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Neurotransmitter Physiology

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101. Aliphatic polyamines in physiology and diseases. (PubMed)

Aliphatic polyamines in physiology and diseases. Aliphatic polyamines are a family of polycationic molecules derived from decarboxylation of the amino acid ornithine that classically comprise three molecules: putrescine, spermidine and spermine. In-cell polyamine homeostasis is tightly controlled at key steps of cell metabolism. Polyamines are involved in an array of cellular functions from DNA stabilization, and regulation of gene expression to ion channel function and, particularly, cell (...) proliferation. As such, aliphatic polyamines play an essential role in rapidly dividing cells such as in the immune system and digestive tract. Because of their role in cell proliferation, polyamines are also involved in carcinogenesis, prompting intensive research into polyamine metabolism as a target in cancer therapy. More recently, another aliphatic polyamine, agmatine, the decarboxylated derivative of arginine, has been identified as a neurotransmitter in mammals, and investigations have focused on its

2014 Clinical nutrition (Edinburgh, Scotland)

102. Bioengineering of Physiologically Functional Intrinsically Innervated Human Internal Anal Sphincter Constructs (PubMed)

and cultured from intestinal tissues of adult human donors. These constructs expressed markers for contractile smooth muscle, glial cells, and mature neuronal populations. The constructs responded appropriately to physiologically relevant neurotransmitters, and neural network integration was demonstrated by responses to electrical field stimulation. The ability of enteric neuroprogenitor cells to differentiate into neuronal populations provides enormous potential for functional innervation of a variety (...) Bioengineering of Physiologically Functional Intrinsically Innervated Human Internal Anal Sphincter Constructs Muscle replacement for patients suffering from extensive tissue loss or dysfunction is a major objective of regenerative medicine. To achieve functional status, bioengineered muscle replacement constructs require innervation. Here we describe a method to bioengineer functionally innervated gut smooth muscle constructs using neuronal progenitor cells and smooth muscle cells isolated

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2014 Tissue engineering. Part A

103. Anorectal Physiology/Pathophysiology in the Elderly (PubMed)

Anorectal Physiology/Pathophysiology in the Elderly Anorectal medical disorders facing the elderly include fecal incontinence, fecal impaction with overflow fecal incontinence, chronic constipation, dyssynergic defecation, hemorrhoids, anal fissure, and pelvic floor disorders. This article discusses the latest advances in age-related changes in morphology and function of anal sphincter, changes in cellular and molecular biology, alterations in neurotransmitters and reflexes, and their impact

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2014 Clinics in Geriatric Medicine

104. Lesions of the frontal cortex of the rat: changes in neurotransmitter systems in sub-cortical regions [proceedings] (PubMed)

Animals Brain metabolism Cerebral Cortex drug effects physiology Desipramine pharmacology Hydroxydopamines pharmacology Male Neurotransmitter Agents metabolism Rats 1978 11 1 1978 11 1 0 1 1978 11 1 0 0 ppublish 31222 PMC1668590 Brain Res. 1971 Aug 20;31(2):295-311 5569152 Br J Pharmacol. 1978 Mar;62(3):402P 638332 Brain Res. 1978 Feb 10;141(2):267-81 626903 (...) Lesions of the frontal cortex of the rat: changes in neurotransmitter systems in sub-cortical regions [proceedings] 31222 1979 02 12 2018 11 13 0007-1188 64 3 1978 Nov British journal of pharmacology Br. J. Pharmacol. Lesions of the frontal cortex of the rat: changes in neurotransmitter systems in sub-cortical regions [proceedings]. 430P Carter C J CJ Pycock C J CJ eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Hydroxydopamines 0 Neurotransmitter Agents TG537D343B Desipramine IM

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1978 British journal of pharmacology

105. Newer neurotransmitters in pain control. (PubMed)

Newer neurotransmitters in pain control. 44440 1980 06 27 2018 11 13 0003-3006 26 3 1979 May-Jun Anesthesia progress Anesth Prog Newer neurotransmitters in pain control. 66-71 Trieger N N eng Journal Article Review United States Anesth Prog 0043533 0003-3006 0 Analgesics 0 Endorphins 0 Neurotransmitter Agents D Q Analgesics history Endorphins physiology Humans Neurophysiology trends Neurotransmitter Agents history physiology 46 1979 5 1 1979 5 1 0 1 1979 5 1 0 0 ppublish 44440 PMC2516006

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1979 Anesthesia progress

106. Normal Sleep, Sleep Physiology, and Sleep Deprivation: General Principles (Overview)

Normal Sleep, Sleep Physiology, and Sleep Deprivation: General Principles (Overview) Normal Sleep, Sleep Physiology, and Sleep Deprivation: Normal Sleep in Adults, Infants, and the Elderly, Sleep Physiology, Circadian Rhythms That Influence Sleep Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method (...) =getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4ODIyNi1vdmVydmlldw== processing > Normal Sleep, Sleep Physiology, and Sleep Deprivation Updated: Dec 03, 2015 Author: M Suzanne Stevens, MD, MS, D-ABSM; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections Normal Sleep, Sleep Physiology, and Sleep Deprivation Normal Sleep in Adults, Infants, and the Elderly Normal sleep is divided into non–rapid eye movement (NREM) and rapid eye movement (REM

2014 eMedicine.com

107. Exercise Physiology (Overview)

Exercise Physiology (Overview) Exercise Physiology: Overview, Basic Concepts -- Sex Differences, Musculoskeletal System Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvODg0ODQtb3ZlcnZpZXc= processing > Exercise (...) Physiology Updated: Oct 20, 2015 Author: Amer Suleman, MD; Chief Editor: Craig C Young, MD Share Email Print Feedback Close Sections Sections Exercise Physiology Overview Overview Exercise represents one the highest levels of extreme stresses to which the body can be exposed. For example, in a person who has an extremely high fever approaching the level of lethality, the body metabolism increases to approximately 100% above normal; by comparison, the metabolism of the body during a marathon race

2014 eMedicine.com

108. Exercise Physiology (Diagnosis)

Exercise Physiology (Diagnosis) Exercise Physiology: Overview, Basic Concepts -- Sex Differences, Musculoskeletal System Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvODg0ODQtb3ZlcnZpZXc= processing > Exercise (...) Physiology Updated: Oct 20, 2015 Author: Amer Suleman, MD; Chief Editor: Craig C Young, MD Share Email Print Feedback Close Sections Sections Exercise Physiology Overview Overview Exercise represents one the highest levels of extreme stresses to which the body can be exposed. For example, in a person who has an extremely high fever approaching the level of lethality, the body metabolism increases to approximately 100% above normal; by comparison, the metabolism of the body during a marathon race

2014 eMedicine.com

109. Normal Sleep, Sleep Physiology, and Sleep Deprivation: General Principles (Treatment)

Normal Sleep, Sleep Physiology, and Sleep Deprivation: General Principles (Treatment) Normal Sleep, Sleep Physiology, and Sleep Deprivation: Normal Sleep in Adults, Infants, and the Elderly, Sleep Physiology, Circadian Rhythms That Influence Sleep Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method (...) =getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4ODIyNi1vdmVydmlldw== processing > Normal Sleep, Sleep Physiology, and Sleep Deprivation Updated: Dec 03, 2015 Author: M Suzanne Stevens, MD, MS, D-ABSM; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections Normal Sleep, Sleep Physiology, and Sleep Deprivation Normal Sleep in Adults, Infants, and the Elderly Normal sleep is divided into non–rapid eye movement (NREM) and rapid eye movement (REM

2014 eMedicine.com

110. Exercise Physiology (Treatment)

Exercise Physiology (Treatment) Exercise Physiology: Overview, Basic Concepts -- Sex Differences, Musculoskeletal System Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvODg0ODQtb3ZlcnZpZXc= processing > Exercise (...) Physiology Updated: Oct 20, 2015 Author: Amer Suleman, MD; Chief Editor: Craig C Young, MD Share Email Print Feedback Close Sections Sections Exercise Physiology Overview Overview Exercise represents one the highest levels of extreme stresses to which the body can be exposed. For example, in a person who has an extremely high fever approaching the level of lethality, the body metabolism increases to approximately 100% above normal; by comparison, the metabolism of the body during a marathon race

2014 eMedicine.com

111. Normal Sleep, Sleep Physiology, and Sleep Deprivation: General Principles (Follow-up)

Normal Sleep, Sleep Physiology, and Sleep Deprivation: General Principles (Follow-up) Normal Sleep, Sleep Physiology, and Sleep Deprivation: Normal Sleep in Adults, Infants, and the Elderly, Sleep Physiology, Circadian Rhythms That Influence Sleep Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method (...) =getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4ODIyNi1vdmVydmlldw== processing > Normal Sleep, Sleep Physiology, and Sleep Deprivation Updated: Dec 03, 2015 Author: M Suzanne Stevens, MD, MS, D-ABSM; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections Normal Sleep, Sleep Physiology, and Sleep Deprivation Normal Sleep in Adults, Infants, and the Elderly Normal sleep is divided into non–rapid eye movement (NREM) and rapid eye movement (REM

2014 eMedicine.com

112. Exercise Physiology (Follow-up)

Exercise Physiology (Follow-up) Exercise Physiology: Overview, Basic Concepts -- Sex Differences, Musculoskeletal System Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvODg0ODQtb3ZlcnZpZXc= processing > Exercise (...) Physiology Updated: Oct 20, 2015 Author: Amer Suleman, MD; Chief Editor: Craig C Young, MD Share Email Print Feedback Close Sections Sections Exercise Physiology Overview Overview Exercise represents one the highest levels of extreme stresses to which the body can be exposed. For example, in a person who has an extremely high fever approaching the level of lethality, the body metabolism increases to approximately 100% above normal; by comparison, the metabolism of the body during a marathon race

2014 eMedicine.com

113. Normal Sleep, Sleep Physiology, and Sleep Deprivation: General Principles (Diagnosis)

Normal Sleep, Sleep Physiology, and Sleep Deprivation: General Principles (Diagnosis) Normal Sleep, Sleep Physiology, and Sleep Deprivation: Normal Sleep in Adults, Infants, and the Elderly, Sleep Physiology, Circadian Rhythms That Influence Sleep Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method (...) =getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4ODIyNi1vdmVydmlldw== processing > Normal Sleep, Sleep Physiology, and Sleep Deprivation Updated: Dec 03, 2015 Author: M Suzanne Stevens, MD, MS, D-ABSM; Chief Editor: Selim R Benbadis, MD Share Email Print Feedback Close Sections Sections Normal Sleep, Sleep Physiology, and Sleep Deprivation Normal Sleep in Adults, Infants, and the Elderly Normal sleep is divided into non–rapid eye movement (NREM) and rapid eye movement (REM

2014 eMedicine.com

114. Dopamine in human follicular fluid is associated with cellular uptake and metabolism-dependent generation of reactive oxygen species in granulosa cells: implications for physiology and pathology. (PubMed)

Dopamine in human follicular fluid is associated with cellular uptake and metabolism-dependent generation of reactive oxygen species in granulosa cells: implications for physiology and pathology. Is the neurotransmitter dopamine (DA) in the human ovary involved in the generation of reactive oxygen species (ROS)?Human ovarian follicular fluid contains DA, which causes the generation of ROS in cultured human granulosa cells (GCs), and alterations of DA levels in follicular fluid and DA uptake (...) /metabolism in GCs in patients with polycystic ovary syndrome (PCOS) are linked to increased levels of ROS.DA is an important neurotransmitter in the brain, and the metabolism of DA results in the generation of ROS. DA was detected in human ovarian homogenates, but whether it is present in follicular fluid and plays a role in the follicle is not known.We used human follicular fluid from patients undergoing in vitro fertilization (IVF), GCs from patients with or without PCOS and also employed mathematical

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2013 Human Reproduction

115. Central Regulation of Pituitary-Thyroid Axis Under Physiological and Pathophysiological Conditions. (PubMed)

Central Regulation of Pituitary-Thyroid Axis Under Physiological and Pathophysiological Conditions. TRH is a tripeptide amide that functions as a neurotransmitter but also serves as a neurohormone that has a critical role in the central regulation of the hypothalamic-pituitary-thyroid axis. Hypophysiotropic TRH neurons involved in this neuroendocrine process are located in the hypothalamic paraventricular nucleus and secrete TRH into the pericapillary space of the external zone of the median (...) to the regulation of hypophysiotropic TRH neurons under physiological and pathophysiological conditions.

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2013 Endocrine Reviews

116. Molecular bases of circadian rhythmicity in renal physiology and pathology. (PubMed)

sensitivity, physical activity, vascular tone, autonomic function and neurotransmitter release from sympathetic innervations. The circadian rhythmicity of body physiology is driven by central and peripheral biological clockworks and entrained by the geophysical light/dark cycle. Chronodisruption, defined as the mismatch between environmental-social cues and physiological-behavioral patterns, causes internal desynchronization of periodic functions, leading to pathophysiological mechanisms underlying (...) Molecular bases of circadian rhythmicity in renal physiology and pathology. The physiological processes that maintain body homeostasis oscillate during the day. Diurnal changes characterize kidney functions, comprising regulation of hydro-electrolytic and acid-base balance, reabsorption of small solutes and hormone production. Renal physiology is characterized by 24-h periodicity and contributes to circadian variability of blood pressure levels, related as well to nychthemeral changes of sodium

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2013 Transplantation

117. Effect of Tyrosine on Behavioral, Physiological and Nutritional Status During Survive, Evade, Resist, Escape (SERE) School

Effect of Tyrosine on Behavioral, Physiological and Nutritional Status During Survive, Evade, Resist, Escape (SERE) School Effect of Tyrosine on Behavioral, Physiological and Nutritional Status During Survive, Evade, Resist, Escape (SERE) School - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Tyrosine on Behavioral, Physiological and Nutritional Status During Survive, Evade, Resist, Escape (SERE) School The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01823276 Recruitment Status : Completed

2013 Clinical Trials

118. The Effects of Cannabis Use in People With Schizophrenia on Clinical, Neuropsychological and Physiological Phenotypes

Schizophrenia Marijuana Abuse Schizophrenia Spectrum and Other Psychotic Disorders Mental Disorders Substance-Related Disorders Chemically-Induced Disorders Dronabinol Hallucinogens Physiological Effects of Drugs Psychotropic Drugs Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Cannabinoid Receptor Agonists Cannabinoid Receptor Modulators Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Hormones Hormones, Hormone Substitutes, and Hormone (...) The Effects of Cannabis Use in People With Schizophrenia on Clinical, Neuropsychological and Physiological Phenotypes The Effects of Cannabis Use in People With Schizophrenia on Clinical, Neuropsychological and Physiological Phenotypes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2013 Clinical Trials

119. Psychological, Physiological, Endocrine, and Pharmacokinetic Effects of LSD in a Controlled Study

Hallucinogens Physiological Effects of Drugs Psychotropic Drugs Serotonin Antagonists Serotonin Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Serotonin Receptor Agonists (...) Psychological, Physiological, Endocrine, and Pharmacokinetic Effects of LSD in a Controlled Study Psychological, Physiological, Endocrine, and Pharmacokinetic Effects of LSD in a Controlled Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2013 Clinical Trials

120. State-dependent and reflex drives to the upper airway: basic physiology with clinical implications (PubMed)

State-dependent and reflex drives to the upper airway: basic physiology with clinical implications The root cause of the most common and serious of the sleep disorders is impairment of breathing, and a number of factors predispose a particular individual to hypoventilation during sleep. In turn, obstructive hypopneas and apneas are the most common of the sleep-related respiratory problems and are caused by dysfunction of the upper airway as a conduit for airflow. The overarching principle (...) sleep; 2) convergence of diverse neurotransmitters and signaling pathways onto one root mechanism that may explain pharyngeal motor suppression in sleep and drug-induced brain sedation; 3) the lateral reticular formation as a key hub of respiratory and reflex drives to the upper airway.

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2013 Journal of Applied Physiology

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