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Neurotransmitter Physiology

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21761. Effect of Oral Pregabalin on Spinal Neurotransmitters in Patients Undergoing Knee Replacement

Last Verified: November 2012 Keywords provided by Asokumar Buvanendran, Rush University Medical Center: Pregabalin CSF Neurotransmitter Additional relevant MeSH terms: Layout table for MeSH terms Pregabalin Neurotransmitter Agents Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anticonvulsants Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating Hormones and Agents Anti-Anxiety (...) Effect of Oral Pregabalin on Spinal Neurotransmitters in Patients Undergoing Knee Replacement Effect of Oral Pregabalin on Spinal Neurotransmitters in Patients Undergoing Knee Replacement - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2008 Clinical Trials

21762. Relationship Between Neurotransmitter Receptor Polymorphisms, Plasma Concentrations and Clinical Response to Clozapine

ClinicalTrials.gov Identifier: Other Study ID Numbers: 199901018 First Posted: December 28, 2007 Last Update Posted: May 12, 2017 Last Verified: May 2017 Keywords provided by Delwyn D. Miller, University of Iowa: clozapine, schizophrenia Additional relevant MeSH terms: Layout table for MeSH terms Schizophrenia Schizophrenia Spectrum and Other Psychotic Disorders Mental Disorders Clozapine Neurotransmitter Agents Serotonin Antagonists Serotonin Agents Molecular Mechanisms of Pharmacological Action Physiological (...) Relationship Between Neurotransmitter Receptor Polymorphisms, Plasma Concentrations and Clinical Response to Clozapine Relationship Between Neurotransmitter Receptor Polymorphisms, Plasma Concentrations and Clinical Response to Clozapine - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2007 Clinical Trials

21763. Nutritional and Neurotransmitter Changes in PKU Subjects on BH4

Nutritional and Neurotransmitter Changes in PKU Subjects on BH4 Nutritional and Neurotransmitter Changes in PKU Subjects on BH4 - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Nutritional (...) and Neurotransmitter Changes in PKU Subjects on BH4 (BH4&PKU) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00688844 Recruitment Status : Completed First Posted : June 3, 2008 Results First Posted : August 20, 2014 Last Update Posted : June 8, 2015 Sponsor: Emory University Collaborators: BioMarin Pharmaceutical

2008 Clinical Trials

21764. TEMPORAL NEUROTRANSMITTER CONDITIONING RESTORES THE FUNCTIONAL ACTIVITY OF ADULT SPINAL-CORD NEURONS IN LONG-TERM CULTURE (Full text)

, has arisen as a major impediment to their physiological relevance. In this report, we demonstrate that single temporal doses of the neurotransmitters serotonin, glutamate (N-acetyl-DL-glutamic acid) and acetylcholine-chloride lead to the full electrophysiological functional recovery of adult mammalian spinal cord neurons, when they are cultured under defined serum-free conditions. Approximately 60% of the neurons treated regained their electrophysiological signature, often firing single, double (...) TEMPORAL NEUROTRANSMITTER CONDITIONING RESTORES THE FUNCTIONAL ACTIVITY OF ADULT SPINAL-CORD NEURONS IN LONG-TERM CULTURE The ability to culture functional adult mammalian spinal cord neurons represents an important step in the understanding and treatment of a spectrum of neurological disorders including spinal cord injury. Previously, the limited functional recovery of these cells, as characterized by a diminished ability to initiate action potentials and to exhibit repetitive firing patterns

2007 Experimental neurology PubMed abstract

21765. Tonotopic Variation in the Calcium Dependence of Neurotransmitter Release and Vesicle Pool Replenishment at Mammalian Auditory Ribbon Synapses (Full text)

Tonotopic Variation in the Calcium Dependence of Neurotransmitter Release and Vesicle Pool Replenishment at Mammalian Auditory Ribbon Synapses The mammalian cochlea is specialized to recognize and process complex auditory signals with remarkable acuity and temporal precision over a wide frequency range. The quality of the information relayed to the auditory afferent fibers mainly depends on the transfer characteristics of inner hair cell (IHC) ribbon synapses. To investigate the biophysical (...) properties of the synaptic machinery, we measured changes in membrane capacitance (DeltaC(m)) in low-frequency (apical region, approximately 300 Hz) and high-frequency (basal, approximately 30 kHz) gerbil IHCs maintained in near physiological conditions (1.3 mm extracellular Ca(2+) and body temperature). With maturation, the Ca(2+) efficiency of exocytosis improved in both apical and basal IHCs and was more pronounced in the latter. Prehearing IHCs showed a similar Ca(2+) cooperativity of exocytosis

2008 The Journal of neuroscience : the official journal of the Society for Neuroscience PubMed abstract

21766. Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system (Full text)

NPB or NPBW(1) have a gender-specific phenotype, with moderate obesity evident in males but not females. Further investigation is required to elucidate the precise physiological role of NPB and NPW as neurotransmitters. (...) Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system Deorphanised G-protein-coupled receptors represent new and expanding targets for drug development. Neuropeptide B (NPB) and W (NPW) have recently been identified as the cognate endogenous ligands for the orphan receptor GPR7, now designated as NPBW(1). NPB and NPW also bound to a second related orphan receptor, GPR8, now designated as NPBW(2) that is present in humans but not rats or mice. In humans, high

2006 British journal of pharmacology PubMed abstract

21767. Brain-derived neurotrophic factor amplifies neurotransmitter responses and promotes synaptic communication in the enteric nervous system. (Abstract)

Brain-derived neurotrophic factor amplifies neurotransmitter responses and promotes synaptic communication in the enteric nervous system. Besides its role in neuronal growth and differentiation, brain-derived neurotrophic factor (BDNF) has been implicated in the control of peristalsis where it serves to enhance gastrointestinal motility.To unravel the cellular mechanisms governing BDNF's effect on motility.Studies were performed in primary myenteric neuron cultures and whole-mount preparations (...) derived from guinea pig ileum. Expression of BDNF and its tropomyosin-related kinase B (TrkB) receptor was assessed by immunohistochemistry. Intracellular Ca(2+) concentration ([Ca(2+)](i)) changes in myenteric neurons were monitored using Fluo-4, and neurotransmitter release kinetics at enteric synapses were evaluated with FM1-43 imaging.Immunohistochemistry revealed the presence of BDNF and TrkB in mucosa, submucosal plexus and myenteric ganglia. Primary cultures also expressed BDNF and TrkB

2007 Gut

21768. Neuronally released sympathetic neurotransmitters stimulate splenic interferon-gamma secretion from T cells in early type II collagen-induced arthritis. (Abstract)

the role of sympathetic neurotransmitters in splenic secretion of IFNgamma and KC shortly after the onset of CIA.At different time points during CIA, we determined the density of sympathetic nerve fibers in the spleens of mice. Spleens were removed when the mouse joints were assessed an arthritis score of 3 (at approximately day 32). Spleen slices (0.35 mm thick) were transferred to superfusion microchambers to allow observation of the effects of physiologically released sympathetic neurotransmitters (...) Neuronally released sympathetic neurotransmitters stimulate splenic interferon-gamma secretion from T cells in early type II collagen-induced arthritis. The sympathetic nervous system confers a proinflammatory effect during the early phase of type II collagen-induced arthritis (CIA). These effects might be mediated by up-regulation of cytokines such as interferon-gamma (IFNgamma) or chemokines such as CXCL1 (cytokine-induced neutrophil chemoattractant, or KC). This study aimed to identify

2008 Arthritis and Rheumatism

21769. Sexually dimorphic effects of prenatal stress on cognition, hormonal responses, and central neurotransmitters. (Full text)

Sexually dimorphic effects of prenatal stress on cognition, hormonal responses, and central neurotransmitters. Exposure to stress during gestation results in physiological and behavioral alterations that persist into adulthood. This study examined the effects of prenatal stress on the postnatal expression of sexually differentiated cognitive, hormonal, and neurochemical profiles in male and female rats. Pregnant dams were subjected to restraint stress three times daily for 45 min during d 14-21

2004 Endocrinology PubMed abstract

21770. Neurotransmitter antagonism in management of irritable bowel syndrome. (Abstract)

Neurotransmitter antagonism in management of irritable bowel syndrome. 10744083 2000 04 11 2015 06 16 0140-6736 355 9209 2000 Mar 25 Lancet (London, England) Lancet Neurotransmitter antagonism in management of irritable bowel syndrome. 1030-1 Lembo T T Department of Medicine, Harvard Medical School Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. eng Clinical Trial Comment Journal Article Multicenter Study Randomized Controlled Trial England Lancet 2985213R 0140-6736 0 Carbolines 0 (...) Serotonin Antagonists 13Z9HTH115 alosetron 333DO1RDJY Serotonin AIM IM Lancet. 2000 Mar 25;355(9209):1035-40 10744088 Carbolines therapeutic use Colonic Diseases, Functional drug therapy physiopathology Humans Serotonin physiology Serotonin Antagonists therapeutic use 2000 4 1 9 0 2000 4 15 9 0 2000 4 1 9 0 ppublish 10744083 S0140-6736(00)02028-6 10.1016/S0140-6736(00)02028-6

2000 Lancet (London, England) Controlled trial quality: uncertain

21771. Inhibition of N-methyl-D-aspartate- and kainic acid-induced neurotransmitter release by omega-conotoxin GVIA. (Full text)

there was a tendency towards inhibition. 4. The results suggest that although NMDA- and KA-receptors are pharmacologically distinct, the N-type, but not the L-type, VSCC plays a small but significant role in neurotransmitter release induced by both NMDA and KA. It remains to be determined whether the N-type VSCC are involved in the physiological and/or pathological manifestations of excitatory amino acid receptor stimulation. (...) Inhibition of N-methyl-D-aspartate- and kainic acid-induced neurotransmitter release by omega-conotoxin GVIA. 1. The role of voltage-sensitive calcium channels (VSCC) in N-methyl-D-aspartate (NMDA)- and kainic acid (KA)-evoked neurotransmitter release from rat cortical and hippocampal brain slices was evaluated by determining the effects of omega-conotoxin GVIA, an inhibitor of neuronal L- and N-type VSCC, and PN 200-110, a selective inhibitor of L-type VSCC. 2. Selective antagonists

1989 British journal of pharmacology PubMed abstract

21772. Electrophysiology of mouse parotid acini: effects of electrical field stimulation and ionophoresis of neurotransmitters. (Full text)

Electrophysiology of mouse parotid acini: effects of electrical field stimulation and ionophoresis of neurotransmitters. 1. Intracellular micro-electrode recordings of membrane potential and input resistance were made from surface acini of mouse parotid glands placed in a Perspex tissue bath through which oxygenated physiological saline solutions were circulated. The acinar cells were stimulated by microionophoresis of both acetylcholine (ACh) and adrenaline (Ad) from extracellular (...) -) containing media; and to blockade of neurotransmitter release in calcium-free media. 6. The field-stimulation and ACh responses were recorded at different levels of membrane potential within the same cells by applying either hyperpolarizing or depolarizing direct current through the recording electrode. The membrane potential at which the initial potential change undergoes reversal, i.e. changes from a depolarization to a hyperpolarization, is known as the equilibrium or reversal potential, EFS and EACh

1980 The Journal of physiology PubMed abstract

21773. To muster a cluster: Anchoring neurotransmitter receptors at synapses (Full text)

To muster a cluster: Anchoring neurotransmitter receptors at synapses 9520364 1998 05 01 2018 11 13 0027-8424 95 7 1998 Mar 31 Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. To muster a cluster: anchoring neurotransmitter receptors at synapses. 3341-3 Colledge M M Department of Physiology, University of North Carolina, Chapel Hill, NC 27599-7545, USA. Froehner S C SC eng Journal Article United States Proc Natl Acad Sci U S A 7505876 (...) 0027-8424 0 Muscle Proteins 0 Receptors, Neurotransmitter 0 Receptors, Nicotinic 0 peripheral membrane protein 43K IM Animals Humans Muscle Proteins chemistry physiology Neuromuscular Junction physiology Receptors, Neurotransmitter physiology Receptors, Nicotinic chemistry physiology Synapses physiology Synaptic Transmission physiology 1998 5 9 1998 5 9 0 1 1998 5 9 0 0 ppublish 9520364 PMC33847 Proc Natl Acad Sci U S A. 1974 Apr;71(4):1376-8 4524643 Nature. 1997 Jan 30;385(6615):439-42 9009191 J

1998 Proceedings of the National Academy of Sciences of the United States of America PubMed abstract

21774. Neurotransmitter Receptors in Fetal Tissue Transplants: Expression and Functional Significance (Full text)

, display a patchy distribution which is dissimilar to that in the corresponding adult host tissue. This manuscript discusses this "abnormal" receptor distribution and possible explanations. Electrophysiological studies have indicated that some of the transplant receptors respond to physiological and pharmacological stimulation, suggesting that they are functional. However, the association of receptor expression with behavioral recovery is uncertain. The expression of neurotransmitter receptors (...) Neurotransmitter Receptors in Fetal Tissue Transplants: Expression and Functional Significance Numerous studies have examined receptor expression in neural transplants and their possible role in transplant-induced functional recovery from lesion-induced deficits. Herein we attempt to summarize the results of these studies, especially those from studies involving striatal transplants. Autoradiographic studies indicate that dopamine D1 and D2, muscarinic, cholinergic, 5-HT2, opiate mu, beta

1993 Journal of neural transplantation & plasticity PubMed abstract

21775. Neurotransmitter diversity and its functional significance. (Full text)

physiology Neurotransmitter Agents physiology Peptides metabolism Receptors, Neurotransmitter physiology 1985 3 1 1985 3 1 0 1 1985 3 1 0 0 ppublish 2857791 PMC1289631 10.1177/014107688507800303 Science. 1978 Jan 13;199(4325):146-52 22932 Science. 1978 Oct 27;202(4366):390-402 212832 Science. 1980 Aug 29;209(4460):976-83 6157191 Annu Rev Neurosci. 1980;3:227-68 6158283 Proc Natl Acad Sci U S A. 1981 Aug;78(8):5235-9 6272296 Am J Physiol. 1984 Mar;246(3 Pt 1):C184-94 6142651 Brain Res. 1982 Dec 2;252(1 (...) Neurotransmitter diversity and its functional significance. 2857791 1985 04 16 2018 11 13 0141-0768 78 3 1985 Mar Journal of the Royal Society of Medicine J R Soc Med Neurotransmitter diversity and its functional significance. 189-92 Bloom F E FE eng Journal Article England J R Soc Med 7802879 0141-0768 0 Amines 0 Amino Acids 0 Neurotransmitter Agents 0 Peptides 0 Receptors, Neurotransmitter IM Amines metabolism Amino Acids metabolism Electrophysiology Humans Membrane Potentials Neurons

1985 Journal of the Royal Society of Medicine PubMed abstract

21776. Can the Ca2+ hypothesis and the Ca2+-voltage hypothesis for neurotransmitter release be reconciled? (Full text)

Can the Ca2+ hypothesis and the Ca2+-voltage hypothesis for neurotransmitter release be reconciled? It is well established that Ca2+ plays a key role in promoting the physiological depolarization-induced release (DIR) of neurotransmitters from nerve terminals (Ca2+ hypothesis). Yet, evidence has accumulated for the Ca2+-voltage hypothesis, which states that not only is Ca2+ required, but membrane potential as such also plays a pivotal role in promoting DIR. An essential aspect of the Ca2 (...) + concentration. Spontaneous release in turn is governed by a subset of the molecular scheme for DIR, under conditions of no depolarization. Prevailing estimates for the intracellular calcium concentration, [Ca2+]i, in physiological DIR rely on experiments under conditions of CIR. Our theory suggests that these estimates are too high, because depolarization is absent in these experiments and [Ca2+]i is held at high levels for an extended period.

2002 Proceedings of the National Academy of Sciences of the United States of America PubMed abstract

21777. Recent aspects of gonadal hormone and neurotransmitter interactions with synovial and immune cells: implications in rheumatoid arthritis (Full text)

@unige.it Straub R H RH eng Journal Article Review England Ann Rheum Dis 0372355 0003-4967 0 Gonadal Steroid Hormones 0 Neurotransmitter Agents IM Arthritis, Rheumatoid immunology physiopathology Autoimmune Diseases immunology physiopathology Gonadal Steroid Hormones physiology Humans Immunity, Cellular Neurotransmitter Agents physiology Synovial Membrane physiopathology 69 2000 9 8 11 0 2000 10 7 11 1 2000 9 8 11 0 ppublish 10976076 PMC1753272 Clin Exp Rheumatol. 1993 Nov-Dec;11(6):597-601 8299250 J (...) Recent aspects of gonadal hormone and neurotransmitter interactions with synovial and immune cells: implications in rheumatoid arthritis 10976076 2000 10 04 2018 11 13 0003-4967 59 9 2000 Sep Annals of the rheumatic diseases Ann. Rheum. Dis. Recent aspects of gonadal hormone and neurotransmitter interactions with synovial and immune cells: implications in rheumatoid arthritis. 657-61 Cutolo M M Division of Rheumatology Department of Internal Medicine University of Genova, Genova, Italy. mcutolo

2000 Annals of the Rheumatic Diseases PubMed abstract

21778. Neurotransmitter-induced currents in retinal bipolar cells of the axolotl, Ambystoma mexicanum. (Full text)

Neurotransmitter-induced currents in retinal bipolar cells of the axolotl, Ambystoma mexicanum. 1. Whole-cell patch clamping was used to study the membrane properties of isolated bipolar cells and the currents evoked in them by putative retinal neurotransmitters. 2. Isolated bipolar cells show an approximately ohmic response to voltage steps over most of the physiological response range, with an average input resistance of 1.3 G omega and resting potential of -35 mV. These values

1987 The Journal of physiology PubMed abstract

21779. Photophysics of a neurotransmitter: ionization and spectroscopic properties of serotonin. (Full text)

Photophysics of a neurotransmitter: ionization and spectroscopic properties of serotonin. The neurotransmitter serotonin plays a modulatory role in the regulation of various cognitive and behavioral functions such as sleep, mood, pain, depression, anxiety, and learning by binding to a number of serotonin receptors present upon the cell surface. The spectroscopic properties of serotonin and their modulation with ionization state have been studied. Results show that serotonin fluorescence (...) in nonpolar media has been studied. No significant binding or partitioning of serotonin to membranes under physiological conditions was observed. Serotonin fluorescence in solvents of lower polarity is characterized by an enhancement in intensity and a blue shift in emission maximum, although the solvatochromism is much less pronounced than in tryptophan. In view of the multiple roles played by the serotonergic systems in the central and peripheral nervous systems, these results are relevant to future

1996 Biophysical journal PubMed abstract

21780. Role of calcium and phosphoinositides in the actions of certain hormones and neurotransmitters. (Full text)

United States J Clin Invest 7802877 0021-9738 0 Calmodulin 0 Diglycerides 0 Hormones 0 Neurotransmitter Agents 0 Phosphatidylinositols 0 Receptors, Cell Surface EC 2.7.- Protein Kinases EC 2.7.11.13 Protein Kinase C SY7Q814VUP Calcium AIM IM Animals Calcium physiology Calmodulin physiology Diglycerides physiology Hormones physiology Humans Neurotransmitter Agents physiology Phosphatidylinositols physiology Protein Kinase C Protein Kinases physiology Receptors, Cell Surface physiology 59 1985 6 1 1985 (...) Role of calcium and phosphoinositides in the actions of certain hormones and neurotransmitters. 2861213 1985 07 30 2018 11 13 0021-9738 75 6 1985 Jun The Journal of clinical investigation J. Clin. Invest. Role of calcium and phosphoinositides in the actions of certain hormones and neurotransmitters. 1753-7 Exton J H JH eng AM18660 AM NIADDK NIH HHS United States AM33291 AM NIADDK NIH HHS United States Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

1985 Journal of Clinical Investigation PubMed abstract

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