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101. Neurology Measures in FA Children

Neurology Measures in FA Children Neurology Measures in FA Children - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Neurology Measures in FA Children The safety and scientific validity of this study (...) : Investigators seek to identify biological and clinical tests to be used in future clinical trials. The purpose of this research study is to learn more about Friedreich's Ataxia (FA) progression in children. There will be biannual visits which will include a core set of tests and procedures. These include: a collection of medical history, detailed neurological exam, ataxia scales, and health questionnaires. At each visit, blood and cheek swab samples will be obtained to monitor frataxin levels. A select

2018 Clinical Trials

102. Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study

Observational Model: Cohort Time Perspective: Other Target Follow-Up Duration: 10 Years Official Title: Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study: an Ambispective, Multicentre, Open Cohort Study Actual Study Start Date : September 21, 2017 Estimated Primary Completion Date : September 22, 2026 Estimated Study Completion Date : September 22, 2027 Resource links provided by the National Library of Medicine related topics: available for: (AHRQ) related information: Groups (...) Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2018 Clinical Trials

103. Cerebral embolization during endovascular infrarenal, juxtarenal, and suprarenal aortic aneurysm repair, high-risk maneuvers, and associated neurologic outcomes. (Abstract)

invasive manipulation of wires and cannulas within the aorta, but research into cerebral emboli during aortic aneurysm repair and cognitive or neurologic injury is scarce and limited to thoracic aneurysms. This study prospectively studied embolic phenomena detected in the middle cerebral artery during infrarenal, juxtarenal, and thoracic endovascular aortic repair (TEVAR) and investigated links to delirium, stroke, and postoperative cognitive decline.There were 60 patients who received continuous left (...) Cerebral embolization during endovascular infrarenal, juxtarenal, and suprarenal aortic aneurysm repair, high-risk maneuvers, and associated neurologic outcomes. Risk factors for postoperative cognitive decline after noncardiac surgery are multifactorial and poorly understood. Evidence suggests that perioperative microembolic damage to the brain on movement of wires and catheters during endovascular aortic procedures may play an important role. Endovascular aortic aneurysm repair requires

2018 Journal of Vascular Surgery

104. Brain Stimulation for Neurological Patients

: Double (Participant, Outcomes Assessor) Primary Purpose: Treatment Official Title: Brain Stimulation for Neurological Patients Actual Study Start Date : January 24, 2017 Estimated Primary Completion Date : January 1, 2020 Estimated Study Completion Date : January 1, 2020 Resource links provided by the National Library of Medicine related topics: related topics: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: Group A NEUROLITH Cycle 1: Active treatment Cycle 2: Sham (...) Brain Stimulation for Neurological Patients Brain Stimulation for Neurological Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Brain Stimulation for Neurological Patients The safety and scientific

2018 Clinical Trials

105. Ginkgolide With Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Neurological Improving Trial

Ginkgolide With Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Neurological Improving Trial Ginkgolide With Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Neurological Improving Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Ginkgolide With Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Neurological Improving Trial (GIANT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier

2018 Clinical Trials

106. The role of carboxy-terminal cross-linking telopeptide of type I collagen, dual x-ray absorptiometry bone strain and Romberg test in a new osteoporotic fracture risk evaluation: A proposal from an observational study. Full Text available with Trip Pro

The role of carboxy-terminal cross-linking telopeptide of type I collagen, dual x-ray absorptiometry bone strain and Romberg test in a new osteoporotic fracture risk evaluation: A proposal from an observational study. The consolidated way of diagnosing and treating osteoporosis in order to prevent fragility fractures has recently been questioned by some papers, which complained of overdiagnosis and consequent overtreatment of this pathology with underestimating other causes of the fragility (...) fractures, like falls. A new clinical approach is proposed for identifying the subgroup of patients prone to fragility fractures. This retrospective observational study was conducted from January to June 2015 at the Nuclear Medicine-Bone Metabolic Unit of the of the Fondazione IRCCS Ca' Granda, Milan, Italy. An Italian population of 125 consecutive postmenopausal women was investigated for bone quantity and bone quality. Patients with neurological diseases regarding balance and vestibular dysfunction

2018 PLoS ONE

107. Quality Improvement in Neurology: Dementia Management Quality Measures

Quality Improvement in Neurology: Dementia Management Quality Measures Quality Improvement in Neurology: Dementia Management Quality Measures Logging In... × Welcome to GeriatricsCareOnline! AGS or ADGAP MEMBER Attention AGS Members! As an AGS Member, you already have an account automatically set up on GeriatricsCareOnline.org. Your username and password are the same that you use to log onto MyAGS. (If you do not remember your MyAGS credentials, ). Please do not register for a new user account (...) if you are an AGS member - if you create a new account, you will not be recognized as a member in the system. Username Password remember Remember me Login NON-AGS MEMBER Username Password Remember me Login Search: Toggle navigation Search: Dementia Management Quality Measures PRODUCT DETAILS × PIN Subscriprion Validating... Product Titile : Quality Improvement in Neurology: Dementia Management Quality Measures Enter PIN * × PIN Subscriprion Subscription is completed successfully. Click OK button

2014 American Geriatrics Society

108. Efficacy and safety of medical marijuana in selected neurologic disorders

Efficacy and safety of medical marijuana in selected neurologic disorders Systematic review: Efficacy and safety of medical marijuana in selected neurologic disorders | Neurology Advertisement Search for this keyword Main menu User menu Search Search for this keyword The most widely read and highly cited peer-reviewed neurology journal Share April 29, 2014 ; 82 (17) Special Article Systematic review: Efficacy and safety of medical marijuana in selected neurologic disorders Report (...) of the Guideline Development Subcommittee of the American Academy of Neurology Barbara S. Koppel , John C.M. Brust , Terry Fife , Jeff Bronstein , Sarah Youssof , Gary Gronseth , David Gloss First published April 28, 2014, DOI: https://doi.org/10.1212/WNL.0000000000000363 Barbara S. Koppel From the Department of Neurology (B.S.K.), New York Medical College, New York; the Department of Neurology (J.C.M.B.), Columbia University College of Physicians & Surgeons, New York Neurological Institute, New York

2014 American Academy of Neurology

109. Psychomotor developmental disorders: a link to antidepressants?

Psychomotor developmental disorders: a link to antidepressants? Prescrire IN ENGLISH - Spotlight: Archive ''Psychomotor developmental disorders: a link to antidepressants?'', 1 February 2013 {1} {1} {1} | | > > > Psychomotor developmental disorders: a link to antidepressants? Spotlight: Archives Every month, the subjects in Prescrire’s Spotlight. 2013 :  |   |  Spotlight Archives Psychomotor developmental disorders: a link to antidepressants? It is best to avoid prescribing SSRI (...) of malformation, especially cardiac, after exposure in early pregnancy. Other studies also suggest a risk to the infant’s neurological development. One study has shown a significant delay in psychomotor development in infants aged 6 to 40 months who have been exposed to SSRI antidepressants in the womb. Findings from other studies have been more reassuring. However, the overall results are not convincing. Above all it is clear that not enough is known about the long-term and potentially severe consequences

2014 Prescrire

110. Corneal cross-linking for keratoconus caused by compulsive eye rubbing in patients with Tourette syndrome: Three case reports. Full Text available with Trip Pro

Corneal cross-linking for keratoconus caused by compulsive eye rubbing in patients with Tourette syndrome: Three case reports. Eye rubbing is an important risk factor for keratoconus progression. Tourette syndrome (TS) is a neurological disorder, and approximately 50% of individuals with TS exhibit obsessive-compulsive behaviors including eye rubbing. We report the effects of corneal cross-linking (CXL) on the progression of keratoconus combined with psychiatric treatment for 3 patients

2019 Medicine

111. Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease. (Abstract)

). This relation was also observed in the perilesional zones, which became stronger in the proximity of WMH (p = 0.03).BBB impairment and hypoperfusion appear in the WMH and NAWM, which increase in the proximity of the WMH, and are linked. Both BBB and CBF are regulated in the neurovascular unit (NVU) and the observed link might be due to the physiologic regulation mechanism of the NVU. This link may suggest an early overall deterioration of this unit.© 2019 American Academy of Neurology. (...) Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease. To investigate the link between blood-brain-barrier (BBB) permeability and cerebral blood flow (CBF) and the relation with white matter hyperintensities (WMH) in cerebral small vessel disease (cSVD).Twenty-seven patients with cSVD received dynamic susceptibility contrast and dynamic contrast-enhanced MRI to determine CBF and BBB permeability (expressed as leakage rate and volume), respectively

2019 Neurology

112. Interleukin 9 alterations linked to alzheimer disease in african americans. Full Text available with Trip Pro

Interleukin 9 alterations linked to alzheimer disease in african americans. Compared to older Caucasians, older African Americans have higher risks of developing Alzheimer disease (AD) and lower cerebrospinal fluid (CSF) tau biomarker levels. It is not known whether tau-related differences begin earlier in life or whether race modifies other AD-related biomarkers such as inflammatory proteins.We performed multiplex cytokine analysis in a healthy middle-aged cohort with family history of AD (n (...) = 68) and an older cohort (n = 125) with normal cognition (NC), mild cognitive impairment, or AD dementia. After determining baseline interleukin (IL)-9 level and AD-associated IL-9 change to differ according to race, we performed immunohistochemical analysis for proteins mechanistically linked to IL-9 in brains of African Americans and Caucasians (n = 38), and analyzed postmortem IL-9-related gene expression profiles in the publicly available Mount Sinai cohort (26 African Americans and 180

2019 Annals of Neurology

113. Soluble ST2 links inflammation to outcome after subarachnoid hemorrhage. (Abstract)

Soluble ST2 links inflammation to outcome after subarachnoid hemorrhage. To investigate whether soluble growth stimulation expressed gene 2 (sST2), a prognostic marker in cardiovascular and inflammatory disorders, is associated with neurological injury after aneurysmal subarachnoid hemorrhage (SAH).We studied SAH patients from 2 independent cohorts. Outcome assessments included functional status at 90 days using the modified Rankin Scale (mRS), mortality, and delayed cerebral ischemia (DCI (...)  ± 272 AU vs 34,869 ± 183 AU, p < 0.001).Plasma sST2 predicts DCI, functional outcome, and mortality after SAH, independent of clinical and radiographic markers. Elevated sST2 is also associated with changes in CD14+ CD16+ monocytes. ANN NEUROL 2019;86:384-394.© 2019 American Neurological Association.

2019 Annals of Neurology

114. Amylin as a potential link between type 2 diabetes and alzheimer disease. (Abstract)

Amylin as a potential link between type 2 diabetes and alzheimer disease. Alzheimer disease (AD) is the leading cause of dementia, and although its etiology remains unclear, it seems that type 2 diabetes mellitus (T2DM) and other prediabetic states of insulin resistance could contribute to the appearance of sporadic AD. As such, we have assessed whether tau and β-amyloid (Aβ) deposits might be present in pancreatic tissue of subjects with AD, and whether amylin, an amyloidogenic protein (...) new evidence of a potential overlap in the mechanisms underlying the pathogenesis of T2DM and AD. ANN NEUROL 2019;86:539-551.© 2019 American Neurological Association.

2019 Annals of Neurology

115. Quantitative MR neurography biomarkers in 5q-linked spinal muscular atrophy. (Abstract)

Quantitative MR neurography biomarkers in 5q-linked spinal muscular atrophy. To characterize and quantify peripheral nerve lesions and muscle degeneration in clinically, genetically, and electrophysiologically well-classified, nonpediatric patients with 5q-linked spinal muscular atrophy (SMA) by high-resolution magnetic resonance neurography (MRN).Thirty-one adult patients with genetically confirmed 5q-linked SMA types II, IIIa, and IIIb and 31 age- and sex-matched healthy volunteers were (...) prospectively investigated. All patients received neurologic, physiotherapeutic, and electrophysiologic assessments. MRN at 3.0T with anatomic coverage from the lumbosacral plexus and proximal thigh down to the tibiotalar joint was performed with dual-echo 2D relaxometry sequences with spectral fat saturation and a 3D T2-weighted inversion recovery sequence. Detailed quantification of nerve injury by morphometric and microstructural MRN markers and qualitative classification of fatty muscle degeneration

2019 Neurology

116. Mild behavioral impairment is linked to worse cognition and brain atrophy in Parkinson disease. (Abstract)

Mild behavioral impairment is linked to worse cognition and brain atrophy in Parkinson disease. To evaluate the associations of mild behavioral impairment (MBI) with cognitive deficits and patterns of gray matter changes in Parkinson disease (PD).Sixty patients with PD without dementia and 29 healthy controls underwent a cognitive neuropsychological evaluation and structural MRI scan. MBI was evaluated with the MBI Checklist (MBI-C), a rating scale designed to elicit emergent neuropsychiatric (...) deficits in PD, which have been associated with a faster rate of progression to dementia. These initial results suggest that MBI might be an early and important marker for incident cognitive decline and dementia in patients with PD.© 2019 American Academy of Neurology.

2019 Neurology

117. Bimanual Gesture Imitation Links to Cognition and Olfaction. (Abstract)

Bimanual Gesture Imitation Links to Cognition and Olfaction. Given the need to detect subclinical changes in brain health that sometimes occur with aging in apparently healthy older adults, we assessed whether bimanual gesture imitation performance, simple to assess clinically, can detect age effects and alterations in cognition, olfaction, and movement.Cross-sectional study.Baltimore Longitudinal Study of Aging.Men and women, aged 22 to 101 years, without cognitive impairment, dementia, stroke (...) with younger age. After adjustment, a worse score was associated with worse olfaction, executive function, and visuospatial ability. Gesture imitation score was not associated with other cognitive measures or motor function.In persons without clinically detectable neurological conditions, poor bimanual gesture imitation is associated with other indicators of brain health, including olfaction and selected cognitive function domains. Bimanual gesture imitation may be useful clinically to detect subtle brain

2019 Journal of the American Geriatrics Society

118. Weight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people. (Abstract)

Weight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people. Anandamide, a major endocannabinoid, participates in energy metabolism homeostasis and neurobehavioral processes. In a secondary analysis of an open-label, randomized controlled trial, we investigated the long-term effect of aerobic exercise on resting plasma anandamide, and explored its relationship with changes in body weight, cardiorespiratory fitness, and mood status (...) in healthy, physically inactive individuals. Participants recruited between March 2013 to August 2015 at the UNIFESP's Neurology/Psychobiology Department were randomly allocated into a 12-weeks supervised moderate exercise program, or into waitlist, control condition. Thirty-four participants (age = 38 ± 11.5, BMI = 26.6 ± 3.6) were intention to treat-analysed (Exercise: n = 17; Control: n = 17). After intervention, there were significant decreases in plasma anandamide (p < .01), anger, anxiety, and body

2019 Physiology & behavior Controlled trial quality: uncertain

119. Levodopa-induced dyskinesia is closely linked to progression of frontal dysfunction in PD. (Abstract)

Levodopa-induced dyskinesia is closely linked to progression of frontal dysfunction in PD. To assess the relationship between the development of levodopa-induced dyskinesia (LID) and longitudinal changes in cognition.In this retrospective cohort study, we recruited 119 patients with Parkinson disease (PD) who underwent baseline and follow-up neuropsychological evaluations and were treated with levodopa for >5 years. On the basis of LID development, the patients were classified as patients (...) ) in the PD-LID- group.These results demonstrated that LID was closely associated with the progression of cognitive decline, especially frontal executive dysfunction, and the development of PD dementia.© 2019 American Academy of Neurology.

2019 Neurology

120. Voice and swallowing dysfunction in X-linked dystonia parkinsonism. (Abstract)

Voice and swallowing dysfunction in X-linked dystonia parkinsonism. To systematically characterize and describe voice and swallowing manifestations in patients with X-linked dystonia parkinsonism (XDP) and correlate with quality-of-life (QOL) measures.Thirty-four patients with XDP with communication and swallowing difficulties underwent neurological examination, head and neck examination, nasopharyngoscopy, QOL surveys (Swallowing Quality of Life questionnaire [SWAL-QOL] and Voice Handicap (...) and voice impairment in XDP is not well characterized and presents a more distinctive phenomenology than other neurological disorders, with a unique set of challenges for treatment. This is the first study to systematically evaluate laryngeal and pharyngeal dysfunction in XDP patients and correlate with QOL measures.4 Laryngoscope, 130:171-177, 2020.© 2019 The American Laryngological, Rhinological and Otological Society, Inc.

2019 Laryngoscope

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