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Neutropenic Colitis

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1. Neutropenic Colitis

Neutropenic Colitis Neutropenic Colitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Neutropenic Colitis Neutropenic Colitis Aka (...) : Neutropenic Colitis , Neutropenic Enterocolitis , Typhlitis From Related Chapters II. Epidemiology Rare, but catastrophic cause of in patients on III. Pathophysiology Results from -induced GI mucosa toxicity (and ) with subsequent superinfection Necrotizing colitis involving cecum (but can also affect and proximal ) Similar process as with in newborns IV. Risk Factors Immunosuppression (more than with solid tumors) V. Symptoms Abdominal cramping VI. Signs Typical presentation is with a toxic or septic

2018 FP Notebook

2. Neutropenic Enterocolitis in Critically Ill Patients: Spectrum of the Disease and Risk of Invasive Fungal Disease. (Abstract)

multicentric retrospective cohort study between January 2010 and August 2017.Six French ICUs members of the Groupe de Recherche Respiratoire en Onco-Hématologie research network.Adult neutropenic patients hospitalized in the ICU with a diagnosis of enteritis and/or colitis. Patients with differential diagnosis (Clostridium difficile colitis, viral colitis, inflammatory enterocolitis, mesenteric ischemia, radiation-induced gastrointestinal toxicity, and Graft vs Host Disease) were excluded.None.We included (...) Neutropenic Enterocolitis in Critically Ill Patients: Spectrum of the Disease and Risk of Invasive Fungal Disease. Neutropenic enterocolitis occurs in about 5.3% of patients hospitalized for hematologic malignancies receiving chemotherapy. Data from critically ill patients with neutropenic enterocolitis are scarce. Our objectives were to describe the population of patients with neutropenic enterocolitis admitted to an ICU and to investigate the risk factors of invasive fungal disease.A

2019 Critical Care Medicine

3. Incidence of Neutropenic Enterocolitis Study in Acute Myeloid Leukemia Patients During Intensive Therapy

according to international recommandations (ECIL and IDSA) with antibiotherapy and antifungal strategy. Although the patients suffer of digestive symptoms, intestinale complications are really less explored. Neutropenic enterocolitis (NE), cytomegalovirus (CMV) colitis, Clostridium difficile colitis, specific lesion, ischemic colitis are not well-known. No prospective study evaluate NE and these digestive complications which have high morbi-mortality rates. Condition or disease Intervention/treatment (...) Incidence of Neutropenic Enterocolitis Study in Acute Myeloid Leukemia Patients During Intensive Therapy Incidence of Neutropenic Enterocolitis Study in Acute Myeloid Leukemia Patients During Intensive Therapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2018 Clinical Trials

4. Neutropenic enterocolitis Full Text available with Trip Pro

Neutropenic enterocolitis Neutropenic colitis is a severe condition usually affecting immunocompromised patients. Its exact pathogenesis is not completely understood. The main elements in disease onset appear to be intestinal mucosal injury together with neutropenia and the weakened immune system of the afflicted patients. These initial conditions lead to intestinal edema, engorged vessels, and a disrupted mucosal surface, which becomes more vulnerable to bacterial intramural invasion (...) . Chemotherapeutic agents can cause direct mucosal injury (mucositis) or can predispose to distension and necrosis, thereby altering intestinal motility. This article aims to review current concepts regarding neutropenic colitis' pathogenesis, diagnosis, and management.

2017 World Journal of Gastroenterology

5. Neutropenic Colitis

Neutropenic Colitis Neutropenic Colitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Neutropenic Colitis Neutropenic Colitis Aka (...) : Neutropenic Colitis , Neutropenic Enterocolitis , Typhlitis From Related Chapters II. Epidemiology Rare, but catastrophic cause of in patients on III. Pathophysiology Results from -induced GI mucosa toxicity (and ) with subsequent superinfection Necrotizing colitis involving cecum (but can also affect and proximal ) Similar process as with in newborns IV. Risk Factors Immunosuppression (more than with solid tumors) V. Symptoms Abdominal cramping VI. Signs Typical presentation is with a toxic or septic

2015 FP Notebook

6. Clostridium difficile Colitis and Neutropenic Fever Associated with Docetaxel Chemotherapy in a Patient with Advanced Extramammary Paget's Disease Full Text available with Trip Pro

Clostridium difficile Colitis and Neutropenic Fever Associated with Docetaxel Chemotherapy in a Patient with Advanced Extramammary Paget's Disease Extramammary Paget's disease is a rare cutaneous malignant neoplasm. Previous studies indicated the efficacy of docetaxel in advanced cases. The common side effects of docetaxel are usually tolerable and seldom life-threatening. We experienced a case of severe pseudomembranous colitis and neutropenic fever that developed just after the first cycle (...) of docetaxel chemotherapy. To the best of our knowledge, there are few reports of pseudomembranous colitis associated with docetaxel administration for skin cancers. The patient showed complete resolution of her symptoms within 2 weeks with an oral metronidazole therapy. During the second and third cycles, the patient received docetaxel safely with lower doses. The present case indicated that pseudomembranous colitis should be included in the differential diagnosis when assessing patients who develop

2012 Case reports in dermatology

7. Neutropenic Enterocolitis: New Insights Into a Deadly Entity. (Abstract)

Neutropenic Enterocolitis: New Insights Into a Deadly Entity. Neutropenic enterocolitis (NE) is a deadly ileocecal-based disease seen in patients with a recent history of chemotherapy. As histology is not included in the current diagnostic criteria, the pathologic features of NE are poorly understood. We undertook a multi-institutional study of NE, and report helpful clinical clues, such as immunosuppression (n=20/20), recent chemotherapy (n=17/18), neutropenia (n=16/18) gastrointestinal (...) ). Seventy-nine percent (n=15/19) of patients with histologically confirmed NE died: 47% (n=7/15) of these deaths were attributed to NE and the remainder to the patients' underlying conditions. Importantly, we observed a clinical diagnostic discordancy rate of 35% (n=9/26): 15% (n=3/20) of histologically confirmed NE were clinically unsuspected, and 26% (n=6/23) of clinically suspected NE represented a different disease process. Alternative diagnoses included unspecified colitis, infection, graft-versus

2015 American Journal of Surgical Pathology

8. Neutropenic Enterocolitis (Follow-up)

nonlymphocytic (myelogenous) leukemia. Cancer . 1986 Feb 1. 57 (3):603-9. . Fike FB, Mortellaro V, Juang D, St Peter SD, Andrews WS, Snyder CL. Neutropenic colitis in children. J Surg Res . 2011 Sep. 170 (1):73-6. . Jain Y, Arya LS, Kataria R. Neutropenic enterocolitis in children with acute lymphoblastic leukemia. Pediatr Hematol Oncol . 2000 Jan-Feb. 17 (1):99-103. . Buyukasik Y, Ozcebe OI, Haznedaroglu IC, et al. Neutropenic enterocolitis in adult leukemias. Int J Hematol . 1997 Jul. 66 (1):47-55. . Aksoy (...) with malignancy: a single center experience. J Pediatr Hematol Oncol . 2011 Apr. 33 (3):e98-100. . Mullassery D, Bader A, Battersby AJ, et al. Diagnosis, incidence, and outcomes of suspected typhlitis in oncology patients--experience in a tertiary pediatric surgical center in the United Kingdom. J Pediatr Surg . 2009 Feb. 44 (2):381-5. . Ettinghausen SE. Collagenous colitis, eosinophilic colitis, and neutropenic colitis. Surg Clin North Am . 1993 Oct. 73 (5):993-1016. . Park YB, Lee JW, Cho BS, et al

2014 eMedicine.com

9. Neutropenic Enterocolitis (Treatment)

nonlymphocytic (myelogenous) leukemia. Cancer . 1986 Feb 1. 57 (3):603-9. . Fike FB, Mortellaro V, Juang D, St Peter SD, Andrews WS, Snyder CL. Neutropenic colitis in children. J Surg Res . 2011 Sep. 170 (1):73-6. . Jain Y, Arya LS, Kataria R. Neutropenic enterocolitis in children with acute lymphoblastic leukemia. Pediatr Hematol Oncol . 2000 Jan-Feb. 17 (1):99-103. . Buyukasik Y, Ozcebe OI, Haznedaroglu IC, et al. Neutropenic enterocolitis in adult leukemias. Int J Hematol . 1997 Jul. 66 (1):47-55. . Aksoy (...) with malignancy: a single center experience. J Pediatr Hematol Oncol . 2011 Apr. 33 (3):e98-100. . Mullassery D, Bader A, Battersby AJ, et al. Diagnosis, incidence, and outcomes of suspected typhlitis in oncology patients--experience in a tertiary pediatric surgical center in the United Kingdom. J Pediatr Surg . 2009 Feb. 44 (2):381-5. . Ettinghausen SE. Collagenous colitis, eosinophilic colitis, and neutropenic colitis. Surg Clin North Am . 1993 Oct. 73 (5):993-1016. . Park YB, Lee JW, Cho BS, et al

2014 eMedicine.com

10. Neutropenic Enterocolitis (Overview)

. Typhlitis. An 18-year experience and postmortem review. Cancer . 1990 Feb 15. 65 (4):1041-7. . Shamberger RC, Weinstein HJ, Delorey MJ, Levey RH. The medical and surgical management of typhlitis in children with acute nonlymphocytic (myelogenous) leukemia. Cancer . 1986 Feb 1. 57 (3):603-9. . Fike FB, Mortellaro V, Juang D, St Peter SD, Andrews WS, Snyder CL. Neutropenic colitis in children. J Surg Res . 2011 Sep. 170 (1):73-6. . Jain Y, Arya LS, Kataria R. Neutropenic enterocolitis in children (...) Kingdom. J Pediatr Surg . 2009 Feb. 44 (2):381-5. . Ettinghausen SE. Collagenous colitis, eosinophilic colitis, and neutropenic colitis. Surg Clin North Am . 1993 Oct. 73 (5):993-1016. . Park YB, Lee JW, Cho BS, et al. Incidence and etiology of overt gastrointestinal bleeding in adult patients with aplastic anemia. Dig Dis Sci . 2010 Jan. 55 (1):73-81. . [Guideline] Schnell D, Azoulay E, Benoit D, et al. Management of neutropenic patients in the intensive care unit (NEWBORNS EXCLUDED) recommendations

2014 eMedicine.com

11. Neutropenic Enterocolitis (Diagnosis)

. Typhlitis. An 18-year experience and postmortem review. Cancer . 1990 Feb 15. 65 (4):1041-7. . Shamberger RC, Weinstein HJ, Delorey MJ, Levey RH. The medical and surgical management of typhlitis in children with acute nonlymphocytic (myelogenous) leukemia. Cancer . 1986 Feb 1. 57 (3):603-9. . Fike FB, Mortellaro V, Juang D, St Peter SD, Andrews WS, Snyder CL. Neutropenic colitis in children. J Surg Res . 2011 Sep. 170 (1):73-6. . Jain Y, Arya LS, Kataria R. Neutropenic enterocolitis in children (...) Kingdom. J Pediatr Surg . 2009 Feb. 44 (2):381-5. . Ettinghausen SE. Collagenous colitis, eosinophilic colitis, and neutropenic colitis. Surg Clin North Am . 1993 Oct. 73 (5):993-1016. . Park YB, Lee JW, Cho BS, et al. Incidence and etiology of overt gastrointestinal bleeding in adult patients with aplastic anemia. Dig Dis Sci . 2010 Jan. 55 (1):73-81. . [Guideline] Schnell D, Azoulay E, Benoit D, et al. Management of neutropenic patients in the intensive care unit (NEWBORNS EXCLUDED) recommendations

2014 eMedicine.com

12. Omega-3 poly-unsaturated fatty acids for the prevention of severe neutropenic enterocolitis in patients with acute myeloid leukemia. (Abstract)

Omega-3 poly-unsaturated fatty acids for the prevention of severe neutropenic enterocolitis in patients with acute myeloid leukemia. Neutropenic enterocolitis is a potentially fatal complication of myeloablative chemotherapy in patients with acute myeloid leukemia. Omega-3 polyunsaturated fatty acids (PUFA) are precursors of potent anti-inflammatory prostaglandins. Our aim was to explore the safety and effectiveness of omega-3 PUFA added to parenteral nutrition in protecting leukemia patients (...) from severe enterocolitis. Fourteen patients with acute myeloid leukemia who received omega-3 PUFA in a Phase II trial were compared with 66 consecutive control patients not getting this intervention. We performed crude and adjusted comparisons, using inverse probability of treatment weighting for adjusted analysis, and blind outcome assessment to minimize assessor bias. Primary outcome was severe enterocolitis (≥Grade 3). The crude odds ratio of Grade 3 colitis or higher was 1.36 (95% CI 0.37

2013 Nutrition and cancer

13. Micafungin Versus Intravenous Itraconazole as Empirical Antifungal Therapy for Febrile Neutropenic Patients With Hematological Diseases

Micafungin Versus Intravenous Itraconazole as Empirical Antifungal Therapy for Febrile Neutropenic Patients With Hematological Diseases Micafungin Versus Intravenous Itraconazole as Empirical Antifungal Therapy for Febrile Neutropenic Patients With Hematological Diseases - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning (...) You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Micafungin Versus Intravenous Itraconazole as Empirical Antifungal Therapy for Febrile Neutropenic Patients With Hematological Diseases The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier

2011 Clinical Trials

14. Catheter-Related Acremonium kiliense Fungemia in a Patient with Ulcerative Colitis under Treatment with Infliximab Full Text available with Trip Pro

Catheter-Related Acremonium kiliense Fungemia in a Patient with Ulcerative Colitis under Treatment with Infliximab Acremonium spp. are filamentous, cosmopolitan fungi commonly isolated from plant debris and soil. They are infrequent pathogens in humans. Acremonium fungemia has been reported in neutropenic patients associated with central venous catheters and in nonneutropenic patients receiving long-term total parenteral nutrition. TNF-α blockade is associated with fungal infections (...) , but no Acremonium spp. infection had been reported up to the present. In this paper, we present a patient with ulcerative colitis who developed Acremonium kiliense fungemia associated with infliximab therapy while receiving total parenteral nutrition. The patient was successfully treated with voriconazole. Acremonium sp. infection must be suspected as another cause of fungal infection in patients under treatment with infliximab.

2011 Case reports in infectious diseases

15. Clostridioides difficile Infection in Adults and Children

are required. d. The role of probiotics in prevention and treatment of C. difficile colitis is unclear, and their use is not currently recommended for inpatients. Avoid the use of probiotics in immunocompromised patients (transplant recipients, unintact gut mucosa, neutropenic patients, HIV/AIDS patients, etc.) and patients with severe C. difficile colitis. e. Cholestyramine binds PO vancomycin and may decrease its efficacy. Avoid concomitant use. 7 UMHS C. difficile Infection in Adults and Children 12 (...) Patients: Diagnosis Definitive diagnosis of CDI requires either the presence of toxigenic C. difficile in stool with compatible symptoms, or clinical evidence of pseudomembranous colitis (Table 2, Figure 4). Once identified, CDI should be classified according to severity (Table 3). Although risk factors for CDI (Table 1) should guide suspicion for CDI, testing should be ordered only when indicated (Figure 1). Use judgment and consider not testing in patients that have recently started tube feeds

2020 University of Michigan Health System

16. Assessment of acute abdomen

/strangulated hernia Cholecystitis Gastric ulcer Appendicitis Ectopic pregnancy Pelvic inflammatory disease Acute pancreatitis Acute diverticulitis Ulcerative colitis Crohn's disease Cholelithiasis Gastrointestinal malignancy Hepatic abscess Fitz-Hugh Curtis syndrome Mallory-Weiss tear Abdominal wall haematoma Hereditary Mediterranean fever Typhilitis (neutropenic enterocolitis) Narcotic withdrawal Hepatitis Gastroenteritis Infectious colitis Sickle cell crisis Endometriosis Testicular torsion Kidney stones (...) Pyelonephritis Volvulus Intussusception Duodenal ulcer Ruptured ovarian cyst Ovarian torsion Abdominal aortic dissection Ruptured aortic aneurysm Acute mesenteric ischaemia and infarction Meckel's diverticulitis Psoas abscess Oesophageal perforation (Boerhaave’s syndrome) Ischaemic colitis Ruptured splenic artery aneurysm Budd-Chiari syndrome Splenic infarct Uraemia Diabetic ketoacidosis Addisonian crisis Hypercalcaemia Acute intermittent porphyria Radiation enteritis Heavy metal poisoning Spider bite

2018 BMJ Best Practice

17. Assessment of acute abdomen

/strangulated hernia Cholecystitis Gastric ulcer Appendicitis Ectopic pregnancy Pelvic inflammatory disease Acute pancreatitis Acute diverticulitis Ulcerative colitis Crohn's disease Cholelithiasis Gastrointestinal malignancy Hepatic abscess Fitz-Hugh Curtis syndrome Mallory-Weiss tear Abdominal wall haematoma Hereditary Mediterranean fever Typhilitis (neutropenic enterocolitis) Narcotic withdrawal Hepatitis Gastroenteritis Infectious colitis Sickle cell crisis Endometriosis Testicular torsion Kidney stones (...) Pyelonephritis Volvulus Intussusception Duodenal ulcer Ruptured ovarian cyst Ovarian torsion Abdominal aortic dissection Ruptured aortic aneurysm Acute mesenteric ischaemia and infarction Meckel's diverticulitis Psoas abscess Oesophageal perforation (Boerhaave’s syndrome) Ischaemic colitis Ruptured splenic artery aneurysm Budd-Chiari syndrome Splenic infarct Uraemia Diabetic ketoacidosis Addisonian crisis Hypercalcaemia Acute intermittent porphyria Radiation enteritis Heavy metal poisoning Spider bite

2018 BMJ Best Practice

19. Appropriate Use Criteria: Imaging of the Abdomen and Pelvis

in the diagnosis of diverticulitis. 21 Enteritis and colitis Includes neutropenic colitis and radiation enteritis, and excludes inflammatory bowel disease. Advanced imaging is considered medically necessary for diagnosis and management when the results of imaging will impact management. Imaging of the Abdomen and Pelvis Copyright © 2019. AIM Specialty Health. All Rights Reserved. 16 IMAGING STUDY - CT abdomen and/or pelvis Foreign body (Pediatric only) Advanced imaging is considered medically necessary (...) Tumor or neoplasm – not otherwise referenced 12 Female Reproductive System and Obstetrics 12 Adenomyosis 12 Adnexal mass 12 Endometriosis 13 Obstetric indications 13 Uterine artery embolization procedures 13 Gastrointestinal Conditions 14 Appendicitis 14 Bowel obstruction 14 Constipation (Pediatric only) 15 Diverticulitis 15 Enteritis and colitis 15 Foreign body (Pediatric only) 16 Gastrointestinal bleeding (Pediatric only) 16 Henoch-Schonlein purpura (Pediatric only) 16 Inflammatory bowel disease

2019 AIM Specialty Health

20. CRACKCast Episode 183 – The Immunocompromised Patient

Points Immunocompromised persons who present with acute infections, especially those that are neutropenic, may appear deceptively benign only to deteriorate rapidly if they are not evaluated and treated urgently. Early use of broad-spectrum antibiotics is indicated after obtaining appropriate cultures of all potential sites of infection, including intravascular catheters. Immunocompromised patients can have serious local or systemic infections without fever, which may be manifested by unexplained (...) tachypnea or tachycardia, mental status changes, metabolic acidosis, increased volume requirements, rapid changes in serum glucose or sodium concentration, or acute abdominal pain. In neutropenic cancer patients, most severe infections and almost all instances of bacteremia occur when the neutrophil count is less than 100 cells/mL. In neutropenic patients, the temperature should be measured orally or tympanically, not rectally. In neutropenic cancer patients, pneumonia and anorectal infection are more

2018 CandiEM

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