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Normal Pressure Hydrocephalus

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161. Differences in Cerebrospinal Fluid Biomarkers between Clinically Diagnosed Idiopathic Normal Pressure Hydrocephalus and Alzheimer’s Disease (PubMed)

Differences in Cerebrospinal Fluid Biomarkers between Clinically Diagnosed Idiopathic Normal Pressure Hydrocephalus and Alzheimer’s Disease In the present study, cerebrospinal fluid (CSF) profiles were assessed to determine how idiopathic normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD) differs.Subjects were drawn from patients who underwent lumbar punctures as part of their diagnostic evaluations in the Banner Sun Health Research Institute Memory Disorders clinic

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2014 Journal of Alzheimer's disease & Parkinsonism

162. Normal Pressure Hydrocephalus (Overview)

Normal Pressure Hydrocephalus (Overview) Normal Pressure Hydrocephalus: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE1MDkyNC1vdmVydmlldw== processing > Normal (...) Pressure Hydrocephalus Updated: Oct 19, 2018 Author: Michael J Schneck, MD, MBA; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections Normal Pressure Hydrocephalus Overview Practice Essentials Normal pressure hydrocephalus (NPH) is a clinical symptom complex caused by the build-up of cerebrospinal fluid. This condition is characterized by abnormal gait, urinary incontinence, and (potentially reversible) dementia. See the image below. T2-weighted MRI showing dilatation

2014 eMedicine.com

163. Normal Pressure Hydrocephalus (Treatment)

Normal Pressure Hydrocephalus (Treatment) Normal Pressure Hydrocephalus Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE1MDkyNC10cmVhdG1lbnQ (...) = processing > Normal Pressure Hydrocephalus Treatment & Management Updated: Oct 19, 2018 Author: Michael J Schneck, MD, MBA; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections Normal Pressure Hydrocephalus Treatment Medical Care A levodopa challenge may be helpful to rule out idiopathic Parkinson disease. Patients with normal pressure hydrocephalus (NPH) have no significant response to levodopa or dopamine agonists. Next: Surgical Care Surgical CSF shunting remains

2014 eMedicine.com

164. Normal Pressure Hydrocephalus (Follow-up)

Normal Pressure Hydrocephalus (Follow-up) Normal Pressure Hydrocephalus Follow-up: Prognosis, Patient Education Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE1MDkyNC1mb2xsb3d1cA== processing > Normal Pressure (...) Hydrocephalus Follow-up Updated: Oct 19, 2018 Author: Michael J Schneck, MD, MBA; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections Normal Pressure Hydrocephalus Follow-up Prognosis The overall prognosis of NPH remains poor both due to a lack of improvement in some patients following surgery as well as a significant complication rate. In a study by Vanneste et al, one of the more comprehensive studies described above, marked improvement was noted in only 21% of patients

2014 eMedicine.com

165. Normal Pressure Hydrocephalus (Diagnosis)

Normal Pressure Hydrocephalus (Diagnosis) Normal Pressure Hydrocephalus: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE1MDkyNC1vdmVydmlldw== processing > Normal (...) Pressure Hydrocephalus Updated: Oct 19, 2018 Author: Michael J Schneck, MD, MBA; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections Normal Pressure Hydrocephalus Overview Practice Essentials Normal pressure hydrocephalus (NPH) is a clinical symptom complex caused by the build-up of cerebrospinal fluid. This condition is characterized by abnormal gait, urinary incontinence, and (potentially reversible) dementia. See the image below. T2-weighted MRI showing dilatation

2014 eMedicine.com

166. Normal Pressure Hydrocephalus

Normal Pressure Hydrocephalus Imaging in Normal Pressure Hydrocephalus: Practice Essentials, Computed Tomography, Magnetic Resonance Imaging Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMzQyODI3LW92ZXJ2aWV3 (...) processing > Imaging in Normal Pressure Hydrocephalus Updated: Jan 23, 2018 Author: Lourdes Nunez-Atahualpa, MD; Chief Editor: James G Smirniotopoulos, MD Share Email Print Feedback Close Sections Sections Imaging in Normal Pressure Hydrocephalus Practice Essentials First described by Hakim and Adams in 1965, normal pressure hydrocephalus (NPH) refers to a clinical entity consisting of the triad of gait disturbance, dementia, and incontinence, coupled with the laboratory findings of normal cerebrospinal

2014 eMedicine Radiology

167. Surgical management of normal pressure hydrocephalus: a systematic review

Surgical management of normal pressure hydrocephalus: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect

2017 PROSPERO

168. A randomised trial of high and low pressure level settings on an adjustable ventriculoperitoneal shunt valve for idiopathic normal pressure hydrocephalus: results of the Dutch evaluation programme Strata shunt (DEPSS) trial. (PubMed)

A randomised trial of high and low pressure level settings on an adjustable ventriculoperitoneal shunt valve for idiopathic normal pressure hydrocephalus: results of the Dutch evaluation programme Strata shunt (DEPSS) trial. In treating idiopathic normal pressure hydrocephalus (INPH) with a shunt there is always a risk of underdrainage or overdrainage. The hypothesis is tested whether patients treated using an adjustable valve preset at the highest opening pressure leads to comparable good (...) clinical results with less subdural effusions than in a control group with an opening pressure preset at a low pressure level.A multicentre prospective randomised trial was performed on a total of 58 patients suspected of INPH. Thirty patients were assigned to (control) group 1 and received a Strata shunt (Medtronic, Goleta, USA) with the valve preset at a performance level (PL) of 1.0, while 28 patients were assigned to group 2 and received a Strata shunt with the valve preset at PL 2.5. In this group

2013 Neurosurgery and Psychiatry

169. Overdrainage shunt complications in idiopathic normal-pressure hydrocephalus and lumbar puncture opening pressure. (PubMed)

Overdrainage shunt complications in idiopathic normal-pressure hydrocephalus and lumbar puncture opening pressure. Management of idiopathic normal-pressure hydrocephalus (iNPH) is hard because the diagnosis is difficult and shunt surgery has high complication rates. An important complication is overdrainage, which often can be treated with adjustable-shunt valve manipulations but also may result in the need for subdural hematoma evacuation. The authors evaluated shunt surgery overdrainage (...) complications in iNPH and their relationship to lumbar puncture opening pressure (LPOP).The authors reviewed the charts of 164 consecutive patients with iNPH who underwent shunt surgery at their institution from 2005 to 2011. They noted age, sex, presenting symptoms, symptom duration, hypertension, body mass index (BMI), imaging findings of atrophy, white matter changes, entrapped sulci, LPOP, valve opening pressure (VOP) setting, number of valve adjustments, serious overdrainage (subdural hematoma

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2013 Journal of Neurosurgery

170. Miethke proSA® adjustable gravitational shunt for hydrocephalus

it is recommended that no further research on behalf of HealthPACT is warranted at this time. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Cerebrospinal Fluid Shuntss; Drainage; Gravitation; Hydrocephalus; Hydrocephalus, Normal Pressure; Intracranial Pressure Language Published English Country of organisation Australia English summary An English language summary is available. Address for correspondence 199 Ward Street, North Adelaide SA 5006, Australia Tel: +61 8 8219 0900, Fax (...) Miethke proSA® adjustable gravitational shunt for hydrocephalus Miethke proSA® adjustable gravitational shunt for hydrocephalus Miethke proSA® adjustable gravitational shunt for hydrocephalus Australian Safety and Efficacy Register of New Interventional Procedures -Surgical (ASERNIP-S) Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation

2014 Health Technology Assessment (HTA) Database.

171. A Trial of High and Low Pressure Level Settings on a Programmable Ventriculoperitoneal Shunt Valve for Idiopathic Normal Pressure Hydrocephalus

A Trial of High and Low Pressure Level Settings on a Programmable Ventriculoperitoneal Shunt Valve for Idiopathic Normal Pressure Hydrocephalus A Trial of High and Low Pressure Level Settings on a Programmable Ventriculoperitoneal Shunt Valve for Idiopathic Normal Pressure Hydrocephalus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Trial of High and Low Pressure Level Settings on a Programmable Ventriculoperitoneal Shunt Valve for Idiopathic Normal Pressure Hydrocephalus The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details

2012 Clinical Trials

172. The European iNPH Multicentre Study on the predictive values of resistance to CSF outflow and the CSF Tap Test in patients with idiopathic normal pressure hydrocephalus. (PubMed)

The European iNPH Multicentre Study on the predictive values of resistance to CSF outflow and the CSF Tap Test in patients with idiopathic normal pressure hydrocephalus. The objective was to determine the sensitivity, specificity, and positive and negative predictive values of the CSF Tap Test (CSF TT) and resistance to CSF outflow (Rout) for the outcome of shunting in a sample of patients with idiopathic normal pressure hydrocephalus (iNPH).115 patients were included in this European

2013 Neurosurgery and Psychiatry

173. Safety and efficacy of gravitational shunt valves in patients with idiopathic normal pressure hydrocephalus: a pragmatic, randomised, open label, multicentre trial (SVASONA). (PubMed)

Safety and efficacy of gravitational shunt valves in patients with idiopathic normal pressure hydrocephalus: a pragmatic, randomised, open label, multicentre trial (SVASONA). To investigate whether gravitational valves reduce the risk of overdrainage complications compared with programmable valves in ventriculoperitoneal (VP) shunt surgery for idiopathic normal pressure hydrocephalus (iNPH).Patients with iNPH may benefit from VP shunting but are prone to overdrainage complications during

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2013 Neurosurgery and Psychiatry

174. Predictors of subsequent overdrainage and clinical outcomes after ventriculoperitoneal shunting for idiopathic normal pressure hydrocephalus. (PubMed)

Predictors of subsequent overdrainage and clinical outcomes after ventriculoperitoneal shunting for idiopathic normal pressure hydrocephalus. Little is known about variables associated with overdrainage complications and neurofunctional and health-related quality of life outcomes in idiopathic normal-pressure hydrocephalus (iNPH) patients after shunt surgery.To identify candidate demographic and disease-specific predictors of overdrainage and patient-related outcomes, allowing for more

2013 Neurosurgery

175. The callosal angle measured on MRI as a predictor of outcome in idiopathic normal-pressure hydrocephalus. (PubMed)

The callosal angle measured on MRI as a predictor of outcome in idiopathic normal-pressure hydrocephalus. Different neuroimaging biomarkers have been studied to find a tool for prediction of response to CSF shunting in idiopathic normal-pressure hydrocephalus (iNPH). The callosal angle (CA) has been described as useful in discriminating iNPH from ventricular dilation secondary to atrophy. However, the usefulness of the CA as a prognostic tool for the selection of shunt candidates among patients

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2013 Journal of Neurosurgery

176. Association between Milder Brain Deformation before a Shunt Operation and Improvement in Cognition and Gait in Idiopathic Normal Pressure Hydrocephalus. (PubMed)

Association between Milder Brain Deformation before a Shunt Operation and Improvement in Cognition and Gait in Idiopathic Normal Pressure Hydrocephalus. We investigated the association between the degree of deformation of the brain before shunt operation and improvement of gait and cognitive impairment after shunt operation in 16 patients with idiopathic normal pressure hydrocephalus (iNPH). We evaluated gait and cognitive impairment and measured the cerebrospinal fluid volume in the ventricles

2013 Dementia and Geriatric Cognitive Disorders

177. Idiopathic normal-pressure hydrocephalus: Pathophysiology and diagnosis by CSF biomarkers. (PubMed)

Idiopathic normal-pressure hydrocephalus: Pathophysiology and diagnosis by CSF biomarkers. This observational study aimed to explore the pathophysiology of idiopathic normal-pressure hydrocephalus (iNPH) and to evaluate the diagnostic and prognostic value of CSF biomarkers.Lumbar CSF of patients with iNPH and healthy elderly individuals (HI) and ventricular CSF (VCSF) from the patients with iNPH pre and 6 months postsurgery were analyzed by ELISA. We analyzed neurofilament light protein (NFL

2013 Neurology

178. Natural course of idiopathic normal pressure hydrocephalus. (PubMed)

Natural course of idiopathic normal pressure hydrocephalus. The natural course of idiopathic normal pressure hydrocephalus (iNPH) has not been thoroughly studied. The consequences of postponing shunt treatment are largely unknown. We aimed to describe the effects of waiting for more than 6 months before surgery and to compare the outcome with that seen in patients who waited for less than 3 months.33 patients (iNPHDelayed) underwent an initial investigation (Pre-op 1), followed by re

2013 Neurosurgery and Psychiatry

179. Role of Endoscopic Third Ventriculostomy and Ventriculoperitoneal Shunt in Idiopathic Normal Pressure Hydrocephalus: Preliminary Results of a Randomized Clinical Trial. (PubMed)

Role of Endoscopic Third Ventriculostomy and Ventriculoperitoneal Shunt in Idiopathic Normal Pressure Hydrocephalus: Preliminary Results of a Randomized Clinical Trial. Currently, the most common treatment for idiopathic normal pressure hydrocephalus (INPH) is a ventriculoperitoneal shunt (VPS), generally with programmable valve implantation. Endoscopic third ventriculostomy (ETV) is another treatment option, and it does not require prosthesis implantation.To compare the functional neurological (...) based on the results of 6 clinical scales: mini-mental, Berg balance, dynamic gait index, functional independence measure, timed up and go, and normal pressure hydrocephalus.There was a statistically significant difference between the 2 groups after 12 months of follow-ups, and the VPS group showed better improvement results (ETV = 50%, VPS = 76.9%).Compared with ETV, VPS is a superior method because it had better functional neurological outcomes 12 months after surgery.

2013 Neurosurgery

180. Predictive Value of Flow MRI in Normal Pressure Hydrocephalus Surgery

Predictive Value of Flow MRI in Normal Pressure Hydrocephalus Surgery Predictive Value of Flow MRI in Normal Pressure Hydrocephalus Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Predictive Value (...) of Flow MRI in Normal Pressure Hydrocephalus Surgery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01815775 Recruitment Status : Completed First Posted : March 21, 2013 Last Update Posted : March 21, 2013 Sponsor: Centre Hospitalier Universitaire, Amiens Information provided by (Responsible Party

2013 Clinical Trials

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