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141. Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila. (PubMed)

Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila. Although the role of typical Rho GTPases and other Rho-linked proteins in synaptic plasticity and cognitive function and dysfunction is widely acknowledged, the role of atypical Rho GTPases (such as RHOBTB2) in neurodevelopment has barely been characterized. We have now identified de novo missense variants clustering in the BTB-domain-encoding (...) locomotor defects. Knockdown of RhoBTB in the Drosophila dendritic arborization neurons resulted in a decreased number of dendrites, thus suggesting a role of RhoBTB in dendritic development. We have established missense variants in the BTB-domain-encoding region of RHOBTB2 as causative for a developmental and epileptic encephalopathy and have elucidated the role of atypical Rho GTPase RhoBTB in Drosophila neurological function and possibly dendrite development.Copyright © 2017 American Society of Human

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2017 American Journal of Human Genetics

142. Zika Virus: An Emerging Infectious Disease with Serious Perinatal and Neurologic Complications. (PubMed)

infection likely has gone undetected, misdiagnosed, or both for many years. ZIKV is somewhat unique among flaviviruses in its ability to also be transmitted through sexual contact, nonsexual body fluids, and perinatally. The relatively recent detection of the link between ZIKV infection and Guillain-Barré syndrome and fetal neurological defects, including microcephaly, has prompted intense efforts aimed at the development of new and specific diagnostic tests. Infection with ZIKV has been postulated (...) Zika Virus: An Emerging Infectious Disease with Serious Perinatal and Neurologic Complications. Zika virus (ZIKV) is a flavivirus that is primarily transmitted by Aedes aegypti, the mosquito vector also important in transmission of the flaviviruses responsible for dengue fever, yellow fever, and chikungunya. Because of occurrence in the same geographic regions, serologic cross-reactivity, and similar but often less severe clinical manifestations, such as dengue and chikungunya infections, ZIKV

2017 Journal of Allergy and Clinical Immunology

143. Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus-Infected Patients in Brazil. (PubMed)

Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus-Infected Patients in Brazil. Zika virus (ZIKV) infections have been linked to different levels of clinical outcomes, ranging from mild rash and fever to severe neurological complications and congenital malformations.We investigated the clinical and immunological response, focusing on the immune mediators profile in 95 acute ZIKV-infected adult patients from Campinas (...) , Brazil. These patients included 6 pregnant women who later delivered during the course of this study. Clinical observations were recorded during hospitalization. Levels of 45 immune mediators were quantified using multiplex microbead-based immunoassays.Whereas 11.6% of patients had neurological complications, 88.4% displayed mild disease of rash and fever. Several immune mediators were specifically higher in ZIKV-infected patients, and levels of interleukin 10, interferon gamma-induced protein 10 (IP

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2017 Journal of Infectious Diseases

144. Neurologic Complications Associated With the Zika Virus in Brazilian Adults. (PubMed)

Neurologic Complications Associated With the Zika Virus in Brazilian Adults. There are no prospective cohort studies assessing the incidence and spectrum of neurologic manifestations secondary to Zika virus (ZIKV) infection in adults.To evaluate the rates of acute ZIKV infection among patients hospitalized with Guillain-Barré syndrome (GBS), meningoencephalitis, or transverse myelitis.A prospective, observational cohort study was conducted at a tertiary referral center for neurological diseases (...) in Rio de Janeiro, Brazil, between December 5, 2015, and May 10, 2016, among consecutive hospitalized adults (>18 years of age) with new-onset acute parainfectious or neuroinflammatory disease. All participants were tested for a series of arbovirosis. Three-month functional outcome was assessed.Samples of serum and cerebrospinal fluid were tested for ZIKV using real-time reverse-transcriptase-polymerase chain reaction and an IgM antibody-capture enzyme-linked immunosorbent assay. Clinical

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2017 JAMA neurology

145. Ginkgo biloba L. attenuates spontaneous recurrent seizures and associated neurological conditions in lithium-pilocarpine rat model of temporal lobe epilepsy through inhibition of mammalian target of rapamycin pathway hyperactivation. (PubMed)

Ginkgo biloba L. attenuates spontaneous recurrent seizures and associated neurological conditions in lithium-pilocarpine rat model of temporal lobe epilepsy through inhibition of mammalian target of rapamycin pathway hyperactivation. Ginkgo biloba L. (Ginkgoaceae) has been widely used in traditional medicine for variety of neurological conditions particularly behavioral and memory impairments.The present study was envisaged to explore the effect of a standardized fraction of Ginkgo biloba (...) hyperactivation linked with recurrent seizures.Copyright © 2017. Published by Elsevier B.V.

2017 Journal of Ethnopharmacology

146. The gut microbiome in human neurological disease: A review. (PubMed)

to neurological health to be examined. Emerging evidence links perturbations in the gut microbiota to neurological disease, including disease risk, activity, and progression. This review provides an overview of the recent advances in microbiome research in relation to neuro(auto)immune and neurodegenerative conditions affecting humans, such as multiple sclerosis, neuromyelitis optica spectrum disorders, Parkinson disease, Alzheimer disease, Huntington disease, and amyotrophic lateral sclerosis. Study design (...) The gut microbiome in human neurological disease: A review. Almost half the cells and 1% of the unique genes found in our bodies are human, the rest are from microbes, predominantly bacteria, archaea, fungi, and viruses. These microorganisms collectively form the human microbiota, with most colonizing the gut. Recent technological advances, open access data libraries, and application of high-throughput sequencing have allowed these microbes to be identified and their contribution

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2017 Annals of Neurology

147. Devices for Ambulatory Monitoring of Sleep-Associated Disorders in Children with Neurological Diseases (PubMed)

Devices for Ambulatory Monitoring of Sleep-Associated Disorders in Children with Neurological Diseases Good sleep quality is essential for a child's wellbeing. Early sleep problems have been linked to the later development of emotional and behavioral disorders and can negatively impact the quality of life of the child and his or her family. Sleep-associated conditions are frequent in the pediatric population, and even more so in children with neurological problems. Monitoring devices can help (...) intervention of events like seizures. Optimal monitoring devices will be patient- and diagnosis-specific, but may include a combination of modalities such as ambulatory electroencephalograms, actigraphy, and pulse oximetry. We will summarize the current literature on ambulatory sleep devices for detecting sleep disorders in children with neurological diseases.

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2017 Children

148. Parameters of Neurological Deficit After Thoracolumbar Fractures

: October 31, 2018 Estimated Study Completion Date : December 31, 2018 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Intervention Details: Radiation: computed tomography ct will be done to detect radiological risk factors for neurological deficits after thoracolumbar fractures Outcome Measures Go to Primary Outcome Measures : neurological examination according to ASIA scale [ Time Frame: one year ] It is a scale that measures degrees of neurological (...) Parameters of Neurological Deficit After Thoracolumbar Fractures Parameters of Neurological Deficit After Thoracolumbar Fractures - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Parameters of Neurological

2017 Clinical Trials

149. The Role of the Circadian System in Neurological Sleep-wake Disorders

The Role of the Circadian System in Neurological Sleep-wake Disorders The Role of the Circadian System in Neurological Sleep-wake Disorders - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Role (...) of the Circadian System in Neurological Sleep-wake Disorders (PNP) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03356938 Recruitment Status : Recruiting First Posted : November 29, 2017 Last Update Posted : November 30, 2017 See

2017 Clinical Trials

150. Neuroimaging Biomarkers of Prognosis in Motor Functional Neurological Disorders

biological understanding of mFND by investigating neuroimaging biomarkers linked to prognosis. An improved understanding of the neuropathophysiology of mFND will provide a critical step in elucidating diagnostic, prognostic and treatment response biomarkers. Aim: Identify structural and functional biomarkers of prognosis at 6-months in patients with motor functional neurological disorders receiving an updated standard of care. H1: Favorable mFND prognosis at 6 months post initial evaluation (...) integrity. Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 49 participants Observational Model: Cohort Time Perspective: Prospective Official Title: Neuroimaging Biomarkers of Prognosis in Motor Functional Neurological Disorders Actual Study Start Date : September 1, 2017 Estimated Primary Completion Date : August 31, 2022 Estimated Study Completion Date : August 31, 2022 Resource links provided by the National Library of Medicine related topics

2017 Clinical Trials

151. NEUROlogical Prognosis After Cardiac Arrest in Kids

NEUROlogical Prognosis After Cardiac Arrest in Kids NEUROlogical Prognosis After Cardiac Arrest in Kids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. NEUROlogical Prognosis After Cardiac Arrest in Kids (...) : August 2019 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Intervention/treatment Cardiac Arrest Questionnaire Children who will survive 3 months after Cardiac Arrest Other: Questionnaire To telephone the patient/family to look into how the patient is doing, moderate/severe brain damage. Outcome Measures Go to Primary Outcome Measures : Survival with good neurodevelopmental outcome assessed using the Vineland Adaptive Behavioral Score

2017 Clinical Trials

152. Olfactory Function in Latino Farmworkers over Two Years: Longitudinal Exploration of Subclinical Neurological Effects of Pesticide Exposure (PubMed)

Olfactory Function in Latino Farmworkers over Two Years: Longitudinal Exploration of Subclinical Neurological Effects of Pesticide Exposure We compared patterns of olfactory function over 2 years in pesticide-exposed male Latino farmworkers and male Latino workers in industries without pesticide exposure.At five points over 2 years, workers completed tests of odor threshold (16 concentrations of n-butanol) using a well-established methodology. Tests at two or more time points were completed (...) by 156 farmworkers and 118 non-farmworkers.Farmworkers required significantly higher odorant concentrations at Contact 1 and across the 2-year follow-up to detect the odor. When adjusted for Contact 1, between-group differences persisted, but odor threshold performance did not worsen over time.Pesticide exposure has been linked to neurodegenerative disease, as has declining olfactory function. Persistently poorer olfactory function among pesticide-exposed workers suggests the need to monitor

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2017 Journal of Occupational and Environmental Medicine

153. Autologous Stem/Stromal Cells in Neurological Disorders and Disease

information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 300 participants Allocation: Non-Randomized Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Use Of Autologous Stem Cell Use In Neurological Non-neoplastic Disorders And Disease Estimated Study Start Date : January 1, 2020 Estimated Primary Completion Date : January 1, 2023 Estimated Study Completion Date : January 1, 2023 Resource links provided by the National (...) Autologous Stem/Stromal Cells in Neurological Disorders and Disease Autologous Stem/Stromal Cells in Neurological Disorders and Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Autologous Stem

2017 Clinical Trials

154. Neurologic Manifestations of the Arbovirus Infection in Colombia

: Observational [Patient Registry] Estimated Enrollment : 150 participants Observational Model: Case-Control Time Perspective: Prospective Target Follow-Up Duration: 4 Weeks Official Title: Neurovirus Emerging in the Americas Study (NEAS): Neurologic Manifestations of the Arbovirus Dengue, Chikungunya and Zika Infections in Colombia Actual Study Start Date : January 1, 2016 Estimated Primary Completion Date : December 31, 2019 Estimated Study Completion Date : December 31, 2019 Resource links provided (...) Neurologic Manifestations of the Arbovirus Infection in Colombia Neurologic Manifestations of the Arbovirus Infection in Colombia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Neurologic Manifestations

2017 Clinical Trials

155. Converting Elderly Kidney Transplant Recipients From Tacrolimus to Envarsus to Limit Neurological AE and Improve QOL

Elderly Kidney Transplant Recipients From Tacrolimus to Envarsus to Limit Neurological Adverse Events and Improve Quality of Life Actual Study Start Date : July 1, 2017 Estimated Primary Completion Date : June 1, 2019 Estimated Study Completion Date : September 1, 2019 Resource links provided by the National Library of Medicine related topics: available for: Groups and Cohorts Go to Group/Cohort Intervention/treatment Tacrolimus XR Drug: Tacrolimus XR (Envarsus) Elderly patients (age 60 or older (...) Converting Elderly Kidney Transplant Recipients From Tacrolimus to Envarsus to Limit Neurological AE and Improve QOL Converting Elderly Kidney Transplant Recipients From Tacrolimus to Envarsus to Limit Neurological AE and Improve QOL - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2017 Clinical Trials

156. Is Anesthetic Loss of Consciousness a Top Down or Bottom up Phenomenon. What Does the Neurologic Examination Say?.

Is Anesthetic Loss of Consciousness a Top Down or Bottom up Phenomenon. What Does the Neurologic Examination Say?. Is Anesthetic Loss of Consciousness a Top Down or Bottom up Phenomenon. What Does the Neurologic Examination Say?. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Is Anesthetic Loss of Consciousness a Top Down or Bottom up Phenomenon. What Does the Neurologic Examination Say?. (Top&Bottom) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03140982 Recruitment Status : Completed First

2017 Clinical Trials

157. Cerebral Oxygenation and Neurological Outcomes FOllowing CriticAL Illness-2

or disease Critical Illness Respiratory Failure Shock Delirium Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 200 participants Observational Model: Cohort Time Perspective: Prospective Official Title: Cerebral Oxygenation and Neurological Outcomes FOllowing CriticAL Illness-2 Actual Study Start Date : October 13, 2017 Estimated Primary Completion Date : June 2022 Estimated Study Completion Date : June 2023 Resource links provided by the National (...) Cerebral Oxygenation and Neurological Outcomes FOllowing CriticAL Illness-2 Cerebral Oxygenation and Neurological Outcomes FOllowing CriticAL Illness-2 - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2017 Clinical Trials

158. Impact of Neurological Diseases on the Prognosis of Bullous Pemphigoid: A Retrospective Study of 178 Patients

, 2015 Resource links provided by the National Library of Medicine related topics: resources: Groups and Cohorts Go to Group/Cohort Intervention/treatment group "Bullous pemphigoid" Patients consulting at dermatology department of Reims Teaching Hospital for bullous pemphigoid between 1997 and 2011. Other: Data record Outcome Measures Go to Primary Outcome Measures : neurological disease [ Time Frame: Day 0 ] neurological disease are dementia (Alzheimers disease or other dementia), Parkinson's (...) Impact of Neurological Diseases on the Prognosis of Bullous Pemphigoid: A Retrospective Study of 178 Patients Impact of Neurological Diseases on the Prognosis of Bullous Pemphigoid: A Retrospective Study of 178 Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2017 Clinical Trials

159. Establishment of Genetic Basis for Neurological Disease by Genetic Screening

Establishment of Genetic Basis for Neurological Disease by Genetic Screening Establishment of Genetic Basis for Neurological Disease by Genetic Screening - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Establishment of Genetic Basis for Neurological Disease by Genetic Screening The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03322306 Recruitment Status : Recruiting First Posted : October 26, 2017 Last Update Posted : January 31

2017 Clinical Trials

160. Effect of Acupuncture Intervention on Improving Neurological Function and Antiinflammation in Patients With Acute Ischemic Stroke

Assignment Masking: Triple (Participant, Care Provider, Outcomes Assessor) Primary Purpose: Treatment Official Title: Acupuncture Intervention to Improve Neurological Function and Anti-inflammatory Effect in Patients With Acute Ischemic Stroke (ANAIS) Actual Study Start Date : March 30, 2017 Actual Primary Completion Date : December 18, 2018 Estimated Study Completion Date : April 30, 2019 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm (...) Effect of Acupuncture Intervention on Improving Neurological Function and Antiinflammation in Patients With Acute Ischemic Stroke Acupuncture Intervention to Improve Neurological Function and Anti-inflammatory Effect in Acute Ischemic Stroke (ANAIS) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2017 Clinical Trials

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