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121. Quantitative MR neurography biomarkers in 5q-linked spinal muscular atrophy. (PubMed)

Quantitative MR neurography biomarkers in 5q-linked spinal muscular atrophy. To characterize and quantify peripheral nerve lesions and muscle degeneration in clinically, genetically, and electrophysiologically well-classified, nonpediatric patients with 5q-linked spinal muscular atrophy (SMA) by high-resolution magnetic resonance neurography (MRN).Thirty-one adult patients with genetically confirmed 5q-linked SMA types II, IIIa, and IIIb and 31 age- and sex-matched healthy volunteers were (...) prospectively investigated. All patients received neurologic, physiotherapeutic, and electrophysiologic assessments. MRN at 3.0T with anatomic coverage from the lumbosacral plexus and proximal thigh down to the tibiotalar joint was performed with dual-echo 2D relaxometry sequences with spectral fat saturation and a 3D T2-weighted inversion recovery sequence. Detailed quantification of nerve injury by morphometric and microstructural MRN markers and qualitative classification of fatty muscle degeneration

2019 Neurology

122. Mild behavioral impairment is linked to worse cognition and brain atrophy in Parkinson disease. (PubMed)

Mild behavioral impairment is linked to worse cognition and brain atrophy in Parkinson disease. To evaluate the associations of mild behavioral impairment (MBI) with cognitive deficits and patterns of gray matter changes in Parkinson disease (PD).Sixty patients with PD without dementia and 29 healthy controls underwent a cognitive neuropsychological evaluation and structural MRI scan. MBI was evaluated with the MBI Checklist (MBI-C), a rating scale designed to elicit emergent neuropsychiatric (...) deficits in PD, which have been associated with a faster rate of progression to dementia. These initial results suggest that MBI might be an early and important marker for incident cognitive decline and dementia in patients with PD.© 2019 American Academy of Neurology.

2019 Neurology

123. Interleukin 9 alterations linked to alzheimer disease in african americans. (PubMed)

Interleukin 9 alterations linked to alzheimer disease in african americans. Compared to older Caucasians, older African Americans have higher risks of developing Alzheimer disease (AD) and lower cerebrospinal fluid (CSF) tau biomarker levels. It is not known whether tau-related differences begin earlier in life or whether race modifies other AD-related biomarkers such as inflammatory proteins.We performed multiplex cytokine analysis in a healthy middle-aged cohort with family history of AD (n (...) = 68) and an older cohort (n = 125) with normal cognition (NC), mild cognitive impairment, or AD dementia. After determining baseline interleukin (IL)-9 level and AD-associated IL-9 change to differ according to race, we performed immunohistochemical analysis for proteins mechanistically linked to IL-9 in brains of African Americans and Caucasians (n = 38), and analyzed postmortem IL-9-related gene expression profiles in the publicly available Mount Sinai cohort (26 African Americans and 180

2019 Annals of Neurology

124. Soluble ST2 links inflammation to outcome after subarachnoid hemorrhage. (PubMed)

Soluble ST2 links inflammation to outcome after subarachnoid hemorrhage. To investigate whether soluble growth stimulation expressed gene 2 (sST2), a prognostic marker in cardiovascular and inflammatory disorders, is associated with neurological injury after aneurysmal subarachnoid hemorrhage (SAH).We studied SAH patients from 2 independent cohorts. Outcome assessments included functional status at 90 days using the modified Rankin Scale (mRS), mortality, and delayed cerebral ischemia (DCI (...)  ± 272 AU vs 34,869 ± 183 AU, p < 0.001).Plasma sST2 predicts DCI, functional outcome, and mortality after SAH, independent of clinical and radiographic markers. Elevated sST2 is also associated with changes in CD14+ CD16+ monocytes. ANN NEUROL 2019;86:384-394.© 2019 American Neurological Association.

2019 Annals of Neurology

125. Amylin as a potential link between type 2 diabetes and alzheimer disease. (PubMed)

Amylin as a potential link between type 2 diabetes and alzheimer disease. Alzheimer disease (AD) is the leading cause of dementia, and although its etiology remains unclear, it seems that type 2 diabetes mellitus (T2DM) and other prediabetic states of insulin resistance could contribute to the appearance of sporadic AD. As such, we have assessed whether tau and β-amyloid (Aβ) deposits might be present in pancreatic tissue of subjects with AD, and whether amylin, an amyloidogenic protein (...) new evidence of a potential overlap in the mechanisms underlying the pathogenesis of T2DM and AD. ANN NEUROL 2019;86:539-551.© 2019 American Neurological Association.

2019 Annals of Neurology

126. Bimanual Gesture Imitation Links to Cognition and Olfaction. (PubMed)

Bimanual Gesture Imitation Links to Cognition and Olfaction. Given the need to detect subclinical changes in brain health that sometimes occur with aging in apparently healthy older adults, we assessed whether bimanual gesture imitation performance, simple to assess clinically, can detect age effects and alterations in cognition, olfaction, and movement.Cross-sectional study.Baltimore Longitudinal Study of Aging.Men and women, aged 22 to 101 years, without cognitive impairment, dementia, stroke (...) with younger age. After adjustment, a worse score was associated with worse olfaction, executive function, and visuospatial ability. Gesture imitation score was not associated with other cognitive measures or motor function.In persons without clinically detectable neurological conditions, poor bimanual gesture imitation is associated with other indicators of brain health, including olfaction and selected cognitive function domains. Bimanual gesture imitation may be useful clinically to detect subtle brain

2019 Journal of the American Geriatrics Society

127. Metabolic and Structural Characterization of Hub's Vulnerability in Neurological Diseases Assessed by Ultra High Field Structural and Functional MRI

Metabolic and Structural Characterization of Hub's Vulnerability in Neurological Diseases Assessed by Ultra High Field Structural and Functional MRI Metabolic and Structural Characterization of Hub's Vulnerability in Neurological Diseases Assessed by Ultra High Field Structural and Functional MRI - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Metabolic and Structural Characterization of Hub's Vulnerability in Neurological Diseases Assessed by Ultra High Field Structural and Functional MRI The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical

2017 Clinical Trials

128. Epidural Stimulation After Neurologic Damage

Epidural Stimulation After Neurologic Damage Epidural Stimulation After Neurologic Damage - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Epidural Stimulation After Neurologic Damage (E-STAND) The safety (...) Study Completion Date : January 2023 Resource links provided by the National Library of Medicine related topics: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: Epidural Spinal Cord Stimulation Epidural Spinal Cord Stimulation Device: Epidural Spinal Cord Stimulation epidural spinal cord stimulator Outcome Measures Go to Primary Outcome Measures : Change in Volitional Response Index Magnitude [ Time Frame: Months: 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 ] Brain

2017 Clinical Trials

129. Protocol to Monitor the Neurological Development of Infants With Exposure in Utero From Birth to 15 Months in Tanezumab Clinical Studies

Protocol to Monitor the Neurological Development of Infants With Exposure in Utero From Birth to 15 Months in Tanezumab Clinical Studies Protocol to Monitor the Neurological Development of Infants With Exposure in Utero From Birth to 15 Months in Tanezumab Clinical Studies - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study (...) Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Protocol to Monitor the Neurological Development of Infants With Exposure in Utero From Birth to 15 Months in Tanezumab Clinical Studies The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care

2017 Clinical Trials

130. Vascular and Neurologic Exploration of Small Nervous Fiber by Sudoscanner and QST

Vascular and Neurologic Exploration of Small Nervous Fiber by Sudoscanner and QST Vascular and Neurologic Exploration of Small Nervous Fiber by Sudoscanner and QST - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Vascular and Neurologic Exploration of Small Nervous Fiber by Sudoscanner and QST The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03044340 Recruitment Status : Completed First Posted : February 7, 2017 Last Update Posted : March 14, 2018 Sponsor: Groupe Hospitalier Paris Saint Joseph

2017 Clinical Trials

131. Validation and Standardization of a Battery Evaluation of the Socio-emotional Functions in Various Neurological Pathologies

Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Diagnostic Official Title: Validation and Standardization of a Battery Evaluation of the Socio-emotional Functions in Various Neurological Pathologies Actual Study Start Date : September 9, 2016 Estimated Primary Completion Date : September 9, 2019 Estimated Study Completion Date : September 9, 2019 Resource links provided by the National Library of Medicine related topics: resources: Arms and Interventions Go to Arm Intervention (...) Validation and Standardization of a Battery Evaluation of the Socio-emotional Functions in Various Neurological Pathologies Validation and Standardization of a Battery Evaluation of the Socio-emotional Functions in Various Neurological Pathologies - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2017 Clinical Trials

132. Effect of Oral Menthol on the Swallow Response of Patients With Oropharyngeal Dysphagia Associated With Neurological Diseases and Aging

Intervention Model: Parallel Assignment Masking: Triple (Participant, Care Provider, Investigator) Primary Purpose: Treatment Official Title: Effect of Oral Menthol on the Swallow Response of Patients With Oropharyngeal Dysphagia Associated With Neurological Diseases and Aging Actual Study Start Date : May 2013 Actual Primary Completion Date : December 2014 Actual Study Completion Date : January 2015 Resource links provided by the National Library of Medicine related topics: available for: Arms (...) Effect of Oral Menthol on the Swallow Response of Patients With Oropharyngeal Dysphagia Associated With Neurological Diseases and Aging Effect of Oral Menthol on the Swallow Response of Patients With Oropharyngeal Dysphagia Associated With Neurological Diseases and Aging - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning

2017 Clinical Trials

133. Carbon Dioxide Surgical Field Flooding and Aortic No-touch Off-pump Coronary Artery Bypass Grafting to Reduce Neurological Injuries After Surgical Coronary Revascularization (CANON): a Randomised, Controlled, Investigator and Patient Blinded Single Center

Title: Carbon Dioxide Surgical Field Flooding and Aortic No-touch Off-pump Coronary Artery Bypass Grafting to Reduce Neurological Injuries After Surgical Coronary Revascularization (CANON): a Randomised, Controlled, Investigator and Patient Blinded Single Center Superiority Trial With Three Parallel Arms. Actual Study Start Date : February 28, 2017 Estimated Primary Completion Date : February 28, 2020 Estimated Study Completion Date : February 28, 2020 Resource links provided by the National Library (...) Carbon Dioxide Surgical Field Flooding and Aortic No-touch Off-pump Coronary Artery Bypass Grafting to Reduce Neurological Injuries After Surgical Coronary Revascularization (CANON): a Randomised, Controlled, Investigator and Patient Blinded Single Center Carbon Dioxide Surgical Field Flooding and Aortic No-touch Off-pump Coronary Artery Bypass Grafting to Reduce Neurological Injuries After Surgical Coronary Revascularization (CANON): a Randomised, Controlled, Investigator and Patient Blinded

2017 Clinical Trials

134. Evaluation of Neurological Status and School Readiness in Preterm Preschoolers

Duration: 1 Day Official Title: Evaluation of Neurological Status and School Readiness of Preterm Children in Preschool Period Actual Study Start Date : December 17, 2016 Estimated Primary Completion Date : July 17, 2017 Estimated Study Completion Date : July 17, 2018 Resource links provided by the National Library of Medicine related topics: (AHRQ) related information: Groups and Cohorts Go to Group/Cohort Preterm Preschoolers Preterm children who haven't attend school. Term Preschoolers Term children (...) Evaluation of Neurological Status and School Readiness in Preterm Preschoolers Evaluation of Neurological Status and School Readiness in Preterm Preschoolers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2017 Clinical Trials

135. Effects of Remote Ischemic Preconditioning With Postconditioning on Neurologic Outcome

Effects of Remote Ischemic Preconditioning With Postconditioning on Neurologic Outcome Effects of Remote Ischemic Preconditioning With Postconditioning on Neurologic Outcome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Effects of Remote Ischemic Preconditioning With Postconditioning on Neurologic Outcome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03072914 Recruitment Status : Completed First Posted : March 7, 2017 Last Update Posted : August 23, 2018 Sponsor: Seoul National University

2017 Clinical Trials

136. Prospective randomized controlled comparison of posterior vs. posterior-anterior stabilization of thoracolumbar incomplete cranial burst fractures in neurological intact patients: the RASPUTHINE pilot study. (PubMed)

Prospective randomized controlled comparison of posterior vs. posterior-anterior stabilization of thoracolumbar incomplete cranial burst fractures in neurological intact patients: the RASPUTHINE pilot study. If surgery for thoracolumbar incomplete cranial burst fractures (Magerl A3.1.1) is necessary, the ideal stabilization strategy still remains undetermined. To justify posterior-anterior stabilization, which generates higher costs and potentially higher morbidity vs. posterior-only (...) endpoint showed less but insignificant (p = 0.67) disability for the interventional group over the control group (13.3 vs. 19.3%). Comparison of preoperative bisegmental kyphosis in supine position with the bisegmental kyphosis at 24-month FU in upright position showed a worsened kyphosis for the control group (10.7° → 15.6°), whereas an improved kyphosis (11° → 8.3°) was detectable for the interventional group.The results of this pilot RCT showed less disability for the posterior-anterior group linked

2017 European Spine Journal

137. Biomarkers And Neurological Outcome in Neonates (BANON)

Biomarkers And Neurological Outcome in Neonates (BANON) Biomarkers And Neurological Outcome in Neonates (BANON) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Biomarkers And Neurological Outcome (...) Collaborator: University Hospital Tuebingen Information provided by (Responsible Party): Life Science Inkubator Study Details Study Description Go to Brief Summary: Validation of biomarkers in a human population for their ability to diagnose the severity of neonatal asphyxia. These biomarkers linked to asphyxia have been identified in animal studies and a preliminary human study. Condition or disease Asphyxia Neonatorum Detailed Description: The aim of the study is to validate the application

2017 Clinical Trials

138. The Influence of Neuromuscular Reversal on Neurological Physical Exam Time in Lumbar Neurosurgical Cases.

Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Intervention/treatment Group S Group S: Group sugammadex Patients in this group received sugammadex at the end of the surgery, as neuromuscular reversal agent. Neurological physical exam time was recorded. Diagnostic Test: Neurological physical exam Neurological physical exam is performed in all patients at the OR table, immediately after the operation. Group N Group N: Group Neostigmine (...) The Influence of Neuromuscular Reversal on Neurological Physical Exam Time in Lumbar Neurosurgical Cases. The Influence of Neuromuscular Reversal on Neurological Physical Exam Time in Lumbar Neurosurgical Cases. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2017 Clinical Trials

139. Chart Review: Central Motor Conduction Time in Neurological Disorders

conduction time (PMCT), the cortical motor evoked potential (MEP) latency and amplitude will be used to calculate CMCT, clinical patient factors pertinent to estimation of CMCT as well clinically significant physical exam findings will be recorded as well. Clinical diagnoses and neurological exams will be extracted from medical records Patient identifiers will be de-linked after compiling data from medical records Outcome measures - Results of CMCT using TMS in different diagnoses will be summarized (...) links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Chart Review Existing records of patients within the NINDS database who have had TMS performed to measure central motor conduction time (CMCT). Outcome Measures Go to Primary Outcome Measures : Summary of central motor conduction studies in neurological disorders [ Time Frame: Study completion ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate

2017 Clinical Trials

140. Relationship Between Neurological Disability and Visual Impairment in Patients With ALS or Friedreich's Ataxia

will be repeated in all cases at 6 months. Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 90 participants Observational Model: Case-Control Time Perspective: Prospective Official Title: Relationship Between Neurological Disability and Visual Impairment in Patients With ALS or Friedreich's Ataxia Actual Study Start Date : July 2015 Estimated Primary Completion Date : January 2020 Estimated Study Completion Date : February 2020 Resource links provided (...) Relationship Between Neurological Disability and Visual Impairment in Patients With ALS or Friedreich's Ataxia Relationship Between Neurological Disability and Visual Impairment in Patients With ALS or Friedreich's Ataxia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2017 Clinical Trials

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