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141. Metoclopramide: risk of neurological adverse effects

Metoclopramide: risk of neurological adverse effects Metoclopramide: risk of neurological adverse effects - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Metoclopramide: risk of neurological adverse effects Restricted dose and duration of use. Published 11 December 2014 From: Therapeutic area: , , , , , Contents Article date: August 2013 The European Medicines Agency’s Committee on Medicinal Products for Human Use has reviewed the benefits and risks of the antiemetic (...) metoclopramide. The review was done at the request of the French medicines regulatory agency (ANSM), following concerns over side effects and efficacy. The review confirmed the well known risks of neurological effects such as short-term extrapyramidal disorders and tardive dyskinesia. The conclusion of the review was that these risks outweigh the benefits in long-term or high-dose treatment. The EU review has recommended changes that include a restriction to the dose and duration of use to help minimise

2013 MHRA Drug Safety Update

142. Cohort study: Elderly in-hospital cardiac arrest patients who are resuscitated with neurological recovery experience favourable long-term survival similar to non-arrest heart failure patients

Cohort study: Elderly in-hospital cardiac arrest patients who are resuscitated with neurological recovery experience favourable long-term survival similar to non-arrest heart failure patients Elderly in-hospital cardiac arrest patients who are resuscitated with neurological recovery experience favourable long-term survival similar to non-arrest heart failure patients | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can (...) cardiac arrest patients who are resuscitated with neurological recovery experience favourable long-term survival similar to non-arrest heart failure patients Article Text Prognosis Cohort study Elderly in-hospital cardiac arrest patients who are resuscitated with neurological recovery experience favourable long-term survival similar to non-arrest heart failure patients T Jared Bunch Statistics from Altmetric.com Commentary on: Chan PS , Nallamothu BK , Krumholz HM , et al . American Heart Association

2013 Evidence-Based Medicine

143. Tolvaptan (Samsca?): over-rapid increase in serum sodium risking serious neurological events

Tolvaptan (Samsca?): over-rapid increase in serum sodium risking serious neurological events Tolvaptan (Samsca▼): over-rapid increase in serum sodium risking serious neurological events - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Tolvaptan (Samsca▼): over-rapid increase in serum sodium risking serious neurological events Careful monitoring of serum sodium important, co-administration of other drugs that may increase serum sodium not recommended. Published 11 December 2014 (...) . However, there have been reports of serious neurological events (see below: advice for healthcare professionals) in patients treated with tolvaptan where the correction of serum sodium has exceeded the suggested rate. Further information on the rates at which serum sodium should increase is also set out in the advice for healthcare professionals. Serum sodium should be closely monitored in patients receiving tolvaptan, especially those with very low serum sodium (<120 mmol/L) at baseline or where

2012 MHRA Drug Safety Update

144. Linking Digital Smartphone Behaviour With Brain Function

Information provided by (Responsible Party): University of Zurich Study Details Study Description Go to Brief Summary: This study will thus examine daily behaviour based on smartphone use and link it to the neurological and neuropsychological status as well as to neuroradiological studies that are part of the clinical routine. The study will examine behaviour changes before and after surgery, and how this change in measured behaviour with the smartphone relates to today's "gold standard", namely (...) Linking Digital Smartphone Behaviour With Brain Function Linking Digital Smartphone Behaviour With Brain Function - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Linking Digital Smartphone Behaviour

2018 Clinical Trials

145. A Study to Evaluate the Safety and Tolerability of V114 and Prevnar 13â„¢ in Healthy Infants (V114-031/PNEU-LINK)

A Study to Evaluate the Safety and Tolerability of V114 and Prevnar 13â„¢ in Healthy Infants (V114-031/PNEU-LINK) A Study to Evaluate the Safety and Tolerability of V114 and Prevnar 13™ in Healthy Infants (V114-031/PNEU-LINK) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. A Study to Evaluate the Safety and Tolerability of V114 and Prevnar 13™ in Healthy Infants (V114-031/PNEU-LINK) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov

2018 Clinical Trials

146. Lesional Evaluation of High Risk Patients With Neoatherosclerosis Treated With Rosuvastatin and Eicosapentaenoic Acid Using Optical Coherence Tomography(OCT)[LINK IT TWO]

Lesional Evaluation of High Risk Patients With Neoatherosclerosis Treated With Rosuvastatin and Eicosapentaenoic Acid Using Optical Coherence Tomography(OCT)[LINK IT TWO] Lesional Evaluation of High Risk Patients With Neoatherosclerosis Treated With Rosuvastatin and Eicosapentaenoic Acid Using Optical Coherence Tomography(OCT)[LINK IT TWO] - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search (...) for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Lesional Evaluation of High Risk Patients With Neoatherosclerosis Treated With Rosuvastatin and Eicosapentaenoic Acid Using Optical Coherence Tomography(OCT)[LINK IT TWO] The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has

2018 Clinical Trials

147. Linking Cognitive Functioning to Multimodal Imaging in Multiple Sclerosis (MS)

Linking Cognitive Functioning to Multimodal Imaging in Multiple Sclerosis (MS) Linking Cognitive Functioning to Multimodal Imaging in Multiple Sclerosis (MS) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Linking Cognitive Functioning to Multimodal Imaging in Multiple Sclerosis (MS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03723356 Recruitment Status : Recruiting First Posted : October 29, 2018 Last Update Posted

2018 Clinical Trials

148. Is interleukin-6 the link between low LDL cholesterol and increased non-cardiovascular mortality in the elderly? Full Text available with Trip Pro

Is interleukin-6 the link between low LDL cholesterol and increased non-cardiovascular mortality in the elderly? 29682295 2019 01 30 2053-3624 5 1 2018 Open heart Open Heart Is interleukin-6 the link between low LDL cholesterol and increased non-cardiovascular mortality in the elderly? e000789 10.1136/openhrt-2018-000789 DiNicolantonio James J JJ Mid America Heart Institute, Kansas, USA. McCarty Mark F MF Catalytic Longevity, Encinitas, California, USA. eng Editorial 2018 04 13 England Open (...) Biomarkers Prev. 2016 Aug;25(8):1231-9 27277846 Lancet. 1987 Aug 8;2(8554):298-301 2886765 Neurology. 2007 Mar 6;68(10):737-42 17182976 Metabolism. 1988 Sep;37(9):859-65 3419323 Arch Gerontol Geriatr. 2017 Nov;73:257-262 28866452 Lancet. 2012 Mar 31;379(9822):1214-24 22421340 BMJ. 1994 Feb 5;308(6925):373-9 8124144 J Natl Cancer Inst. 1982 Nov;69(5):989-96 6957662 Curr Opin Clin Nutr Metab Care. 2002 Mar;5(2):153-8 11844981 Ann Rheum Dis. 2017 Nov;76(11):1949-1952 28916714 Am J Epidemiol. 1992 Jun 1;135

2018 Open heart

149. Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing Full Text available with Trip Pro

Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing Pain is a prevalent symptom of Parkinson's disease, and is effectively treated by deep brain stimulation of the subthalamic nucleus (STN). However, the link between pain and the STN remains unclear. In the present work, using in vivo electrophysiology in rats, we report that STN neurons exhibit complex tonic and phasic responses to noxious stimuli. We also show that nociception is altered following (...) lesions of the STN, and characterize the role of the superior colliculus and the parabrachial nucleus in the transmission of nociceptive information to the STN, physiologically from both structures and anatomically in the case of the parabrachial nucleus. We show that STN nociceptive responses are abnormal in a rat model of PD, suggesting their dependence on the integrity of the nigrostriatal dopaminergic system. The STN-linked nociceptive network that we reveal is likely to be of considerable

2018 eLife

150. Modeling Congenital Disorders of N-Linked Glycoprotein Glycosylation in Drosophila melanogaster Full Text available with Trip Pro

Modeling Congenital Disorders of N-Linked Glycoprotein Glycosylation in Drosophila melanogaster Protein glycosylation, the enzymatic addition of N-linked or O-linked glycans to proteins, serves crucial functions in animal cells and requires the action of glycosyltransferases, glycosidases and nucleotide-sugar transporters, localized in the endoplasmic reticulum and Golgi apparatus. Congenital Disorders of Glycosylation (CDGs) comprise a family of multisystemic diseases caused by mutations (...) in genes encoding proteins involved in glycosylation pathways. CDGs are classified into two large groups. Type I CDGs affect the synthesis of the dolichol-linked Glc3Man9GlcNac2 precursor of N-linked glycosylation or its transfer to acceptor proteins. Type II CDG (CDG-II) diseases impair either the trimming of the N-linked oligosaccharide, the addition of terminal glycans or the biosynthesis of O-linked oligosaccharides, which occur in the Golgi apparatus. So far, over 100 distinct forms of CDGs

2018 Frontiers in genetics

151. To ERV Is Human: A Phenotype-Wide Scan Linking Polymorphic Human Endogenous Retrovirus-K Insertions to Complex Phenotypes Full Text available with Trip Pro

To ERV Is Human: A Phenotype-Wide Scan Linking Polymorphic Human Endogenous Retrovirus-K Insertions to Complex Phenotypes Approximately 8% of the human genome is comprised of endogenous retroviral insertions (ERVs) originating from historic retroviral integration into germ cells. The function of ERVs as regulators of gene expression is well established. Less well studied are insertional polymorphisms of ERVs and their contribution to the heritability of complex phenotypes. The most recent (...) integration of ERV, HERV-K, is expressed in a range of complex human conditions from cancer to neurologic diseases. Using an in-house computational pipeline and whole-genome sequencing data from the diverse 1,000 Genomes Phase 3 population (n = 2,504), we identified 46 polymorphic HERV-K insertions that are tagged by adjacent single nucleotide polymorphisms (SNPs). To test the potential role of polymorphic HERV-K in the heritability of complex diseases, existing databases were queried for enrichment

2018 Frontiers in genetics

152. Quantitative Systems Pharmacology Modeling of Acid Sphingomyelinase Deficiency and the Enzyme Replacement Therapy Olipudase Alfa Is an Innovative Tool for Linking Pathophysiology and Pharmacology Full Text available with Trip Pro

) is an enzyme replacement therapy under development for the non-neurological manifestations of ASMD. We present a quantitative systems pharmacology (QSP) model supporting the clinical development of olipudase alfa. The model is multiscale and mechanistic, linking the enzymatic deficiency driving the disease to molecular-level, cellular-level, and organ-level effects. Model development was informed by natural history, and preclinical and clinical studies. By considering patient-specific pharmacokinetic (PK (...) Quantitative Systems Pharmacology Modeling of Acid Sphingomyelinase Deficiency and the Enzyme Replacement Therapy Olipudase Alfa Is an Innovative Tool for Linking Pathophysiology and Pharmacology Acid sphingomyelinase deficiency (ASMD) is a rare lysosomal storage disorder with heterogeneous clinical manifestations, including hepatosplenomegaly and infiltrative pulmonary disease, and is associated with significant morbidity and mortality. Olipudase alfa (recombinant human acid sphingomyelinase

2018 CPT: pharmacometrics & systems pharmacology

153. Perioperative stroke and hyperhomocysteinemia: a possible pathogenic link Full Text available with Trip Pro

Perioperative stroke and hyperhomocysteinemia: a possible pathogenic link 29739176 2018 11 14 2005-6419 71 4 2018 Aug Korean journal of anesthesiology Korean J Anesthesiol Perioperative stroke and hyperhomocysteinemia: a possible pathogenic link. 332-333 10.4097/kja.d.18.00046 Acampa Maurizio M Department of Neurological and Sensorineural Sciences, University Hospital of Siena, "Santa Maria alle Scotte" General Hospital, Siena, Italy. Lazzerini Pietro Enea PE Department of Medical Sciences (...) , Surgery and Neurosciences, University of Siena, Siena, Italy. Martini Giuseppe G Department of Neurological and Sensorineural Sciences, University Hospital of Siena, "Santa Maria alle Scotte" General Hospital, Siena, Italy. eng Journal Article 2018 05 09 Korea (South) Korean J Anesthesiol 101502451 2005-6419 2018 02 19 2018 02 27 2018 5 10 6 0 2018 5 10 6 1 2018 5 10 6 0 ppublish 29739176 kja.d.18.00046 10.4097/kja.d.18.00046 PMC6078878 Clin Transplant. 2011 Jan-Feb;25(1):119-25 19878513 J Stroke

2018 Korean journal of anesthesiology

154. Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage Full Text available with Trip Pro

Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage Infection with Zika virus (ZIKV) manifests in a broad spectrum of disease ranging from mild illness to severe neurological complications and little is known about Zika immunopathogenesis.To define the immunologic biomarkers that correlate with acute ZIKV infection.We characterized the levels of circulating cytokines, chemokines, and growth

2018 Memórias do Instituto Oswaldo Cruz

155. αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family Full Text available with Trip Pro

αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family α-Catenins are actin-filament binding proteins and critical subunits of the cadherin-catenin cell-cell adhesive complex. They are found in nominally-defined epithelial (E), neural (N), and testis (T) forms transcribed from three distinct genes. While most of α-catenin research has focused on the developmentally essential founding member, αE-catenin, this review discusses recent studies on αT-catenin (...) (CTNNA3), a developmentally dispensable isoform that is emerging as relevant to cardiac, allergic and neurological diseases.

2018 Tissue barriers

156. Presynaptic congenital myasthenic syndrome with altered synaptic vesicle homeostasis linked to compound heterozygous sequence variants in RPH3A Full Text available with Trip Pro

Presynaptic congenital myasthenic syndrome with altered synaptic vesicle homeostasis linked to compound heterozygous sequence variants in RPH3A Monogenic defects of synaptic vesicle (SV) homeostasis have been implicated in many neurologic diseases, including autism, epilepsy, and movement disorders. In addition, abnormal vesicle exocytosis has been associated with several endocrine dysfunctions.We report an 11 year old girl with learning disabilities, tremors, ataxia, transient hyperglycemia (...) the binding of rabphilin 3a to 14-3-3, which is a proposed regulator of synaptic transmission and plasticity. In contrast, the binding of rabphilin 3a to 14-3-3 is only marginally impaired by p.Val464Leu; thus, the pathogenic role of p.Val464Leu remains unclear.In summary, we report a patient with a multisystem neurologic disorder and altered SV regulation attributed to defects in RPH3A, which grants further studies of this gene in human disorders of synaptic transmission.© 2018 The Authors. Molecular

2018 Molecular Genetics & Genomic Medicine

157. Coexistence of Amyotrophic Lateral Sclerosis in the Proband of an X-Linked Charcot-Marie-Tooth Disease Type 1 Pedigree in China Full Text available with Trip Pro

Coexistence of Amyotrophic Lateral Sclerosis in the Proband of an X-Linked Charcot-Marie-Tooth Disease Type 1 Pedigree in China 29629536 2018 11 14 1738-6586 14 2 2018 Apr Journal of clinical neurology (Seoul, Korea) J Clin Neurol Coexistence of Amyotrophic Lateral Sclerosis in the Proband of an X-Linked Charcot-Marie-Tooth Disease Type 1 Pedigree in China. 261-263 10.3988/jcn.2018.14.2.261 Feng Shu Yan SY Department of Neurophysiology, Henan Provincial People's Hospital, Zhenzhou, China. Feng (...) Shu Man SM Department of Neurology, Henan Provincial People's Hospital, Zhenzhou, China. Li Liu Yi LY Department of Neurophysiology, Henan Provincial People's Hospital, Zhenzhou, China. Zou Zhang Yu ZY Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, China. pumczzy@gmail.com. eng Case Reports Letter Korea (South) J Clin Neurol 101252374 1738-6586 The authors have no financial conflicts of interest. 2018 01 10 2018 02 02 2018 02 02 2018 4 10 6 0 2018 4 10 6 0 2018 4 10 6 1

2018 Journal of clinical neurology (Seoul, Korea)

158. Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons. Full Text available with Trip Pro

Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons. Amyotrophic lateral sclerosis (ALS) is the most common adult-onset neuromuscular disorder characterised by selective loss of motor neurons leading to fatal paralysis. Current therapeutic approaches are limited in their effectiveness. Substantial advances in understanding ALS disease mechanisms has come from the identification (...) the effects of SOD1G93A were potentiated in the double transgenic line (DAOR199W/SOD1G93A). Although overall survival was not affected, onset of neurological signs was significantly earlier in female double transgenic animals than their female SOD1G93A littermates (125 days vs 131 days, P = 0.0239). In summary, some significant in vivo effects of DAOR199W on motor neuron function (i.e. kyphosis and loss of motor neurons) were detected which were most marked in females and could contribute to the earlier

2017 PLoS ONE

159. A novel function of N-linked glycoproteins, alpha-2-HS-glycoprotein and hemopexin: Implications for small molecule compound-mediated neuroprotection. Full Text available with Trip Pro

A novel function of N-linked glycoproteins, alpha-2-HS-glycoprotein and hemopexin: Implications for small molecule compound-mediated neuroprotection. Therapeutic agents to the central nervous system (CNS) need to be efficiently delivered to the target site of action at appropriate therapeutic levels. However, a limited number of effective drugs for the treatment of neurological diseases has been developed thus far. Further, the pharmacological mechanisms by which such therapeutic agents can (...) oxidative injury in cultured human neuronal cells. It is also noted that the WN1316 cytoprotective activity observed in cultured cells is totally dependent upon the addition of fetal bovine serum in culture medium. These findings led us to postulate some serum factors being tightly linked to the WN1316 efficacy. In this study, we sieved through fetal bovine serum proteins and identified two N-linked glycoproteins, alpha-2-HS-glycoprotein (AHSG) and hemopexin (HPX), requisites to exert the WN1316

2017 PLoS ONE

160. White matter lesions: Spatial heterogeneity, links to risk factors, cognition, genetics, and atrophy. Full Text available with Trip Pro

White matter lesions: Spatial heterogeneity, links to risk factors, cognition, genetics, and atrophy. To investigate spatial heterogeneity of white matter lesions or hyperintensities (WMH).MRI scans of 1,836 participants (median age 52.2 ± 13.16 years) encompassing a wide age range (22-84 years) from the cross-sectional Study of Health in Pomerania (Germany) were included as discovery set identifying spatially distinct components of WMH using a structural covariance approach. Scans of 307 (...) and with pronounced atrophy including AD-related regions. AD polygenic risk score was associated with the dorsal periventricular component in the elderly. Cognitive decline was associated with the dorsal component.These results support the hypothesis that the appearance of WMH follows age and disease-dependent regional distribution patterns, potentially influenced by differential underlying pathophysiologic mechanisms, and possibly with a differential link to vascular and neurodegenerative changes.© 2018 American

2018 Neurology

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