How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

260 results for

Normocytic Anemia

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

181. Crohn Disease (Overview)

the large joints (eg, hips, knees, ankles) See for more detail. Diagnosis Laboratory data for Crohn disease are nonspecific, as follows: The CBC may show hypochromic microcytic anemia, from iron deficiency due to GI blood loss, or normocytic anemia of chronic disease levels of acute-phase reactants (ESR and CRP) are often elevated in patients with Crohn disease but may be normal Hypoalbuminemia is common Additional common deficiencies include iron and micronutrients (eg, folic acid, vitamin B-12, serum (...) in approximately 45% of patients Tanner staging may indicate pubertal delay, which may precede the onset of intestinal symptoms The most common cutaneous manifestations are erythema nodosum and pyoderma gangrenosum Skin examination may also reveal pallor in patients with anemia or jaundice in those with concomitant liver disease The most common ocular findings are episcleritis and anterior uveitis The most common extraintestinal manifestations of Crohn disease are arthritis and arthralgia, typically involving

2014 eMedicine Pediatrics

182. Hepatoblastoma (Overview)

abdomen: Rare; occur if the tumor ruptures Severe anemia: Occurs occasionally, as a result of tumor rupture and hemorrhage See for more detail. Diagnosis Lab studies Complete blood count (CBC) with differential: Normochromic normocytic anemia and thrombocytosis may be present Liver enzyme levels: Moderately elevated in 15-30% of patients α-fetoprotein (AFP) - levels in hepatoblastoma are often as high as 100,000-300,000 mcg/mL Imaging studies Radiography: Reveals mass in the right upper quadrant

2014 eMedicine Pediatrics

183. Myelofibrosis (Overview)

blood abnormalities (eg, normocytic anemia, thrombocytopenia, or leukocytosis with left shift) Endocrinologic testing (eg, hyper- or hypoparathyroidism) Rheumatologic evaluation Blood urea nitrogen (BUN) and creatinine testing (to rule out renal dysfunction) Coombs (direct antiglobulin) test Purified protein derivative (PPD) test Chromosomal analysis in any child with onset before age 2 years The following imaging studies may be helpful: Abdominal ultrasonography Abdominal computed tomography (CT (...) relative. Clinical symptoms may be mild; some patients are asymptomatic at presentation. Manifestations of disease may include, but are not limited to, the following: Pallor (anemia) Bruising, petechiae, or bleeding (thrombocytopenia) Fever Weight loss Night sweats Bone pain Left upper quadrant pain Splenomegaly (frequent), hepatomegaly, or lymphadenopathy [ ] Stigmata of a predisposing condition See for more detail. Diagnosis Laboratory testing may include the following: Evaluation for peripheral

2014 eMedicine Pediatrics

184. Lead Poisoning

calcification in the cerebellar hemispheres and minor calcification in the subcortical area of the cerebral hemispheres and basal ganglia. In addition, T2-weighted MRI showed high signal intensity in the periventricular white matter, basal ganglia, insula, posterior thalamus, and pons. The patient in the study by Schrote et al had a 25-year history of normochromic normocytic anemia with moderate basophilic stippling, mild renal failure, hyperuricemia, and abnormal porphyrins. The patient also reported (...) and its owner. The patient had worked on refurbished houses, removing old paint, and complained of decreased cognition, fatigue, and muscle cramps. He had a depressed affect, postural tremor, right-arm weakness with partial denervation on electromyelography, and borderline-low sensory nerve action potential amplitudes. A mild anemia and elevated serum and urine lead levels supported a diagnosis of lead neuropathy. Chelation therapy led to an increase in urine lead excretion without symptomatic

2014 eMedicine Radiology

185. Hypopituitarism (Treatment)

of osteoporosis due to decreased bone density and result in hypogonadism in men and women. In men, symptoms include decreased libido, varying degrees of erectile dysfunction, decreased ejaculate, muscle weakness, and fatigue. Men with long-standing hypogonadism have decreased hair growth, soft testes, and gynecomastia. Patients may be anemic due to decreased erythropoietin production, which causes a normochromic, normocytic anemia. Pubic and axillary hair growth is usually normal unless a concomitant ACTH (...) , decreased axillary and pubic hair, anemia of chronic disease, dilutional hyponatremia, hypoglycemia, hypotension, and shock. Symptoms are nearly identical to those of primary adrenal insufficiency but can be differentiated by lack of hyperpigmentation. Hyperpigmentation occurs in a long feedback loop in which a cortisol deficiency results in increased production of ACTH by the pituitary. The ACTH precursor coupled to melanocyte-stimulating hormone is not produced in patients with pituitary disease

2014 eMedicine Emergency Medicine

186. Hypopituitarism (Overview)

of osteoporosis due to decreased bone density and result in hypogonadism in men and women. In men, symptoms include decreased libido, varying degrees of erectile dysfunction, decreased ejaculate, muscle weakness, and fatigue. Men with long-standing hypogonadism have decreased hair growth, soft testes, and gynecomastia. Patients may be anemic due to decreased erythropoietin production, which causes a normochromic, normocytic anemia. Pubic and axillary hair growth is usually normal unless a concomitant ACTH (...) , decreased axillary and pubic hair, anemia of chronic disease, dilutional hyponatremia, hypoglycemia, hypotension, and shock. Symptoms are nearly identical to those of primary adrenal insufficiency but can be differentiated by lack of hyperpigmentation. Hyperpigmentation occurs in a long feedback loop in which a cortisol deficiency results in increased production of ACTH by the pituitary. The ACTH precursor coupled to melanocyte-stimulating hormone is not produced in patients with pituitary disease

2014 eMedicine Emergency Medicine

187. Pyruvate Kinase Deficiency (Diagnosis)

a splenectomy and cholecystectomy. In patients who had a splenectomy without simultaneous cholecystectomy, 48% later required a cholecystectomy. [ ] (See the image below.) Peripheral blood smear in a child with splenectomy and pyruvate kinase deficiency. Signs and symptoms The following are evident in pyruvate kinase deficiency: Mild to severe normochromic and normocytic anemia Reticulocytosis Symmetrical growth delay Failure to thrive Cholecystolithiasis: Usually after the first decade of life but possibly (...) Reticulocyte count Serum bilirubin level study Peripheral blood film examination Normochromic, normocytic, or macrocytic anemia, together with reticulocytosis in the absence of blood loss, is suggestive of hemolysis. A negative Coombs test result helps to exclude immune hemolysis. The enzyme activity rate in most patients with pyruvate kinase deficiency is 5-25% of normal, with measurement of the intermediates (2,3-diphosphoglycerol and glucose-6-phosphate) proximal to the enzyme defect helping to confirm

2014 eMedicine.com

188. Lecithin-Cholesterol Acyltransferase Deficiency (Diagnosis)

of the mutated gene product. However, numerous other lab studies can be used in the diagnosis of these diseases. Lab findings in familial LCAT deficiency include the following: Complete blood count (CBC) - Normochromic normocytic anemia with anisopoikilocytosis, target cells, stomatocytes, and hematologic evidence of hemolysis may be present Urinalysis - Proteinuria is commonly detected during the second or third decade of life; less common findings include hyaline and granular casts and red blood cells (...) , and erythrocytes. Patients may present with HDL deficiency, corneal opacification, hemolytic anemia, hypertension, hypertriglyceridemia, and proteinuria. Fish eye disease is characterized by partial reduction of LCAT and only manifests as progressive corneal opacification. Occurrence Familial LCAT deficiency and fish eye disease are rare. Out of 70 families screened worldwide, at least 60 patients with either familial LCAT deficiency or fish eye disease have been reported. [ ] Race- and age-related

2014 eMedicine.com

189. Hyperglucagonemia (Diagnosis)

, necrolytic migratory erythema (NME), and diabetes. [ , , , , , , ] The diabetes mellitus associated with glucagonoma syndrome tends to be mild and usually can be controlled with diet and/or oral hypoglycemic agents. Typically, the associated anemia is normochromic normocytic, although macrocytic anemia has been described in some patients. is thought to occur in as many as 30% of patients with glucagonoma syndrome. Diagnosis is aided by the typical skin appearance of patients with NME

2014 eMedicine.com

190. Pure Red Cell Aplasia (Diagnosis)

Updated: May 03, 2017 Author: Paul Schick, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Pure Red Cell Aplasia Overview Practice Essentials Pure red cell aplasia (PRCA) is an uncommon disorder in which maturation arrest occurs in the formation of erythrocytes. [ , ] Erythroblasts are virtually absent in bone marrow; however, white blood cell and platelet production are normal. The anemia due to PRCA is usually normocytic but can be macrocytic. In 1922 (...) , Kaznelson recognized that this condition was a different entity from , which presents as pancytopenia. The characteristics of PRCA (see ) include the following: Severe anemia Reticulocyte count <1% The presence of less than 0.5% mature erythroblasts in the bone marrow Normocellular bone marrow in most cases The etiology of PRCA is heterogeneous. A congenital form of PRCA was initially described by Joseph in 1936 and by Diamond and Blackfan in 1938. Congenital PRCA is a lifelong disorder

2014 eMedicine.com

191. Hematologic Disease and Pregnancy (Diagnosis)

or normocytic anemia etiologies are as follows: Hemorrhagic anemia Early iron deficiency anemia Anemia of chronic disease Anemia associated with bone marrow suppression Anemia associated with chronic renal insufficiency Anemia associated with endocrine dysfunction Autoimmune hemolytic anemia Anemia associated with hypothyroidism or hypopituitarism Hereditary spherocytosis Hemolytic anemia associated with paroxysmal nocturnal hemoglobinuria MCV greater than 100 fL or macrocytic anemia etiologies (...) Hematologic Disease and Pregnancy (Diagnosis) Anemia and Thrombocytopenia in Pregnancy: Anemias in Pregnancy, Sickle Cell Hemoglobinopathies in Pregnancy, Thalassemias in Pregnancy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

192. Acute Myelocytic Leukemia (Diagnosis)

and additional marrow studies. The World Health Organization (WHO) classifies AML into groups as follows (rarely used in pediatrics): AML with characteristic cytogenetic translocations AML with multilineage dysplasia AML and myelodysplasia syndromes secondary to therapy AML not otherwise categorized Testing The hallmark of AML is the reduction or absence of normal hematopoietic elements. Anemia is usually normocytic, with a lower-than-expected reticulocyte count for the hemoglobin level. The decrease (...) with notable morbidity and mortality. Signs and symptoms Signs and symptoms of pediatric acute myelocytic leukemia (AML) can be divided into the following: (1) those caused by a deficiency of normally functioning cells, (2) those due to the proliferation and infiltration of the abnormal leukemic cell population, and (3) constitutional symptoms. Symptoms due to a deficiency of normally functioning cells include the following: Cytopenias: Can result from a deficiency of normally functioning cells Anemia

2014 eMedicine Pediatrics

193. Wegener Granulomatosis (Overview)

squamous cell carcinoma have been reported Additional findings Cardiac: Pericardial rub, myocardial infarction, or sudden death Gastrointestinal: Abdominal pain may be present with splanchnic vasculitis See for more detail. Diagnosis Routine laboratory tests are nonspecific in GPA. Results may include the following: Abnormal kidney function tests and urinalysis in patients with renal involvement Rheumatoid factor is positive in a low titer in two thirds of patients CBC: Mild normochromic normocytic (...) anemia is present in 50% of patients; leukocytosis is common, with a neutrophil predominance Elevated inflammatory markers (ESR, CRP) Antineutrophil cytoplasmic antibody (ANCA) testing Cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA) directed against PR3 is most specific for GPA Some patients with GPA express perinuclear-staining ANCA (p-ANCA) specific for myeloperoxidase (MPO) Combining immunofluorescence and ELISA enhances the sensitivity and specificity of a diagnosis of an ANCA-associated

2014 eMedicine Pediatrics

194. Wegener Granulomatosis (Diagnosis)

of patients CBC: Mild normochromic normocytic anemia is present in 50% of patients; leukocytosis is common, with a neutrophil predominance Elevated inflammatory markers (ESR, CRP) Antineutrophil cytoplasmic antibody (ANCA) testing Cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA) directed against PR3 is most specific for GPA Some patients with GPA express perinuclear-staining ANCA (p-ANCA) specific for myeloperoxidase (MPO) Combining immunofluorescence and ELISA enhances the sensitivity

2014 eMedicine Pediatrics

195. Hypopituitarism (Diagnosis)

of osteoporosis due to decreased bone density and result in hypogonadism in men and women. In men, symptoms include decreased libido, varying degrees of erectile dysfunction, decreased ejaculate, muscle weakness, and fatigue. Men with long-standing hypogonadism have decreased hair growth, soft testes, and gynecomastia. Patients may be anemic due to decreased erythropoietin production, which causes a normochromic, normocytic anemia. Pubic and axillary hair growth is usually normal unless a concomitant ACTH (...) , decreased axillary and pubic hair, anemia of chronic disease, dilutional hyponatremia, hypoglycemia, hypotension, and shock. Symptoms are nearly identical to those of primary adrenal insufficiency but can be differentiated by lack of hyperpigmentation. Hyperpigmentation occurs in a long feedback loop in which a cortisol deficiency results in increased production of ACTH by the pituitary. The ACTH precursor coupled to melanocyte-stimulating hormone is not produced in patients with pituitary disease

2014 eMedicine Emergency Medicine

196. Hypopituitarism (Follow-up)

of osteoporosis due to decreased bone density and result in hypogonadism in men and women. In men, symptoms include decreased libido, varying degrees of erectile dysfunction, decreased ejaculate, muscle weakness, and fatigue. Men with long-standing hypogonadism have decreased hair growth, soft testes, and gynecomastia. Patients may be anemic due to decreased erythropoietin production, which causes a normochromic, normocytic anemia. Pubic and axillary hair growth is usually normal unless a concomitant ACTH (...) , decreased axillary and pubic hair, anemia of chronic disease, dilutional hyponatremia, hypoglycemia, hypotension, and shock. Symptoms are nearly identical to those of primary adrenal insufficiency but can be differentiated by lack of hyperpigmentation. Hyperpigmentation occurs in a long feedback loop in which a cortisol deficiency results in increased production of ACTH by the pituitary. The ACTH precursor coupled to melanocyte-stimulating hormone is not produced in patients with pituitary disease

2014 eMedicine Emergency Medicine

197. Pyruvate Kinase Deficiency (Treatment)

a splenectomy and cholecystectomy. In patients who had a splenectomy without simultaneous cholecystectomy, 48% later required a cholecystectomy. [ ] (See the image below.) Peripheral blood smear in a child with splenectomy and pyruvate kinase deficiency. Signs and symptoms The following are evident in pyruvate kinase deficiency: Mild to severe normochromic and normocytic anemia Reticulocytosis Symmetrical growth delay Failure to thrive Cholecystolithiasis: Usually after the first decade of life but possibly (...) Reticulocyte count Serum bilirubin level study Peripheral blood film examination Normochromic, normocytic, or macrocytic anemia, together with reticulocytosis in the absence of blood loss, is suggestive of hemolysis. A negative Coombs test result helps to exclude immune hemolysis. The enzyme activity rate in most patients with pyruvate kinase deficiency is 5-25% of normal, with measurement of the intermediates (2,3-diphosphoglycerol and glucose-6-phosphate) proximal to the enzyme defect helping to confirm

2014 eMedicine.com

198. A 62-year-old man with fluctuating neurological deficits and skin lesions. (PubMed)

a maculopapular and erythematous rash in the groin, genitalia, and buttocks. The results of an initial neurological examination were normal, including his higher mental functions. An initial blood workup revealed normocytic normochromic anemia. The results of cerebrospinal fluid studies were unremarkable. Magnetic resonance imaging of his brain at hospital admission revealed multifocal increased T2 signals in the subcortical white matter. A conventional cerebral angiogram was unremarkable. A biopsy specimen

Full Text available with Trip Pro

2013 JAMA neurology

199. Late stage erythroid precursor production is impaired in mice with chronic inflammation. (PubMed)

Late stage erythroid precursor production is impaired in mice with chronic inflammation. We and others have shown previously that over-expression of hepcidin antimicrobial peptide, independently of inflammation, induces several features of anemia of inflammation and chronic disease, including hypoferremia, sequestration of iron stores and iron-restricted erythropoiesis. Because the iron-restricted erythropoiesis evident in hepcidin transgenic mice differs from the normocytic, normochromic (...) anemia most often observed in anemia of inflammation, we tested the hypothesis that chronic inflammation may contribute additional features to anemia of inflammation which continue to impair erythropoiesis following the acute phase of inflammation in which hepcidin is active.We compared erythropoiesis and iron handling in mice with turpentine-induced sterile abscesses with erythropoiesis and iron handling in hepcidin transgenic mice. We compared erythrocyte indices, expression of genes

Full Text available with Trip Pro

2012 Haematologica

200. Phase II, Single-Center, Oral Panobinostat in Combination With Lenalidomide and Dexamethasone in Multiple Myeloma (MM)

Working Group criteria (IMWG, 2003), as defined as the following three criteria: Clonal plasma cells >10% on bone marrow biopsy A monoclonal protein (paraprotein) in either serum or urine(except in cases of non-secretory myeloma) Evidence of end-organ damage felt related to the plasma cell disorder (related organ or tissue impairment, ROTI, commonly referred to by the acronym "CRAB"): Hypercalcemia serum Ca ≥ 11.5 mg/dL or Renal insufficiency attributable to myeloma. Serum creatinine > 2mg/dL Anemia (...) : Normochromic, normocytic with a hemoglobin value > 2g/dL below the lower limit of normal or a hemoglobin <10 g/dL Bone lesions (lytic lesions, severe osteopenia or pathologic fractures Patients must have received at least one prior line of therapy. For example; One prior line of therapy may consist of all predetermined components of induction followed by autologous stem cell transplantation and maintenance. Patient has relapsed or relapsed/refractory MM. Relapsed is defined as the development of disease

2012 Clinical Trials

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>