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Normocytic Anemia

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261. Vitamin Deficiency, Dependency, and Toxicity - Riboflavin

Table: ). Riboflavin is essentially nontoxic. (See also .) Riboflavin Deficiency Riboflavin deficiency usually occurs with other B vitamin deficiencies. Symptoms and signs include sore throat, lesions of the lips and mucosa of the mouth, glossitis, conjunctivitis, seborrheic dermatitis, and normochromic-normocytic anemia. Diagnosis is usually clinical. Treatment consists of oral or, if needed, IM riboflavin. Etiology Primary riboflavin deficiency results from inadequate intake of the following

2013 Merck Manual (19th Edition)

262. Lead Poisoning

, BUN, serum creatinine, plasma glucose, and PbBs. An abdominal x-ray should be taken to look for lead particles, which are radiopaque. X-rays of long bones are taken in children. Horizontal, metaphyseal lead bands representing lack of bone remodeling and increased Ca deposition in the zones of provisional calcification in children’s long bones are somewhat specific for poisoning with lead or other heavy metals but are insensitive. Normocytic or microcytic anemia suggests lead toxicity, particularly (...) poisoning in children may cause intellectual disability, seizure disorders, aggressive behavior disorders, developmental regression, chronic abdominal pain, and anemia. In adults Adults with occupational exposure characteristically develop symptoms (eg, personality changes, headache, abdominal pain, neuropathy) over several weeks or longer. Encephalopathy is unusual. Adults may develop loss of sex drive, infertility, and, in men, erectile dysfunction. In children and adults Anemia may develop because

2013 Merck Manual (19th Edition)

263. Tivantinib in Treating Patients With Relapsed, or Relapsed and Refractory Multiple Myeloma

mmol/L or 11.5 mg/dL) Renal insufficiency attributable to myeloma (serum creatinine > 1.9 mg/dL) Anemia; normochromic, normocytic with a hemoglobin value >= 2 g/dL below the lower limit of normal, or a hemoglobin or < 10 g/dL Bone lytic lesions, severe osteopenia, or pathologic fractures Patients with a biopsy-proven plasmacytoma and either a serum or urine monoclonal protein will also be considered to have met the diagnostic criteria for multiple myeloma in the absence of clonal marrow (...) Posted: March 13, 2015 Last Verified: March 2014 Keywords provided by National Cancer Institute (NCI): c-Met Inhibitor ARQ-197 tivantinib multiple myeloma plasma cell proliferative disorder Hypercalcemia hematologic malignancy plasma cell dyscrasia cast nephropathy amyloidosis osteolysis Renal insufficiency Anemia Bone lytic lesions severe osteopenia pathologic fractures biopsy-proven plasmacytoma Additional relevant MeSH terms: Layout table for MeSH terms Multiple Myeloma Neoplasms, Plasma Cell

2011 Clinical Trials

264. Safety and Tolerability Study of SNS01-T in Relapsed or Refractory B Cell Malignancies (Multiple Myeloma, B Cell Lymphoma, or Plasma Cell Leukemia (PCL)

accompanied by an abnormal kappa to lambda ratio (<0.26 or >1.65) Evidence of end-organ damage that can be attributed to the underlying plasma cell proliferative disorder, specifically, one or more of the following: Hypercalcemia: serum calcium >11.5 mg/100 mL Renal insufficiency: serum creatinine >2mg/dL Anemia: normochromic, normocytic with a hemoglobin value >2 g/100 mL below the lower limit of normal or a hemoglobin value <10 g/100 mL Bone lesions: lytic lesions, severe osteopenia, or pathologic

2011 Clinical Trials

265. Syncope in cardiac amyloidosis and chronic ischemic heart disease: A case report Full Text available with Trip Pro

disease who presented to the cardiology department because of syncope due to slow atrial fibrillation. Laboratory tests revealed a monoclonal spike in the gamma fraction and impairment of renal function, normocytic anemia, mild hypercalcemia, hypoalbuminemia and increased levels of beta-2 microglobulin. Suspicion of cardiac involvement was supported by the echocardiographic pattern and increased levels of troponin I and brain natriuretic peptide, along with clinical signs of heart failure and systemic

2011 Experimental & Clinical Cardiology

266. A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice. Full Text available with Trip Pro

postinfection, two-thirds of the infected mice died after exhibiting high and persistent viremia, leukocytosis, IFN-γ cytokinenemia, normocytic anemia, and thrombocytopenia. EBV-infected mice also showed systemic organ infiltration by activated CD8(+) T cells and prominent hemophagocytosis in BM, spleen, and liver. Notably, the level of EBV load in plasma correlated directly with both the activation frequency of CD8(+) T cells and the level of IFN-γ in plasma. Moreover, high levels of EBV-encoded small RNA1

2011 Blood

267. Hemoglobin Full Text available with Trip Pro

trimesters of pregnant women must be at least 11 g/dL and at least 10.5 g/dL during the 2nd trimester. Dehydration or hyperhydration can greatly influence measured hemoglobin levels. Albumin can indicate hydration status. If the concentration is below normal, this is called anemia. Anemias are classified by the size of red blood cells, the cells that contain hemoglobin in vertebrates. The anemia is called "microcytic" if red cells are small, "macrocytic" if they are large, and "normocytic" otherwise (...) may be present in variants of α thalassemia. (α 2 β S 2 ) – A variant form of hemoglobin found in people with sickle cell disease. There is a variation in the β-chain gene, causing a change in the properties of hemoglobin, which results in sickling of red blood cells. (α 2 β C 2 ) – Another variant due to a variation in the β-chain gene. This variant causes a mild chronic . (α 2 β E 2 ) – Another variant due to a variation in the β-chain gene. This variant causes a mild chronic hemolytic anemia

2012 Wikipedia

268. Rheumatoid arthritis

, and may want to consider prescribing routine use of low doses of aspirin if the gastrointestinal effects are tolerable. Blood [ ] is by far the most common abnormality of the blood cells which can be caused by a variety of mechanisms. The chronic inflammation caused by RA leads to raised levels, leading to where iron is poorly absorbed and also sequestered into . The red cells are of normal size and color (normocytic and normochromic). A usually only occurs in people with with an enlarged liver (...) are always safe, there is sometimes a hesitancy to report their use which may increase the risk of adverse reaction. The following are under investigation for treatments for RA, based on preliminary promising results (not recommended for clinical use yet): , , , , and . has noted that, "In particular, the herb thunder god vine (Tripterygium wilfordii) can have serious side effects." There is conflicting evidence on the role of -stimulating agents for treatment of anemia in persons with rheumatoid

2012 Wikipedia

269. Crohn's disease

in a normocytic anemia. Other causes of anemia include medication used in treatment of inflammatory bowel disease, like azathioprine, which can lead to cytopenia, and sulfasalazine, which can also result in . Testing for antibodies (ASCA) and (ANCA) has been evaluated to identify inflammatory diseases of the intestine and to differentiate Crohn's disease from ulcerative colitis. Furthermore, increasing amounts and levels of serological antibodies such as ASCA, antilaminaribioside [Glc(β1,3)Glb(β); ALCA (...) in which the immune system attacks the , is also more common in Crohn's disease and may cause fatigue, a pale appearance, and other symptoms common in . , a deformity of the ends of the fingers, may also be a result of Crohn's disease. Finally, Crohn's disease increases the risk of , or thinning of the bones. Individuals with osteoporosis are at increased risk of . People with Crohn's disease may develop anemia due to , , , or due to . The most common is iron deficiency anemia from chronic , reduced

2012 Wikipedia

270. Evaluation of Erythrocytes, Platelets, and Serum Iron Profile in Dogs with Chronic Enteropathy Full Text available with Trip Pro

metabolism were evaluated before and after treatment. A mild normocytic or microcytic anemia and thrombocytosis were identified, respectively in 18.0% and 31.8% of CE dogs. No significant differences between pre- and posttreatment of hematocrit, haemoglobin, and mean corpuscular volume, platelet count and mean platelet volume were found. Statistical analysis pointed out significant differences between pre- and posttreatment in serum iron (P < .03) and unsaturated iron binding capacity (UIBC) (P < .01

2010 Veterinary medicine international

271. Malarial anaemia and nitric oxide induced megaloblastic anaemia: a review on the causes of malarial anaemia. (Abstract)

Malarial anaemia and nitric oxide induced megaloblastic anaemia: a review on the causes of malarial anaemia. Direct destruction and ineffective erythropoesis does not adequately explain the cause of anaemia in malaria. It is possible that there are more other mechanisms involved besides the causes described till date in malarial anaemia. The effect of NO on erythropoesis and a major haematological abnormality (microcytic/normocytic/megaloblastic picture) can significantly be observed (...) on repeated exposure. In addition, NO can inhibit the enzyme methionine synthase so functional vit B12 deficiency state may occur which can lead to megaloblastic anaemia. This review will focus on causation of malarial anaemia and nitric oxide induced megaloblastic anaemia.

2009 Journal of Vector Borne Disease

272. What is the definitive test to diagnose psoriatic arthropathy?

arthritis and a similar comparison is undertaken in an age-matched and sex-matched normal population, rheumatoid factor positivity generally is found to be comparable in both groups. The erythrocyte sedimentation rate may be elevated in patients with active psoriatic joint disease, but elevations higher than 100 mm/h (Westergren method) are uncommon. Severe skin and joint disease may be associated with a mild normochromic normocytic anemia and leukocytosis. Acute phase reactants, such as alpha2

2005 TRIP Answers

273. A Novel Mutation of the Spectrin Gene

to normal and a novel Sp mutation. Quantitation of RBC membrane proteins of the propositus with atypical non-microcytic HPP revealed 48% spectrin dimers (control 10%) due to a marked increase in the 74kD I Sp peptide. There was only a slight decrease in the spectrin/band 3 ratio, which correlated with the normocytic morphology. There was also an abnormal Sp peptide at 41kD suggesting presence of LELY. Sequencing of his Sp gene revealed heterozygosity for a novel mutation in exon 2, codon 34: CGG->CCG (...) by University of Utah: Spectrin Gene Hereditary Elliptocytosis (HE) Hereditary Pyropoikilocytosis (HPP) Genetics Additional relevant MeSH terms: Layout table for MeSH terms Elliptocytosis, Hereditary Anemia, Hemolytic, Congenital Anemia, Hemolytic Anemia Hematologic Diseases Genetic Diseases, Inborn

2008 Clinical Trials

274. Examining Risk Factors for Atypical Antipsychotic Metabolic Side Effects

, or normocytic anemia with a B12 deficiency Inclusion criteria for Phase 2B: At least 18 years old and presence of a DSM-IV diagnosis of schizophrenia, schizophreniform disorder, schizoaffective disorder, or psychosis NOS Receiving atypical antipsychotic medication for at least 6 months Currently meet ≥ 2 of the NCEP-ATP-III criteria for metabolic syndrome No medication changes within the last two months Vitamin B12 levels within normal laboratory levels No illicit drug use in the past month Exclusion

2008 Clinical Trials

275. An unusual complication of CSOM — Lateral sinus thrombosis with lung abscess: A clinicoradiological study Full Text available with Trip Pro

medicine. Chest examination revealed dull areas on percussion and areas with bronchial breath sounds on auscultation bilaterally. Otological examination revealed right attic retraction pocket filled with cholesteatoma, post-auricular tenderness and Greisinger's sign along with foul smelling muco-purulent discharge.Routine blood investigations revealed normocytic normochromic anaemia, polymorpho-nuclear leucocytosis and raised ESR. Audiological investigations showed a right-sided mixed hearing loss

2007 Indian Journal of Otolaryngology and Head & Neck Surgery

276. The numb chin syndrome as an early manifestation of giant-cell (temporal) arteritis: a case report. (Abstract)

The numb chin syndrome as an early manifestation of giant-cell (temporal) arteritis: a case report. We describe a 70-year-old woman with a 2-month history of a numb chin and gradually increasing bilateral headache and malaise. Neurological examination disclosed chin hypoesthesia while investigations showed a normocytic anemia, ESR of 100, and CRP of 72. A CT brain scan, chest X-ray, and bone scan showed no evidence of malignancy. Temporal arteritis was suspected and prednisolone started

2005 Headache

277. Folic acid deficiency modifies the haematopoietic response to recombinant human erythropoietin in maintenance dialysis patients. Full Text available with Trip Pro

) patients with normocytic normochromic anaemia. Nineteen patients received erythropoietin-alpha intravenously thrice weekly. The study design was a prospective crossover (ABA) comparison of the effects of intravenously administered high doses of folic acid on haemoglobin levels and EPO doses, with 6 months active supplementation (B) and two periods of 6 months duration each without folic acid supplementation (A).The two patient groups did not differ at recruitment. Red blood cell folate levels were (...) normal in patients with normocytic anaemia, but they were subnormal in all patients with macrocytic anaemia. Compared to the first period without folic acid supplementation, patients with macrocytic anaemia had significantly higher haemoglobin levels despite lower EPO doses after 6 months high-dose folic acid, and red cells had become normocytic. The removal of folic acid supplementation resulted in re-occurrence of macrocytosis and in a significantly lower response to rHu-EPO. In contrast, high-dose

2006 Transplantation

278. Lead poisoning from a toy necklace. (Abstract)

Lead poisoning from a toy necklace. A 4-year-old, previously healthy boy experienced intermittent abdominal pain for several weeks. He was diagnosed with probable gastroenteritis, but his symptoms worsened. Laboratory tests revealed normocytic anemia, and an abdominal radiograph showed a metallic foreign body in the stomach, without evidence of obstruction. Endoscopy resulted in the retrieval of a quarter and a medallion pendant from the stomach. A venous blood lead level measurement

2004 Pediatrics

279. Low testosterone and high C-reactive protein concentrations predict low hematocrit in type 2 diabetes. Full Text available with Trip Pro

concentration (r = 0.41; P < 0.0004). Patients with CRP <3 mg/l had a higher hematocrit (42.7 +/- 0.7%) than those with CRP >3 mg/l (39.9 +/- 1.1%; P < 0.05). The prevalence of normocytic normochromic anemia (hemoglobin <13 g/dl) was 23% in the entire group, whereas it was 37.8% in the men with hypogonadotrophic hypogonadism and 3% in the eugonadal men (P < 0.01). Erythropoietin concentration was elevated or high normal in all 11 patients with anemia in whom it was tested.We conclude that hypogonadotrophic (...) hypogonadism in male type 2 diabetic subjects is associated with a lower hematocrit and a frequent occurrence of mild normocytic normochromic anemia with normal or high erythropoietin concentrations. In these patients, hematocrit is also inversely related to CRP concentration. Thus, low testosterone and chronic inflammatory mechanisms may contribute to mild anemia. Such patients may also have a high risk of atherosclerotic cardiovascular events in view of their markedly elevated CRP concentrations.

2006 Diabetes Care

280. The prevalence, nature, and importance of hematologic abnormalities in heart failure. (Abstract)

The prevalence, nature, and importance of hematologic abnormalities in heart failure. Anemia is an adverse prognostic marker in heart failure (HF), but its cause and relationships with other comorbidities are uncertain.All index emergency HF admissions to one urban hospital during the year 2000 were studied.Of 528 consecutive admissions with HF, 45% of patients (51% men and 38% women) had anemia (Hb <13 g/dL in men and <11.5 in women), which was usually normocytic. Anemia was equally common (...) ). One hundred twenty-five (54%) anemic patients died, compared with 93 (32%) nonanemic patients (P < .00001), and anemia was a predictor of death (in patients with reduced or preserved systolic function) and death or hospital readmission.Renal dysfunction is one probable cause of anemia in HF. The overlap of anemia and lymphopenia suggest that hematopoiesis may be more generally depressed. Anemia is a predictor of adverse outcome in HF, irrespective of systolic function.

2006 American Heart Journal

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