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101. Analysis of the Sweat Response According to the Pathology in Neurologic Patients

on parasympathetic tone and BP variations depend on vasomotor sympathetic response. Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 450 participants Observational Model: Cohort Time Perspective: Retrospective Official Title: Analysis of the Sweat Response According to the Pathology in Neurologic Actual Study Start Date : March 2015 Actual Primary Completion Date : March 2017 Actual Study Completion Date : March 2017 Resource links provided by the National (...) Analysis of the Sweat Response According to the Pathology in Neurologic Patients Analysis of the Sweat Response According to the Pathology in Neurologic Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2018 Clinical Trials

102. ER Dynamics and Derangement in Neurological Diseases Full Text available with Trip Pro

ER Dynamics and Derangement in Neurological Diseases The endoplasmic reticulum (ER) is a morphologically dynamic organelle containing different membrane subdomains with distinct cellular functions. Numerous observations have revealed that ER stress response induced by disturbed ER homeostasis is linked to various neurological/neurodegenerative disorders. In contrast, recent findings unveil that ER structural derangements are linked to the progression of several neurological diseases (...) . The derangements involve two distinct, and likely opposing pathways. One is dysfunction of ER dynamics machinery, leading to disruption of ER network organization. Another one is facilitation of pre-existing machinery, leading to generation of markedly-ordered de novo membranous structure. Restoring the ER network can be the effective way toward the cure of ER-deranged neurological disorders.

2018 Frontiers in neuroscience

103. The role of tRNA synthetases in neurological and neuromuscular disorders Full Text available with Trip Pro

The role of tRNA synthetases in neurological and neuromuscular disorders Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed enzymes responsible for charging tRNAs with their cognate amino acids, therefore essential for the first step in protein synthesis. Although the majority of protein synthesis happens in the cytosol, an additional translation apparatus is required to translate the 13 mitochondrial DNA-encoded proteins important for oxidative phosphorylation. Most ARS genes (...) in these cellular compartments are distinct, but two genes are common, encoding aminoacyl-tRNA synthetases of glycine (GARS) and lysine (KARS) in both mitochondria and the cytosol. Mutations in the majority of the 37 nuclear-encoded human ARS genes have been linked to a variety of recessive and dominant tissue-specific disorders. Current data indicate that impaired enzyme function could explain the pathogenicity, however not all pathogenic ARSs mutations result in deficient catalytic function; thus

2018 FEBS letters

104. Genetic diversity of equine herpesvirus 1 isolated from neurological, abortigenic and respiratory disease outbreaks Full Text available with Trip Pro

. Phylogenetic analysis of regions spanning 80% of the genome showed that up to 13 viral clades have been circulating in the United Kingdom and that most of these are continuing to circulate. Abortion isolates grouped into nine clades, and neurological isolates grouped into five. Most neurological isolates had the N752D substitution, whereas most abortion isolates did not, although three of the neurological isolates from linked outbreaks had a different polymorphism. Finally, bioinformatic analysis suggested (...) Genetic diversity of equine herpesvirus 1 isolated from neurological, abortigenic and respiratory disease outbreaks Equine herpesvirus 1 (EHV-1) causes respiratory disease, abortion, neonatal death and neurological disease in equines and is endemic in most countries. The viral factors that influence EHV-1 disease severity are poorly understood, and this has hampered vaccine development. However, the N752D substitution in the viral DNA polymerase catalytic subunit has been shown statistically

2018 Transboundary and emerging diseases

105. Metacognition in Neurological Injury

in Neurological Samples Actual Study Start Date : December 13, 2018 Estimated Primary Completion Date : August 2020 Estimated Study Completion Date : August 2020 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Intervention/treatment Neurological injury Paper and pencil/computerized assessments of cognitive functioning and metacognitive performance will be administered. Behavioral: metacognitive performance Paper and pencil/computerized tests (...) Metacognition in Neurological Injury Metacognition in Neurological Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Metacognition in Neurological Injury The safety and scientific validity

2018 Clinical Trials

106. Post-malaria neurological syndrome: four cases, review of the literature and clarification of the nosological framework Full Text available with Trip Pro

Post-malaria neurological syndrome: four cases, review of the literature and clarification of the nosological framework Post-malaria neurological syndrome (PMNS) is a debated entity, defined by neurological complications following a post-malaria symptom-free period and a negative blood smear. Four cases of PMNS are hereby reported and a review the literature performed to clarify the nosological framework of this syndrome.A French teaching hospital infectious diseases database was investigated (...) for all PMNS cases occurring between 1999 and 2016 and the PubMed database for cases reported by other institutions after 1997. A case was defined by the de novo appearance of neurological signs following a post-malaria symptom-free period, a negative blood smear, and no bacterial or viral differential diagnoses.Four patients from the database and 48 from PubMed, including 4 following Plasmodium vivax infection were found matching the definition. In the institution, the estimated PMNS incidence rate

2018 Malaria journal

107. The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series Full Text available with Trip Pro

The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series During 2015-16 Brazil experienced the largest epidemic of Zika virus ever reported. This arthropod-borne virus (arbovirus) has been linked to Guillain-Barré syndrome (GBS) in adults but other neurological associations are uncertain. Chikungunya virus has caused outbreaks in Brazil since 2014 but associated neurological disease has rarely been reported here. We (...) investigated adults with acute neurological disorders for Zika, chikungunya and dengue, another arbovirus circulating in Brazil.We studied adults who had developed a new neurological condition following suspected Zika virus infection between 1st November 2015 and 1st June 2016. Cerebrospinal fluid (CSF), serum, and urine were tested for evidence of Zika, chikungunya, and dengue viruses.Of 35 patients studied, 22 had evidence of recent arboviral infection. Twelve had positive PCR or IgM for Zika, five

2018 PLoS neglected tropical diseases

108. An investigation into closed-loop treatment of neurological disorders based on sensing mitochondrial dysfunction Full Text available with Trip Pro

An investigation into closed-loop treatment of neurological disorders based on sensing mitochondrial dysfunction Dynamic feedback based closed-loop medical devices offer a number of advantages for treatment of heterogeneous neurological conditions. Closed-loop devices integrate a level of neurobiological feedback, which allows for real-time adjustments to be made with the overarching aim of improving treatment efficacy and minimizing risks for adverse events. One target which has not been (...) extensively explored as a potential feedback component in closed-loop therapies is mitochondrial function. Several neurodegenerative and psychiatric disorders including Parkinson's disease, Major Depressive disorder and Bipolar disorder have been linked to perturbations in the mitochondrial respiratory chain. This paper investigates the potential to monitor this mitochondrial function as a method of feedback for closed-loop neuromodulation treatments. A generic model of the closed-loop treatment

2018 Journal of neuroengineering and rehabilitation

109. Rett syndrome: a neurological disorder with metabolic components Full Text available with Trip Pro

Rett syndrome: a neurological disorder with metabolic components Rett syndrome (RTT) is a neurological disorder caused by mutations in the X-linked gene methyl-CpG-binding protein 2 (MECP2), a ubiquitously expressed transcriptional regulator. Despite remarkable scientific progress since its discovery, the mechanism by which MECP2 mutations cause RTT symptoms is largely unknown. Consequently, treatment options for patients are currently limited and centred on symptom relief. Thought (...) to be an entirely neurological disorder, RTT research has focused on the role of MECP2 in the central nervous system. However, the variety of phenotypes identified in Mecp2 mutant mouse models and RTT patients implicate important roles for MeCP2 in peripheral systems. Here, we review the history of RTT, highlighting breakthroughs in the field that have led us to present day. We explore the current evidence supporting metabolic dysfunction as a component of RTT, presenting recent studies that have revealed

2018 Open biology

110. Evolutionary Perspective on Sex Differences in the Expression of Neurological Diseases. (Abstract)

Evolutionary Perspective on Sex Differences in the Expression of Neurological Diseases. Sex-specific brain and cognitive deficits emerge with malnutrition, some infectious and neurodegenerative diseases, and often with prenatal or postnatal toxin exposure. These deficits are described in disparate literatures and are generally not linked to one another. Sexual selection may provide a unifying framework that integrates our understanding of these deficits and provides direction for future studies (...) of mitochondrial energy capture and control of oxidative stress that in turn links these traits to current advances in neuroenergetics, stress endocrinology, and toxicology. The key idea is that the elaboration of these cognitive abilities, with more underlying gray matter or more extensive inter-modular white matter connections, makes them particularly sensitive to disruptions in mitochondrial functioning and oxidative stress. A framework of human sexually selected cognitive abilities and underlying brain

2018 Progress in Neurobiology

111. Arousal Response Tool for Neurological Disease

Arousal Response Tool for Neurological Disease Arousal Response Tool for Neurological Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Arousal Response Tool for Neurological Disease (ART_ND (...) Intervention/treatment Phase Parkinson Disease Stroke Healthy Device: MS Band 2 Behavioral: Emotion Assessment Behavioral: Single Task Behavioral: Dual Task Behavioral: Rest Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 45 participants Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Basic Science Official Title: Arousal Response Tool for Neurological

2018 Clinical Trials

112. Neurology Measures in FA Children

Neurology Measures in FA Children Neurology Measures in FA Children - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Neurology Measures in FA Children The safety and scientific validity of this study (...) : Investigators seek to identify biological and clinical tests to be used in future clinical trials. The purpose of this research study is to learn more about Friedreich's Ataxia (FA) progression in children. There will be biannual visits which will include a core set of tests and procedures. These include: a collection of medical history, detailed neurological exam, ataxia scales, and health questionnaires. At each visit, blood and cheek swab samples will be obtained to monitor frataxin levels. A select

2018 Clinical Trials

113. Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study

Observational Model: Cohort Time Perspective: Other Target Follow-Up Duration: 10 Years Official Title: Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study: an Ambispective, Multicentre, Open Cohort Study Actual Study Start Date : September 21, 2017 Estimated Primary Completion Date : September 22, 2026 Estimated Study Completion Date : September 22, 2027 Resource links provided by the National Library of Medicine related topics: available for: (AHRQ) related information: Groups (...) Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2018 Clinical Trials

114. Cerebral embolization during endovascular infrarenal, juxtarenal, and suprarenal aortic aneurysm repair, high-risk maneuvers, and associated neurologic outcomes. (Abstract)

invasive manipulation of wires and cannulas within the aorta, but research into cerebral emboli during aortic aneurysm repair and cognitive or neurologic injury is scarce and limited to thoracic aneurysms. This study prospectively studied embolic phenomena detected in the middle cerebral artery during infrarenal, juxtarenal, and thoracic endovascular aortic repair (TEVAR) and investigated links to delirium, stroke, and postoperative cognitive decline.There were 60 patients who received continuous left (...) Cerebral embolization during endovascular infrarenal, juxtarenal, and suprarenal aortic aneurysm repair, high-risk maneuvers, and associated neurologic outcomes. Risk factors for postoperative cognitive decline after noncardiac surgery are multifactorial and poorly understood. Evidence suggests that perioperative microembolic damage to the brain on movement of wires and catheters during endovascular aortic procedures may play an important role. Endovascular aortic aneurysm repair requires

2018 Journal of Vascular Surgery

115. Brain Stimulation for Neurological Patients

: Double (Participant, Outcomes Assessor) Primary Purpose: Treatment Official Title: Brain Stimulation for Neurological Patients Actual Study Start Date : January 24, 2017 Estimated Primary Completion Date : January 1, 2020 Estimated Study Completion Date : January 1, 2020 Resource links provided by the National Library of Medicine related topics: related topics: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: Group A NEUROLITH Cycle 1: Active treatment Cycle 2: Sham (...) Brain Stimulation for Neurological Patients Brain Stimulation for Neurological Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Brain Stimulation for Neurological Patients The safety and scientific

2018 Clinical Trials

116. Ginkgolide With Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Neurological Improving Trial

Ginkgolide With Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Neurological Improving Trial Ginkgolide With Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Neurological Improving Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Ginkgolide With Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Neurological Improving Trial (GIANT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier

2018 Clinical Trials

117. The role of carboxy-terminal cross-linking telopeptide of type I collagen, dual x-ray absorptiometry bone strain and Romberg test in a new osteoporotic fracture risk evaluation: A proposal from an observational study. Full Text available with Trip Pro

The role of carboxy-terminal cross-linking telopeptide of type I collagen, dual x-ray absorptiometry bone strain and Romberg test in a new osteoporotic fracture risk evaluation: A proposal from an observational study. The consolidated way of diagnosing and treating osteoporosis in order to prevent fragility fractures has recently been questioned by some papers, which complained of overdiagnosis and consequent overtreatment of this pathology with underestimating other causes of the fragility (...) fractures, like falls. A new clinical approach is proposed for identifying the subgroup of patients prone to fragility fractures. This retrospective observational study was conducted from January to June 2015 at the Nuclear Medicine-Bone Metabolic Unit of the of the Fondazione IRCCS Ca' Granda, Milan, Italy. An Italian population of 125 consecutive postmenopausal women was investigated for bone quantity and bone quality. Patients with neurological diseases regarding balance and vestibular dysfunction

2018 PLoS ONE

118. Quality Improvement in Neurology: Dementia Management Quality Measures

Quality Improvement in Neurology: Dementia Management Quality Measures Quality Improvement in Neurology: Dementia Management Quality Measures Logging In... × Welcome to GeriatricsCareOnline! AGS or ADGAP MEMBER Attention AGS Members! As an AGS Member, you already have an account automatically set up on GeriatricsCareOnline.org. Your username and password are the same that you use to log onto MyAGS. (If you do not remember your MyAGS credentials, ). Please do not register for a new user account (...) if you are an AGS member - if you create a new account, you will not be recognized as a member in the system. Username Password remember Remember me Login NON-AGS MEMBER Username Password Remember me Login Search: Toggle navigation Search: Dementia Management Quality Measures PRODUCT DETAILS × PIN Subscriprion Validating... Product Titile : Quality Improvement in Neurology: Dementia Management Quality Measures Enter PIN * × PIN Subscriprion Subscription is completed successfully. Click OK button

2014 American Geriatrics Society

119. Efficacy and safety of medical marijuana in selected neurologic disorders

Efficacy and safety of medical marijuana in selected neurologic disorders Systematic review: Efficacy and safety of medical marijuana in selected neurologic disorders | Neurology Advertisement Search for this keyword Main menu User menu Search Search for this keyword The most widely read and highly cited peer-reviewed neurology journal Share April 29, 2014 ; 82 (17) Special Article Systematic review: Efficacy and safety of medical marijuana in selected neurologic disorders Report (...) of the Guideline Development Subcommittee of the American Academy of Neurology Barbara S. Koppel , John C.M. Brust , Terry Fife , Jeff Bronstein , Sarah Youssof , Gary Gronseth , David Gloss First published April 28, 2014, DOI: https://doi.org/10.1212/WNL.0000000000000363 Barbara S. Koppel From the Department of Neurology (B.S.K.), New York Medical College, New York; the Department of Neurology (J.C.M.B.), Columbia University College of Physicians & Surgeons, New York Neurological Institute, New York

2014 American Academy of Neurology

120. Psychomotor developmental disorders: a link to antidepressants?

Psychomotor developmental disorders: a link to antidepressants? Prescrire IN ENGLISH - Spotlight: Archive ''Psychomotor developmental disorders: a link to antidepressants?'', 1 February 2013 {1} {1} {1} | | > > > Psychomotor developmental disorders: a link to antidepressants? Spotlight: Archives Every month, the subjects in Prescrire’s Spotlight. 2013 :  |   |  Spotlight Archives Psychomotor developmental disorders: a link to antidepressants? It is best to avoid prescribing SSRI (...) of malformation, especially cardiac, after exposure in early pregnancy. Other studies also suggest a risk to the infant’s neurological development. One study has shown a significant delay in psychomotor development in infants aged 6 to 40 months who have been exposed to SSRI antidepressants in the womb. Findings from other studies have been more reassuring. However, the overall results are not convincing. Above all it is clear that not enough is known about the long-term and potentially severe consequences

2014 Prescrire

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