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Nikolskys Sign

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101. Stevens-Johnson Syndrome

pathognomonic. Lesions may become bullous and later rupture. The skin becomes susceptible to secondary infection. Urticarial lesions are usually not pruritic. Nikolsky sign is positive (mechanical pressure to skin leading to blistering within minutes or hours). Mucosal involvement: erythema, oedema, sloughing, blistering, ulceration and necrolysis. Eye: conjunctivitis, corneal ulcerations. Genital: erosive vulvovaginitis or balanitis. Differential diagnosis Acute generalised exanthematous pustulosis (...) and diarrhoea, and malaise. Mucocutaneous lesions develop suddenly and clusters of outbreaks last from 2-4 weeks. The lesions are usually not pruritic. Mouth: severe oromucosal ulceration. Respiratory involvement may cause a cough productive of a thick purulent sputum. Patients with genitourinary involvement may complain of dysuria or an inability to pass urine. Ocular symptoms: painful red eye, purulent conjunctivitis, photophobia, blepharitis. Signs General examination: fever, tachycardia, hypotension

2008 Mentor

102. Toxic Epidermal Necrolysis

form and then coalesce. They generally increase in number over 3-4 days (sometimes hours). The epidermis can then slough in sheets. There may be hyperpyrexia. Hypotension and tachycardia can develop secondary to dehydration and hypovolaemia. Nikolsky's sign may be positive: if areas of seemingly normal skin between lesions are rubbed, the epidermis easily separates from its underlying surface. Differential diagnosis . (chemical, light or heat). . , (generally of slower onset). . . (desquamation

2008 Mentor

103. Dermatological Descriptive Terms

of periodontal disease that affects the gums. Miscellaneous terms In Köbner's phenomenon, lesions arise in an area of trauma. This is typical of psoriasis and lichen planus. Dermatographism (dermatographia) is the ability to write on skin. It occurs with urticaria. If a firm instrument, like an orange stick, is used to make lines or letters on the skin then, shortly afterwards, the wheal will form and the pattern of marks will be very obvious. In Nikolsky's sign, the skin of a bulla is lightly rubbed

2008 Mentor

104. Prevention of Contrast-Induced Nephropathy in the Emergency Department

injection may have important implications for the risk of contrast-induced nephropathy. Arteriography generally requires larger contrast volumes than CT scans, which increases the probability of nephropathy. x 9 Nikolsky, E., Mehran, R., Turcot, D. et al. Impact of chronic kidney disease on prognosis of patients with diabetes mellitus treated with percutaneous coronary intervention. Am J Cardiol. 2004 ; 94 : 300–305 | | | | | In addition, this higher risk of contrast-induced nephropathy is compounded

2007 Evidence-Based Emergency Medicine

105. Amniotic membrane transplantation in acute phase of toxic epidermal necrolysis with severe corneal involvement. (PubMed)

Amniotic membrane transplantation in acute phase of toxic epidermal necrolysis with severe corneal involvement. To report successful management of acute stage toxic epidermal necrolysis (TEN) by amniotic membrane transplantation.Interventional case report. METHOD/INTERVENTION: A 6-year-old boy who had convulsions and fever due to encephalitis was treated by oral phenobarbital. Two weeks later, he developed a high fever and skin rashes involving >40% of the body, with a positive Nikolsky sign

2006 Ophthalmology

106. Increased activity of plasma and tissue kallikreins, plasma kininase II and salivary kallikrein in pemphigus foliaceus (fogo selvagem). (PubMed)

-weight kininogen (HK) and low-molecular-weight kininogen (LK), and the activity of plasma kallikrein, tissue kallikrein and kininase II in plasma of patients with PF presenting with Nikolsky's sign. As kidneys and salivary glands are relevant sources of tissue kallikrein for plasma, we also evaluated urinary/salivary kallikrein and urinary kininase II activities.Fifteen patients and 15 age- and sex-matched controls were studied. Kininogen levels were determined by enzyme-linked immunosorbent assay

2005 British Journal of Dermatology

107. New Exfoliative Toxin Produced by a Plasmid-Carrying Strain of Staphylococcus hyicus (PubMed)

SHET caused exfoliation of the epidermis as determined by the so-called Nikolsky sign when inoculated into 1-day-old chickens. The new SHET was serologically different from Staphylococcus aureus exfoliative toxins (ETs) (ETA, ETB, and ETC) and from the SHET from the plasmidless strain but showed the same molecular weight as the other serotypes of toxins on SDS-PAGE. It was thermolabile and lost its toxicity after being heated at 60 degrees C for 30 min. We propose that the new SHET be designated

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1999 Infection and immunity

108. A new type of staphylococcal exfoliative toxin from a Staphylococcus aureus strain isolated from a horse with phlegmon. (PubMed)

gel electrophoresis (7.5% polyacrylamide). The new sET elicited general exfoliation of the epidermis with the so-called Nikolsky sign when inoculated into both 3-day-old mice and 1-day-old chicks, whereas sETA and sETB from human strains of S. aureus caused exfoliation in a 3-day-old mouse alone and shET from a porcine strain of Staphylococcus hyicus caused exfoliation in 1-day-old chicks alone. Intraepidermal splitting was observed at the granular layer of the epidermis of mice inoculated

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1994 Infection and immunity

109. Microscopic Nikolsky's sign. (PubMed)

Microscopic Nikolsky's sign. Nikolsky's sign is a useful clinical sign in patients with active pemphigus. It does not however, indicate the level of split in the skin, and is seldom present in partially-treated patients. The purpose of this study was two fold: (i) to document the microscopic or subclinical counterpart of clinical Nikolsky's sign; and (ii) to improve the diagnostic yield of routine histopathology in pemphigus patients in whom the lesions are infected/old and are therefore

1999 Clinical and experimental dermatology

110. The Nikolsky sign in staphylococcal scalded skin syndrome (PubMed)

The Nikolsky sign in staphylococcal scalded skin syndrome 9875032 1999 01 12 2008 11 20 1468-2044 79 3 1998 Sep Archives of disease in childhood Arch. Dis. Child. The Nikolsky sign in staphylococcal scalded skin syndrome. 290 Moss C C Gupta E E eng Case Reports Comment Letter England Arch Dis Child 0372434 0003-9888 AIM IM Arch Dis Child. 1998 Jan;78(1):85-8 9534685 Epidermis pathology Female Humans Infant Staphylococcal Scalded Skin Syndrome diagnosis pathology Thumb injuries 1999 1 6 1999 1 6

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1998 Archives of Disease in Childhood

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