iron replacement in pregnancy is not recommended in the UK. Women with known haemoglobinopathy should have serum ferritin checked and be offered oral supplements if their ferritin level is low (<30 μg/L). Women with unknown haemoglobinopathy status with a normocytic or microcytic anaemia, should start a trial of oral iron and haemoglobinopathy screening should be offered. Non-anaemic women at increased risk of iron (...) bleeding. Parasitic diseases (eg, hookworm, schistosomiasis). Epidemiology Anaemia in pregnancy is a common problem. In the UK, prevalence is estimated to be 24.4% antenatally. [ ] Nearly a third of women are anaemic postpartum. Worldwide prevalence of anaemia in pregnancy is estimated to be around 38% (compared to 29% of non-pregnant women). [ ] Presentation Anaemia in pregnancy may be asymptomatic. However, the following symptoms are most common: Fatigue Dyspnoea Dizziness The patient may appear pale

2008 Mentor

327. Anaemia of Chronic Disease

evidence, UK and European Guidelines. You may find the article more useful, or one of our other . In this article In This Article Anaemia of Chronic Disease In this article The World Health Organization's criterion for anaemia in adult men is haemoglobin (Hb) values less than 130 g/L, non-pregnant women less than 120 g/L and pregnant women less than 110 g/L. Children aged 6 months to 6 years are considered anaemic at Hb levels less than 110 g/L, and children aged 6-11 years are considered anaemic when (...) (3):345-52. ; British Committeee for Standards in Haematology (May 2013) ; Novel erythropoiesis-stimulating agents: a new era in anemia management. Clin J Am Soc Nephrol. 2008 Jan3(1):200-7. Epub 2007 Dec 12. ; Erythropoiesis-stimulating agents for anaemia in chronic heart failure patients. Cochrane Database Syst Rev. 2010 Jan 20(1):CD007613. ; Erythropoiesis-stimulating agents in cancer patients: ESMO recommendations for use. Ann Oncol. 2009 May20 Suppl 4:159-61. Hi I really need some help.I had

2008 Mentor

328. Anaemia in Chronic Renal Disease

evidence, UK and European Guidelines. You may find the article more useful, or one of our other . In this article In This Article Anaemia in Chronic Kidney Disease In this article Aetiology [ , ] In patients with chronic kidney disease, normochromic normocytic anaemia mainly develops from decreased renal synthesis of erythropoietin. The anaemia becomes more severe as the glomerular filtration rate (GFR) progressively decreases. No reticulocyte response occurs, red blood cell survival is decreased (...) ). Comparing patients with similar eGFR and erythropoietin levels, those with type 2 diabetes are generally more anaemic. [ ] Presentation It is often diagnosed by routine review blood tests. Renal anaemia may lead to the onset or aggravation of lethargy, cold intolerance and loss of stamina. Anaemia increases cardiac output, therefore contributing to the development of left ventricular hypertrophy and dilatation. Differential diagnosis [ ] Causes of anaemia in patients with CKD, other than renal failure

2008 Mentor

329. Haemolytic Anaemia

and disseminated intravascular coagulation). A normal MCV and mean corpuscular haemoglobin (MCH): consistent with a normocytic hypochromic anaemia. [ ] High MCH and MCH concentration (MCHC): suggest spherocytosis. Coombs' test: the direct Coombs' test is used clinically when immune-mediated haemolytic anaemia (antibody-mediated destruction of RBCs) is suspected. Cold agglutinins: a high titre of anti-I antibody may be found in mycoplasma infections and a high titre of anti-I antibody may be found in haemolysis (...) :550-3. doi: 10.12659/AJCR.892136. ; Online Mendelian Inheritance in Man (OMIM) ; Online Mendelian Inheritance in Man (OMIM) ; Hemolytic anemia. Am Fam Physician. 2004 Jun 169(11):2599-606. ; Red blood cell destruction in autoimmune hemolytic anemia: role of complement and potential new targets for therapy. Biomed Res Int. 20152015:363278. doi: 10.1155/2015/363278. Epub 2015 Jan 29. ; Autoimmune haemolytic anaemia - a practical guide to cope with a diagnostic and therapeutic challenge. Neth J Med

2008 Mentor

330. Laboratory Evaluation of Anemia Full Text available with Trip Pro

Laboratory Evaluation of Anemia The laboratory evaluation of anemia begins with a complete blood count and reticulocyte count. The anemia is then categorized as microcytic, macrocytic or normocytic, with or without reticulocytosis. Examination of the peripheral smear and a small number of specific tests confirm the diagnosis. The serum iron level, total iron-binding capacity, serum ferritin level and hemoglobin electrophoresis generally separate the microcytic anemias. The erythrocyte size (...) -distribution width may be particularly helpful in distinguishing iron deficiency from thalassemia minor. Significant changes have occurred in the laboratory evaluation of macrocytic anemia, and a new syndrome of nitrous oxide-induced megaloblastosis and neurologic dysfunction has been recognized. A suggested approach to the hemolytic anemias includes using the micro-Coombs' test and ektacytometry. Finally, a number of causes have been identified for normocytic anemia without reticulocytosis, including

1987 Western Journal of Medicine

331. Anemia, Growth Failure and Hypothyroidism Full Text available with Trip Pro

Anemia, Growth Failure and Hypothyroidism A 12-year-old Caucasian female presented to her family physician with an old complaint of anemia and a new complaint of failure to grow. The anemia, first observed four years previously, had been diagnosed as iron deficiency, but had never satisfactorily responded to adequate iron therapy. Investigation of the failure to grow resulted in a diagnosis of hypothyroidism with related normochromic normocytic anemia.This case serves to review the rather (...) complicated relationship between hypothyroidism and the three types of anemia. The case report also reminds family physicians of several diagnostic principles: the importance of knowing stages in the evolution of disease; the importance of time and repeated contact with patients; the importance of diagnostic pathways and investigation of symptoms, and after diagnosis is established, the importance of ongoing monitoring of the patient.

1980 Canadian Family Physician

332. Anemia in the Elderly Full Text available with Trip Pro

Anemia in the Elderly Physicians disagree in defining the normal range for hemoglobin in the elderly patient. In order to understand this controversy and make rational decisions in patient management, it is important to understand the physiological factors that may give rise to variation from normal. Although the spectrum of disease seen in geriatrics may differ from that seen in children and young adults, the pathophysiology of anemia does not change and should be thought of in terms (...) of microcytic, macrocytic, or normocytic. The variation from normal in the elderly is usually small and does not allow a physician to ascribe the difference to age alone.

1989 Canadian Family Physician

333. Lack of angiotensin II–facilitated erythropoiesis causes anemia in angiotensin-converting enzyme–deficient mice Full Text available with Trip Pro

Lack of angiotensin II–facilitated erythropoiesis causes anemia in angiotensin-converting enzyme–deficient mice While nephrologists often observe reduced hematocrit associated with inhibitors of angiotensin-converting enzyme (ACE), the basis for this effect is not well understood. We now report that two strains of ACE knockout mice have a normocytic anemia associated with elevated plasma erythropoietin levels. (51)Cr labeling of red cells showed that the knockout mice have a normal total (...) blood volume but a reduced red cell mass. ACE knockout mice, which lack tissue ACE, are anemic despite having normal renal function. These mice have increased plasma levels of the peptide acetyl-SDKP, a possible stem cell suppressor. However, they also show low plasma levels of angiotensin II. Infusion of angiotensin II for 2 weeks increased hematocrit to near normal levels. These data suggest that angiotensin II facilitates erythropoiesis, a conclusion with implications for the management

2000 Journal of Clinical Investigation

334. Possible ameliorative effect of taurine in the treatment of iron-deficiency anaemia in female university students of Gaza, Palestine. (Abstract)

) and serum concentrations of iron, total iron binding capacity (TIBC), ferritin and taurine were determined. Samples from 17 normocytic, normochromic, and non-anaemic subjects were used as baseline controls. At base-line, 81 of the 730 subjects (11.1%) had microcytosis/hypochromasia, 26 (3.6%) were diagnosed as beta-thalassemia carriers, none of which was iron deficient. Four subjects had microcytosis of unknown cause. Fifty-one subjects (all females) had iron-deficiency anaemia and were included (...) Possible ameliorative effect of taurine in the treatment of iron-deficiency anaemia in female university students of Gaza, Palestine. The aim of the study was to evaluate the haematological effects of adding the antioxidant taurine to iron sulfate in the treatment of iron-deficiency anaemia (IDA). A sample of 730 students from Al-Azhar University, Gaza, in Palestine underwent screening with complete blood counts and serum samples. In subjects with microcytosis/hypochromasia, Alpha2 delta2 (HbA2

2002 European journal of haematology Controlled trial quality: uncertain

335. How do I diagnose and manage normocytic anaemia in a diabetic patient?

to an algorithm for investigation An article published in the ‘American Family Physician’ on normocytic anaemia discusses the diagnosis, causes and management of this condition. The abstract to this article reads: “ Anemia is a common problem that is often discovered on routine laboratory tests. Its prevalence increases with age, reaching 44 percent in men older than 85 years. Normocytic anemia is the most frequently encountered type of anemia. Anemia of chronic disease, the most common normocytic anemia (...) with a glomerular filtration rate [3] References 1. GPNotebook. Normocytic anaemia. ( ) 2. Brill J and Baumgardner D. Normocytic anemia. American Family Physician 2000;62(10).( ) 3. Li Vecchi M, Fuiano G and Francesco M et al. Prevalence and severity of anaemia in patients with type 2 diabetic nephropathy and different degrees of chronic renal insufficiency. Nephron Clin Pract. 2007;105(2):c62-7. ( ) Answered 15 May 2008 Follow us: © 2019 Trip Database Ltd. company number 04316414. Trip is proud to be made

2008 TRIP Answers

336. In a patient with an asymptomatic mild normocytic normochromic anaemia, (Hb 11.5 in a male aged 65), when iron levels are low, but ferritin levels are normal, is it safe to monitor without investigati

In a patient with an asymptomatic mild normocytic normochromic anaemia, (Hb 11.5 in a male aged 65), when iron levels are low, but ferritin levels are normal, is it safe to monitor without investigati In a patient with an asymptomatic mild normocytic normochromic anaemia, (Hb 11.5 in a male aged 65), when iron levels are low, but ferritin levels are normal, is it safe to monitor without investigation, or should investigation for iron deficiency be sought? - Trip Database or use your Google (...) questions please contact us via jon.brassey@tripdatabase.com In a patient with an asymptomatic mild normocytic normochromic anaemia, (Hb 11.5 in a male aged 65), when iron levels are low, but ferritin levels are normal, is it safe to monitor without investigation, or should investigation for iron deficiency be sought? Using TRIP, we found two sources of information that may be of use to read in more detail. Below are the links, but we include some extracts. The British Society of Gastroenterology

2006 TRIP Answers

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