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Norepinephrine

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41. Persistence with selective serotonin (norepinephrine) reuptake inhibitors in Germany-A retrospective database analysis. (Abstract)

Persistence with selective serotonin (norepinephrine) reuptake inhibitors in Germany-A retrospective database analysis. Selective serotonin (norepinephrine) reuptake inhibitors (SS(N)RIs) are used in the treatment of depression. The aim of this study was to assess the persistence with SS(N)RIs in outpatients treated by general practitioners (GP) or psychiatrists (PSY) in Germany, and to investigate the association between persistence and the following factors: age, gender, specialty

2019 Journal of Affective Disorders

42. Norepinephrine-Induced Stimulation of Kir4.1/Kir5.1 Is Required for the Activation of NaCl Transporter in Distal Convoluted Tubule. Full Text available with Trip Pro

Norepinephrine-Induced Stimulation of Kir4.1/Kir5.1 Is Required for the Activation of NaCl Transporter in Distal Convoluted Tubule. The stimulation of β-adrenergic receptor increases thiazide-sensitive NaCl cotransporter (NCC), an effect contributing to salt-sensitive hypertension by sympathetic stimulation. We now test whether the stimulation of β-adrenergic receptor-induced activation of NCC is achieved through activating basolateral Kir4.1 in the distal convoluted tubule (DCT). Application (...) of norepinephrine increased the basolateral 40 pS K+ channel (Kir4.1/Kir5.1 heterotetramer) in the DCT. The stimulatory effect of norepinephrine on the K+ channel was mimicked by cAMP analogue but abolished by inhibiting PKA (protein kinase A). Also, the effect of norepinephrine on the K+ channel in the DCT was recapitulated by isoproterenol but not by α-adrenergic agonist and blocked by propranolol, suggesting that norepinephrine effect on the K+ channel was mediated by β-adrenergic receptor. The whole-cell

2019 Hypertension

43. Terlipressin versus norepinephrine to prevent milrinone-induced systemic vascular hypotension in cardiac surgery patient with pulmonary hypertension. Full Text available with Trip Pro

Terlipressin versus norepinephrine to prevent milrinone-induced systemic vascular hypotension in cardiac surgery patient with pulmonary hypertension. Milrinone at inotropic doses requires the addition of a vasoconstrictive drug. We hypothesized that terlipressin use could selectively recover the systemic vascular hypotension induced by milrinone without increasing the pulmonary vascular resistance (PVR) and mean pulmonary artery pressure (MPAP) as norepinephrine in cardiac surgery (...) patients.Patients with pulmonary hypertension were enrolled in this study. At the start of rewarming a milrinone 25 μg/kg bolus over 10 min followed by infusion at the rate of 0.25 μg/kg/min. Just after the loading dose of milrinone, the patients were randomized to receive norepinephrine infusion at a dose of 0.1 μg/kg/min (norepinephrine group) or terlipressin infusion at a dose of 2 μg/kg/h (terlipressin group). Heart rate, mean arterial blood pressure (MAP), central venous pressure, MPAP, systemic vascular

2019 Annals of cardiac anaesthesia Controlled trial quality: uncertain

44. Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans. Full Text available with Trip Pro

Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans. Cardiovascular risk rapidly increased following exposure to air pollution. Changes in human autonomic regulation have been implicated based on epidemiological associations between exposure estimates and indirect autonomic nervous system measurements. We conducted a mechanistic study to test the hypothesis that, in healthy older individuals, well-defined experimental (...) deep breathing, and during a Valsalva manoeuvre. Catechols and inflammatory marker levels were measured in venous blood samples. Induced sputum was obtained 3.5 h after exposure. Combined exposure to UFP + O3 but not UFP alone, caused a significant increase in sputum neutrophils and circulating leucocytes. Norepinephrine was modestly increased while the ratio between plasma dihydroxyphenylglycol (DHPG) and norepinephrine levels, a marker for norepinephrine clearance, was reduced with UFP + O3

2019 Scientific reports Controlled trial quality: uncertain

45. The effects of repeated binge drinking on arterial stiffness and urinary norepinephrine levels in young adults. Full Text available with Trip Pro

The effects of repeated binge drinking on arterial stiffness and urinary norepinephrine levels in young adults. The aim of this study was to investigate the effect of repeated binge drinking and moderate alcohol consumption in young adults on arterial stiffness and sympathetic activity.We enrolled 49 healthy young adults, free of cardiovascular diseases (25 men; age: 23.5 ± 0.4 years; BMI: 23.4 ± 0.4 kg/m; mean ± S.E). Individuals included were those with a history of repeated binge drinking (...) (>2 years duration; n = 20), drank at moderate levels (MODs, >5 years duration; n = 16) and abstained from alcohol (last 2-3 years; n = 13). Arterial stiffness was assessed using carotid to femoral pulse wave velocity (cfPWV) and sympathetic activity was assessed using 24-h urinary norepinephrine levels. Also measured was aortic SBP and augmentation index (AIx), a measure of wave reflection.Binge drinkers and MODs had higher cfPWV than alcohol abstainers (0.6 and 0.5 m/s, respectively; P ≤ 0.04

2019 Journal of Hypertension

46. Feasibility of closed-loop titration of norepinephrine infusion in patients undergoing moderate- and high-risk surgery. Full Text available with Trip Pro

Feasibility of closed-loop titration of norepinephrine infusion in patients undergoing moderate- and high-risk surgery. Vasopressor agents are used to prevent intraoperative hypotension and ensure adequate perfusion. Vasopressors are usually administered as intermittent boluses or manually adjusted infusions, but this practice requires considerable time and attention. We have developed a closed-loop vasopressor (CLV) controller to correct hypotension more efficiently. Here, we conducted a proof (...) -of-concept study to assess the feasibility and performance of CLV control in surgical patients.Twenty patients scheduled for elective surgical procedures were included in this study. The goal of the CLV system was to maintain MAP within 5 mm Hg of the target MAP by automatically adjusting the rate of a norepinephrine infusion using MAP values recorded continuously from an arterial catheter. The primary outcome was the percentage of time that patients were hypotensive, as defined by a MAP of 5 mm Hg below

2019 British Journal of Anaesthesia

47. A randomized double-blind study comparing prophylactic norepinephrine and ephedrine infusion for preventing maternal spinal hypotension during elective cesarean section under spinal anesthesia: A CONSORT-compliant article. Full Text available with Trip Pro

A randomized double-blind study comparing prophylactic norepinephrine and ephedrine infusion for preventing maternal spinal hypotension during elective cesarean section under spinal anesthesia: A CONSORT-compliant article. Studies have shown the efficacy of norepinephrine in the treatment of maternal hypotension during cesarean section by comparing it to treatment with phenylephrine. However, few studies have compared the efficacy of norepinephrine to ephedrine.Ninety-seven women undergoing (...) elective cesarean section were administered norepinephrine at 4 μg/minute (group N; n = 48) or ephedrine at 4 mg/minute (group E; n = 49) immediately postspinal anesthesia, with an on-off titration to maintain systolic blood pressure (SBP) at 80% to 120% of baseline. A rescue bolus of 8 μg norepinephrine was given whenever SBP reached the predefined lower limit. Our primary outcome was the incidence of tachycardia. Secondary outcomes included the incidence of bradycardia, hypertension, hypotension

2019 Medicine

48. Association Between US Norepinephrine Shortage and Mortality Among Patients With Septic Shock. (Abstract)

Association Between US Norepinephrine Shortage and Mortality Among Patients With Septic Shock. Drug shortages in the United States are common, but their effect on patient care and outcomes has rarely been reported.To assess changes to patient care and outcomes associated with a 2011 national shortage of norepinephrine, the first-line vasopressor for septic shock.Retrospective cohort study of 26 US hospitals in the Premier Healthcare Database with a baseline rate of norepinephrine use (...) of at least 60% for patients with septic shock. The cohort included adults with septic shock admitted to study hospitals between July 1, 2008, and June 30, 2013 (n = 27 835).Hospital-level norepinephrine shortage was defined as any quarterly (3-month) interval in 2011 during which the hospital rate of norepinephrine use decreased by more than 20% from baseline.Use of alternative vasopressors was assessed and a multilevel mixed-effects logistic regression model was used to evaluate the association between

2017 JAMA

49. Is the Addition of Vasopressin to Norepinephrine Beneficial for the Treatment of Septic Shock?

Is the Addition of Vasopressin to Norepinephrine Beneficial for the Treatment of Septic Shock? SystematicReviewSnapshot TAKE-HOME MESSAGE The addition of low-dose vasopressin to norepinephrine may not signi?cantly reduce mortality in adult patients with septic shock. METHODS DATA SOURCES MEDLINE (1966 to 2011) and CENTRAL (1800 to 2011) data- bases were searched and ab- stracts from recent major confer- ences were reviewed by 3 of the authors. STUDY SELECTION Randomized controlled trials evalu (...) was calculated with a ?xed-effect model and was represented with forest plots; heterogeneity was evaluated with a 2 test. Subgroup analysis of just patients with sepsis was per- formed. Individual study investiga- tors were contacted as necessary for clari?cation after data were extracted. Study quality was Is the Addition of Vasopressin to Norepinephrine Bene?cial for the Treatment of Septic Shock? EBEM Commentators John P. Sandifer, MD Alan E. Jones, MD Department of Emergency Medicine University

2013 Annals of Emergency Medicine Systematic Review Snapshots

50. Dopamine versus Norepinephrine For the Treatment of Septic Shock

Dopamine versus Norepinephrine For the Treatment of Septic Shock SystematicReviewSnapshot TAKE-HOME MESSAGE Dopamine administration is associated with a higher incidence of arrhythmias and increased risk of death compared with norepinephrine in the treatment of septic shock. METHODS DATA SOURCES The search included MEDLINE, EMBASE, Scopus databases, and the Cochrane registry of clinical trials (through June 30, 2011). Google Scholar, clinical trials.org, controlled-trials.com, and ab- stracts (...) of major congresses (2005 to 2010) were also searched. STUDY SELECTION Studies providing outcome data on the use of dopamine com- pared with norepinephrine in the treatment of septic shock were included; observational and ran- domized controlled trials were evaluated separately. Animal trials, pediatric trials, and crossover de- sign trials were excluded. DATA EXTRACTION AND SYNTHESIS Two authors independently ex- tracted data from all studies, and the Cochrane risk of bias tool was used. Twenty-eight

2012 Annals of Emergency Medicine Systematic Review Snapshots

51. Serotonin norepinephrine re-uptake inhibitor (SNRI)-, selective norepinephrine reuptake inhibitor (S-NRI)-, and exogenously administered norepinephrine-induced takotsubo syndrome: Analysis of published cases. (Abstract)

Serotonin norepinephrine re-uptake inhibitor (SNRI)-, selective norepinephrine reuptake inhibitor (S-NRI)-, and exogenously administered norepinephrine-induced takotsubo syndrome: Analysis of published cases. Takotsubo syndrome (TS) may be triggered by numerous physical stress factors including exogenous Norepinephrine administration. The aim of this study is to report on the clinical features and outcome of serotonin-norepinephrine reuptake inhibitor (SNRI)-, selective NRI (S-NRI (...) )-, and exogenously administered norepinephrine-induced TS in a largest possible cohort of published cases.A computer assisted search of the electronic data base Pubmed was performed from 1990 to August 2016. All cases deemed to have SNRI-, S-NRI-, and norepinephrine-induced TS were retrieved.Twenty two cases of SNRI-, S-NRI-, and norepinephrine-induced TS were retrieved from the literature. At presentation, the 22 patients with TS were 11 to 82years of age (mean age 49.9±20years). Seventeen of 21 (81

2016 International journal of cardiology

52. A randomized, double-blind, placebo-controlled, crossover study to evaluate the human abuse liability of solriamfetol, a selective dopamine and norepinephrine reuptake inhibitor. Full Text available with Trip Pro

A randomized, double-blind, placebo-controlled, crossover study to evaluate the human abuse liability of solriamfetol, a selective dopamine and norepinephrine reuptake inhibitor. This study evaluated the human abuse potential of solriamfetol (formerly JZP-110), a selective dopamine and norepinephrine reuptake inhibitor with robust wake-promoting effects.Adults with a recent history of recreational polydrug use, including stimulants, and who met criteria in a Qualification Phase were randomized

2018 Journal of psychopharmacology (Oxford, England) Controlled trial quality: uncertain

53. Does prophylactic ondansetron reduce norepinephrine consumption in patients undergoing cesarean section with spinal anesthesia? (Abstract)

Does prophylactic ondansetron reduce norepinephrine consumption in patients undergoing cesarean section with spinal anesthesia? Spinal anesthesia-induced hypotension (SAIH) during cesarean delivery is not rare and frequently leads to materno-fetal discrepancy and collapse. More recently, norepinephrine has been proposed for the prevention and treatment of SAIH with fewer tendencies to decrease heart rate and cardiac output. Ondansetron has been reported to reduce the incidence of SAIH (...) in patients undergoing cesarean section. The aim of the present study was to assess the effect of prophylactic ondansetron on the incidence of SAIH, norepinephrine consumption, and adverse effects.We recruited 108 parturients with uncomplicated pregnancies undergoing elective cesarean delivery under spinal anesthesia. The parturients were divided into two groups randomly. The first group (n = 54) received 8 mg ondansetron IV (group O) and the second group (n = 54) received the same volume (4 ml) of saline

2018 Journal of anesthesia Controlled trial quality: uncertain

54. Re: Intraoperative Continuous Norepinephrine Infusion Combined with Restrictive Deferred Hydration Significantly Reduces the Need for Blood Transfusion in Patients Undergoing Open Radical Cystectomy: Results of a Prospective Randomised Trial. (Abstract)

Re: Intraoperative Continuous Norepinephrine Infusion Combined with Restrictive Deferred Hydration Significantly Reduces the Need for Blood Transfusion in Patients Undergoing Open Radical Cystectomy: Results of a Prospective Randomised Trial. 27302775 2018 07 26 2018 12 02 1527-3792 195 4 Pt 1 2016 04 The Journal of urology J. Urol. Re: Intraoperative Continuous Norepinephrine Infusion Combined with Restrictive Deferred Hydration Significantly Reduces the Need for Blood Transfusion in Patients (...) Undergoing Open Radical Cystectomy: Results of a Prospective Randomised Trial. 902-3 10.1016/j.juro.2016.01.041 S0022-5347(16)00075-6 Chang Sam S SS eng Journal Article Comment 2016 01 22 United States J Urol 0376374 0022-5347 0 Vasoconstrictor Agents X4W3ENH1CV Norepinephrine AIM IM Eur Urol. 2014 Aug;66(2):352-60 24012203 Blood Transfusion Cystectomy Humans Norepinephrine Prospective Studies Urinary Bladder Neoplasms Vasoconstrictor Agents 2016 01 14 2016 6 16 6 0 2016 6 16 6 0 2018 7 27 6 0 ppublish

2018 The Journal of urology Controlled trial quality: uncertain

55. Perivascular Adipocytes Store Norepinephrine by Vesicular Transport. Full Text available with Trip Pro

Perivascular Adipocytes Store Norepinephrine by Vesicular Transport. Objective- Perivascular adipose tissue (PVAT) contains an independent adrenergic system that can take up, metabolize, release, and potentially synthesize the vasoactive catecholamine norepinephrine. Norepinephrine has been detected in PVAT, but the mechanism of its protection within this tissue is unknown. Here, we investigate whether PVAT adipocytes can store norepinephrine using VMAT (vesicular monoamine transporter (...) ). Approach and Results- High-performance liquid chromatography identified norepinephrine in normal male Sprague Dawley rat aortic, superior mesenteric artery, and mesenteric resistance vessel PVATs, and retroperitoneal fat. Real-time polymerase chain reaction revealed VMAT1 and VMAT2 mRNA expression in the adipocytes and stromal vascular fraction of mesenteric resistance vessel PVAT. Immunofluorescence demonstrated the presence of VMAT1 and VMAT2, and the colocalization of VMAT2 with norepinephrine

2018 Thrombosis and Vascular Biology

56. [Comparison of effect of norepinephrine and terlipressin on patients with ARDS combined with septic shock: a prospective single-blind randomized controlled trial]. (Abstract)

[Comparison of effect of norepinephrine and terlipressin on patients with ARDS combined with septic shock: a prospective single-blind randomized controlled trial]. To approach the effect of different vasopressor on hemodynamics, volume responsiveness, fluid volume balance, renal function and prognosis in patients with acute respiratory distress syndrome (ARDS) complicated with septic shock.A prospective single-blind randomized controlled trial was conducted. ARDS patients with septic shock (...) admitted to the Department of Critical Care Medicine of Jiangxi Provincial People's Hospital from January 1st, 2015 to May 1st, 2016 were enrolled. The patients satisfied ARDS Berlin diagnostic criteria, over 15 years old, needing vasopressor after fluid resuscitation were enrolled. The patients were divided into norepinephrine group (NE group) and terlipressin group (TP group) by randomise number table derived by computer. Patients in TP group were given terlipressin (0.01-0.04 U/min

2018 Zhonghua wei zhong bing ji jiu yi xue Controlled trial quality: uncertain

57. Effects of Dopamine and Norepinephrine on Exercise-induced Oculomotor Fatigue. (Abstract)

Effects of Dopamine and Norepinephrine on Exercise-induced Oculomotor Fatigue. Fatigue-induced impairments in the control of eye movements are detectable via reduced eye movement velocity after a bout of prolonged, strenuous exercise. Slower eye movements caused by neural fatigue within the oculomotor system can be prevented by caffeine, and the upregulation of central catecholamines may be responsible for this effect. This study explored the individual contribution of dopamine (...) and norepinephrine to fatigue-related impairments in oculomotor control.The influence of a dopamine reuptake inhibitor (methylphenidate) and a norepinephrine reuptake inhibitor (reboxetine) was assessed in 12 cyclists performing 180 min of stationary cycling within a placebo-controlled crossover design. Eye movement kinematics (saccades, smooth pursuit, and optokinetic nystagmus) were measured using infrared oculography. Visual attention was assessed with overt and covert spatial attention tasks.Exercise-induced

2018 Medicine and science in sports and exercise Controlled trial quality: uncertain

58. Selective Serotonin Reuptake Inhibitor (SSRI) and Serotonin-Norepinephrine Reuptake inhibitor (SNRI) associated Cutaneous Adverse Drug Reactions (CADRs): A systematic review of case reports and case series

Selective Serotonin Reuptake Inhibitor (SSRI) and Serotonin-Norepinephrine Reuptake inhibitor (SNRI) associated Cutaneous Adverse Drug Reactions (CADRs): A systematic review of case reports and case series Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears

2020 PROSPERO

59. Clinical benefits of norepinephrine or serotonin-based drugs to treat opioid use disorder. A systematic review and meta-analysis

Clinical benefits of norepinephrine or serotonin-based drugs to treat opioid use disorder. A systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2020 PROSPERO

60. Pharmacological norepinephrine transporter inhibition for the prevention of vasovagal syncope: a systematic review and meta-analysis

Pharmacological norepinephrine transporter inhibition for the prevention of vasovagal syncope: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record

2020 PROSPERO

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