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Nevus Simplex

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1. Nevus Simplex

Nevus Simplex Nevus Simplex Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Nevus Simplex Nevus Simplex Aka: Nevus Simplex , Salmon (...) Patch , Nevus Telangiectaticus , Stork bite , Angel's Kiss II. Epidemiology : 33-40% of newborns III. Pathophysiology Persistent fetal vessels Dilated dermal capillaries (telangiectases) IV. Differential Diagnosis ( ) Contrast with Nevus Simplex which is typically bilateral V. Signs Flat, pink (or salmon colored) vascular patch Blanch on compression May become more prominent with crying Distribution and Course: Often symmetric - involving the bilateral face Glabellar area (Angel's Kiss) Resolves

2018 FP Notebook

2. Extensive lentigo simplex, linear epidermolytic nevus and epidermolytic nevus comedonicus caused by a somatic mutation in KRT10. (PubMed)

Extensive lentigo simplex, linear epidermolytic nevus and epidermolytic nevus comedonicus caused by a somatic mutation in KRT10. 25495838 2016 04 12 2015 07 15 1365-2133 173 1 2015 Jul The British journal of dermatology Br. J. Dermatol. Extensive lentigo simplex, linear epidermolytic naevus and epidermolytic naevus comedonicus caused by a somatic mutation in KRT10. 293-6 10.1111/bjd.13616 Samuelov L L Department of Dermatology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv, 64239 (...) Humans Hyperkeratosis, Epidermolytic genetics Keratin-10 genetics Lentigo genetics Male Mutation genetics Nevus, Pigmented genetics Skin Neoplasms genetics 2014 12 16 6 0 2014 12 17 6 0 2016 4 14 6 0 ppublish 25495838 10.1111/bjd.13616

2014 British Journal of Dermatology

3. Malignant melanoma arising in the setting of epidermolysis bullosa simplex: an important distinction from epidermolysis bullosa nevus. (PubMed)

Malignant melanoma arising in the setting of epidermolysis bullosa simplex: an important distinction from epidermolysis bullosa nevus. Patients with epidermolysis bullosa (EB) do not carry a significantly increased risk of melanoma but are prone to developing large, markedly atypical melanocytic nevi (EB nevi), which may mimic melanoma clinically and histologically. Many authors now favor a conservative approach in managing atypical pigmented lesions in patients with EB.We present the case (...) of a 30-year-old woman with severe EB simplex who sought care for a large red and black ulcerated plaque. The clinical differential diagnosis included EB nevus and melanoma. An incisional punch biopsy specimen revealed an atypical melanocytic proliferation with focal florid pagetoid spread and involving elongated rete ridges, consistent with invasive acral lentiginous melanoma. The subsequent amputation was confirmatory. Micrometastasis was detected in 1 of 5 sentinel lymph nodes.To our knowledge

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2013 JAMA dermatology (Chicago, Ill.)

4. Nevus Simplex

Nevus Simplex Nevus Simplex Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Nevus Simplex Nevus Simplex Aka: Nevus Simplex , Salmon (...) Patch , Nevus Telangiectaticus , Stork bite , Angel's Kiss II. Epidemiology : 33-40% of newborns III. Pathophysiology Persistent fetal vessels Dilated dermal capillaries (telangiectases) IV. Differential Diagnosis ( ) Contrast with Nevus Simplex which is typically bilateral V. Signs Flat, pink (or salmon colored) vascular patch Blanch on compression May become more prominent with crying Distribution and Course: Often symmetric - involving the bilateral face Glabellar area (Angel's Kiss) Resolves

2015 FP Notebook

5. Speckled Lentiginous Nevus (Follow-up)

A large unilateral speckled lentiginous nevus that contains numerous small dark macules. Extensive speckled lentiginous nevus. Prominent basal layer pigmentation similar to that seen in lentigo simplex (hematoxylin-eosin stain, original magnification X200). Elongated rete ridges and lentiginous proliferation of melanocytes at the dermal-epidermal junction (hematoxylin-eosin stain, original magnification X200). Junctional melanocytic nevus composed of small nests of melanocytes and lentiginous (...) Speckled Lentiginous Nevus (Follow-up) Speckled Lentiginous Nevus Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2MTk5MC10cmVhdG1lbnQ

2014 eMedicine.com

6. Speckled Lentiginous Nevus (Treatment)

A large unilateral speckled lentiginous nevus that contains numerous small dark macules. Extensive speckled lentiginous nevus. Prominent basal layer pigmentation similar to that seen in lentigo simplex (hematoxylin-eosin stain, original magnification X200). Elongated rete ridges and lentiginous proliferation of melanocytes at the dermal-epidermal junction (hematoxylin-eosin stain, original magnification X200). Junctional melanocytic nevus composed of small nests of melanocytes and lentiginous (...) Speckled Lentiginous Nevus (Treatment) Speckled Lentiginous Nevus Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2MTk5MC10cmVhdG1lbnQ

2014 eMedicine.com

7. Speckled Lentiginous Nevus (Overview)

lentiginous nevus that contains numerous small dark macules. Extensive speckled lentiginous nevus. Prominent basal layer pigmentation similar to that seen in lentigo simplex (hematoxylin-eosin stain, original magnification X200). Elongated rete ridges and lentiginous proliferation of melanocytes at the dermal-epidermal junction (hematoxylin-eosin stain, original magnification X200). Junctional melanocytic nevus composed of small nests of melanocytes and lentiginous melanocytic proliferation at the dermal (...) Speckled Lentiginous Nevus (Overview) Speckled Lentiginous Nevus: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2MTk5MC1vdmVydmlldw== processing > Speckled Lentiginous

2014 eMedicine.com

8. Speckled Lentiginous Nevus (Diagnosis)

A large unilateral speckled lentiginous nevus that contains numerous small dark macules. Extensive speckled lentiginous nevus. Prominent basal layer pigmentation similar to that seen in lentigo simplex (hematoxylin-eosin stain, original magnification X200). Elongated rete ridges and lentiginous proliferation of melanocytes at the dermal-epidermal junction (hematoxylin-eosin stain, original magnification X200). Junctional melanocytic nevus composed of small nests of melanocytes and lentiginous (...) Speckled Lentiginous Nevus (Diagnosis) Speckled Lentiginous Nevus: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2MTk5MC1vdmVydmlldw== processing > Speckled

2014 eMedicine.com

9. Nevus simplex: A reconsideration of nomenclature, sites of involvement, and disease associations. (PubMed)

Nevus simplex: A reconsideration of nomenclature, sites of involvement, and disease associations. Nevus simplex (NS) is a common birthmark on the forehead, glabella, upper eyelids, and nape. More widespread involvement can be confused with port-wine stains (nevus flammeus) and other vascular birthmarks.To further categorize the anatomic locations in infants with extensive NS and evaluate for any possible disease associations.We conducted a retrospective review of patients with extensive NS seen (...) at two tertiary care centers.Twenty-seven patients with extensive NS were identified. All had at least one typical site of involvement: glabella (77.8%), nape (59.3%), and eyelids (55.6%). Additional sites were the scalp, including the vertex, occiput, parietal (66.7%); nose (66.7%); lip (59.2%); lumbosacral skin (55.6%); and upper and mid back (14.8 %).Retrospective nature of the study and relatively small sample size.We propose the term "nevus simplex complex" for NS with more widespread

2010 Journal of American Academy of Dermatology

10. Neonatal jaundice

and/or excretion) · Congenital infections: o Cytomegalovirus (CMV), Herpes simplex virus o Toxoplasmosis, rubella, syphilis, varicella zoster, parvovirus B19 causing hepatitis · Inborn errors of metabolism (e.g. urea cycle defects, galactasaemia, fatty acid oxidation defects) Decreased excretion of bilirubin 4,23,25 · Conditions causing abnormal biliary ducts, e.g. Alagille Syndrome, choledochal cyst · Increased enterohepatic bilirubin recirculation o Bowel obstruction, pyloric stenosis o Meconium ileus (...) /inflammatory process (note: may be false negative near onset of infection) o Blood culture–unwell baby of any age o Urine–microscopy and culture § Urinary tract infection is a potential cause of prolonged jaundice o Investigate for congenital infections if there are other indications , e.g. clinical signs of suggestive history, severe jaundice, elevated conjugated bilirubin, thrombocytopenia § Toxoplasmosis § Rubella § Cytomegalovirus (CMV) § Herpes simplex virus § Syphilis · Investigate for inborn errors

2018 Queensland Health

11. Genetics of Skin Cancer (PDQ®): Health Professional Version

, as discussed below, skin cancer patients are encouraged to follow screening recommendations for the general population for sites other than the skin. Major Genes for Basal Cell Carcinoma PTCH1 Pathogenic variants in the coding for the transmembrane receptor protein PTCH1, or PTCH, are associated with basal cell nevus syndrome (BCNS) and cutaneous BCCs. (Refer to the section of this summary for more information.) PTCH1 , the human homolog of the Drosophila segment polarity gene patched ( ptc (...) to Basal Cell Cancer Basal cell nevus syndrome BCNS, also known as Gorlin Syndrome, Gorlin-Goltz syndrome, and nevoid BCC syndrome, is an autosomal dominant disorder with an estimated prevalence of 1 in 57,000 individuals.[ ] The syndrome is notable for complete penetrance and high levels of , as evidenced by evaluation of individuals with identical but widely varying phenotypes.[ , ] The clinical features of BCNS differ more among families than within families.[ ] BCNS is primarily associated

2018 PDQ - NCI's Comprehensive Cancer Database

12. Melanoma Treatment (PDQ®): Health Professional Version

% of the cases arise in apparently normal areas of the skin. Although melanoma can occur anywhere, including on mucosal surfaces and the uvea, melanoma in women occurs more commonly on the extremities, and in men it occurs most commonly on the trunk or head and neck.[ ] Early signs in a nevus that would suggest a malignant change include the following: Darker or variable discoloration. Itching. An increase in size or the development of satellites. Ulceration or bleeding (later signs). Melanomas

2018 PDQ - NCI's Comprehensive Cancer Database

13. A Practice Guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: Referral Indications for Cancer Predisposition Assessment

person 170,171 (Table 8). Von Hippel–Lindau syndrome (OMiM 193300) Von Hippel–Lindau syndrome is caused by mutations in the VHL gene and is characterized by RCC (clear cell histology), hemangioblastomas, pheochromocytomas, and endolymphatic sac tumors. Simplex cases of central nervous system hemangio- blastoma, pheochromocytoma, and endolymphatic sac tumor are each sufficient to warrant genetic counseling referral. VHL mutations are detected in 10–40% of individuals with isolated central nervous (...) or periungual fibroma • Hypomelanotic macules (=3) • Shagreen patch (connective tissue nevus) • Cortical tuber in the brain • Subependymal glial nodule • Subependymal giant cell astrocytoma • Multiple retinal nodular hamartomas • Cardiac rhabdomyomas, single or multiple • Lymphangiomyomatosis • Renal angiomyolipoma Minor criteria • Multiple, randomly distributed pits in dental enamel • Hamartomatous rectal polyps • Bone cysts • “Confetti” skin lesions • Multiple renal cysts • Nonrenal hamartoma • Cerebral

2015 American College of Medical Genetics and Genomics

14. Genetics of Skin Cancer (PDQ®): Health Professional Version

, as discussed below, skin cancer patients are encouraged to follow screening recommendations for the general population for sites other than the skin. Major Genes for Basal Cell Carcinoma PTCH1 Pathogenic variants in the coding for the transmembrane receptor protein PTCH1, or PTCH, are associated with basal cell nevus syndrome (BCNS) and cutaneous BCCs. (Refer to the section of this summary for more information.) PTCH1 , the human homolog of the Drosophila segment polarity gene patched ( ptc (...) to Basal Cell Cancer Basal cell nevus syndrome BCNS, also known as Gorlin Syndrome, Gorlin-Goltz syndrome, and nevoid BCC syndrome, is an autosomal dominant disorder with an estimated prevalence of 1 in 57,000 individuals.[ ] The syndrome is notable for complete penetrance and high levels of , as evidenced by evaluation of individuals with identical but widely varying phenotypes.[ , ] The clinical features of BCNS differ more among families than within families.[ ] BCNS is primarily associated

2016 PDQ - NCI's Comprehensive Cancer Database

15. Melanoma Treatment (PDQ®): Health Professional Version

% of the cases arise in apparently normal areas of the skin. Although melanoma can occur anywhere, including on mucosal surfaces and the uvea, melanoma in women occurs more commonly on the extremities, and in men it occurs most commonly on the trunk or head and neck.[ ] Early signs in a nevus that would suggest a malignant change include the following: Darker or variable discoloration. Itching. An increase in size or the development of satellites. Ulceration or bleeding (later signs). Melanomas

2016 PDQ - NCI's Comprehensive Cancer Database

16. The Molecular Revolution in Cutaneous Biology: Emerging Landscape in Genomic Dermatology: New Mechanistic Ideas, Gene Editing, and Therapeutic Breakthroughs. (PubMed)

, some of which have already proven clinical efficacy in RDEB. Improved understanding of the pathogenesis of skin disorders has led to the development of specific drugs or repurposing of existing medicines as in basal cell nevus syndrome, alopecia areata, melanoma and EB simplex. These discoveries pave the way for improved targeted personalized medicine for rare and frequent diseases. It is likely that a growing number of orphan skin diseases will benefit from combinatory new therapies in a near

2017 Journal of Investigative Dermatology

17. Solar Lentigo

by excessive deposition of melanin from an increased number of melanocytes in the cell layer directly above the basement membrane of the epidermis. Formation is usually related to sun exposure during youth, and the lesions do not typically progress to malignancy. Definition (MSH) Small circumscribed melanoses resembling, but differing histologically from, freckles. The concept includes senile lentigo ('liver spots') and nevoid lentigo (nevus spilus, lentigo simplex) and may also occur in association

2018 FP Notebook

18. Hemangioma

, hemangiomas strawberry , strawberry birthmark , capillary haemangioma , mark strawberry , strawberry hemangioma , strawberry naevus , hemangioma strawberry , juvenile hemangioma , Mark;raspberry , Mark;strawberry , hemangioma simplex , infantile hemangioma , nevus capillary , birthmarks strawberry , marks strawberry , plexiform hemangioma , strawberry angioma , Infantile Hemangioma , Juvenile Hemangioma , Capillary hemangioma , Hemangioma simplex , Infantile hemangioma , Plexiform hemangioma , Juvenile (...) hemangioma , Strawberry mark , Raspberry mark of skin , Strawberry hemangioma of skin , Strawberry mark of skin , Angiomatous naevus , Angiomatous naevus of skin , Angiomatous nevus , Angiomatous nevus of skin , Capillary haemangioma , Capillary haemangioma of skin , Capillary hemangioma of skin , Capillary naevus , Capillary naevus of skin , Capillary nevus , Capillary nevus of skin , Congenital vascular naevus , Congenital vascular nevus , Haemangioma simplex , Infantile haemangioma , Juvenile

2018 FP Notebook

19. Skin Cancer, Melanoma

commonly on the extremities, and in men it occurs most commonly on the trunk or head and neck.[ ] Early signs in a nevus that would suggest a malignant change include the following: Darker or variable discoloration. Itching. An increase in size or the development of satellites. Ulceration or bleeding (later signs). Melanomas with characteristic asymmetry, border irregularity, color variation, and large diameter. Diagnosis A biopsy, preferably by local excision, should be performed for any suspicious

2012 PDQ - NCI's Comprehensive Cancer Database

20. Genetics of Skin Cancer

Cell Carcinoma PTCH1 in the coding for the transmembrane receptor protein PTCH1, or PTCH, are associated with basal cell nevus syndrome (BCNS) and cutaneous BCCs. (Refer to the section of this summary for more information.) PTCH1 , the human homolog of the Drosophila segment polarity gene patched ( ptc ), is an integral component of the hedgehog signaling pathway, which serves many developmental (appendage development, embryonic segmentation, neural tube differentiation) and regulatory (maintenance (...) of BAP1 nuclear expression was observed in 17 of 19 BCCs from these individuals but none of 22 control BCC specimens.[ ] Loss of BAP1 nuclear expression was also reported in a series of 7 BCCs from individuals with loss of function BAP1 variants, but only in 1 of 31 sporadic BCCs.[ ] Syndromes Associated With a Predisposition to Basal Cell Cancer Basal cell nevus syndrome BCNS, also known as Gorlin Syndrome, Gorlin-Goltz syndrome, and nevoid BCC syndrome, is an disorder with an estimated prevalence

2012 PDQ - NCI's Comprehensive Cancer Database

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