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Norepinephrine

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161. Digital necrosis: a potential risk of high-dose norepinephrine Full Text available with Trip Pro

Digital necrosis: a potential risk of high-dose norepinephrine 28781738 2018 11 13 2042-0986 8 8 2017 Aug Therapeutic advances in drug safety Ther Adv Drug Saf Digital necrosis: a potential risk of high-dose norepinephrine. 259-261 10.1177/2042098617712669 Daroca-Pérez Rafael R Internal Medicine Department, Hospital of San Pedro, Logroño, La Rioja, Spain. Carrascosa Miguel F MF Internal Medicine Department, Hospital of Laredo, Avda Derechos Humanos s/n, 39770 Laredo, Cantabria, Spain. eng

2017 Therapeutic advances in drug safety

162. Detection of Norepinephrine in Whole Blood via Fast Scan Cyclic Voltammetry Full Text available with Trip Pro

Detection of Norepinephrine in Whole Blood via Fast Scan Cyclic Voltammetry Bioelectronic Medicines is an emerging field that capitalizes on minimally-invasive technology to stimulate the autonomic nervous system in order to evoke therapeutic biomolecular changes at the end-organ. The goal of Bioelectronic Medicines is to realize both 'precision and personalized' medicine. 'Precise' stimulation of neural circuitry creates biomolecular changes targeted exactly where needed to maximize (...) nerve stimulation to be used for continuous titration of therapy. In this study we examine the feasibility of using fast scan cyclic voltammetry (FSCV) to measure norepinephrine levels, a neurochemical relevant to end-organ function, directly from blood. FSCV is a well-understood method for measuring electroactive neurochemicals in the central nervous system with high temporal and high spatial resolution that has yet to be adapted to the study of the autonomic nervous system. The results demonstrate

2017 IEEE International Symposium on Medical Measurements and Applications : proceedings. IEEE International Symposium on Medical Measurements and Applications

163. Erratum to: Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine Full Text available with Trip Pro

Erratum to: Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine 28468661 2018 11 13 1466-609X 21 1 2017 05 04 Critical care (London, England) Crit Care Erratum to: Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine. 98 10.1186/s13054-017-1680-7 Mehta Sangeeta S Department of Medicine and Interdepartmental Division of Critical Care Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. smehta

2017 Critical Care Controlled trial quality: uncertain

164. A Positron Emission Tomography Study of Norepinephrine Transporter Occupancy and Its Correlation with Symptom Response in Depressed Patients Treated with Quetiapine XR Full Text available with Trip Pro

A Positron Emission Tomography Study of Norepinephrine Transporter Occupancy and Its Correlation with Symptom Response in Depressed Patients Treated with Quetiapine XR Quetiapine is effective in treating depressive symptoms in major depressive disorder and bipolar disorder, but the mechanisms underlying its antidepressants effects are unknown. Norquetiapine, a metabolite of quetiapine, has high affinity for norepinephrine transporter, which might account for its therapeutic efficacy.In (...) this study, we used positron emission tomography with (S,S)-[11C]O-methyl reboxetine to estimate norepinephrine transporter density and assess the relationship between norepinephrine transporter occupancy by quetiapine XR and improvement in depression in patients with major depressive disorder (n=5) and bipolar disorder (n=5). After the baseline positron emission tomography scan, patients were treated with quetiapine XR with a target dose of 150 mg in major depressive disorder and 300 mg in bipolar

2017 International Journal of Neuropsychopharmacology

165. Heterogeneous effects of norepinephrine on spontaneous and stimulus-driven activity in the male accessory olfactory bulb Full Text available with Trip Pro

Heterogeneous effects of norepinephrine on spontaneous and stimulus-driven activity in the male accessory olfactory bulb Norepinephrine (NE) release has been linked to experience-dependent plasticity in many model systems and brain regions. Among these is the rodent accessory olfactory system (AOS), which is crucial for detecting and processing socially relevant environmental cues. The accessory olfactory bulb (AOB), the first site of chemosensory information processing in the AOS, receives (...) . Neurons with increased spontaneous activity demonstrated a net decrease in chemosensory discriminability. These results reveal that noradrenergic signaling in the AOB causes cell-specific changes in chemosensory tuning, even among similar projection neurons.NEW & NOTEWORTHY Norepinephrine (NE) is released throughout the brain in many behavioral contexts, but its impacts on information processing are not well understood. We studied the impact of NE on chemosensory tuning in the mouse accessory

2017 Journal of neurophysiology

166. Beta-adrenoceptor Activation by Norepinephrine Enhances Lipopolysaccharide-induced Matrix Metalloproteinase-9 Expression Through the ERK/JNK-c-Fos Pathway in Human THP-1 Cells Full Text available with Trip Pro

Beta-adrenoceptor Activation by Norepinephrine Enhances Lipopolysaccharide-induced Matrix Metalloproteinase-9 Expression Through the ERK/JNK-c-Fos Pathway in Human THP-1 Cells Atherosclerosis is a chronic inflammatory disease, which leads to thrombosis and acute coronary syndrome. Matrix metalloproteinase-9 (MMP-9) is involved in the stability of the extracellular matrix (ECM) and atherosclerosis plaque. Until now, it is established that lipopolysaccharide (LPS) and norepinephrine (NE

2017 Journal of atherosclerosis and thrombosis

167. Ontogeny of Norepinephrine Transporter Expression and Antidepressant-Like Response to Desipramine in Wild-Type and Serotonin Transporter Mutant Mice Full Text available with Trip Pro

Ontogeny of Norepinephrine Transporter Expression and Antidepressant-Like Response to Desipramine in Wild-Type and Serotonin Transporter Mutant Mice Depression is a major public health concern with symptoms that are often poorly controlled by treatment with common antidepressants. This problem is compounded in juveniles and adolescents, because therapeutic options are limited to selective serotonin reuptake inhibitors (SSRIs). Moreover, therapeutic benefits of SSRIs are often especially limited (...) in certain subpopulations of depressed patients, including children and carriers of low-expressing serotonin transporter (SERT) gene variants. Tricyclic antidepressants (TCAs) offer an alternative to SSRIs; however, how age and SERT expression influence antidepressant response to TCAs is not understood. We investigated the relation between antidepressant-like response to the TCA desipramine using the tail suspension test and saturation binding of [3H]nisoxetine to the norepinephrine transporter (NET

2017 The Journal of pharmacology and experimental therapeutics

168. Norepinephrine Versus Phenylephrine Variable Infusion in Cesarean Delivery

Norepinephrine Versus Phenylephrine Variable Infusion in Cesarean Delivery Norepinephrine Versus Phenylephrine Variable Infusion in Cesarean Delivery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Norepinephrine Versus Phenylephrine Variable Infusion in Cesarean Delivery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03248791 Recruitment Status : Recruiting First Posted : August 14, 2017 Last Update Posted : January 23

2017 Clinical Trials

169. Cardiac Index Changes With Ephedrine, Phenylephrine, Ondansetron and Norepinephrine During Spinal Anesthesia

Cardiac Index Changes With Ephedrine, Phenylephrine, Ondansetron and Norepinephrine During Spinal Anesthesia Cardiac Index Changes With Ephedrine, Phenylephrine, Ondansetron and Norepinephrine During Spinal Anesthesia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Cardiac Index Changes With Ephedrine, Phenylephrine, Ondansetron and Norepinephrine During Spinal Anesthesia (EPhON) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03421860 Recruitment Status : Completed First Posted : February 5, 2018

2017 Clinical Trials

170. Effects of the novel norepinephrine prodrug, droxidopa, on ambulatory blood pressure in patients with neurogenic orthostatic hypotension. Full Text available with Trip Pro

Effects of the novel norepinephrine prodrug, droxidopa, on ambulatory blood pressure in patients with neurogenic orthostatic hypotension. The prodrug droxidopa increases blood pressure (BP) in patients with neurogenic orthostatic hypotension. The BP profile of droxidopa in neurogenic orthostatic hypotension patients (n = 18) was investigated using ambulatory BP monitoring. Following dose optimization and a washout period, 24-hour "off-drug" data were collected. "On-drug" assessment

2017 Journal of the American Society of Hypertension : JASH Controlled trial quality: uncertain

171. Cerebrospinal fluid (CSF) levels of serotonin, norepinephrine and dopamine metabolites among suicide attempters: a literature review and random-effects meta-analysis

Cerebrospinal fluid (CSF) levels of serotonin, norepinephrine and dopamine metabolites among suicide attempters: a literature review and random-effects meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

172. Terlipressin versus norepinephrine for septic shock: a systematic review and meta-analysis

Terlipressin versus norepinephrine for septic shock: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites

2019 PROSPERO

173. Effect of serotonin-norepinephrine reuptake inhibitors for patients with chemotherapy-induced painful peripheral neuropathy: a meta-analysis

Effect of serotonin-norepinephrine reuptake inhibitors for patients with chemotherapy-induced painful peripheral neuropathy: a meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration

2019 PROSPERO

174. Norepinephrine vs Phenylephrine in cesarean delivery under spinal anesthesia: a systematic literature review and meta-analysis

Norepinephrine vs Phenylephrine in cesarean delivery under spinal anesthesia: a systematic literature review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2019 PROSPERO

175. Comparison of norepinephrine and phenylephrine in treating spinal anesthesia-induced hypotension in cesarean section: a meta-analysis

Comparison of norepinephrine and phenylephrine in treating spinal anesthesia-induced hypotension in cesarean section: a meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2019 PROSPERO

176. The Effect of Norepinephrine Versus Dopamine in Renal Transplant Recipients on Postoperative Graft Function

The Effect of Norepinephrine Versus Dopamine in Renal Transplant Recipients on Postoperative Graft Function The Effect of Norepinephrine Versus Dopamine in Renal Transplant Recipients on Postoperative Graft Function - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. The Effect of Norepinephrine Versus Dopamine in Renal Transplant Recipients on Postoperative Graft Function The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier

2017 Clinical Trials

177. Small Doses of Pituitrin Versus Norepinephrine for the Management of Vasoplegic Syndrome in Patients After Cardiac Surgery

Small Doses of Pituitrin Versus Norepinephrine for the Management of Vasoplegic Syndrome in Patients After Cardiac Surgery Small Doses of Pituitrin Versus Norepinephrine for the Management of Vasoplegic Syndrome in Patients After Cardiac Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. Small Doses of Pituitrin Versus Norepinephrine for the Management of Vasoplegic Syndrome in Patients After Cardiac Surgery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our

2017 Clinical Trials

178. Norepinephrine-targeted Therapy for Action Control in Parkinson Disease

Norepinephrine-targeted Therapy for Action Control in Parkinson Disease Norepinephrine-targeted Therapy for Action Control in Parkinson Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Norepinephrine (...) Academy of Neurology Information provided by (Responsible Party): Katherine Eder McDonell, Vanderbilt University Medical Center Study Details Study Description Go to Brief Summary: The purpose of this study is to find out whether droxidopa, a medication that increases norepinephrine levels, may be effective in improving some aspects of cognition and movement in Parkinson's disease (PD). Condition or disease Intervention/treatment Phase Parkinson Disease Drug: Droxidopa Drug: Carbidopa Phase 4 Detailed

2017 Clinical Trials

179. Norepinephrine Versus Ephedrine in Treatment of Hypotension During Spinal Anesthesia for Caesarean Section

Norepinephrine Versus Ephedrine in Treatment of Hypotension During Spinal Anesthesia for Caesarean Section Norepinephrine Versus Ephedrine in Treatment of Hypotension During Spinal Anesthesia for Caesarean Section - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Norepinephrine Versus Ephedrine in Treatment of Hypotension During Spinal Anesthesia for Caesarean Section The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03163407 Recruitment Status : Completed First Posted : May 23, 2017 Last Update Posted : May

2017 Clinical Trials

180. Norepinephrine Infusion Different Doses in Cesarean Delivery

Norepinephrine Infusion Different Doses in Cesarean Delivery Norepinephrine Infusion Different Doses in Cesarean Delivery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Norepinephrine Infusion Different (...) Study Description Go to Brief Summary: three doses (0.025 mcg/Kg/min, 0.050 mcg/Kg/min, and 0.075 mcg/Kg/min) of norepinephrine will be compared for prophylaxis against Post-spinal anesthesia hypotension during Cesarean delivery. Condition or disease Intervention/treatment Phase Cesarean Section Complications Drug: norepinephrine infusion (0.025 mcg/Kg/min) Drug: norepinephrine infusion (0.050 mcg/Kg/min) Drug: norepinephrine infusion (0.075 mcg/Kg/min) Drug: Bupivacaine Phase 4 Detailed Description

2017 Clinical Trials

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