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Newborn Reflexes

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1. Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (Full Version)

Introduction Circumcision is the oldest planned operative procedure in the history of the human civilization, but there continues to be a lack of consensus and strong opposing views on whether universal neonatal circumcision should be adopted as a public health measure. The recent American Academy of Pediatrics (AAP) guideline on male circumcision (MC) reversed its prior stand, stating that the “health benefits of newborn male circumcision outweigh the risks,” and justify access to the procedure (...) Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (Full Version) CUAJ • February 2018 • Volume 12, Issue 2 © 2018 Canadian Urological Association E76 CUA GUideline Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (full version) Cite as: Can Urol Assoc J 2017;12(2):E76-99. http://dx.doi.org/10.5489/cuaj.5033 Published online December 1, 2017

2018 Canadian Urological Association

2. Neonatal stabilisation for retrieval

) [refer to Queensland Clinical Guideline: Hypoxic-ischaemic encephalopathy (HIE) 11 ] · Seizures [refer to Queensland Clinical Guideline: Neonatal seizures 12 ] · Severe neonatal abstinence syndrome [refer to Queensland Clinical Guideline: Perinatal substance use–neonatal 13 ] · Hyperbilirubinemia [refer to Queensland Clinical Guideline Neonatal jaundice 14 ] · Persistent hypoglycaemia [refer to Queensland Clinical Guideline Newborn hypoglycaemia 15 ] · Sepsis · Conditions requiring specialty (...) Guideline: Neonatal seizures 12 · Abdomen—soft, distended, masses, bowel sounds · Umbilicus—dry, ooze, clamp secure · IV site [refer to Table 14. Intravascular access] Fluid intake · NBM · Glucose 10% infusion rate [refer to Table 14. Intravascular access] BGL · Maintain BGL greater than or equal to 2.6 mmol/L · Refer Table 12. Glucose monitoring and management · Refer to Queensland Clinical Guideline: Newborn hypoglycaemia 15 Output · Gastric aspirate—colour and volume · Urine—amount, frequency, colour

2018 Clinical Practice Guidelines Portal

3. Neonatal jaundice

. Treatments of no benefit 28 Table 24. Emerging research 29 Table 25. Parent information 30 Refer to online version, destroy printed copies after use Page 6 of 40 Queensland Clinical Guideline: Neonatal jaundice 1 Introduction Jaundice is one of the most common conditions requiring medical attention in newborn babies. 18 Approximately 60% of term and 80% of preterm babies develop jaundice in the first week of life. 19 In 2015 in Queensland 3.2% of all babies born had jaundice requiring phototherapy. 20 (...) leading to dehydration and increased enterohepatic circulation 4,27 Haematological 18,23,28 · Factors causing haemolysis (immune or non-immune) 4 · Polycythaemia · Haematoma or bruising Gastrointestinal 29 · Bowel obstruction Other 4,23 · Infection · Prematurity · Male Refer to online version, destroy printed copies after use Page 8 of 40 Queensland Clinical Guideline: Neonatal jaundice 3 Causes of jaundice Jaundice peaking on the third to fifth day of life is likely to be caused by normal newborn

2018 Queensland Health

4. Bumetanide, an Inhibitor of NKCC1 (Na-K-2Cl Cotransporter Isoform 1), Enhances Propofol-Induced Loss of Righting Reflex but Not Its Immobilizing Actions in Neonatal Rats. Full Text available with Trip Pro

Bumetanide, an Inhibitor of NKCC1 (Na-K-2Cl Cotransporter Isoform 1), Enhances Propofol-Induced Loss of Righting Reflex but Not Its Immobilizing Actions in Neonatal Rats. Gamma-aminobutyric acid (GABA) has been shown to induce excitation on immature neurons due to increased expression of Na+-K+-2Cl- co-transporter isoform 1 (NKCC1), and the transition of GABAergic signaling from excitatory to inhibitory occurs before birth in the rat spinal cord and spreads rostrally according (...) to the developmental changes in cation-chloride co-transporter expression. We previously showed that midazolam activates the hippocampal CA3 area and induces less sedation in neonatal rats compared with adolescent rats in an NKCC1-dependent manner. In the present study, we tested the hypothesis that propofol-induced loss of righting reflex (LORR) but not immobilizing actions are modulated by NKCC1-dependent mechanisms and reduced in neonatal rats compared with adolescent rats. We estimated neuronal activity

2016 PLoS ONE

5. Newborn Reflexes

Newborn Reflexes Newborn Reflexes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Newborn Reflexes Newborn Reflexes Aka: Newborn (...) with one hand across chest As feet touch ground, baby makes walking motion V. Exam: Protective Reflex Soft cloth is placed over the babies eyes and nose Baby arches head and turns head side to side Brings both hands to face to swipe cloth away VI. Exam: Rooting Reflex Touch newborn on either side of cheek Baby turns to find Sucking mechanism on finger is divided into 3 steps Front of laps on finger Back of massages middle of the finger Esophagus pulls on tip of finger VII. Exam: Tonic Neck (Fencing

2018 FP Notebook

6. Perinatal substance use: neonatal

in the nursery Adapted from: Commonwealth of Australia. National clinical guidelines for the management of drug use during pregnancy, birth and the early development years of the newborn. 2006. Verklan M, Walden M. Core curriculum for Neontal Intensive Care Nursing. St. Louis Missouri: Saunders; 2015. D'Apolito KC. Assessing neonates for neonatal abstinence: are you reliable? J Perinat Neonatal Nurs. 2014; 28(3):220-31. Queensland Clinical Guideline: Perinatal substance use: neonatal Refer to online version (...) after each feed Poor feeding • Offer small frequent feeds from the breast or slow flow teat • Feed in quiet, calm surrounding with minimal noise and disturbance Trembling • Wrap baby in sheet or light blanket/wrap Fever • Avoid too many blankets or clothes on baby • Cotton clothes and wraps are suitable Adapted from: Commonwealth of Australia. National clinical guidelines for the management of drug use during pregnancy, birth and the early development years of the newborn. 2006. Nelson M. Neonatal

2017 Queensland Health

7. Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock Full Text available with Trip Pro

/CCM.0000000000002425 Special Article Free Objectives: The American College of Critical Care Medicine provided 2002 and 2007 guidelines for hemodynamic support of newborn and pediatric septic shock . Provide the 2014 update of the 2007 American College of Critical Care Medicine “Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock .” Design: Society of Critical Care Medicine members were identified from general solicitation at Society of Critical Care Medicine (...) resistance and artery pressures can remain elevated and the ductus arteriosus can remain open for the first 6 weeks of life, whereas the foramen ovale may remain probe patent for years. Sepsis-induced acidosis and hypoxia can increase pulmonary vascular resistance and artery pressure and maintain patency of the ductus arteriosus, resulting in persistent pulmonary hypertension of the newborn (PPHN) and persistent fetal circulation. Neonatal septic shock with PPHN is associated with increased right

2017 Society of Critical Care Medicine

8. Breastfeeding - Promoting and Supporting the Initiation, Exclusivity, and Continuation of Breastfeeding in Newborns, Infants and Young Children

, Exclusivity, and Continuation of Breastfeeding for Newborns, Infants, and Y oung Children ABBREVIATION TERM LGBTQ+ lesbian, gay, bisexual, transgender, queer or questioning, and other LOA leave of absence NICU neonatal intensive care unit NQuIRE ® Nursing Quality Indicators for Reporting and Evaluation RNAO Registered Nurses’ Association of Ontario SIDS sudden infant death syndrome SUPC sudden unexpected postnatal collapse THC tetrahydrocannabinol T2DM type 2 diabetes mellitus UK United Kingdom of Great (...) Breastfeeding - Promoting and Supporting the Initiation, Exclusivity, and Continuation of Breastfeeding in Newborns, Infants and Young Children Best Practice Guideline JULY 2018 Breastfeeding - Promoting and Supporting the Initiation, Exclusivity, and Continuation of Breastfeeding for Newborns, Infants, and Y oung Children Third Edition Best Practice GuidelineDisclaimer These guidelines are not binding on nurses or the organizations that employ them. The use of these guidelines should

2018 Registered Nurses' Association of Ontario

9. Gestational and Postnatal Modulation of Esophageal Sphincter Reflexes in Human Premature Neonates. Full Text available with Trip Pro

Gestational and Postnatal Modulation of Esophageal Sphincter Reflexes in Human Premature Neonates. Effects of gestational age (GA) and postnatal maturation on upper and lower esophageal sphincter (UES and LES) reflex development remain unclear. We hypothesized very-preterm (VPT) born neonates (< 32 wk GA) have delayed maturation of UES contractile reflex (UESCR) and LES relaxation reflex (LESRR) vs. preterm (PT) born (32-37 wk GA) neonates.Using provocative manometry, effects of 1,263 graded (...) and LESRR durations (P = 0.2). Differences were noted in LESRR duration in VPT vs. PT neonates for air stimuli (P = 0.04). With liquid stimuli, increasing GA was associated with decreasing response onset latencies to UESCR and LESRR (P < 0.05), and increasing LESRR duration (P = 0.02).Using GA as categorical or continuous variable, vagus-mediated mechano-sensitive and liquid-sensitive reflex characteristics of UESCR and LESRR are distinct; LESRR differs with varying intrauterine maturation suggesting

2015 Pediatric Research

10. Middle ear muscle reflex measurement in neonates: Comparison between 1000Hz and 226Hz probe tones. (Abstract)

Middle ear muscle reflex measurement in neonates: Comparison between 1000Hz and 226Hz probe tones. Middle ear muscle reflex (MEMR) evaluation assists in diagnosing hearing problems because normal responses depend on preconditions of a healthy auditory system. Studies in neonates recording the acoustic reflex with 226Hz probes have described high rates of absence. Other studies using a high frequency probe have found higher rates of presence in normal neonates. However, few studies have compared (...) results between low and high frequency probes in the same newborns.To comparatively assess the ipsilateral acoustic reflex recorded by 226Hz and 1000Hz probes in newborns.A total of 77 newborns, with the presence of transient otoacoustic emissions, underwent tympanometry, wideband acoustic immittance, and ipsilateral reflex investigations with 226Hz and 1000Hz tone probes.The acoustic reflex was activated at a much lower intensity with all activating stimuli using the 1000Hz probe compared

2015 International Journal of Pediatric Otorhinolaryngology

11. Sensitivity and Specificity of Red Reflex Test in Newborn Eye Screening. (Abstract)

Sensitivity and Specificity of Red Reflex Test in Newborn Eye Screening. To validate the sensitivity of an isolated red reflex test in detection of ocular abnormalities of the anterior and posterior segments in newborns.Red reflex test and comprehensive eye examinations including external inspection, pupil examination, hand-held slit lamp examination, and RetCam fundus imaging (Clarity Medical Systems, Pleasanton, California) were performed in 7641 newborns. All results were documented (...) as negative or positive. Sensitivity and specificity of red reflex test were calculated by the use of comprehensive eye examinations as the reference standard. Anterior abnormalities were separated from posterior abnormalities, and the sensitivity of red reflex test for each group was calculated.The proportion of abnormalities that were correctly classified by red reflex test was greater in anterior segment group (sensitivity = 99.6%, 95% CI 97.1%-100%) than in the posterior group (sensitivity = 4.1%, 95

2016 Journal of Pediatrics

12. Human gestational N-methyl-d-aspartate receptor autoantibodies impair neonatal murine brain function. Full Text available with Trip Pro

amplitudes of spontaneous excitatory postsynaptic currents in young neonates (-34.4%). NR1 AB-treated animals displayed increased early postnatal mortality (+27.2%), impaired neurodevelopmental reflexes, altered blood pH, and reduced bodyweight. During adolescence and adulthood, animals showed hyperactivity (+27.8% median activity over 14 days), lower anxiety, and impaired sensorimotor gating. NR1 ABs caused long-lasting neuropathological effects also in aged mice (10 months), such as reduced volumes (...) Human gestational N-methyl-d-aspartate receptor autoantibodies impair neonatal murine brain function. Maternal autoantibodies are a risk factor for impaired brain development in offspring. Antibodies (ABs) against the NR1 (GluN1) subunit of the N-methyl-d-aspartate receptor (NMDAR) are among the most frequently diagnosed anti-neuronal surface ABs, yet little is known about effects on fetal development during pregnancy.We established a murine model of in utero exposure to human recombinant NR1

2019 Annals of Neurology

13. Introduction to Resuscitation of the Newborn Infant

apply? The term “newborn” refers to the infant in the first minutes to hours following birth. In contrast, the neonatal period is defined as the first 28 days of life. Infancy includes the neonatal period and extends through the first 12 months of life. Guidelines 13.1-13.10 and the Newborn Life Support algorithm are specifically for the care of infants during the neonatal period, and particularly for newborn infants. The exact age at which paediatric techniques and in particular, compression (...) -ventilation ratios, should replace neonatal methods is unknown, especially for very small premature infants. For term neonates beyond the newborn period, and particularly in those with known or suspected cardiac aetiology of their arrest, paediatric techniques may be used (see Paediatric Advanced Life Support Guidelines 12.1-12.7). Who is this audience for these guidelines? Guidelines 13.1-13.10 and the Newborn Life Support algorithm are for health professionals and those who provide healthcare

2016 Australian Resuscitation Council

14. Newborn Nursing Care Pathway

history) Assess mother’s/ family/ supports understanding of newborn physiology and capacity to identify variances that may require further assessments Refer to: • Skin Norm and Normal Variations • Outer canthus aligned with upper ear • Dark or slate blue color • Blink reflex present • Edematous lids • Sclera clear • No tears • Pupils equal and reactive to light • May see subconjunctival hemorrhage • Administer eye prophylaxis (after completion of initial feeding or by 1 hour after birth) 20 promotes (...) Services BC Physiological Assessment 0 – 12 hours Period of Stability (POS) >12 – 24 hours >24 – 72 hours >72 hours – 7 days and beyond MOutH Assess: • Lips for colour • Tongue midline • Frenulum • Palate • Reflexes • Oral health and care Assess mother’s/ family/ supports understanding of newborn physiology and capacity to identify variances that may require further assessments Refer to: • Feeding Norm and Normal Variations • Mucosa moist smooth and pink • May have epithelial pearls • Tongue midline

2015 British Columbia Perinatal Health Program

15. Intravenous and Oral Fosfomycin in Hospitalised Neonates With Clinical Sepsis

Intravenous and Oral Fosfomycin in Hospitalised Neonates With Clinical Sepsis Intravenous and Oral Fosfomycin in Hospitalised Neonates With Clinical Sepsis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Intravenous and Oral Fosfomycin in Hospitalised Neonates With Clinical Sepsis (NeoFosfo) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03453177 Recruitment Status : Recruiting First Posted : March 5, 2018 Last Update Posted

2018 Clinical Trials

16. MUSCLE-SPARING VERSUS STANDARD POSTEROLATERAL THORACOTOMY IN NEONATES WITH ESOPHAGEAL ATRESIA Full Text available with Trip Pro

of hospitalization in the neonatal intensive care unit, the time in ventilator, the time of returning the shoulder function, the time of returning the Moro reflex, and the mortality between the two techniques.The data showed no differences between the two groups in basic information (weight, height, gender, numbers of prematurity neonates and caesarean). The results on the size of the scar in the MST group was significantly lower than in the PLT group. Also, the time of returning the shoulder function in MST (...) group was earlier than in PLT group. There were no significant differences in the duration since the beginning the surgery to see the pleura, the time of being hospitalized in intensive unit, the time that the infant required ventilator, returning time of the Moro reflex in 1st and 3rd months after the operation, and the mortality rates between MST and PLT groups.It seems that the advantages of using MST over PLT procedure in neonates include the earlier shoulder function recovery and also superior

2018 Arquivos Brasileiros de Cirurgia Digestiva : ABCD Controlled trial quality: uncertain

17. Alpha2-Containing Glycine Receptors Promote Neonatal Spontaneous Activity of Striatal Medium Spiny Neurons and Support Maturation of Glutamatergic Inputs Full Text available with Trip Pro

activity and the frequency of miniature AMPA receptor-mediated currents in MSNs. This reduction in spontaneous activity and glutamatergic signaling can attribute to the observed changes in neonatal behavioral phenotypes as seen in ultrasonic vocalizations and righting reflex. In adult Glra2-knockout animals, the glutamatergic synapses in MSNs remain functionally underdeveloped. The number of glutamatergic synapses and release probability at presynaptic site remain unaffected, but the amount (...) Alpha2-Containing Glycine Receptors Promote Neonatal Spontaneous Activity of Striatal Medium Spiny Neurons and Support Maturation of Glutamatergic Inputs Glycine receptors (GlyRs) containing the α2 subunit are highly expressed in the developing brain, where they regulate neuronal migration and maturation, promote spontaneous network activity and subsequent development of synaptic connections. Mutations in GLRA2 are associated with autism spectrum disorder, but the underlying pathophysiology

2018 Frontiers in molecular neuroscience

18. Sex-Specific Consequences of Neonatal Stress on Cardio-Respiratory Inhibition Following Laryngeal Stimulation in Rat Pups Full Text available with Trip Pro

Sex-Specific Consequences of Neonatal Stress on Cardio-Respiratory Inhibition Following Laryngeal Stimulation in Rat Pups The presence of liquid near the larynx of immature mammals triggers prolonged apneas with significant O2 desaturations and bradycardias. When excessive, this reflex (the laryngeal chemoreflex; LCR) can be fatal. Our understanding of the origins of abnormal LCR are limited; however, perinatal stress and male sex are risk factors for cardio-respiratory failure in infants (...) . Because exposure to stress during early life has deleterious and sex-specific consequences on brain development it is plausible that respiratory reflexes are vulnerable to neuroendocrine dysfunction. To address this issue, we tested the hypothesis that neonatal maternal separation (NMS) is sufficient to exacerbate LCR-induced cardio-respiratory inhibition in anesthetized rat pups. Stressed pups were separated from their mother 3 h/d from postnatal days 3 to 12. At P14-P15, pups were instrumented

2018 eNeuro

19. Early neonatal Glutaric aciduria type I hidden by perinatal asphyxia: a case report Full Text available with Trip Pro

Early neonatal Glutaric aciduria type I hidden by perinatal asphyxia: a case report Perinatal asphyxia (PA) occurs in about 2 to 10 per 1000 live full-term births. Although neonatal epileptic seizures are observed in up to 60% of cases, PA may mimic or subtend other conditions. Hypoxia related brain injury is particularly relevant, as it may have permanent effects on neuropsychomotor development. Antepartum obstetric conditions, may, in turn, lead to hypoxic-ischemic damage to the fetus (...) and the newborn, often underlying PA. Herein, a case of PA that hid and triggered signs and symptoms of Glutaric Aciduria type I (GA-I), is reported.R.F. was born at term after prolonged labour, by induced vaginal delivery with the Kristeller manoeuvre. He presented with severe asphyxia and asystoly. Immediate cardiopulmonary resuscitation promptly restored cardiorespiratory parameters, allowing for early extubation 30 min after. During the following hours, severe axial muscle hypotonia with an increased tone

2018 Italian journal of pediatrics

20. Incidence and short term outcomes of neonates with hypoxic ischemic encephalopathy in a Peri Urban teaching hospital, Uganda: a prospective cohort study Full Text available with Trip Pro

and short term outcomes of Newborns with Hypoxic Ischemic Encephalopathy at St.Francis Hospital, Nsambya.This was a Prospective Cohort study conducted between October 2015 and January 2016 at St. Francis Hospital, Nsambya, Kampala- Uganda. Term Newborn babies were enrolled. Umbilical cord arterial blood gas analysis was done for Newborns with low Apgar scores at 5 min. Clinical examination was done on all newborns within 48 h of life, for features of encephalopathy. Neonates with Hypoxic Ischemic (...) Incidence and short term outcomes of neonates with hypoxic ischemic encephalopathy in a Peri Urban teaching hospital, Uganda: a prospective cohort study Hypoxic Ischemic Encephalopathy carries high case fatality rates ranging between 10-60%, with 25% of survivors have an adverse long-term neurodevelopment outcome. Despite the above, there is paucity of data regarding its magnitude and short term outcomes in a low resource setting like Uganda. Therefore we set out to determine the incidence

2018 Maternal health, neonatology and perinatology

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