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Normal Pressure Hydrocephalus

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181. A Randomized Cross-over Study for Normal Pressure Hydrocephalus

A Randomized Cross-over Study for Normal Pressure Hydrocephalus A Randomized Cross-over Study for Normal Pressure Hydrocephalus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Randomized Cross-over Study (...) for Normal Pressure Hydrocephalus (ARCS NPH) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01798641 Recruitment Status : Completed First Posted : February 26, 2013 Results First Posted : November 2, 2018 Last Update Posted : November 2, 2018 Sponsor: Johns Hopkins University Collaborators: Aesculap, Inc

2013 Clinical Trials

182. A reply to the letter to the editor regarding “microstructural changes of the corticospinal tract in idiopathic normal pressure hydrocephalus: a comparison of diffusion tensor and diffusional kurtosis imaging” (PubMed)

A reply to the letter to the editor regarding “microstructural changes of the corticospinal tract in idiopathic normal pressure hydrocephalus: a comparison of diffusion tensor and diffusional kurtosis imaging” 23989463 2014 06 19 2018 12 02 1432-1920 55 11 2013 Nov Neuroradiology Neuroradiology A reply to the letter to the editor regarding "microstructural changes of the corticospinal tract in idiopathic normal pressure hydrocephalus: a comparison of diffusion tensor and diffusional (...) kurtosis imaging". 1425 10.1007/s00234-013-1275-1 Hori Masaaki M Department of Radiology, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, 113-8421, Japan, mahori@juntendo.ac.jp. Nakanishi Atsushi A Aoki Shigeki S eng Letter Comment 2013 08 29 Germany Neuroradiology 1302751 0028-3940 IM Neuroradiology. 2013 Aug;55(8):971-6 23728069 Neuroradiology. 2013 Nov;55(11):1423-4 24005831 Diffusion Tensor Imaging methods Female Humans Hydrocephalus, Normal Pressure pathology Image

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2013 Neuroradiology

183. Systematic review of the outcome of shunt surgery in idiopathic normal-pressure hydrocephalus. (PubMed)

Systematic review of the outcome of shunt surgery in idiopathic normal-pressure hydrocephalus. Early surgical series of shunt insertion for idiopathic normal-pressure hydrocephalus reported a low rate of short-term improvement with a relatively high rate of mortality and morbidity; subsequently shunt insertion was recommended for patients in whom there is favourable risk-to-benefit ratio.Bibliographic search for studies that objectively assessed the outcome following shunt insertion (...) in idiopathic normal-pressure hydrocephalus was done; the aim was to estimate the outcome of shunt insertion in terms of improvement rates and associated mortality and morbidity.A total of 64 studies of 3,063 patients were reviewed. Positive improvement following shunt insertion was reported in an average of 71 % of patients with an average 1 % mortality. Results from studies published in the last 5 years showed 82 % improvement following shunt insertion, mortality of 0.2 %, and combined common

2013 Acta neurochirurgica

184. Flow MRI in Normal Pressure Hydrocephalus

Flow MRI in Normal Pressure Hydrocephalus Flow MRI in Normal Pressure Hydrocephalus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Flow MRI in Normal Pressure Hydrocephalus (HydroFlux) The safety (...) Study Description Go to Brief Summary: Normal pressure hydrocephalus diagnosis based on quantitative study of cerebro-spinal fluid and blood flow by phase contrast magnetic resonance imaging. Condition or disease Intervention/treatment Phase Normal Pressure Hydrocephalus Other: Flow imaging Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 144 participants Allocation: Non-Randomized Intervention Model: Single Group

2013 Clinical Trials

185. Diagnosis and management of idiopathic normal-pressure hydrocephalus (PubMed)

Diagnosis and management of idiopathic normal-pressure hydrocephalus The diagnosis and management of idiopathic normal-pressure hydrocephalus (iNPH), a disorder of gait impairment, incontinence, and dementia that affects elderly patients, incorporates an organized approach using familiar principles for neurologists. The starting point is a comprehensive history and neurologic examination, review of neuroimaging, and evaluation of the differential diagnosis. Coexisting disorders should

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2013 Neurology: Clinical Practice

186. EEG and Neuronal Activity Topography analysis can predict effectiveness of shunt operation in idiopathic normal pressure hydrocephalus patients (PubMed)

EEG and Neuronal Activity Topography analysis can predict effectiveness of shunt operation in idiopathic normal pressure hydrocephalus patients Idiopathic normal pressure hydrocephalus (iNPH) is a neuropsychiatric syndrome characterized by gait disturbance, cognitive impairment and urinary incontinence that affect elderly individuals. These symptoms can potentially be reversed by cerebrospinal fluid (CSF) drainage or shunt operation. Prior to shunt operation, drainage of a small amount of CSF (...) or "CSF tapping" is usually performed to ascertain the effect of the operation. Unfortunately, conventional neuroimaging methods such as single photon emission computed tomography (SPECT) and functional magnetic resonance imaging (fMRI), as well as electroencephalogram (EEG) power analysis seem to have failed to detect the effect of CSF tapping on brain function. In this work, we propose the use of Neuronal Activity Topography (NAT) analysis, which calculates normalized power variance (NPV) of EEG

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2013 NeuroImage : Clinical

187. Pulsatility in CSF dynamics: pathophysiology of idiopathic normal pressure hydrocephalus. (PubMed)

Pulsatility in CSF dynamics: pathophysiology of idiopathic normal pressure hydrocephalus. It is suggested that disturbed CSF dynamics are involved in the pathophysiology of idiopathic normal pressure hydrocephalus (INPH). The pulsatility curve describes the relationship between intracranial pressure (ICP) and the amplitude of cardiac related ICP pulsations. The position of baseline ICP on the curve provides information about the physiological state of the CSF dynamic system. The objective (...) of the study was to investigate if shunt surgery modifies the pulsatility curve and the baseline position on the curve, and how this relates to gait improvement in INPH.51 INPH patients were investigated with lumbar CSF dynamic investigations preoperatively and 5 months after shunt surgery. During the investigation, ICP was measured at baseline, and then a CSF sample was removed, resulting in pressure reduction. After this, ICP was regulated with an automated infusion protocol, with a maximum increase

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2013 Neurosurgery and Psychiatry

188. Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 1: Introduction and methodology

with results in patients with “normalpressure hydrocephalus were excluded if the study en- rolled fewer than 80% of the target patient population. • Studies that enrolled mixed patient populations were included only if separate results were reported for the target population. The results of the target population were the only results considered as evidence to sup- port our recommendations. • The study was a full article report of a clinical study. • The study was not a meeting abstract, editorial, letter (...) Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 1: Introduction and methodology J Neurosurg: Pediatrics / Volume 14 / November 2014 J Neurosurg Pediatrics (Suppl) 14:3–7, 2014 3 ©AANS, 2014 P ediatric hydrocephalus is the most common surgi- cally correctable neurological problem in infants, children, and adolescents. It is estimated that hy- drocephalus may occur with the frequency of 1 in every 500 children. There are multiple causes of this disorder

2014 Congress of Neurological Surgeons

189. Improving Infant Hydrocephalus Outcomes in Uganda

in the general population is 10±3. Incidence of ETV/CPC treatment failure [ Time Frame: 6 months post-treatment ] Treatment failure or success will be determined with the use of clinical and radiographic criteria. Treatment success will be determined as the shift in the growth of head circumference to a normal rate, as plotted on a standard growth chart; decompression of the anterior fontanel; relief of symptoms of elevated intracranial pressure, such as irritability and vomiting; resolution of down-gaze (...) Improving Infant Hydrocephalus Outcomes in Uganda Improving Infant Hydrocephalus Outcomes in Uganda - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Improving Infant Hydrocephalus Outcomes in Uganda

2018 Clinical Trials

190. Diffusion tensor imaging in elderly patients with idiopathic normal pressure hydrocephalus or Parkinson’s disease: diagnosis of gait abnormalities (PubMed)

Diffusion tensor imaging in elderly patients with idiopathic normal pressure hydrocephalus or Parkinson’s disease: diagnosis of gait abnormalities Gait abnormalities in the elderly, characterized by short steps and frozen gait, can be caused by several diseases, including idiopathic normal pressure hydrocephalus (INPH), and Parkinson's disease (PD). We analyzed the relationship between these two conditions and their association with gait abnormalities using laboratory test data and findings

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2012 Fluids and barriers of the CNS

191. Normal Pressure Hydrocephalus as Cause of Urinary Incontinence – A Shunt for Incontinence (PubMed)

Normal Pressure Hydrocephalus as Cause of Urinary Incontinence – A Shunt for Incontinence Normal pressure hydrocephalus is a frequently missed clinical entity with the typical symptom triad of gait disturbance, urinary incontinence and dementia (Hakim's triad) and occurs mostly from the 6th decade of life onwards. Early therapy can lead to a complete reversal of the symptoms. The present case report is intended to draw attention to the clinical entity normal pressure hydrocephalus (NPH) since

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2012 Geburtshilfe Und Frauenheilkunde

192. Conservative versus surgical management of idiopathic normal pressure hydrocephalus: a prospective double-blind randomized controlled trial: study protocol. (PubMed)

Conservative versus surgical management of idiopathic normal pressure hydrocephalus: a prospective double-blind randomized controlled trial: study protocol. There is no level I evidence to indicate whether placement of a shunt is effective in the management of idiopathic normal pressure hydrocephalus (INPH), because no trial has as yet compared the placement of a shunt versus no shunt in a randomized controlled manner. We started recruiting patients into a prospective double-blind randomized

2012 Acta neurochirurgica. Supplement

193. Three-day CSF drainage barely reduces ventricular size in normal pressure hydrocephalus. (PubMed)

Three-day CSF drainage barely reduces ventricular size in normal pressure hydrocephalus. External lumbar drainage (ELD) of CSF is a test to determine the suitability of a shunt for patients with normal pressure hydrocephalus (NPH), but its effect on ventricular volume is not known. This study investigates the effect of 3-day ELD of 500 mL on ventricular size and clinical features in patients with idiopathic NPH.Fifteen patients were investigated in a 1.5-T MRI scanner before and after ELD

2012 Neurology

194. Preoperative and postoperative 1H-MR spectroscopy changes in frontal deep white matter and the thalamus in idiopathic normal pressure hydrocephalus. (PubMed)

Preoperative and postoperative 1H-MR spectroscopy changes in frontal deep white matter and the thalamus in idiopathic normal pressure hydrocephalus. In a previous study we found significantly decreased N-acetyl aspartate (NAA) and total N-acetyl (tNA) groups in the thalamus of patients with idiopathic normal pressure hydrocephalus (iNPH) compared with healthy individuals (HI). No significant difference between the groups could be found in the frontal deep white matter (FDWM).The primary aim

2012 Neurosurgery and Psychiatry

195. Impaired pulsation absorber mechanism in idiopathic normal pressure hydrocephalus. (PubMed)

Impaired pulsation absorber mechanism in idiopathic normal pressure hydrocephalus. The pathophysiology of normal pressure hydrocephalus (NPH), and the related problem of patient selection for treatment of this condition, have been of great interest since the description of this seemingly paradoxical condition nearly 50 years ago. Recently, Eide has reported that measurements of the amplitude of the intracranial pressure (ICP) can both positively and negatively predict response to CSF shunting (...) . Specifically, the fraction of time spent in a "high amplitude" (> 4 mm Hg) state predicted response to shunting, which may represent a marker for hydrocephalic pathophysiology. Increased ICP amplitude might suggest decreased brain compliance, meaning a static measure of a pressure-volume ratio. Recent studies of canine data have shown that the brain compliance can be described as a frequency-dependent function. The normal canine brain seems to show enhanced ability to absorb the pulsations around the heart

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2012 Journal of Neurosurgery

196. Pituitary Function in Patients with Normal Pressure Hydrocephalus before and after Neurosurgical Correction. (PubMed)

Pituitary Function in Patients with Normal Pressure Hydrocephalus before and after Neurosurgical Correction. Little is known about pituitary function in patients with normal pressure hydrocephalus (NPH). This study evaluated pituitary function in a large series of patients awaiting neurosurgical correction for NPH. We also sought to ascertain whether surgical correction of hydrocephalus would result in improvement of any noted pituitary dysfunction.Patients with NPH referred for neurosurgical

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2012 Journal of Clinical Endocrinology and Metabolism

197. [(18)F]Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid β detection in living subjects with normal pressure hydrocephalus: pooled analysis of four studies. (PubMed)

[(18)F]Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid β detection in living subjects with normal pressure hydrocephalus: pooled analysis of four studies. Molecular imaging techniques developed to 'visualize' amyloid in vivo represent a major achievement in Alzheimer's disease (AD) research. This pooled analysis of four studies determined the level of association between uptake of the fibrillar amyloid β positron emission tomography (PET) imaging agent [(18)F (...) ]flutemetamol (Pittsburgh Compound B analog with a 5.5 times longer half-life to enable it to be used in the clinical setting) and neuritic plaques and fibrillar amyloid β measured by pathologic staining of cortical region biopsy samples. Fifty-two patients with suspected normal pressure hydrocephalus underwent prospective (n = 30) or retrospective (n = 22) [(18)F]flutemetamol PET imaging for detection of cerebral cortical fibrillar amyloid β and cortical brain biopsy during intracranial pressure

2012 Acta neuropathologica

198. Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus

Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01618500 Recruitment Status : Unknown Verified

2012 Clinical Trials

199. Primary and Reversible Pisa Syndrome in Juvenile Normal Pressure Hydrocephalus (PubMed)

Primary and Reversible Pisa Syndrome in Juvenile Normal Pressure Hydrocephalus To report a case of Pisa syndrome in a patient with idiopathic normal pressure hydrocephalus, who had never been exposed to psychotropic medications.A 26 years-old, Colombian, male patient, was referred because he had cognitive abnormalities, gait disturbances and urinary incontinence. This patient also displayed pleurothotonos. Neurofunctional evaluation of sensory and motor integration at peripheral and central

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2012 Acta Neuropsychiatrica

200. Normal Pressure Hydrocephalus

Normal Pressure Hydrocephalus Normal Pressure Hydrocephalus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Normal Pressure (...) Hydrocephalus Normal Pressure Hydrocephalus Aka: Normal Pressure Hydrocephalus From Related Chapters II. Pathophysiology See Cerebrospinal Fluid Defined as communicating No obstructive mass Results from decreased CSF absorption Due to scarring or fibrosis of arachnoid granulations Pressure builds within ventricles Baseline pressure higher but in normal range CSF production decreases Ventricles distend Stretch nerve fibers Compress periventricular tissue including vessels Brain parenchymal ischemia III

2015 FP Notebook

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