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Normocytic Anemia

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1. Normocytic Anemia

Normocytic Anemia Normocytic Anemia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Normocytic Anemia Normocytic Anemia Aka (...) : Normocytic Anemia , Anemia of Chronic Disease From Related Chapters II. Evaluation MCV High normal MCV: Evaluate as Serum (TSH) Low normal MCV: Evaluate as High causes Obtain labs Positive labs ( ) Membrane disorders Enzyme defects Negative labs Bleeding without Hypersplenism recovery Normal (suggests hypofunction) Medical disease Consider tests, s, TSH Consider Inflammation See Anemia of Chronic Disease causes below disorder III. Causes: Anemia of Chronic Disease Chronic Inflammation Infection (e.g

2018 FP Notebook

2. CRACKCAST E121 – Anemia, Polycythemia, and White Blood Cell Disorders

unexplained Hb <80 or hematocrit <30% Difficulty obtaining outpatient care when Hb significantly low or major comorbidity [4] Classify the anemias according to MCV Refer to box 112.5 for classification of anemias according to MCV Microcytic (low MCV, hypochromic) T halassemia A nemia of chronic disease I ron deficiency L ead poisoning S ideroblastic anemia Normocytic (normal MCV) Primary bone marrow problem: aplastic anemia, myeloid metaplasia with myelofibrosis, myelophthisic anemia Secondary (...) to underlying disease: hypothyroid, hypoadrenal, hypopituitary, uremia, chronic inflammation, liver disease Macrocytic (high MCV) Vit B12 deficiency / Folate deficiency Liver disease Hypothyroidism [5] What is the differential diagnosis of normocytic anemia? See above [6] What are the 3 different types of thalassemia? Homozygous beta-chain thalassemia (Thalassemia major) Mediterranean, severe anemia, most common single gene disoder Heterozygous beta-chain thalassemia (Thalassemia minor) Mild anemia, mostly

2017 CandiEM

3. Normocytic Anemia

Normocytic Anemia Normocytic Anemia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Normocytic Anemia Normocytic Anemia Aka (...) : Normocytic Anemia , Anemia of Chronic Disease From Related Chapters II. Evaluation MCV High normal MCV: Evaluate as Serum (TSH) Low normal MCV: Evaluate as High causes Obtain labs Positive labs ( ) Membrane disorders Enzyme defects Negative labs Bleeding without Hypersplenism recovery Normal (suggests hypofunction) Medical disease Consider tests, s, TSH Consider Inflammation See Anemia of Chronic Disease causes below disorder III. Causes: Anemia of Chronic Disease Chronic Inflammation Infection (e.g

2015 FP Notebook

4. Chronic anemia due to mitomycin C is drug dose-dependent, normocytic, progressive, related to erythropoietin levels and quantitatively predictable: implications for radiochemotherapy. (PubMed)

Chronic anemia due to mitomycin C is drug dose-dependent, normocytic, progressive, related to erythropoietin levels and quantitatively predictable: implications for radiochemotherapy. Mitomycin C (MC) is used as therapy against solid tumors, also combined with other chemotherapeutic agents or radiotherapy. It may cause acute, subacute, or chronic anemia capable of modifying the results of chemo- and radiotherapy. Erythropoietin may be lowered by cancer itself or because of chemoradiotherapy (...) . There are few studies investigating the relationship between erythropoietin and chronic anemia.We prospectively analyzed the chronic anemia and erythropoietin in 38 patients with solid cancer. Patients were 40 to 82 years of age. MC was randomly given every 3 weeks as a single drug at 10 or 20 mg/m². When myelotoxicity occurred the next therapy cycle was delayed until recovery. RBC indices, hemolysis, erythropoietin, liver and kidney function were studied. MC cycles were 136 (3.6 ± 1.4 per pt), 32 being

2011 Journal of chemotherapy (Florence, Italy)

5. Classification of Anemias

-normal TIBC & transferrin saturation, only ~25% microcytic , Hemoglobinopathy, Lead Overload , Thalassemia normal TIBC, normal to ? serum iron & transferrin saturation major high RDW & minor normal RDW ; Sideroblastic anemia ? RDW MCV 80-100 fL Normocytic anemia Consider loss of blood, Reticulocyte count Blood loss, Hemolysis ? No blood loss ? Treat cause GI or menstrual bleed (Use of ASA/NSAIDs, warfarin etc.), high reticulocyte Anemia of chronic dx normal- ? RDW, low serum iron, low-normal TIBC (...) Classification of Anemias Classification of Anemias 1,2 {Normal hemoglobin (Hgb) Male: 130-180g/L; Female:120-160 g/L; ? Hgb if live at high altitude, ? Hgb if live near the coast}. © www.RxFiles.ca Mar 2017 Red Cell Indices Laboratory Investigations Findings Differential Diagnosis MCV 20mcg/L ? Iron deficiency anemia (IDA) high RDW, low-normal reticulocyte, low serum iron with high TIBC, ? transferrin, ? transferrin saturation & ferritin. Anemia chronic dx normal- ? RDW, low serum iron, low

2014 RxFiles

6. Prevalence of anemia among adults at Hawassa University referral hospital, Southern Ethiopia. (PubMed)

of anemia in the study was 13%. Majority of cases had mild anemia 58.5%, while 19.0%, and 22.5% of the patients had moderate and severe anemia respectively. Overall, the prevalence of mild anemia increases with age, while the prevalence of moderate and severe anemia decreases as age increases. In the present study, the most common anemia was normocytic, which mostly occur in the elderly (61-85) years of age.The CBC parameters help to diagnose and classify anemia in to major components, which might help (...) Prevalence of anemia among adults at Hawassa University referral hospital, Southern Ethiopia. Anemia is a public health problem in Ethiopia. In spite of the fact that anemia is a common health burden with much severe consequences, the prevalence of the different types of anemia and its severity have not yet been well documented in different parts of the country. The study aimed to assess the prevalence of different types of anemia, including severity and association with age and sex of study

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2019 BMC Hematology

7. Association of active Helicobacter pylori infection and anemia in elderly males. (PubMed)

for anemia of the H. pylori positive group was 2.53 (P = .033). No correlation between H. pylori infection and serum iron and ferritin levels was found. The mean corpuscular volume of the H. pylori positive and negative group was 91.17 ± 3.94 fl and 91.17 ± 4.09 fl (mean ± SD), respectively (P = .986). The CRP level in the H. pylori positive group was higher than that in the H. pylori negative group (Median: 0.17 mg/dL vs. 0.10 mg/dL, P < .001).H. pylori infection seems to be associated with normocytic (...) Association of active Helicobacter pylori infection and anemia in elderly males. The prevalence of Helicobacter pylori (H. pylori) infection increases with age. However, the relationship between H. pylori infection and anemia in the elderly population remains to be identified. The aim of this study is to explore whether H. pylori infection is associated with anemia in a male elderly cohort.A cross-sectional study was designed using data collected from asymptomatic male senior citizens (≥ 65

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2019 BMC Infectious Diseases

8. Prevalence of preoperative anemia, abnormal mean corpuscular volume and red cell distribution width among surgical patients in Singapore, and their influence on one year mortality. (PubMed)

achieved 1 year follow-up. Anemia prevalence was 27.8%-mild anemia 15.3%, moderate anemia 12.0% and severe anemia 0.5%. One-year mortality was 3.5%. Anemia increased with age in males, while in females, anemia was more prevalent between 18-49 years and > = 70 years. Most anemics were normocytic. Normocytosis and macrocytosis increased with age, while microcytosis decreased with age. Older age, male gender, higher ASA-PS score, anemia (mild- aHR 1.98; moderate/severe aHR 2.86), macrocytosis (aHR 1.47 (...) Prevalence of preoperative anemia, abnormal mean corpuscular volume and red cell distribution width among surgical patients in Singapore, and their influence on one year mortality. Preoperative anemia and high red cell distribution width (RDW) are associated with higher perioperative mortality. Conditions with high RDW levels can be categorized by mean corpuscular volume (MCV). The relationship between RDW, anemia and MCV may explain causality between high RDW levels and outcomes. We aim

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2017 PLoS ONE

9. Anemia and Adverse Outcomes in a Chronic Obstructive Pulmonary Disease Population with a High Burden of Comorbidities. An Analysis from SPIROMICS. (PubMed)

with outcomes in a large, well-characterized COPD cohort, and attempts to understand the contribution of anemia to outcomes and phenotypes in individuals with other comorbidities.Participants with COPD from SPIROMICS (the Subpopulations and Intermediate Outcome Measures in COPD Study) were analyzed in adjusted models to determine the associations of normocytic anemia with clinical outcomes, computed tomographic measures, and biomarkers. Analysis was additionally performed to understand the independence (...) and possible interactions related to cardiac and metabolic comorbidities.A total of 1,789 individuals with COPD from SPIROMICS had data on hemoglobin, and of these 7.5% (n = 135) were found to have normocytic anemia. Anemic participants were older with worse airflow obstruction, a higher proportion of them were African Americans, and they had a higher burden of cardiac and metabolic comorbidities. Anemia was strongly associated with 6-minute walk distance (β, -61.43; 95% confidence interval [CI], -85.11

2018 Annals of the American Thoracic Society

10. Prevalence of anemia before and after initiation of antiretroviral therapy among HIV infected patients at Black Lion Specialized Hospital, Addis Ababa, Ethiopia: a cross sectional study. (PubMed)

and CD4+ T cell counts were found to be associated with the prevalence of anemia before ART initiation. Among the total number of anemic cases, normocytic normochromic anemia was present in 71% of the cases before ART and in 58.6% of the cases after ART. The prevalence of macrocytic normochromic anemia before and after ART initiation was 4.7 and 27.6% respectively.It is evident from this study that there is a remarkable reduction in the prevalence of anemia after ART initiation. However, a significant (...) Prevalence of anemia before and after initiation of antiretroviral therapy among HIV infected patients at Black Lion Specialized Hospital, Addis Ababa, Ethiopia: a cross sectional study. Anemia is the most common hematological abnormality in Human immunodeficiency virus (HIV) positive patients and a significant predictor of its progression to AIDS or death. This study was aimed to assess the prevalence of anemia before and after initiation of antiretroviral therapy (ART) among HIV positive

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2018 BMC Hematology

11. Preoperative anemia in colorectal cancer: relationships with tumor characteristics, systemic inflammation, and survival (PubMed)

and tumor characteristics, systemic inflammatory markers (modified Glasgow Prognostic Score: mGPS; serum levels of thirteen cytokines, C-reactive protein, albumin), and survival were analyzed. We found that anemia, most frequently normocytic, followed by microcytic, was present in 43% of the patients. Microcytic anemia was most commonly associated with proximal colon tumor location. Average MCV and blood hemoglobin levels were lower in tumors with high T-class. Low blood hemoglobin associated (...) with systemic inflammation, including high mGPS and high serum levels of C-reactive protein and IL-8. Particularly, normocytic anemia associated with higher mGPS. Normocytic anemia associated with a tendency towards worse overall survival (multivariate hazard ratio 1.61, 95% confidence interval 1.07-2.42, p = 0.023; borderline statistical significance considering multiple hypothesis testing). In conclusion, anemia in CRC patients is most frequently normocytic. Proximal tumor location is associated

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2018 Scientific reports

12. Macrocytic anemia is associated with the severity of liver impairment in patients with hepatitis B virus-related decompensated cirrhosis: a retrospective cross-sectional study. (PubMed)

evidently higher MELD scores (10.8 ± 6.6) than those with normocytic anemia (8.0 ± 5.5) or microcytic anemia (6.3 ± 5.1). The association remained robust after adjusting for age, gender, smoking, drinking, and total cholesterol (β = 1.94, CI: 0.81-3.07, P < 0.001).Macrocytic anemia was found to be associated with the severity of liver impairment and might be a predictor for short-term mortality in patients with HBV-related decompensated cirrhosis. (...) Macrocytic anemia is associated with the severity of liver impairment in patients with hepatitis B virus-related decompensated cirrhosis: a retrospective cross-sectional study. Macrocytic anemia is common in liver disease. However, its role in hepatitis B virus (HBV)-related decompensated cirrhosis remains unknown. The aim of the present study was to determine the association between macrocytic anemia and the severity of liver impairment in patients with HBV-related decompensated cirrhosis

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2018 BMC Gastroenterology

13. Anemia in elderly residents of a long-term care institution (PubMed)

men (54%).Anemia in the elderly is a clinical condition associated with increased morbimortality. However, the disorder remains underdiagnosed, resulting in higher risks for older adults. The present study found 76 patients with anemia among the 183 residents at the long-term care institution. The patient profile of this population with anemia is non-smokers, male, aged between 70 and 79 years, with normochromic/normocytic anemia and taking multiple medications. (...) Anemia in elderly residents of a long-term care institution The Brazilian elderly population is growing exponentially, making prevention and treatment of chronic diseases a priority in this age group. Anemia in older adults is underdiagnosed, undervalued and associated with high morbimortality.To assess the prevalence of anemia in the elderly residents of a long-term care institution and to correlate this with individual patient history, the use of polypharmacy and mortality.A retrospective

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2018 Hematology, Transfusion and Cell Therapy

14. Preoperative Anemia in Cardiac Operation: Does Hemoglobin Tell the Whole Story? (PubMed)

. Anemia was characterized as normocytic, microcytic, or macrocytic based on mean corpuscular volume (MCV). Models for hospital complications were developed using multivariable logistic regression. Other outcomes were postoperative transfusion and intensive care unit (ICU) and postoperative hospital lengths of stay.A total of 2,715 patients (26%) were anemic. Of these, 2,365 (87%) had normocytic, 219 (8.1%) microcytic, and 131 (4.8%) macrocytic anemia. Non-anemic patients (n = 2,041, 26%) received (...) transfusions compared with 1,553 (66%) normocytic, 148 (68%) microcytic, and 97 (74%) macrocytic anemia patients. Patients with normocytic or macrocytic anemia had more renal failure (normocytic: odds ratio (OR) 1.9, macrocytic: OR 3.5), other complications (normocytic: OR 1.3, macrocytic: OR 2.2) and death (normocytic: OR 2.0, macrocytic: OR 6.2) than non-anemic patients; patients with microcytic anemia had fewer reoperations (OR 0.35) and less postoperative atrial fibrillation (OR 0.50). Anemic patients

2017 Annals of Thoracic Surgery

15. Gender differences in the impact of anemia on subclinical myocardial damage and cardiovascular mortality in the general population: The Yamagata (Takahata) study. (PubMed)

higher in male subjects with anemia than those without, irrespective of the type of anemia (microcytic, normocytic, and macrocytic). Multivariate logistic regression analysis revealed that anemia was an independent predictor of myocardial damage after adjusting for confounders. During 10years of follow-up, there were 204 all-cause deaths including 57 cardiovascular deaths. Kaplan-Meier analysis demonstrated that cardiovascular mortality was higher in male subjects with anemia than in those without (...) Gender differences in the impact of anemia on subclinical myocardial damage and cardiovascular mortality in the general population: The Yamagata (Takahata) study. Anemia has been shown to worsen cardiovascular diseases. However, it is unclear whether there is a gender difference in the impact of anemia on subclinical myocardial damage and cardiovascular mortality in the general population.A prospective cohort study was conducted in a community based on annual health checks. Serum heart-type

2017 International journal of cardiology

16. Magnitude, Severity, and Morphological Types of Anemia in Hospitalized Children Under the Age of Five in Southern Tanzania (PubMed)

was 8.00g/dL, the interquartile range (IQR) was 4.40g/dL, and the prevalence of anemia was 83.17 percent. The magnitude of mild, moderate, and severe anemia was 9.13 percent, 44.84 percent, and 46.03 percent, respectively, and about half of all anemic children had normocytic anemia. Conclusion Severe anemia is a common health problem among hospitalized children under five years of age in the study area. We recommend screening all admitted children under the age of five for anemia, and clinicians should (...) Magnitude, Severity, and Morphological Types of Anemia in Hospitalized Children Under the Age of Five in Southern Tanzania Introduction Anemia is a significant public health problem among children and women globally. It is one of the most common causes of deaths among children admitted to hospitals in sub-Saharan Africa. Case fatality rates of 6 percent to 18 percent have been reported even in facilities that have blood transfusions services. The purpose of this study was to evaluate

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2017 Cureus

17. Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy (PubMed)

Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy Clinical copper deficiency is now more frequently recognized. Hematologically, it can present as anemia (microcytic, normocytic, or macrocytic) and neutropenia. Thrombocytopenia is relatively rare. Neurologically, it can manifest as myelopathy and peripheral neuropathy simulating subacute combined degeneration. Bone marrow findings can mimic myelodysplasia resulting in occasional inappropriate referral for bone marrow (...) transplantation. Other conditions with similar presentations include infections, drug toxicity, autoimmunity, B12 deficiency, folate deficiency, myelodysplastic syndrome, aplastic anemia, and lymphoma with bone marrow involvement. Hematological, but not neurological, manifestations respond promptly to copper replacement, making early diagnosis essential for good outcome. Common risk factors for copper deficiency are foregut surgery, dietary deficiency, enteropathies with malabsorption, and prolonged

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2017 Journal of community hospital internal medicine perspectives

18. α-klotho and anemia in patients with chronic kidney disease patients: A new perspective (PubMed)

α-klotho and anemia in patients with chronic kidney disease patients: A new perspective Normocytic normochromic anemia is a common complication of chronic kidney disease (CKD) and is associated with numerous adverse consequences. Certain symptoms previously attributed to CKD are now known to be a consequence of anemia. Anemia contributes to an increased cardiac output, and the development of left ventricular hypertrophy, angina and congestive heart failure, leading to high morbidity (...) and mortality in patients with CKD. The multifunctional α-klotho (KL) protein, which is predominantly expressed in the kidneys, is associated with the occurrence of anemia in patients with CKD. The present review presents current evidence on the potential role of α-KL in renal anemia. Low expression of α-KL appears to improve anemia in patients with CKD, and has been hypothesized to be a compensatory mechanism to attenuate the effects of anemia in patients with CKD. Further understanding of the role of α-KL

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2017 Experimental and therapeutic medicine

19. KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease

concentration, other reported results of the CBC may convey important clinical information. The anemia of CKD is hypoproliferative, and in general, normochromic and normocytic. In this regard it is morphologically indistinguishable from the anemia of chronic disease. 10 Folate or vitamin B 12 de?ciencies may lead to macrocytosis, whereas iron de?ciency or inherited disorders of Hb formation (e.g., a-or b-thalassemia) may produce microcytosis. Iron de?ciency, especially if long- standing, is associated (...) KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease VOLUME 2 | ISSUE 4 | AUGUST ?2? 2012 http://www.kidney-international.org OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY OF NEPHROLOGY KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease KI_SuppCover_2.4.indd 1 KI_SuppCover_2.4.indd 1 7/11/12 12:00 PM 7/11/12 12:00 PMKDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease KDIGO gratefully acknowledges the following consortium of sponsors

2012 National Kidney Foundation

20. Diamond Blackfan Anemia: A Nonclassical Patient With Diagnosis Assisted by Genomic Analysis (PubMed)

Diamond Blackfan Anemia: A Nonclassical Patient With Diagnosis Assisted by Genomic Analysis Diamond Blackfan anemia (DBA) is an inherited syndrome usually presenting with severe macrocytic anemia in infancy, paucity of erythroid precursors in the bone marrow, and congenital anomalies. We describe a child with mild, transfusion independent normocytic anemia whose diagnosis of DBA was established by identification of a novel de novo mutation disrupting normal splicing of the ribosomal protein

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2016 Journal of pediatric hematology/oncology

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