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Norepinephrine

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301. Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock

Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock (SCLM) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02640846 Recruitment Status : Unknown Verified December 2015 by Keti Dalla

2015 Clinical Trials

302. Comparison of Norepinephrine and Ephedrine on Hypotension After Spinal Anesthesia in Parturients

Comparison of Norepinephrine and Ephedrine on Hypotension After Spinal Anesthesia in Parturients Comparison of Norepinephrine and Ephedrine on Hypotension After Spinal Anesthesia in Parturients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Comparison of Norepinephrine and Ephedrine on Hypotension After Spinal Anesthesia in Parturients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02542748 Recruitment Status : Completed First Posted : September 7, 2015 Last Update Posted : January 15, 2019 Sponsor

2015 Clinical Trials

303. Duloxetine, dual serotonin and norepinephrine reuptake inhibitor, versus paroxetine, selective serotonin reuptake inhibitor, in the treatment for premature ejaculation. (Abstract)

Duloxetine, dual serotonin and norepinephrine reuptake inhibitor, versus paroxetine, selective serotonin reuptake inhibitor, in the treatment for premature ejaculation. In the current analysis due to the mechanism of effect, we evaluated the treatment benefit of duloxetine 40 mg comparing with paroxetine 20 mg, based on its effects on personal distress and interpersonal difficulty related to ejaculation, perceived control over ejaculation, and satisfaction with sexual intercourse, as well

2015 International urology and nephrology Controlled trial quality: uncertain

304. Levomilnacipran Pharmacokinetics in Healthy Volunteers Versus Patients with Major Depressive Disorder and Implications for Norepinephrine and Serotonin Reuptake Inhibition. (Abstract)

Levomilnacipran Pharmacokinetics in Healthy Volunteers Versus Patients with Major Depressive Disorder and Implications for Norepinephrine and Serotonin Reuptake Inhibition. Levomilnacipran, a selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor, is approved for the treatment of major depressive disorder (MDD) in adults. The objectives of this investigation were to characterize the pharmacokinetic (PK) parameters of levomilnacipran in healthy subjects and in patients with MDD

2015 Clinical therapeutics Controlled trial quality: uncertain

305. Stress and drug Dependence Differentially Modulate Norepinephrine Signaling in Animals with Varied HPA Axis Function. Full Text available with Trip Pro

Stress and drug Dependence Differentially Modulate Norepinephrine Signaling in Animals with Varied HPA Axis Function. Previous work has demonstrated the importance of genetic factors and stress-sensitive circuits in the development of affective disorders. Anxiety and numerous psychological disorders are comorbid with substance abuse, and noradrenergic signaling in the bed nucleus of the stria terminalis (BNST) is thought to be a source of this convergence. Here, we examined the effects (...) of different stressors on behavior and norepinephrine dynamics in the BNST of rat strains known to differ in their HPA-axis function. We compared the effects of acute morphine dependence and social isolation in non-anxious Sprague Dawley (SD) rats, and a depression model, Wistar-Kyoto (WKY) rats. We found a shared phenotype in drug-dependent and singly housed SD rats, characterized by slowed norepinephrine clearance, decreased autoreceptor function, and elevated anxiety. WKY rats exhibited changes

2015 Neuropsychopharmacology

306. Arterial norepinephrine concentration is inversely and independently associated with insulin clearance in obese individuals with metabolic syndrome. Full Text available with Trip Pro

Arterial norepinephrine concentration is inversely and independently associated with insulin clearance in obese individuals with metabolic syndrome. Impaired insulin clearance contributes to the hyperinsulinemia of obesity, yet relatively little is known concerning the pathophysiological determinants of insulin clearance in obese populations.To examine the cross-sectional relationship between insulin clearance and resting sympathetic nervous system activity in a cohort of obese subjects (...) with metabolic syndrome.Unmedicated, nonsmoking subjects (31 male, 27 female; aged 56 ± 1 year; body mass index 33.7 ± 0.6 kg/m(2)) underwent euglycemic hyperinsulinemic clamp to determine insulin sensitivity (M) and insulin clearance, assessment of norepinephrine kinetics, peripheral arterial tonometry, Doppler echocardiography, and oral glucose tolerance test.Univariate correlation analyses showed inverse associations between insulin clearance and arterial norepinephrine concentration (r = -0.44, P = .0006

2015 Journal of Clinical Endocrinology and Metabolism

307. Norepinephrine deficiency with normal blood pressure control in congenital insensitivity to pain with anhidrosis. Full Text available with Trip Pro

Norepinephrine deficiency with normal blood pressure control in congenital insensitivity to pain with anhidrosis. Congenital insensitivity to pain with anhidrosis (CIPA) is caused by mutations in the NKTR1 gene. This affects the development of nerve growth factor (NGF)-dependent neurons including sympathetic cholinergic neurons in the skin, causing anhidrosis. Cardiovascular and blood pressure regulation appears normal, but the integrity of sympathetic adrenergic neurons has not been tested.We (...) examined the effect of posture on blood pressure, heart rate, plasma concentration of catecholamines, vasopressin, endothelin, and renin activity in 14 patients with CIPA, 10 patients with chronically deficient sympathetic activity (pure autonomic failure), and 15 normal age-matched controls.In all 14 patients with CIPA, plasma norepinephrine levels were very low or undetectable and failed to increase when the patient was upright, yet upright blood pressure was well maintained. Plasma epinephrine

2015 Annals of Neurology

308. Norepinephrine and dopamine transmission in 2 limbic regions differentially respond to acute noxious stimulation. Full Text available with Trip Pro

Norepinephrine and dopamine transmission in 2 limbic regions differentially respond to acute noxious stimulation. Central dopamine and norepinephrine regulate behavioral and physiological responses during rewarding and aversive stimuli. Here, we investigated and compared norepinephrine and dopamine transmission in 2 limbic structures, the ventral bed nucleus of the stria terminalis and the nucleus accumbens shell of anesthetized rats, respectively, in response to acute tail pinch, a noxious (...) stimulus. Norepinephrine release in the ventral bed nucleus of the stria terminalis responded monophasically, increasing at the time of the tail pinch and remaining elevated for a period after its cessation. In contrast, dopamine transmission in the nucleus accumbens shell displayed a heterogeneous and time-locked response to tail pinch. For most trials, there was a suppression of extracellular dopamine concentration throughout the duration of the stimuli. At the termination of the stimuli, however

2015 Pain

309. Effect of 0.04% AR-13324, a ROCK, and Norepinephrine Transporter Inhibitor, on Aqueous Humor Dynamics in Normotensive Monkey Eyes. (Abstract)

Effect of 0.04% AR-13324, a ROCK, and Norepinephrine Transporter Inhibitor, on Aqueous Humor Dynamics in Normotensive Monkey Eyes. To determine the mechanism by which topically applied AR-13324, a rho kinase inhibitor, and an inhibitor of the norepinephrine transporter, reduces intraocular pressure (IOP) in normotensive monkey eyes.Seven normotensive monkeys were used. Tonographic outflow facility (C) was measured before drug administration and repeated 6 hours after administration of 50 µL (25

2015 Journal of Glaucoma

310. Randomized Double-blinded Comparison of Norepinephrine and Phenylephrine for Maintenance of Blood Pressure during Spinal Anesthesia for Cesarean Delivery. Full Text available with Trip Pro

Randomized Double-blinded Comparison of Norepinephrine and Phenylephrine for Maintenance of Blood Pressure during Spinal Anesthesia for Cesarean Delivery. During spinal anesthesia for cesarean delivery, phenylephrine can cause reflexive decreases in maternal heart rate and cardiac output. Norepinephrine has weak β-adrenergic receptor agonist activity in addition to potent α-adrenergic receptor activity and therefore may be suitable for maintaining blood pressure with less negative effects (...) on heart rate and cardiac output compared with phenylephrine.In a randomized, double-blinded study, 104 healthy patients having cesarean delivery under spinal anesthesia were randomized to have systolic blood pressure maintained with a computer-controlled infusion of norepinephrine 5 μg/ml or phenylephrine 100 μg/ml. The primary outcome compared was cardiac output. Blood pressure heart rate and neonatal outcome were also compared.Normalized cardiac output 5 min after induction was greater

2015 Anesthesiology Controlled trial quality: predicted high

311. Differential effects of phenylephrine and norepinephrine on peripheral tissue oxygenation during general anaesthesia: A randomised controlled trial. (Abstract)

Differential effects of phenylephrine and norepinephrine on peripheral tissue oxygenation during general anaesthesia: A randomised controlled trial. Phenylephrine and norepinephrine are two vasopressors commonly used to counteract anaesthesia-induced hypotension. Their dissimilar working mechanisms may differentially affect the macro and microcirculation, and ultimately tissue oxygenation.We investigated the differential effect of phenylephrine and norepinephrine on the heart rate (HR), stroke (...) volume (SV), cardiac index (CI), cerebral tissue oxygenation (SctO2) and peripheral tissue oxygenation (SptO2), and rate-pressure product (RPP).A randomised controlled study.Single-centre, University Medical Center Groningen, The Netherlands.Sixty normovolaemic patients under balanced propofol/remifentanil anaesthesia.If the mean arterial pressure (MAP) dropped below 80% of the awake state value, phenylephrine (100 μg + 0.5 μg kg(-1) min(-1)) or norepinephrine (10 μg + 0.05 μg kg(-1) min(-1

2015 European Journal of Anaesthesiology Controlled trial quality: uncertain

312. Disposition and metabolism of [14C]-levomilnacipran, a serotonin and norepinephrine reuptake inhibitor, in humans, monkeys, and rats Full Text available with Trip Pro

Disposition and metabolism of [14C]-levomilnacipran, a serotonin and norepinephrine reuptake inhibitor, in humans, monkeys, and rats Levomilnacipran is approved in the US for the treatment of major depressive disorder in adults. We characterized the metabolic profile of levomilnacipran in humans, monkeys, and rats after oral administration of [(14)C]-levomilnacipran. In vitro binding of levomilnacipran to human plasma proteins was also studied. Unchanged levomilnacipran was the major

2015 Drug design, development and therapy

313. Dextroamphetamine (but Not Atomoxetine) Induces Reanimation from General Anesthesia: Implications for the Roles of Dopamine and Norepinephrine in Active Emergence Full Text available with Trip Pro

Dextroamphetamine (but Not Atomoxetine) Induces Reanimation from General Anesthesia: Implications for the Roles of Dopamine and Norepinephrine in Active Emergence Methylphenidate induces reanimation (active emergence) from general anesthesia in rodents, and recent evidence suggests that dopaminergic neurotransmission is important in producing this effect. Dextroamphetamine causes the direct release of dopamine and norepinephrine, whereas atomoxetine is a selective reuptake inhibitor (...) for norepinephrine. Like methylphenidate, both drugs are prescribed to treat Attention Deficit Hyperactivity Disorder. In this study, we tested the efficacy of dextroamphetamine and atomoxetine for inducing reanimation from general anesthesia in rats. Emergence from general anesthesia was defined by return of righting. During continuous sevoflurane anesthesia, dextroamphetamine dose-dependently induced behavioral arousal and restored righting, but atomoxetine did not (n = 6 each). When the D1 dopamine receptor

2015 PloS one

314. Association of the rs2242446 polymorphism in the norepinephrine transporter gene SLC6A2 and anxious arousal symptoms of posttraumatic stress disorder. Full Text available with Trip Pro

Association of the rs2242446 polymorphism in the norepinephrine transporter gene SLC6A2 and anxious arousal symptoms of posttraumatic stress disorder. 25919853 2015 06 29 2018 11 13 1555-2101 76 4 2015 Apr The Journal of clinical psychiatry J Clin Psychiatry Association of the rs2242446 polymorphism in the norepinephrine transporter gene SLC6A2 and anxious arousal symptoms of posttraumatic stress disorder. e537-8 10.4088/JCP.14l09346 Pietrzak Robert H RH robert.pietrzak@yale.edu. Sumner (...) 0 Norepinephrine Plasma Membrane Transport Proteins 0 SLC6A2 protein, human IM Adolescent Adult African Americans genetics Aged Aged, 80 and over Alleles Anxiety ethnology genetics Arousal genetics Female Genotype Humans Male Michigan Middle Aged Norepinephrine Plasma Membrane Transport Proteins genetics Polymorphism, Single Nucleotide genetics Promoter Regions, Genetic genetics Stress Disorders, Post-Traumatic diagnosis ethnology genetics psychology Young Adult 2015 4 29 6 0 2015 4 29 6 0 2015

2015 Journal of Clinical Psychiatry

315. Distinct pathways for norepinephrine- and opioid-triggered antinociception from the amygdala. Full Text available with Trip Pro

Distinct pathways for norepinephrine- and opioid-triggered antinociception from the amygdala. The amygdala has an important role in pain and pain modulation. We showed previously in animal studies that α2 -adrenoreceptor activation in the central nucleus of the amygdala (CeA) mediates hypoalgesia produced by restraint stress, and that direct application of an α2 -agonist in this region produces analgesia.In the present animal experiments, we investigated the pathways through which α2 -sensitive

2015 European Journal of Pain

316. Norepinephrine Decreases Fluid Requirements and Blood Loss While Preserving Intestinal Villi Microcirculation during Fluid Resuscitation of Uncontrolled Hemorrhagic Shock in Mice. Full Text available with Trip Pro

Norepinephrine Decreases Fluid Requirements and Blood Loss While Preserving Intestinal Villi Microcirculation during Fluid Resuscitation of Uncontrolled Hemorrhagic Shock in Mice. Norepinephrine administration is controversial during hemorrhagic shock resuscitation to stabilize mean arterial pressure (MAP) level because it could have deleterious effects on local circulations. The authors investigated the effect of norepinephrine on intestinal microcirculation during fluid resuscitation (...) in uncontrolled hemorrhagic shock.Mice (n = 6 per group) submitted to an uncontrolled hemorrhagic shock by tail section were randomly assigned to a resuscitation with fluid but without norepinephrine to target a MAP level of 50 mmHg (FR50) or 60 mmHg (FR60) or a resuscitation with fluid and norepinephrine to target a MAP level of 50 mmHg (FRNE50) or 60 mmHg (FRNE60). Intestinal microcirculation was observed by intravital microscopy.Fluid requirements were lower in groups resuscitated with fluid

2015 Anesthesiology

317. Norepinephrine Regulates Condylar Bone Loss via Comorbid Factors. (Abstract)

Norepinephrine Regulates Condylar Bone Loss via Comorbid Factors. Degenerative changes of condylar subchondral bone occur frequently in temporomandibular disorders. Although psychologic stresses and occlusal abnormalities have been implicated in temporomandibular disorder, it is not known if these risks represent synergistic comorbid factors that are involved in condylar subchondral bone degradation that is regulated by the sympathetic nervous system. In the present study, chronic (...) immobilization stress (CIS), chemical sympathectomy, and unilateral anterior crossbite (UAC) were sequentially applied in a murine model. Norepinephrine contents in the subjects' serum and condylar subchondral bone were detected by ELISA; bone and cartilage remodeling parameters and related gene expression in the subchondral bone were examined. Subchondral bone loss and increased subchondral bone norepinephrine level were observed in the CIS and UAC groups. These groups exhibited decreased bone mineral

2015 Journal of Dental Research

318. Effects of duloxetine, a norepinephrine and serotonin reuptake inhibitor, on the urethral continence reflex and bladder activity in rats with cerebral infarction. Full Text available with Trip Pro

Effects of duloxetine, a norepinephrine and serotonin reuptake inhibitor, on the urethral continence reflex and bladder activity in rats with cerebral infarction. We investigated the effect of duloxetine, a norepinephrine and serotonin reuptake inhibitor, on the sneeze induced continence reflex and on bladder function in rats with cerebral infarction.Using urethane anesthesia the effect of duloxetine (1 mg/kg intravenously) on the amplitude of urethral responses during sneezing as well

2015 Journal of Urology

319. Norepinephrine Reduces Reactive Oxygen Species (ROS) and DNA Damage in Ovarian Surface Epithelial Cells Full Text available with Trip Pro

Norepinephrine Reduces Reactive Oxygen Species (ROS) and DNA Damage in Ovarian Surface Epithelial Cells To determine the role of norepinephrine (NE) on DNA damage and reactive oxygen species (ROS) generation in ovarian surface epithelial cells.Non-tumorigenic, immortalized ovarian surface epithelial cells were treated with NE, bleomycin, and bleomycin followed by NE. The comet assay was performed on each treatment group to determine the amount of single and double-strand breaks induced

2015 Journal of bioanalysis & biomedicine

320. Radiosynthesis and first preclinical evaluation of the novel norepinephrine transporter pet-ligand [11C]ME@HAPTHI Full Text available with Trip Pro

Radiosynthesis and first preclinical evaluation of the novel norepinephrine transporter pet-ligand [11C]ME@HAPTHI The norepinephrine transporter (NET) has been demonstrated to be relevant to a multitude of neurological, psychiatric and cardiovascular pathologies. Due to the wide range of possible applications for PET imaging of the NET together with the limitations of currently available radioligands, novel PET tracers for imaging of the cerebral NET with improved pharmacological

2015 EJNMMI research

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