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Normal Pressure Hydrocephalus

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181. Normal Pressure Hydrocephalus

Normal Pressure Hydrocephalus Normal Pressure Hydrocephalus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Normal Pressure (...) Hydrocephalus Normal Pressure Hydrocephalus Aka: Normal Pressure Hydrocephalus From Related Chapters II. Pathophysiology See Cerebrospinal Fluid Defined as communicating No obstructive mass Results from decreased CSF absorption Due to scarring or fibrosis of arachnoid granulations Pressure builds within ventricles Baseline pressure higher but in normal range CSF production decreases Ventricles distend Stretch nerve fibers Compress periventricular tissue including vessels Brain parenchymal ischemia III

2015 FP Notebook

182. Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus

Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01618500 Recruitment Status : Unknown Verified

2012 Clinical Trials

183. Primary and Reversible Pisa Syndrome in Juvenile Normal Pressure Hydrocephalus Full Text available with Trip Pro

Primary and Reversible Pisa Syndrome in Juvenile Normal Pressure Hydrocephalus To report a case of Pisa syndrome in a patient with idiopathic normal pressure hydrocephalus, who had never been exposed to psychotropic medications.A 26 years-old, Colombian, male patient, was referred because he had cognitive abnormalities, gait disturbances and urinary incontinence. This patient also displayed pleurothotonos. Neurofunctional evaluation of sensory and motor integration at peripheral and central

2012 Acta Neuropsychiatrica

184. [(18)F]Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid β detection in living subjects with normal pressure hydrocephalus: pooled analysis of four studies. (Abstract)

[(18)F]Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid β detection in living subjects with normal pressure hydrocephalus: pooled analysis of four studies. Molecular imaging techniques developed to 'visualize' amyloid in vivo represent a major achievement in Alzheimer's disease (AD) research. This pooled analysis of four studies determined the level of association between uptake of the fibrillar amyloid β positron emission tomography (PET) imaging agent [(18)F (...) ]flutemetamol (Pittsburgh Compound B analog with a 5.5 times longer half-life to enable it to be used in the clinical setting) and neuritic plaques and fibrillar amyloid β measured by pathologic staining of cortical region biopsy samples. Fifty-two patients with suspected normal pressure hydrocephalus underwent prospective (n = 30) or retrospective (n = 22) [(18)F]flutemetamol PET imaging for detection of cerebral cortical fibrillar amyloid β and cortical brain biopsy during intracranial pressure

2012 Acta neuropathologica

185. Diffusion tensor imaging in elderly patients with idiopathic normal pressure hydrocephalus or Parkinson’s disease: diagnosis of gait abnormalities Full Text available with Trip Pro

Diffusion tensor imaging in elderly patients with idiopathic normal pressure hydrocephalus or Parkinson’s disease: diagnosis of gait abnormalities Gait abnormalities in the elderly, characterized by short steps and frozen gait, can be caused by several diseases, including idiopathic normal pressure hydrocephalus (INPH), and Parkinson's disease (PD). We analyzed the relationship between these two conditions and their association with gait abnormalities using laboratory test data and findings

2012 Fluids and barriers of the CNS

186. Normal Pressure Hydrocephalus as Cause of Urinary Incontinence – A Shunt for Incontinence Full Text available with Trip Pro

Normal Pressure Hydrocephalus as Cause of Urinary Incontinence – A Shunt for Incontinence Normal pressure hydrocephalus is a frequently missed clinical entity with the typical symptom triad of gait disturbance, urinary incontinence and dementia (Hakim's triad) and occurs mostly from the 6th decade of life onwards. Early therapy can lead to a complete reversal of the symptoms. The present case report is intended to draw attention to the clinical entity normal pressure hydrocephalus (NPH) since

2012 Geburtshilfe Und Frauenheilkunde

187. Impaired pulsation absorber mechanism in idiopathic normal pressure hydrocephalus. Full Text available with Trip Pro

Impaired pulsation absorber mechanism in idiopathic normal pressure hydrocephalus. The pathophysiology of normal pressure hydrocephalus (NPH), and the related problem of patient selection for treatment of this condition, have been of great interest since the description of this seemingly paradoxical condition nearly 50 years ago. Recently, Eide has reported that measurements of the amplitude of the intracranial pressure (ICP) can both positively and negatively predict response to CSF shunting (...) . Specifically, the fraction of time spent in a "high amplitude" (> 4 mm Hg) state predicted response to shunting, which may represent a marker for hydrocephalic pathophysiology. Increased ICP amplitude might suggest decreased brain compliance, meaning a static measure of a pressure-volume ratio. Recent studies of canine data have shown that the brain compliance can be described as a frequency-dependent function. The normal canine brain seems to show enhanced ability to absorb the pulsations around the heart

2012 Journal of Neurosurgery

188. Pituitary Function in Patients with Normal Pressure Hydrocephalus before and after Neurosurgical Correction. Full Text available with Trip Pro

Pituitary Function in Patients with Normal Pressure Hydrocephalus before and after Neurosurgical Correction. Little is known about pituitary function in patients with normal pressure hydrocephalus (NPH). This study evaluated pituitary function in a large series of patients awaiting neurosurgical correction for NPH. We also sought to ascertain whether surgical correction of hydrocephalus would result in improvement of any noted pituitary dysfunction.Patients with NPH referred for neurosurgical

2012 Journal of Clinical Endocrinology and Metabolism

189. Three-day CSF drainage barely reduces ventricular size in normal pressure hydrocephalus. (Abstract)

Three-day CSF drainage barely reduces ventricular size in normal pressure hydrocephalus. External lumbar drainage (ELD) of CSF is a test to determine the suitability of a shunt for patients with normal pressure hydrocephalus (NPH), but its effect on ventricular volume is not known. This study investigates the effect of 3-day ELD of 500 mL on ventricular size and clinical features in patients with idiopathic NPH.Fifteen patients were investigated in a 1.5-T MRI scanner before and after ELD

2012 Neurology

190. Conservative versus surgical management of idiopathic normal pressure hydrocephalus: a prospective double-blind randomized controlled trial: study protocol. Full Text available with Trip Pro

Conservative versus surgical management of idiopathic normal pressure hydrocephalus: a prospective double-blind randomized controlled trial: study protocol. There is no level I evidence to indicate whether placement of a shunt is effective in the management of idiopathic normal pressure hydrocephalus (INPH), because no trial has as yet compared the placement of a shunt versus no shunt in a randomized controlled manner. We started recruiting patients into a prospective double-blind randomized

2012 Acta neurochirurgica. Supplement Controlled trial quality: predicted high

191. Preoperative and postoperative 1H-MR spectroscopy changes in frontal deep white matter and the thalamus in idiopathic normal pressure hydrocephalus. (Abstract)

Preoperative and postoperative 1H-MR spectroscopy changes in frontal deep white matter and the thalamus in idiopathic normal pressure hydrocephalus. In a previous study we found significantly decreased N-acetyl aspartate (NAA) and total N-acetyl (tNA) groups in the thalamus of patients with idiopathic normal pressure hydrocephalus (iNPH) compared with healthy individuals (HI). No significant difference between the groups could be found in the frontal deep white matter (FDWM).The primary aim

2012 Neurosurgery and Psychiatry

192. Ventricular size after shunting for idiopathic normal pressure hydrocephalus. Full Text available with Trip Pro

Ventricular size after shunting for idiopathic normal pressure hydrocephalus. It has been presumed that idiopathic normal pressure hydrocephalus is due to obstruction. We visualized the ventricles in 19 patients subsequent to shunting. We found no consistent relationship between clinical improvement after shunting and reduction in ventricular size. This suggests that the positive effect of shunting in at least some instances is due to some other factor than reduced ventricular size.

1975 Journal of neurology, neurosurgery, and psychiatry

193. Syndrome of normal pressure hydrocephalus: possible relation to hypertensive and arteriosclerotic vasculopathy. Full Text available with Trip Pro

Syndrome of normal pressure hydrocephalus: possible relation to hypertensive and arteriosclerotic vasculopathy. A patient with clinical features of idiopathic normal pressure hydrocephalus, who responded dramatically to shunting, was found a necropsy to have a severe hypertensive and arteriosclerotic vasculopathy with multiple lacunar infarcts. There was no pathological evidence of thickened leptomeninges, fibrosis of the arachnoid villi, or Alzheimer's disease. An abnormal absorption mechanism (...) was demonstrated with cisternography and by an increase in the concentration of homovanillic acid in the cerebrospinal fluid. It is suggested that vascular changes may play an important role in the pathophysiology in some cases of normal pressure hydrocephalus.

1977 Journal of neurology, neurosurgery, and psychiatry

194. Normal-pressure hydrocephalus due to tentorial meningioma. Full Text available with Trip Pro

Normal-pressure hydrocephalus due to tentorial meningioma. Normal-pressure hydrocephalus and the associated triad of dementia, apraxic gait and urinary incontinence may be casued by various, sometimes unsuspected, lesions, usually those that block the flow of cerebrospinal fluid (CSF) around the tentorium. A 58-year-old woman with insidious onset of behaviour and gait problems had occult, normal-pressure hydrocephalus and a tentorial meningioma, resection of which produced complete recovery (...) . This case demonstrates that a distinction must be made between the syndrome of normal-pressure hydrocephalus resulting from disturbance in CSF dynamics and the pathophysiologic features of the underlying lesion.

1976 Canadian Medical Association Journal

195. Monoamine acid metabolites and cerebrospinal fluid dynamics in normal pressure hydrocephalus: preliminary results. Full Text available with Trip Pro

Monoamine acid metabolites and cerebrospinal fluid dynamics in normal pressure hydrocephalus: preliminary results. Lumbar and ventricular CSF concentration of homovanillic acid (HVA) and 5-hydroxy-indole-acetic acid (5-HIAA) have been determined in 13 patients admitted to hospital for suspected normal pressure hydrocephalus. Low values of HVA in lumbar CSF were found in all patients with reduced CSF absorption and CSF flow inversion. The HVA lumbar concentration remained low after shunt (...) procedure; it increased if obstruction of the shunt occurred. The ventricular CSF concentration of HVA was normal before surgery; it became higher, in two cases, after surgery. No important variations were found in the lumbar and ventricular CSF concentration of 5-HIAA. The possible mechanisms and diagnostic value of these findings are discussed.

1975 Journal of neurology, neurosurgery, and psychiatry

196. A clinical, pneumoencephalographic and radioisotopic study of normal-pressure communicating hydrocephalus Full Text available with Trip Pro

A clinical, pneumoencephalographic and radioisotopic study of normal-pressure communicating hydrocephalus Human serum albumin labelled with iodine-133 or technetium-99(m) was injected by the lumbar or cisternal route into patients suspected of having communicating hydrocephalus, and scintigrams were performed up to 24 hours after injection.The CSF isotope studies were shown to be a valuable adjunct to clinical examination and pneumoencephalography in the diagnosis of hydrocephalus (...) . This was especially true in suspected cases of "normal"-pressure hydrocephalus where there may be considerable uncertainty as to which patients with normal pressure and enlarged ventricles will benefit from a shunting procedure. The CSF isotope study provides useful information to the clinician in differentiating patients with symptomatic hydrocephalus from the larger group with dementia, cerebral atrophy and hydrocephalus ex vacuo.

1971 Canadian Medical Association Journal

197. Motor disorder in "normal pressure" hydrocephalus. Full Text available with Trip Pro

Motor disorder in "normal pressure" hydrocephalus. 5008059 1972 03 24 2018 11 13 0007-1447 1 5798 1972 Feb 19 British medical journal Br Med J Motor disorder in "normal pressure" hydrocephalus. 485-6 Chawla J C JC Woodward J J eng Journal Article England Br Med J 0372673 0007-1447 AIM IM Aged Cerebrospinal Fluid Shunts Gait Humans Hydrocephalus complications surgery Male Middle Aged Movement Disorders etiology Posture Quadriplegia etiology 1972 2 19 1972 2 19 0 1 1972 2 19 0 0 ppublish 5008059

1972 British medical journal

198. Neuro-ophthalmologic signs in normal pressure hydrocephalus. Full Text available with Trip Pro

Neuro-ophthalmologic signs in normal pressure hydrocephalus. 4663663 1973 08 28 2018 11 13 0065-9533 70 1972 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc Neuro-ophthalmologic signs in normal pressure hydrocephalus. 103-12 Plotkin M D MD Smith J L JL eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 IM Adult Agnosia complications Arachnoiditis complications Arteriovenous Malformations complications Chronic Disease Craniocerebral Trauma (...) complications Eye Manifestations Female Headache complications Humans Hydrocephalus cerebrospinal fluid diagnosis Hydrocephalus, Normal Pressure diagnosis Male Middle Aged Neurologic Manifestations Occipital Lobe Optic Atrophy complications Papilledema complications Paranoid Disorders etiology Pupil Subarachnoid Hemorrhage complications Vision Disorders complications Visual Acuity Visual Fields 1972 1 1 1972 1 1 0 1 1972 1 1 0 0 ppublish 4663663 PMC1310444 Bull N Y Acad Med. 1966 Oct;42(10):907-17 5231976 J

1972 Transactions of the American Ophthalmological Society

199. Normal Pressure Hydrocephalus Full Text available with Trip Pro

Normal Pressure Hydrocephalus 18730602 2010 06 28 2018 11 13 0008-1264 115 3 1971 Sep California medicine Calif Med Normal pressure hydrocephalus. 49-50 Yatsu F M FM eng Journal Article United States Calif Med 0410260 0008-1264 1971 9 1 0 0 1971 9 1 0 1 1971 9 1 0 0 ppublish 18730602 PMC1518087 N Engl J Med. 1965 Jul 15;273:117-26 14303656 J Neurosurg. 1969 Sep;31(3):279-94 5811831

1971 California Medicine

200. Diabetes mellitus in normal pressure hydrocephalus. Full Text available with Trip Pro

Diabetes mellitus in normal pressure hydrocephalus. Seventeen of 33 patients (51.5%) with normal pressure hydrocephalus were discovered to have diabetes mellitus. This was significantly greater than the 12.1% incidence found in age-matched control subjects. The diabetes was not accounted for either by the patients' ages nor by their physical inactivity due to hospitalisation. Diabetes mellitus concurrent with normal pressure hydrocephalus may result from involvement of hypothalamic (...) and brainstem autonomic structures by the expanding ventricles during the evolution of hydrocephalus.

1977 Journal of neurology, neurosurgery, and psychiatry

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