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Norepinephrine

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61. Bioinspired Honokiol Analogs and Their Evaluation for Activity on the Norepinephrine Transporter Full Text available with Trip Pro

Bioinspired Honokiol Analogs and Their Evaluation for Activity on the Norepinephrine Transporter In traditional Asian medicinal systems, preparations of the root and stem bark of Magnolia species are widely used to treat anxiety and other nervous disturbances. The biphenyl-type neolignans honokiol and magnolol are the main constituents of Magnolia bark extracts. In the central nervous system, Magnolia bark preparations that contain honokiol are thought to primarily interact with γ-aminobutyric (...) acid A (GABAA) receptors. However, stress responses inherently involve the noradrenergic system, which has not been investigated in the pharmacological mechanism of honokiol. We present here interactions of honokiol and other synthesized biphenyl-type neolignans and diphenylmethane analogs with the norepinephrine transporter (NET), which is responsible for the synaptic clearance of norepinephrine and the target of many anxiolytics. Of the synthesized compounds, 16 are new chemical entities, which

2018 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

62. Plasma Concentration of Norepinephrine, β-endorphin, and Substance P in Lame Dairy Cows Full Text available with Trip Pro

Plasma Concentration of Norepinephrine, β-endorphin, and Substance P in Lame Dairy Cows Lameness is a painful and debilitating condition that affects dairy cows worldwide. The aim of this study was to determine the plasma concentration of norepinephrine, β-endorphin, and substance P in dairy cows with lameness and different mobility scores (MS).A total of 100 Friesian and Jersey cows with lameness (parity range: 1-6; weight: 400-500 kg; milk yield: 22-28 L a day, and lactation stage less than (...) 230 days) were selected. Animals were selected and grouped according to MS (MS 0-3; n = 25), and plasma concentration of norepinephrine, substance P, and β-endorphin was measured using ELISA.Cows with MS 3 had higher plasma concentrations of norepinephrine and substance P and lower plasma concentrations of β-endorphins when compared to MS 0 cows.Variations in plasma concentration of norepinephrine, substance P, and β-endorphin could be associated with intense pain states in dairy cows

2018 Journal of Veterinary Research

63. Persistent Stress-Induced Neuroplastic Changes in the Locus Coeruleus/Norepinephrine System Full Text available with Trip Pro

Persistent Stress-Induced Neuroplastic Changes in the Locus Coeruleus/Norepinephrine System Neural plasticity plays a critical role in mediating short- and long-term brain responses to environmental stimuli. A major effector of plasticity throughout many regions of the brain is stress. Activation of the locus coeruleus (LC) is a critical step in mediating the neuroendocrine and behavioral limbs of the stress response. During stressor exposure, activation of the hypothalamic-pituitary-adrenal

2018 Neural plasticity

64. Arousal increases neural gain via the locus coeruleus-norepinephrine system in younger adults but not in older adults Full Text available with Trip Pro

Arousal increases neural gain via the locus coeruleus-norepinephrine system in younger adults but not in older adults In younger adults, arousal amplifies attentional focus to the most salient or goal-relevant information while suppressing other information. A computational model of how the locus coeruleus-norepinephrine (LC-NE) system can implement this increased selectivity under arousal and an fMRI study comparing how arousal affects younger and older adults' processing indicate

2018 Nature human behaviour

65. Comparison of first-line and second-line terlipressin versus sole norepinephrine in fulminant ovine septic shock Full Text available with Trip Pro

Comparison of first-line and second-line terlipressin versus sole norepinephrine in fulminant ovine septic shock The Surviving Sepsis Guidelines suggest the use of vasopressin in case of catecholamine-refractory septic shock. Terlipressin (TP) as a V1-selective AVP analogue is a potential alternative, though data regarding the first-line administration in septic shock are scarce. The present study explored and compared the effects of first-line vs. second-line infusion of TP or sole (...) norepinephrine regarding organ function, fluid and norepinephrine requirements and survival in fulminant ovine septic shock. Peritoneal sepsis was induced in 23 ewes after laparotomy and faecal withdrawal from the caecum. After onset of shock, causal and supportive sepsis therapy (antibiotics, peritoneal lavage, fluids and open-label norepinephrine) was performed in all animals. Concurrently, animals were randomized to receive 0.9% sodium chloride (control group) or TP (2 µg∙kg-1∙h-1, first-line group) after

2018 Scientific reports

66. Neurogenic Pulmonary Edema without Norepinephrine Elevation Full Text available with Trip Pro

Neurogenic Pulmonary Edema without Norepinephrine Elevation 29491317 2018 11 14 1349-7235 57 14 2018 07 15 Internal medicine (Tokyo, Japan) Intern. Med. Neurogenic Pulmonary Edema without Norepinephrine Elevation. 2097-2098 10.2169/internalmedicine.9825-17 Yasui Hideki H Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Japan. Arima Hideyuki H Department of Emergency and Disaster Medicine, Hamamatsu University School of Medicine, Japan. Hozumi Hironao H (...) Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Japan. Department of Emergency and Disaster Medicine, Hamamatsu University School of Medicine, Japan. Suda Takafumi T Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Japan. eng Journal Article 2018 02 28 Japan Intern Med 9204241 0918-2918 neurogenic pulmonary edema norepinephrine traumatic brain injury 2018 3 2 6 0 2018 3 2 6 1 2018 3 2 6 0 ppublish 29491317 10.2169

2018 Internal Medicine

67. Evidence for altered brain reactivity to norepinephrine in Veterans with a history of traumatic stress Full Text available with Trip Pro

Evidence for altered brain reactivity to norepinephrine in Veterans with a history of traumatic stress Increases in the quantity or impact of noradrenergic signaling have been implicated in the pathophysiology of posttraumatic stress disorder (PTSD). This increased signaling may result from increased norepinephrine (NE) release, from altered brain responses to NE, or from a combination of both factors. Here, we tested the hypothesis that Veterans reporting a history of trauma exposure would

2018 Neurobiology of stress

68. Influence of allelic variations in relation to norepinephrine and mineralocorticoid receptors on psychopathic traits: a pilot study Full Text available with Trip Pro

Influence of allelic variations in relation to norepinephrine and mineralocorticoid receptors on psychopathic traits: a pilot study Past findings support a relationship between abnormalities in the amygdala and the presence of psychopathic traits. Among other genes and biomarkers relevant to the amygdala, norepinephrine and mineralocorticoid receptors might both play a role in psychopathy due to their association with traits peripheral to psychopathy. The purpose is to examine if allelic (...) variations in single nucleotide polymorphisms related to norepinephrine and mineralocorticoid receptors play a role in the display of psychopathic traits and executive functions.Fifty-seven healthy participants from the community provided a saliva sample for SNP sampling of rs5522 and rs5569. Participants then completed the Psychopathic Personality Inventory-Short Form (PPI-SF) and the Tower of Hanoi.Allelic variations of both rs5522 and rs5569 were significant when compared to PPI-SF total score

2018 PeerJ

69. Early transcriptional response of human ovarian and fallopian tube surface epithelial cells to norepinephrine Full Text available with Trip Pro

Early transcriptional response of human ovarian and fallopian tube surface epithelial cells to norepinephrine Evidence from human and animal studies suggests that chronic behavioral stress and resulting activation of the sympathetic nervous system may influence initiation and progression of tumors. However, the underlying mechanisms for these observations are poorly understood. The purpose of this study is to explore the effects of adrenergic signaling on cell line models derived from normal (...) cells presumed to originate epithelial ovarian cancers. Here we explored the effects of the stress-related hormone, norepinephrine, on the transcriptional program of normal immortalized ovarian (iOSE) and fallopian tube (iFTSEC) surface epithelial cells. Analysis of RNA-Seq data of treated and untreated cells revealed a significant overlap between the responses in iOSE and iFTSEC cells. Most genes modulated by norepinephrine in ovarian and fallopian tube epithelial cells are already expressed

2018 Scientific reports

70. Development of norepinephrine transporter reuptake inhibition assays using SK-N-BE(2)C cells Full Text available with Trip Pro

Development of norepinephrine transporter reuptake inhibition assays using SK-N-BE(2)C cells This report describes efforts to develop and validate novel norepinephrine transporter reuptake inhibition assays using human neuroblastoma SK-N-BE(2)C cells in 24-well format. Before conducting the assays, the SK-N-BE(2)C cells were first evaluated for their ability to uptake [3H]norepinephrine and were shown to have a saturable uptake with a KM value of 416 nM. Using this determined KM value, reuptake (...) inhibition assays were then conducted with a variety of ligands including antidepressants, as well as piperazine and phenyltropane derivatives. The results obtained with the SK-N-BE(2)C cells indicate that this model system can detect a range of ligand potencies, which compare well with other established transporter assays. Our data suggest that SK-N-BE(2)C cells have potential utility to serve as another model system to detect norepinephrine reuptake inhibition activity.

2018 Heliyon

71. Efficacy and Safety of Different Norepinephrine Regimens for Prevention of Spinal Hypotension in Cesarean Section: A Randomized Trial Full Text available with Trip Pro

Efficacy and Safety of Different Norepinephrine Regimens for Prevention of Spinal Hypotension in Cesarean Section: A Randomized Trial The aim of this paper is to evaluate the efficacy and safety of three different norepinephrine dosing regimens for preventing spinal hypotension in cesarean section. In this randomized double-blinded controlled study, 120 parturients scheduled for elective section delivery under spinal anesthesia were assigned to 1 of 4 groups. In the control group, patients (...) received saline infusion. In three norepinephrine groups, the infusion dosage regimens were 5, 10, and 15 μg/kg/h, respectively. Hypotension was treated with a rescue bolus of 10 μg norepinephrine. The study protocol was continued until the end of surgery. The primary outcome was the proportion of participants that underwent hypotension. The proportion of hypotension participants was significantly reduced in the norepinephrine groups (37.9%, 20%, and 25%, respectively) compared to that in the control

2018 BioMed research international Controlled trial quality: predicted high

72. Interaction of Norepinephrine and Glucocorticoids Modulate Inhibition of Principle Cells of Layer II Medial Entorhinal Cortex in Male Mice Full Text available with Trip Pro

Interaction of Norepinephrine and Glucocorticoids Modulate Inhibition of Principle Cells of Layer II Medial Entorhinal Cortex in Male Mice Spatial memory processing requires functional interaction between the hippocampus and the medial entorhinal cortex (MEC). The grid cells of the MEC are most abundant in layer II and rely on a complex network of local inhibitory interneurons to generate spatial firing properties. Stress can cause spatial memory deficits in males, but the specific underlying (...) mechanisms affecting the known memory pathways remain unclear. Stress activates both the autonomic nervous system and the hypothalamic-pituitary-adrenal axis to release norepinephrine (NE) and glucocorticoids, respectively. Given that adrenergic receptor (AR) and glucocorticoid receptor (GR) expression is abundant in the MEC, both glucocorticoids and NE released in response to stress may have rapid effects on MEC-LII networks. We used whole-cell patch clamp electrophysiology in MEC slice preparations

2018 Frontiers in synaptic neuroscience

73. Septic shock and the use of norepinephrine in an intermediate care unit: Mortality and adverse events. Full Text available with Trip Pro

Septic shock and the use of norepinephrine in an intermediate care unit: Mortality and adverse events. Septic shock is associated with high mortality. Aged and multimorbid patients are not always eligible for intensive care units. Norepinephrine is an accepted treatment for hypotension in septic shock. It is unknown whether norepinephrine has a place in treatment outside an intensive care unit and when given peripherally.To describe mortality, Acute Physiology And Chronic Health Evaluation (...) (APACHE-II), time to mean arterial pressure >65 mmHg, and adverse events in patients with septic shock receiving norepinephrine peripherally in an intermediate care unit.From a retrospective chart review of 91 patients with septic shock treated with norepinephrine for hypotension, ward mortality, 30-, 60- and 90-day mortality, standardized mortality ratio (SMR) and adverse events (necrosis and arrhythmia) were analysed. Administration route via peripheral venous catheter or central venous catheter

2017 PLoS ONE

74. Terlipressin versus norepinephrine as infusion in patients with septic shock: a multicentre, randomised, double-blinded trial. (Abstract)

Terlipressin versus norepinephrine as infusion in patients with septic shock: a multicentre, randomised, double-blinded trial. Recent clinical data suggest that terlipressin, a vasopressin analogue, may be more beneficial in septic shock patients than catecholamines. However, terlipressin's effect on mortality is unknown. We set out to ascertain the efficacy and safety of continuous terlipressin infusion compared with norepinephrine (NE) in patients with septic shock.In this multicentre

2018 Intensive Care Medicine Controlled trial quality: predicted high

75. The role of norepinephrine and alpha-adrenergic receptors in acute stress-induced changes in granulocytes and monocytes. Full Text available with Trip Pro

The role of norepinephrine and alpha-adrenergic receptors in acute stress-induced changes in granulocytes and monocytes. Acute stress induces redistribution of circulating leucocytes in humans. Although effects on lymphocytes as adaptive immune cells are well understood, the mechanisms underlying stress effects on granulocytes and monocytes as innate immune blood cells are still elusive. We investigated whether the stress hormone norepinephrine (NE) and α-adrenergic receptors (α-ADRs) may play

2018 Psychosomatic Medicine

76. Norepinephrine and thyroxine are predictors of fat mass gain in humans with cold-induced brown adipose tissue activation. Full Text available with Trip Pro

Norepinephrine and thyroxine are predictors of fat mass gain in humans with cold-induced brown adipose tissue activation. In healthy adults with detectable cold-induced brown adipose tissue activation (CIBA), the relationships between sympathetic nervous system (SNS) or thyroid activity during energy balance (EBL) with CIBA and body composition change are undetermined.To investigate the relationships between CIBA and thermoneutral catecholamines and thyroid hormones measured during EBL (...) with concomitant measurement of urinary catecholamines and plasma free T3 and free T4. Body composition at baseline and 6 months by dual-energy X-ray absorptiometry.Lower urinary norepinephrine and free T4 were associated with higher CIBA (r = -0.65, P = 0.03; and r = -0.75, P < 0.01, respectively), but CIBA was not associated with 24hEE at thermoneutrality (P = 0.77). Lower CIBA (β = -3.5 kg/standardized uptake value; P < 0.01) predicted fat mass gain, whereas higher urinary norepinephrine and free T4

2018 Journal of Clinical Endocrinology and Metabolism

77. Association of Coprescription of Triptan Antimigraine Drugs and Selective Serotonin Reuptake Inhibitor or Selective Norepinephrine Reuptake Inhibitor Antidepressants With Serotonin Syndrome. Full Text available with Trip Pro

Association of Coprescription of Triptan Antimigraine Drugs and Selective Serotonin Reuptake Inhibitor or Selective Norepinephrine Reuptake Inhibitor Antidepressants With Serotonin Syndrome. In 2006, the US Food and Drug Administration (FDA) issued an advisory warning on the risk of serotonin syndrome with concomitant use of triptans and selective serotonin reuptake inhibitor (SSRI) or selective norepinephrine reuptake inhibitor (SNRI) antidepressants, but the true risk of serotonin syndrome

2018 JAMA neurology

78. Associations between CSF cortisol and CSF norepinephrine in cognitively normal controls and patients with amnestic MCI and AD dementia. Full Text available with Trip Pro

Associations between CSF cortisol and CSF norepinephrine in cognitively normal controls and patients with amnestic MCI and AD dementia. This study evaluated the effects of Alzheimer disease (AD) on the relationship between the brain noradrenergic system and hypothalamic pituitary adrenocortical axis (HPA). Specifically, relationships between cerebrospinal fluid (CSF) norepinephrine (NE) and CSF cortisol were examined in cognitively normal participants and participants with AD dementia

2018 International Journal of Geriatric Psychiatry

79. Norepinephrine exerts an inotropic effect during the early phase of human septic shock. Full Text available with Trip Pro

Norepinephrine exerts an inotropic effect during the early phase of human septic shock. We conducted this study to investigate whether norepinephrine increases cardiac contractility when administered during the early phase of septic shock.We studied 38 patients with septic shock who had been resuscitated for <3 h and whose mean arterial pressure (MAP) remained <65 mm Hg. Echocardiographic variables were obtained before (T0) and after either initiation or an increase in the dose (...) of a norepinephrine infusion to increase MAP to ≥ 65 mm Hg (T1). We collected left ventricular ejection fraction (LVEF), velocity-time integral of the left ventricular outflow tract (VTI), tissue Doppler imaging of mean systolic velocity of the lateral tricuspid annulus (Sa) and of the lateral mitral annulus (Sm), and tricuspid annular plane systolic excursion (TAPSE).There were significant (P<0.05) increases from T0 to T1 in MAP [mean (sd): from 56 (7) to 80 (9) mm Hg], LVEF [from 49 (13) to 56 (13)%], VTI [from

2018 British Journal of Anaesthesia

80. Norepinephrine in Combination with Antimicrobial Therapy Increases both the Bacterial Replication Rate and Bactericidal Activity. Full Text available with Trip Pro

Norepinephrine in Combination with Antimicrobial Therapy Increases both the Bacterial Replication Rate and Bactericidal Activity. We previously demonstrated that the rate and extent of an antimicrobial agent's bactericidal effects were coupled to the bacterial replication rate, the latter of which was modulated with the sodium chloride concentration. Herein, we describe the results from a 24-h one-compartment in vitro infection model study that was designed to demonstrate that an antimicrobial (...) agent's bactericidal effects could be amplified when it is administered with a pharmaceutical agent that increases the bacterial replication rate. The antimicrobial and growth-promoting agents selected were levofloxacin and norepinephrine, respectively. The challenge isolate was Escherichia coli JMI 21711R (levofloxacin MIC, 8 mg/liter). Within the in vitro infection model, a human levofloxacin concentration-time profile (half-life, 7 h) was simulated and the challenge isolate was subjected

2018 Antimicrobial Agents and Chemotherapy

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