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Normal Pressure Hydrocephalus

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141. Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 2: Management of posthemorrhagic hydrocephalus in premature infants

. McCullough DC: A critical evaluation of continuous intracra- nial pressure monitoring in pediatric hydrocephalus. Ch i l d s Br a i n 6:225–241, 1980 51. Ment LR, Duncan CC, Ehrenkranz RA, Kleinman CS, Tay- lor KJ, Scott DT, et al: Randomized low-dose indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight neonates. J Pediatr 112:948–955, 1988 52. Miranda P: Intraventricular hemorrhage and posthemorrhagic hydrocephalus in the preterm infant. M in e rv a P edi a tr 62:79 (...) Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 2: Management of posthemorrhagic hydrocephalus in premature infants J Neurosurg Pediatrics (Suppl) 14:8–23, 2014 8 J Neurosurg: Pediatrics / Volume 14 / November 2014 ©AANS, 2014 A lthough reviews have been recently published, there exists a paucity of guidelines or evidence- based recommendations for the management of posthemorrhagic hydrocephalus (PHH) in infants. 62 Ac- Pediatric hydrocephalus

2014 Congress of Neurological Surgeons

142. An investigation into the clinical impacts of lowering shunt opening pressure in idiopathic normal pressure hydrocephalus: A case series. (Abstract)

An investigation into the clinical impacts of lowering shunt opening pressure in idiopathic normal pressure hydrocephalus: A case series. Idiopathic normal pressure hydrocephalus (iNPH) is a shunt- reversible syndrome of the elderly. Shunt management is aimed at achieving a balance between clinical improvement and the complications associated with overdrainage. Although clinical improvement occurs at low pressure, these benefits may be negated by the increase in complication rates observed (...) at lower pressures. The addition of gravity-switch devices has been shown to reduce over drainage problems even at a low valve pressure setting. At our centre the Miethke proGAV is used and commonly lowered below 5 cmH2O to gain further clinical improvement.To determine whether lowering the opening pressure to below 5cmH2O using the proGAV valve in iNPH patients results in a) improved clinical features; and b) no significant increase in complication rates.A retrospective case series of iNPH patients

2014 British Journal of Neurosurgery

143. FSI simulation of CSF hydrodynamic changes in a large population of non-communicating hydrocephalus patients during treatment process with regard to their clinical symptoms. Full Text available with Trip Pro

FSI simulation of CSF hydrodynamic changes in a large population of non-communicating hydrocephalus patients during treatment process with regard to their clinical symptoms. 3D fluid-structure interaction modelling was utilized for simulation of 13 normal subjects, 11 non-communicating hydrocephalus (NCH) patients at pre-treatment phase, and 3 patients at five post-treatment phases. Evaluation of ventricles volume and maximum CSF pressure (before shunting) following results validation indicated (...) for headache. Continuing this investigation during the treatment process showed that maximum CSF pressure is the most sensitive parameter to patients' clinical symptoms. Maximum CSF pressure has decreased proportional to the level of decrease in clinical symptoms and has returned close to the pressure range in normal subjects faster than other parameters and simultaneous with disappearance of patients' clinical symptoms (from day 81 after shunting). However, phase lag between flow rate and pressure

2018 PLoS ONE

144. Overdrainage shunt complications in idiopathic normal-pressure hydrocephalus and lumbar puncture opening pressure. (Abstract)

Overdrainage shunt complications in idiopathic normal-pressure hydrocephalus and lumbar puncture opening pressure. Management of idiopathic normal-pressure hydrocephalus (iNPH) is hard because the diagnosis is difficult and shunt surgery has high complication rates. An important complication is overdrainage, which often can be treated with adjustable-shunt valve manipulations but also may result in the need for subdural hematoma evacuation. The authors evaluated shunt surgery overdrainage (...) complications in iNPH and their relationship to lumbar puncture opening pressure (LPOP).The authors reviewed the charts of 164 consecutive patients with iNPH who underwent shunt surgery at their institution from 2005 to 2011. They noted age, sex, presenting symptoms, symptom duration, hypertension, body mass index (BMI), imaging findings of atrophy, white matter changes, entrapped sulci, LPOP, valve opening pressure (VOP) setting, number of valve adjustments, serious overdrainage (subdural hematoma

2013 Journal of Neurosurgery

145. Journal club: role of endoscopic third ventriculostomy and ventriculoperitoneal shunt in idiopathic normal pressure hydrocephalus: preliminary results of a randomized clinical trial. Full Text available with Trip Pro

Journal club: role of endoscopic third ventriculostomy and ventriculoperitoneal shunt in idiopathic normal pressure hydrocephalus: preliminary results of a randomized clinical trial. 24141398 2014 06 02 2018 12 02 1524-4040 73 5 2013 Nov Neurosurgery Neurosurgery Journal club: role of endoscopic third ventriculostomy and ventriculoperitoneal shunt in idiopathic normal pressure hydrocephalus: preliminary results of a randomized clinical trial. 908-10 10.1227/NEU.0000000000000121 Ghobrial George (...) M GM Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania. Lang Michael J MJ eng Journal Article Comment United States Neurosurgery 7802914 0148-396X IM Neurosurgery. 2013 May;72(5):845-53; discussion 853-4 23313977 Neurosurgery. 2013 Nov;73(5):911-2 24141399 Endoscopy methods Female Humans Hydrocephalus, Normal Pressure pathology surgery Male Third Ventricle surgery Ventriculoperitoneal Shunt methods Ventriculostomy methods 2013 10 22 6 0 2013 10 22 6 0

2014 Neurosurgery Controlled trial quality: uncertain

146. Response to journal club: role of endoscopic third ventriculostomy and ventriculoperitoneal shunt in idiopathic normal pressure hydrocephalus: preliminary results of a randomized clinical trial. (Abstract)

Response to journal club: role of endoscopic third ventriculostomy and ventriculoperitoneal shunt in idiopathic normal pressure hydrocephalus: preliminary results of a randomized clinical trial. 24141399 2014 06 02 2018 12 02 1524-4040 73 5 2013 Nov Neurosurgery Neurosurgery Response to journal club: role of endoscopic third ventriculostomy and ventriculoperitoneal shunt in idiopathic normal pressure hydrocephalus: preliminary results of a randomized clinical trial. 911-2 10.1227/NEU (...) .0000000000000126 Gomes Pinto Fernando Campos FC *Division of Functional Neurosurgery of the Institute of Psychiatry, Hospital das Clínicas, Universidade de São Paulo, São Paulo, Brazil; ‡Neurosurgery Residency Program-Department of Neurosurgery-Hospital do Servidor Público Estadual de São Paulo, São Paulo, Brazil. de Oliveira Matheus Fernandes MF eng Letter Comment United States Neurosurgery 7802914 0148-396X IM Neurosurgery. 2013 Nov;73(5):908-10 24141398 Endoscopy methods Female Humans Hydrocephalus, Normal

2014 Neurosurgery Controlled trial quality: uncertain

147. Idiopathic normal pressure hydrocephalus: cerebral perfusion measured with pCASL before and repeatedly after CSF removal. Full Text available with Trip Pro

Idiopathic normal pressure hydrocephalus: cerebral perfusion measured with pCASL before and repeatedly after CSF removal. Pseudo-continuous arterial spin labeling (pCASL) measurements were performed in 20 patients with idiopathic normal pressure hydrocephalus (iNPH) to investigate whether cerebral blood flow (CBF) increases during the first 24 hours after a cerebrospinal fluid tap test (CSF TT). Five pCASL magnetic resonance imaging (MRI) scans were performed. Two scans were performed before

2014 Journal of Cerebral Blood Flow and Metabolism

148. Improvement in social function and health-related quality of life after shunt surgery for idiopathic normal-pressure hydrocephalus. Full Text available with Trip Pro

Improvement in social function and health-related quality of life after shunt surgery for idiopathic normal-pressure hydrocephalus. To investigate the impact of shunt surgery on the activity, participation, autonomy, and health-related quality of life (HRQOL) of patients with idiopathic normal-pressure hydrocephalus (iNPH) as well as the effect on caregiver burden.Thirty-seven patients (median age 70 years, range 50-89 years) with iNPH were evaluated before and 6 months after surgery. Symptoms (...) to the same level as found in the normal population. The patients became more independent in physical and cognitive activities, and participation and autonomy improved. The caregiver burden was decreased among caregivers to male patients but remained unchanged on the overall group level.After shunt surgery, patients with iNPH showed improvement in most aspects of social life, they became more independent, and their quality of life returned to nearly normal.

2014 Journal of Neurosurgery

149. Outcome of modern shunt therapy in patients with idiopathic normal pressure hydrocephalus 6 years postoperatively. Full Text available with Trip Pro

Outcome of modern shunt therapy in patients with idiopathic normal pressure hydrocephalus 6 years postoperatively. Shunt therapy in idiopathic normal pressure hydrocephalus (iNPH) can improve symptoms in 84% of patients 1 year postoperatively. Therefore, implantation of a ventriculoperitoneal shunt (VPS) prevents or at least prolongs the time during which patients are not dependent on care from others because of gait disorder or dementia. In this study, the medium-term results of modern shunt

2014 Journal of Neurosurgery

150. Normal Pressure Hydrocephalus Treatment by Acetazolamide

Normal Pressure Hydrocephalus Treatment by Acetazolamide Normal Pressure Hydrocephalus Treatment by Acetazolamide - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Normal Pressure Hydrocephalus Treatment (...) Steiner, Rabin Medical Center Study Details Study Description Go to Brief Summary: Normal pressure hydrocephalus (NPH) is an uncommon cause of dementia possibly reversible with treatment. First described in 1965 it consists of a triad of gait disturbance, cognitive deterioration, and urinary incontinence together with enlarged cerebral ventricles and normal cerebrospinal fluid (CSF) pressure. Foregoing trauma and hemorrhage, infection, mass lesions, or aqueductal stenosis can contribute

2014 Clinical Trials

151. Evaluation of coexistence of Alzheimer's disease in idiopathic normal pressure hydrocephalus using ELISA analyses for CSF biomarkers. Full Text available with Trip Pro

Evaluation of coexistence of Alzheimer's disease in idiopathic normal pressure hydrocephalus using ELISA analyses for CSF biomarkers. We investigated levels of the β-amyloid 1-42 (Aβ42), total tau protein (T-tau) and tau phosphorylated at position threonine 181 (P-tau) in cerebrospinal fluid (CSF) of idiopathic normal pressure hydrocephalus (iNPH) patients and tried to find their clinical implications in the evaluation and treatment of iNPH.Twenty-five possible iNPH patients were prospectively

2014 BMC Neurology

152. Alzheimer CSF biomarkers may be misleading in normal-pressure hydrocephalus. Full Text available with Trip Pro

Alzheimer CSF biomarkers may be misleading in normal-pressure hydrocephalus. This article discusses why CSF biomarkers found in normal-pressure hydrocephalus (NPH) can be misleading when distinguishing NPH from comorbid NPH with Alzheimer disease (AD).We describe NPH CSF biomarkers and how shunt surgery can change them. We hypothesize the effects that hydrocephalus may play on interstitial fluid space and amyloid precursor protein (APP) fragment drainage into the CSF based on a recent report (...) and how this may explain the misleading CSF NPH biomarker findings.In NPH, β-amyloid protein 42 (Aβ42) is low (as in AD), but total tau (t-tau) and phospho-tau (p-tau) levels are normal, providing conflicting biomarker findings. Low Aβ42 supports an AD diagnosis but tau findings do not. Importantly, not only Aβ42, but all APP fragments and tau proteins are low in NPH CSF. Further, these proteins increase after shunting. An increase in interstitial space and APP fragment drainage into the CSF during

2014 Neurology

153. Prevalence of idiopathic normal-pressure hydrocephalus. Full Text available with Trip Pro

Prevalence of idiopathic normal-pressure hydrocephalus. The aim of this study was to determine the prevalence of idiopathic normal-pressure hydrocephalus (iNPH) in elderly persons in a large population-based sample using radiologic and clinical examinations.We examined representative elderly populations aged 70 years and older that had undergone neuropsychiatric evaluations and CT of the brain between 1986 and 2000 (n = 1,238). Gait was evaluated by clinical examination and history of walking

2014 Neurology

154. Differences in Cerebrospinal Fluid Biomarkers between Clinically Diagnosed Idiopathic Normal Pressure Hydrocephalus and Alzheimer’s Disease Full Text available with Trip Pro

Differences in Cerebrospinal Fluid Biomarkers between Clinically Diagnosed Idiopathic Normal Pressure Hydrocephalus and Alzheimer’s Disease In the present study, cerebrospinal fluid (CSF) profiles were assessed to determine how idiopathic normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD) differs.Subjects were drawn from patients who underwent lumbar punctures as part of their diagnostic evaluations in the Banner Sun Health Research Institute Memory Disorders clinic

2014 Journal of Alzheimer's disease & Parkinsonism

155. Should ventriculoatrial shunting be the procedure of choice for normal-pressure hydrocephalus? Full Text available with Trip Pro

Should ventriculoatrial shunting be the procedure of choice for normal-pressure hydrocephalus? Ventriculoatrial (VA) shunting is rarely used for patients with normal-pressure hydrocephalus (NPH), likely due to surgeon technical preference and case reports indicating cardiopulmonary complications. However, these complications have typically been limited to adults in whom VA shunts had been placed when they were children. Few studies have directly compared VA shunting to ventriculoperitoneal (VP

2014 Journal of Neurosurgery

156. Normal Pressure Hydrocephalus (Diagnosis)

Normal Pressure Hydrocephalus (Diagnosis) Normal Pressure Hydrocephalus: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE1MDkyNC1vdmVydmlldw== processing > Normal (...) Pressure Hydrocephalus Updated: Oct 19, 2018 Author: Michael J Schneck, MD, MBA; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections Normal Pressure Hydrocephalus Overview Practice Essentials Normal pressure hydrocephalus (NPH) is a clinical symptom complex caused by the build-up of cerebrospinal fluid. This condition is characterized by abnormal gait, urinary incontinence, and (potentially reversible) dementia. See the image below. T2-weighted MRI showing dilatation

2014 eMedicine.com

157. Normal Pressure Hydrocephalus (Overview)

Normal Pressure Hydrocephalus (Overview) Normal Pressure Hydrocephalus: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE1MDkyNC1vdmVydmlldw== processing > Normal (...) Pressure Hydrocephalus Updated: Oct 19, 2018 Author: Michael J Schneck, MD, MBA; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections Normal Pressure Hydrocephalus Overview Practice Essentials Normal pressure hydrocephalus (NPH) is a clinical symptom complex caused by the build-up of cerebrospinal fluid. This condition is characterized by abnormal gait, urinary incontinence, and (potentially reversible) dementia. See the image below. T2-weighted MRI showing dilatation

2014 eMedicine.com

158. Normal Pressure Hydrocephalus (Treatment)

Normal Pressure Hydrocephalus (Treatment) Normal Pressure Hydrocephalus Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE1MDkyNC10cmVhdG1lbnQ (...) = processing > Normal Pressure Hydrocephalus Treatment & Management Updated: Oct 19, 2018 Author: Michael J Schneck, MD, MBA; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections Normal Pressure Hydrocephalus Treatment Medical Care A levodopa challenge may be helpful to rule out idiopathic Parkinson disease. Patients with normal pressure hydrocephalus (NPH) have no significant response to levodopa or dopamine agonists. Next: Surgical Care Surgical CSF shunting remains

2014 eMedicine.com

159. Normal Pressure Hydrocephalus (Follow-up)

Normal Pressure Hydrocephalus (Follow-up) Normal Pressure Hydrocephalus Follow-up: Prognosis, Patient Education Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE1MDkyNC1mb2xsb3d1cA== processing > Normal Pressure (...) Hydrocephalus Follow-up Updated: Oct 19, 2018 Author: Michael J Schneck, MD, MBA; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections Normal Pressure Hydrocephalus Follow-up Prognosis The overall prognosis of NPH remains poor both due to a lack of improvement in some patients following surgery as well as a significant complication rate. In a study by Vanneste et al, one of the more comprehensive studies described above, marked improvement was noted in only 21% of patients

2014 eMedicine.com

160. Normal Pressure Hydrocephalus

Normal Pressure Hydrocephalus Imaging in Normal Pressure Hydrocephalus: Practice Essentials, Computed Tomography, Magnetic Resonance Imaging Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMzQyODI3LW92ZXJ2aWV3 (...) processing > Imaging in Normal Pressure Hydrocephalus Updated: Jan 23, 2018 Author: Lourdes Nunez-Atahualpa, MD; Chief Editor: James G Smirniotopoulos, MD Share Email Print Feedback Close Sections Sections Imaging in Normal Pressure Hydrocephalus Practice Essentials First described by Hakim and Adams in 1965, normal pressure hydrocephalus (NPH) refers to a clinical entity consisting of the triad of gait disturbance, dementia, and incontinence, coupled with the laboratory findings of normal cerebrospinal

2014 eMedicine Radiology

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