How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

10,874 results for

Norepinephrine

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

41. Norepinephrine-Induced Stimulation of Kir4.1/Kir5.1 Is Required for the Activation of NaCl Transporter in Distal Convoluted Tubule. (Full text)

Norepinephrine-Induced Stimulation of Kir4.1/Kir5.1 Is Required for the Activation of NaCl Transporter in Distal Convoluted Tubule. The stimulation of β-adrenergic receptor increases thiazide-sensitive NaCl cotransporter (NCC), an effect contributing to salt-sensitive hypertension by sympathetic stimulation. We now test whether the stimulation of β-adrenergic receptor-induced activation of NCC is achieved through activating basolateral Kir4.1 in the distal convoluted tubule (DCT). Application (...) of norepinephrine increased the basolateral 40 pS K+ channel (Kir4.1/Kir5.1 heterotetramer) in the DCT. The stimulatory effect of norepinephrine on the K+ channel was mimicked by cAMP analogue but abolished by inhibiting PKA (protein kinase A). Also, the effect of norepinephrine on the K+ channel in the DCT was recapitulated by isoproterenol but not by α-adrenergic agonist and blocked by propranolol, suggesting that norepinephrine effect on the K+ channel was mediated by β-adrenergic receptor. The whole-cell

2019 Hypertension PubMed abstract

42. Persistence with selective serotonin (norepinephrine) reuptake inhibitors in Germany-A retrospective database analysis. (Abstract)

Persistence with selective serotonin (norepinephrine) reuptake inhibitors in Germany-A retrospective database analysis. Selective serotonin (norepinephrine) reuptake inhibitors (SS(N)RIs) are used in the treatment of depression. The aim of this study was to assess the persistence with SS(N)RIs in outpatients treated by general practitioners (GP) or psychiatrists (PSY) in Germany, and to investigate the association between persistence and the following factors: age, gender, specialty

2019 Journal of Affective Disorders

43. Correction to: Norepinephrine in septic shock. (Full text)

Correction to: Norepinephrine in septic shock. The original version of this article unfortunately contained a mistake.

2019 Intensive Care Medicine PubMed abstract

44. Association Between US Norepinephrine Shortage and Mortality Among Patients With Septic Shock. (Abstract)

Association Between US Norepinephrine Shortage and Mortality Among Patients With Septic Shock. Drug shortages in the United States are common, but their effect on patient care and outcomes has rarely been reported.To assess changes to patient care and outcomes associated with a 2011 national shortage of norepinephrine, the first-line vasopressor for septic shock.Retrospective cohort study of 26 US hospitals in the Premier Healthcare Database with a baseline rate of norepinephrine use (...) of at least 60% for patients with septic shock. The cohort included adults with septic shock admitted to study hospitals between July 1, 2008, and June 30, 2013 (n = 27 835).Hospital-level norepinephrine shortage was defined as any quarterly (3-month) interval in 2011 during which the hospital rate of norepinephrine use decreased by more than 20% from baseline.Use of alternative vasopressors was assessed and a multilevel mixed-effects logistic regression model was used to evaluate the association between

2017 JAMA

45. Effects of the discontinuation sequence of norepinephrine and vasopressin on hypotension incidence in patients with septic shock: A meta-analysis. (Abstract)

Effects of the discontinuation sequence of norepinephrine and vasopressin on hypotension incidence in patients with septic shock: A meta-analysis. Although the order of vasopressor initiation in patients with septic shock is established, limited information is available on the order of vasopressor discontinuation.We performed a meta-analysis of nine studies involving 1245 patients in whom norepinephrine (n = 787) or vasopressin (n = 458) was withdrawn first to compare the risk

2019 Heart & Lung

46. Effects of norepinephrine and vasopressin discontinuation order in the recovery phase of septic shock: a systematic review and individual patient data meta-analysis. (Abstract)

Effects of norepinephrine and vasopressin discontinuation order in the recovery phase of septic shock: a systematic review and individual patient data meta-analysis. The impact of vasopressin and norepinephrine discontinuation order in the recovery phase of septic shock remains controversial. This systematic review and patient-level meta-analysis were performed to determine the impact of vasopressin and norepinephrine discontinuation order on clinically significant outcomes in the recovery (...) phase of septic shock.Cumulative Index to Nursing and Allied Health Literature, Embase, PubMed, and ClinicalTrials.gov were searched from inception through November 2018 for studies comparing outcomes after the discontinuation of vasopressin or norepinephrine in septic shock. Individual patient-level data were obtained from included studies and combined using a two-stage meta-analysis.Six studies of low or moderate risk of bias with 957 patients were included. Clinically significant hypotension

2019 Pharmacotherapy

47. Efficacy and safety of norepinephrine versus phenylephrine for the management of maternal hypotension during cesarean delivery with spinal anesthesia: A systematic review and meta-analysis. (Full text)

Efficacy and safety of norepinephrine versus phenylephrine for the management of maternal hypotension during cesarean delivery with spinal anesthesia: A systematic review and meta-analysis. Phenylephrine is the current "gold standard' vasopressor used to treat maternal hypotension in women undergoing cesarean delivery with spinal anesthesia. Since 2015, various studies have explored the use of norepinephrine to manage maternal hypotension. We conducted this systematic review and meta-analysis (...) of available randomized controlled trials (RCTs) to compare the efficacy and safety of norepinephrine and phenylephrine for the prevention and treatment of maternal hypotension.A systematic literature search was conducted using electronic databases, including PubMed, MEDLINE, Embase (Embase.com), and the Cochrane CENTRAL register of controlled trials. Parturients underwent cesarean delivery with spinal anesthesia and received norepinephrine to prevent or treat hypotension were considered. Maternal outcomes

2019 Medicine PubMed abstract

48. Association analysis of norepinephrine transporter polymorphisms and methylphenidate response in ADHD patients. (Abstract)

Association analysis of norepinephrine transporter polymorphisms and methylphenidate response in ADHD patients. Methylphenidate (MPH) is the most frequently prescribed drug in Attention Deficit Hyperactivity Disorder (ADHD). Hitherto mostly the dopamine transporter gene has been studied in MPH-response and only a few studies analyzed the norepinephrine transporter (NET, SLC6A2) gene, although MPH is a potent inhibitor of both dopamine and norepinephrine transporters. We aimed to analyze

2019 Progress in neuro-psychopharmacology & biological psychiatry

49. A randomized double-blind study comparing prophylactic norepinephrine and ephedrine infusion for preventing maternal spinal hypotension during elective cesarean section under spinal anesthesia: A CONSORT-compliant article. (Full text)

A randomized double-blind study comparing prophylactic norepinephrine and ephedrine infusion for preventing maternal spinal hypotension during elective cesarean section under spinal anesthesia: A CONSORT-compliant article. Studies have shown the efficacy of norepinephrine in the treatment of maternal hypotension during cesarean section by comparing it to treatment with phenylephrine. However, few studies have compared the efficacy of norepinephrine to ephedrine.Ninety-seven women undergoing (...) elective cesarean section were administered norepinephrine at 4 μg/minute (group N; n = 48) or ephedrine at 4 mg/minute (group E; n = 49) immediately postspinal anesthesia, with an on-off titration to maintain systolic blood pressure (SBP) at 80% to 120% of baseline. A rescue bolus of 8 μg norepinephrine was given whenever SBP reached the predefined lower limit. Our primary outcome was the incidence of tachycardia. Secondary outcomes included the incidence of bradycardia, hypertension, hypotension

2019 Medicine PubMed abstract

50. Meta-analysis on the Association Between Norepinephrine Transporter Gene rs2242446, rs5569 Polymorphisms and Risk of Major Depressive Disorder. (Abstract)

Meta-analysis on the Association Between Norepinephrine Transporter Gene rs2242446, rs5569 Polymorphisms and Risk of Major Depressive Disorder. The association between norepinephrine transporter (NET) gene polymorphisms and the risk of major depressive disorder (MDD) has been investigated extensively, but with contradictory findings.To clarify such contradiction, a comprehensive meta-analysis was conducted by searching PubMed, EMBASE, Web of Science and China Knowledge Resource Integrated

2019 Archives of medical research

51. Is the Addition of Vasopressin to Norepinephrine Beneficial for the Treatment of Septic Shock?

Is the Addition of Vasopressin to Norepinephrine Beneficial for the Treatment of Septic Shock? SystematicReviewSnapshot TAKE-HOME MESSAGE The addition of low-dose vasopressin to norepinephrine may not signi?cantly reduce mortality in adult patients with septic shock. METHODS DATA SOURCES MEDLINE (1966 to 2011) and CENTRAL (1800 to 2011) data- bases were searched and ab- stracts from recent major confer- ences were reviewed by 3 of the authors. STUDY SELECTION Randomized controlled trials evalu (...) was calculated with a ?xed-effect model and was represented with forest plots; heterogeneity was evaluated with a 2 test. Subgroup analysis of just patients with sepsis was per- formed. Individual study investiga- tors were contacted as necessary for clari?cation after data were extracted. Study quality was Is the Addition of Vasopressin to Norepinephrine Bene?cial for the Treatment of Septic Shock? EBEM Commentators John P. Sandifer, MD Alan E. Jones, MD Department of Emergency Medicine University

2013 Annals of Emergency Medicine Systematic Review Snapshots

52. Dopamine versus Norepinephrine For the Treatment of Septic Shock

Dopamine versus Norepinephrine For the Treatment of Septic Shock SystematicReviewSnapshot TAKE-HOME MESSAGE Dopamine administration is associated with a higher incidence of arrhythmias and increased risk of death compared with norepinephrine in the treatment of septic shock. METHODS DATA SOURCES The search included MEDLINE, EMBASE, Scopus databases, and the Cochrane registry of clinical trials (through June 30, 2011). Google Scholar, clinical trials.org, controlled-trials.com, and ab- stracts (...) of major congresses (2005 to 2010) were also searched. STUDY SELECTION Studies providing outcome data on the use of dopamine com- pared with norepinephrine in the treatment of septic shock were included; observational and ran- domized controlled trials were evaluated separately. Animal trials, pediatric trials, and crossover de- sign trials were excluded. DATA EXTRACTION AND SYNTHESIS Two authors independently ex- tracted data from all studies, and the Cochrane risk of bias tool was used. Twenty-eight

2012 Annals of Emergency Medicine Systematic Review Snapshots

53. Serotonin norepinephrine re-uptake inhibitor (SNRI)-, selective norepinephrine reuptake inhibitor (S-NRI)-, and exogenously administered norepinephrine-induced takotsubo syndrome: Analysis of published cases. (Abstract)

Serotonin norepinephrine re-uptake inhibitor (SNRI)-, selective norepinephrine reuptake inhibitor (S-NRI)-, and exogenously administered norepinephrine-induced takotsubo syndrome: Analysis of published cases. Takotsubo syndrome (TS) may be triggered by numerous physical stress factors including exogenous Norepinephrine administration. The aim of this study is to report on the clinical features and outcome of serotonin-norepinephrine reuptake inhibitor (SNRI)-, selective NRI (S-NRI (...) )-, and exogenously administered norepinephrine-induced TS in a largest possible cohort of published cases.A computer assisted search of the electronic data base Pubmed was performed from 1990 to August 2016. All cases deemed to have SNRI-, S-NRI-, and norepinephrine-induced TS were retrieved.Twenty two cases of SNRI-, S-NRI-, and norepinephrine-induced TS were retrieved from the literature. At presentation, the 22 patients with TS were 11 to 82years of age (mean age 49.9±20years). Seventeen of 21 (81

2016 International journal of cardiology

54. A randomized, double-blind, placebo-controlled, crossover study to evaluate the human abuse liability of solriamfetol, a selective dopamine and norepinephrine reuptake inhibitor. (Full text)

A randomized, double-blind, placebo-controlled, crossover study to evaluate the human abuse liability of solriamfetol, a selective dopamine and norepinephrine reuptake inhibitor. This study evaluated the human abuse potential of solriamfetol (formerly JZP-110), a selective dopamine and norepinephrine reuptake inhibitor with robust wake-promoting effects.Adults with a recent history of recreational polydrug use, including stimulants, and who met criteria in a Qualification Phase were randomized

2018 Journal of psychopharmacology (Oxford, England) Controlled trial quality: uncertain PubMed abstract

55. Does prophylactic ondansetron reduce norepinephrine consumption in patients undergoing cesarean section with spinal anesthesia? (Abstract)

Does prophylactic ondansetron reduce norepinephrine consumption in patients undergoing cesarean section with spinal anesthesia? Spinal anesthesia-induced hypotension (SAIH) during cesarean delivery is not rare and frequently leads to materno-fetal discrepancy and collapse. More recently, norepinephrine has been proposed for the prevention and treatment of SAIH with fewer tendencies to decrease heart rate and cardiac output. Ondansetron has been reported to reduce the incidence of SAIH (...) in patients undergoing cesarean section. The aim of the present study was to assess the effect of prophylactic ondansetron on the incidence of SAIH, norepinephrine consumption, and adverse effects.We recruited 108 parturients with uncomplicated pregnancies undergoing elective cesarean delivery under spinal anesthesia. The parturients were divided into two groups randomly. The first group (n = 54) received 8 mg ondansetron IV (group O) and the second group (n = 54) received the same volume (4 ml) of saline

2018 Journal of anesthesia Controlled trial quality: uncertain

56. Re: Intraoperative Continuous Norepinephrine Infusion Combined with Restrictive Deferred Hydration Significantly Reduces the Need for Blood Transfusion in Patients Undergoing Open Radical Cystectomy: Results of a Prospective Randomised Trial. (Abstract)

Re: Intraoperative Continuous Norepinephrine Infusion Combined with Restrictive Deferred Hydration Significantly Reduces the Need for Blood Transfusion in Patients Undergoing Open Radical Cystectomy: Results of a Prospective Randomised Trial. 27302775 2018 07 26 2018 12 02 1527-3792 195 4 Pt 1 2016 04 The Journal of urology J. Urol. Re: Intraoperative Continuous Norepinephrine Infusion Combined with Restrictive Deferred Hydration Significantly Reduces the Need for Blood Transfusion in Patients (...) Undergoing Open Radical Cystectomy: Results of a Prospective Randomised Trial. 902-3 10.1016/j.juro.2016.01.041 S0022-5347(16)00075-6 Chang Sam S SS eng Journal Article Comment 2016 01 22 United States J Urol 0376374 0022-5347 0 Vasoconstrictor Agents X4W3ENH1CV Norepinephrine AIM IM Eur Urol. 2014 Aug;66(2):352-60 24012203 Blood Transfusion Cystectomy Humans Norepinephrine Prospective Studies Urinary Bladder Neoplasms Vasoconstrictor Agents 2016 01 14 2016 6 16 6 0 2016 6 16 6 0 2018 7 27 6 0 ppublish

2018 The Journal of urology Controlled trial quality: uncertain

57. [Comparison of effect of norepinephrine and terlipressin on patients with ARDS combined with septic shock: a prospective single-blind randomized controlled trial]. (Abstract)

[Comparison of effect of norepinephrine and terlipressin on patients with ARDS combined with septic shock: a prospective single-blind randomized controlled trial]. To approach the effect of different vasopressor on hemodynamics, volume responsiveness, fluid volume balance, renal function and prognosis in patients with acute respiratory distress syndrome (ARDS) complicated with septic shock.A prospective single-blind randomized controlled trial was conducted. ARDS patients with septic shock (...) admitted to the Department of Critical Care Medicine of Jiangxi Provincial People's Hospital from January 1st, 2015 to May 1st, 2016 were enrolled. The patients satisfied ARDS Berlin diagnostic criteria, over 15 years old, needing vasopressor after fluid resuscitation were enrolled. The patients were divided into norepinephrine group (NE group) and terlipressin group (TP group) by randomise number table derived by computer. Patients in TP group were given terlipressin (0.01-0.04 U/min

2018 Zhonghua wei zhong bing ji jiu yi xue Controlled trial quality: uncertain

58. Perivascular Adipocytes Store Norepinephrine by Vesicular Transport. (Full text)

Perivascular Adipocytes Store Norepinephrine by Vesicular Transport. Objective- Perivascular adipose tissue (PVAT) contains an independent adrenergic system that can take up, metabolize, release, and potentially synthesize the vasoactive catecholamine norepinephrine. Norepinephrine has been detected in PVAT, but the mechanism of its protection within this tissue is unknown. Here, we investigate whether PVAT adipocytes can store norepinephrine using VMAT (vesicular monoamine transporter (...) ). Approach and Results- High-performance liquid chromatography identified norepinephrine in normal male Sprague Dawley rat aortic, superior mesenteric artery, and mesenteric resistance vessel PVATs, and retroperitoneal fat. Real-time polymerase chain reaction revealed VMAT1 and VMAT2 mRNA expression in the adipocytes and stromal vascular fraction of mesenteric resistance vessel PVAT. Immunofluorescence demonstrated the presence of VMAT1 and VMAT2, and the colocalization of VMAT2 with norepinephrine

2018 Thrombosis and Vascular Biology PubMed abstract

59. Norepinephrine Boluses for Prevention of Postreperfusion Syndrome in Living Donor Liver Transplantation

Norepinephrine Boluses for Prevention of Postreperfusion Syndrome in Living Donor Liver Transplantation Norepinephrine Boluses for Prevention of Postreperfusion Syndrome in Living Donor Liver Transplantation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Norepinephrine Boluses for Prevention of Postreperfusion Syndrome in Living Donor Liver Transplantation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03773276

2018 Clinical Trials

60. Norepinephrine Infusion Versus Midodrine & Octreotide in Patients With Hepatorenal Syndrome Type 1.

Norepinephrine Infusion Versus Midodrine & Octreotide in Patients With Hepatorenal Syndrome Type 1. Norepinephrine Infusion Versus Midodrine & Octreotide in Patients With Hepatorenal Syndrome Type 1. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Norepinephrine Infusion Versus Midodrine & Octreotide in Patients With Hepatorenal Syndrome Type 1. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03455322 Recruitment Status

2018 Clinical Trials

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>