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61. Fabry disease and multiple sclerosis misdiagnosis: the role of family history and neurological signs (PubMed)

Fabry disease and multiple sclerosis misdiagnosis: the role of family history and neurological signs Fabry disease (FD) is an X-linked inherited lysosomal storage disorder caused by α galactosidase A (α-gal A) deficiency. Central nervous system involvement and chronic white matter lesions are observed in both FD and multiple sclerosis (MS), which can confound the differential diagnosis. We analyzed the GLA gene, which encodes α-gal A, in 86 patients with clinical and neuroradiological findings (...) consistent with MS to determine whether they had FD. We identified four women initially diagnosed with MS who had GLA mutations associated with FD. Our results indicate that family history besides neurological findings should be evaluated in patients with an uncertain diagnosis of MS. Also the involvement of organs outside the central nervous system can support the FD diagnosis.

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2018 Oncotarget

62. Autoimmune Neurological Conditions Associated With Zika Virus Infection (PubMed)

, conjunctivitis, widespread pruritic maculopapular rash, arthralgia and myalgia. ZIKV has been linked to a number of central and peripheral nervous system injuries such as Guillain-Barré syndrome (GBS), transverse myelitis (TM), meningoencephalitis, ophthalmological manifestations, and other neurological complications. Nevertheless, mechanisms of host-pathogen neuro-immune interactions remain incompletely elucidated. This review provides a critical discussion about the possible mechanisms underlying (...) Autoimmune Neurological Conditions Associated With Zika Virus Infection Zika virus (ZIKV) is an emerging flavivirus rapidly spreading throughout the tropical Americas. Aedes mosquitoes is the principal way of transmission of the virus to humans. ZIKV can be spread by transplacental, perinatal, and body fluids. ZIKV infection is often asymptomatic and those with symptoms present minor illness after 3 to 12 days of incubation, characterized by a mild and self-limiting disease with low-grade fever

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2018 Frontiers in molecular neuroscience

63. Metacognition in Neurological Injury

in Neurological Samples Actual Study Start Date : December 13, 2018 Estimated Primary Completion Date : August 2020 Estimated Study Completion Date : August 2020 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Intervention/treatment Neurological injury Paper and pencil/computerized assessments of cognitive functioning and metacognitive performance will be administered. Behavioral: metacognitive performance Paper and pencil/computerized tests (...) Metacognition in Neurological Injury Metacognition in Neurological Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Metacognition in Neurological Injury The safety and scientific validity

2018 Clinical Trials

64. Genetic diversity of equine herpesvirus 1 isolated from neurological, abortigenic and respiratory disease outbreaks (PubMed)

. Phylogenetic analysis of regions spanning 80% of the genome showed that up to 13 viral clades have been circulating in the United Kingdom and that most of these are continuing to circulate. Abortion isolates grouped into nine clades, and neurological isolates grouped into five. Most neurological isolates had the N752D substitution, whereas most abortion isolates did not, although three of the neurological isolates from linked outbreaks had a different polymorphism. Finally, bioinformatic analysis suggested (...) Genetic diversity of equine herpesvirus 1 isolated from neurological, abortigenic and respiratory disease outbreaks Equine herpesvirus 1 (EHV-1) causes respiratory disease, abortion, neonatal death and neurological disease in equines and is endemic in most countries. The viral factors that influence EHV-1 disease severity are poorly understood, and this has hampered vaccine development. However, the N752D substitution in the viral DNA polymerase catalytic subunit has been shown statistically

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2018 Transboundary and emerging diseases

65. The role of tRNA synthetases in neurological and neuromuscular disorders (PubMed)

The role of tRNA synthetases in neurological and neuromuscular disorders Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed enzymes responsible for charging tRNAs with their cognate amino acids, therefore essential for the first step in protein synthesis. Although the majority of protein synthesis happens in the cytosol, an additional translation apparatus is required to translate the 13 mitochondrial DNA-encoded proteins important for oxidative phosphorylation. Most ARS genes (...) in these cellular compartments are distinct, but two genes are common, encoding aminoacyl-tRNA synthetases of glycine (GARS) and lysine (KARS) in both mitochondria and the cytosol. Mutations in the majority of the 37 nuclear-encoded human ARS genes have been linked to a variety of recessive and dominant tissue-specific disorders. Current data indicate that impaired enzyme function could explain the pathogenicity, however not all pathogenic ARSs mutations result in deficient catalytic function; thus

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2018 FEBS letters

66. Reduction of Movement in Neurological Diseases: Effects on Neural Stem Cells Characteristics (PubMed)

animals present an incomplete differentiation/maturation. The overall results support the existence of a link between reduction of exercise and muscle disuse and metabolism in the brain and thus represent valuable new information that could clarify how circumstances such as the absence of load and the lack of movement that occurs in people with some neurological diseases, may affect the properties of NSCs and contribute to the negative manifestations of these conditions. (...) Reduction of Movement in Neurological Diseases: Effects on Neural Stem Cells Characteristics Both astronauts and patients affected by chronic movement-limiting pathologies face impairment in muscle and/or brain performance. Increased patient survival expectations and the expected longer stays in space by astronauts may result in prolonged motor deprivation and consequent pathological effects. Severe movement limitation can influence not only the motor and metabolic systems but also the nervous

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2018 Frontiers in neuroscience

67. Is aluminum exposure a risk factor for neurological disorders? (PubMed)

Is aluminum exposure a risk factor for neurological disorders? Aluminum (Al) is widely found in the nature. Although the relation between Al and neurodegenerative diseases is still controversial, Al is related with many brain diseases including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Al exposure occurs mainly through environment, occupational, and dietary factors for humans. Al exposure with diet can be through foods, food additives, water, and contamination of Al (...) equipment/utensils. The aim of this review is to summarize various hypotheses, which link Al and neurodegeneration, and to determine the roles of Al exposure through different sources including diet, environment, and occupation. Future studies should be done in vulnerable subgroups of population including children, patients receiving antacid or Al-containing pharmeteucials on a daily basis, patients with reduced renal function, and patients on parenteral nutrition regimens that are likely to be affected

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2018 Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

68. Upfront Bevacizumab/témozolomide for Gliomastomas With Neurological Impairment

: Observational Actual Enrollment : 70 participants Observational Model: Case-Only Time Perspective: Retrospective Official Title: Neo-adjuvant Treatment of Glioblastomas With Marked to Severe Neurological Impairment Using Upfront Bevacizumab/témozolomide Association Before an Eventual Radiotherapy. Multicentric Phase II Study Actual Study Start Date : January 1, 2011 Actual Primary Completion Date : May 12, 2017 Actual Study Completion Date : May 12, 2017 Resource links provided by the National Library (...) Upfront Bevacizumab/témozolomide for Gliomastomas With Neurological Impairment Upfront Bevacizumab/témozolomide for Gliomastomas With Neurological Impairment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2018 Clinical Trials

69. Virtual Reality (VR) to Improve Quality of Life in Patients Diagnosed With Neurological Disorders

Virtual Reality (VR) to Improve Quality of Life in Patients Diagnosed With Neurological Disorders Virtual Reality (VR) to Improve Quality of Life in Patients Diagnosed With Neurological Disorders - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Virtual Reality (VR) to Improve Quality of Life in Patients Diagnosed With Neurological Disorders The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03606668 Recruitment Status

2018 Clinical Trials

70. Multimodal Assessment of the Neurological Prognosis of Patients With Brain Lesions on ExtraCorporeal Life Support

Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Intervention Details: Other: clinical examinations Collection of data from the following tests at H0 (as soon as the ECLS is put in place), H12 (within 12 hours following stabilisation of the dynamic state), H24 and every day until complete neurological recovery: right and left pupillometry (3 times) BIS values right and left NIRS values right and left transcranial Doppler neurological clinical (...) Multimodal Assessment of the Neurological Prognosis of Patients With Brain Lesions on ExtraCorporeal Life Support Multimodal Assessment of the Neurological Prognosis of Patients With Brain Lesions on ExtraCorporeal Life Support - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2018 Clinical Trials

71. Preventing Falls and Participation Restrictions in Neurological Diseases

Restrictions in Subjects With Neurological Diseases Actual Study Start Date : January 1, 2015 Actual Primary Completion Date : December 30, 2016 Actual Study Completion Date : January 15, 2017 Resource links provided by the National Library of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Experimental group: Education group Participants in the experimental intervention group (education group) received an educational program and tailored home (...) Preventing Falls and Participation Restrictions in Neurological Diseases Preventing Falls and Participation Restrictions in Neurological Diseases - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Preventing

2018 Clinical Trials

72. Analysis of the Sweat Response According to the Pathology in Neurologic Patients

on parasympathetic tone and BP variations depend on vasomotor sympathetic response. Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 450 participants Observational Model: Cohort Time Perspective: Retrospective Official Title: Analysis of the Sweat Response According to the Pathology in Neurologic Actual Study Start Date : March 2015 Actual Primary Completion Date : March 2017 Actual Study Completion Date : March 2017 Resource links provided by the National (...) Analysis of the Sweat Response According to the Pathology in Neurologic Patients Analysis of the Sweat Response According to the Pathology in Neurologic Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2018 Clinical Trials

73. Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury

to Reduce Body Temperature in Febrile Critically-ill Adults With Acute Neurologic Disease: an Open-label, Blinded Endpoint, Randomized Controlled Trial Actual Study Start Date : November 30, 2018 Estimated Primary Completion Date : July 1, 2019 Estimated Study Completion Date : July 1, 2019 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Acetaminophen standard of care - acetaminophen 650mg (...) Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy

2018 Clinical Trials

74. Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates

Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier

2018 Clinical Trials

75. A Pilot Study of Creative Arts Interventions for Neurology Inpatients

: Interventional (Clinical Trial) Actual Enrollment : 33 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Other Official Title: A Pilot Study of Creative Arts Interventions for Neurology Inpatients in the Epilepsy Monitoring Unit and the Headache Service Actual Study Start Date : September 19, 2017 Actual Primary Completion Date : June 1, 2018 Actual Study Completion Date : June 30, 2018 Resource links provided by the National Library of Medicine related (...) A Pilot Study of Creative Arts Interventions for Neurology Inpatients A Pilot Study of Creative Arts Interventions for Neurology Inpatients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Pilot Study

2018 Clinical Trials

76. Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study

Observational Model: Cohort Time Perspective: Other Target Follow-Up Duration: 10 Years Official Title: Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study: an Ambispective, Multicentre, Open Cohort Study Actual Study Start Date : September 21, 2017 Estimated Primary Completion Date : September 22, 2026 Estimated Study Completion Date : September 22, 2027 Resource links provided by the National Library of Medicine related topics: available for: (AHRQ) related information: Groups (...) Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2018 Clinical Trials

77. Umbilical Cord Blood Mononuclear Cells for Hypoxic Neurologic Injury in Infants With Congenital Diaphragmatic Hernia (CDH)

(Open Label) Primary Purpose: Treatment Official Title: Umbilical Cord Blood Mononuclear Cells for Hypoxic Neurologic Injury in Infants With Congenital Diaphragmatic Hernia (CDH) Actual Study Start Date : August 1, 2018 Estimated Primary Completion Date : November 1, 2027 Estimated Study Completion Date : November 1, 2027 Resource links provided by the National Library of Medicine related topics: related topics: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental (...) Umbilical Cord Blood Mononuclear Cells for Hypoxic Neurologic Injury in Infants With Congenital Diaphragmatic Hernia (CDH) Umbilical Cord Blood Mononuclear Cells for Hypoxic Neurologic Injury in Infants With Congenital Diaphragmatic Hernia (CDH) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2018 Clinical Trials

78. Molecular Imaging and Spectroscopy With Stable Isotopes in Oncology and Neurology

Molecular Imaging and Spectroscopy With Stable Isotopes in Oncology and Neurology Molecular Imaging and Spectroscopy With Stable Isotopes in Oncology and Neurology - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Molecular Imaging and Spectroscopy With Stable Isotopes in Oncology and Neurology (MISSION-ovary) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03526809 Recruitment Status : Recruiting First Posted : May 16, 2018

2018 Clinical Trials

79. Caffeine and Neurologic Recovery Following Surgery and General Anesthesia

controlled trial at the University of Michigan Health System. Primary Purpose: Treatment Official Title: Caffeine and Neurologic Recovery Following Surgery and General Anesthesia Actual Study Start Date : July 10, 2018 Estimated Primary Completion Date : June 11, 2020 Estimated Study Completion Date : July 11, 2020 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Experimental Prepared (...) Caffeine and Neurologic Recovery Following Surgery and General Anesthesia Caffeine and Neurologic Recovery Following Surgery and General Anesthesia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Caffeine

2018 Clinical Trials

80. Developing of Virtual Reality Based Neurologic Examination Teaching Tool(VRNET)

, outcome assessors will be blinded for group allocation. Primary Purpose: Other Official Title: Developing of Virtual Reality Based Neurologic Examination Teaching Tool(VRNET) Estimated Study Start Date : March 2019 Estimated Primary Completion Date : August 31, 2019 Estimated Study Completion Date : August 31, 2019 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: standardized patients with VRNET (...) Developing of Virtual Reality Based Neurologic Examination Teaching Tool(VRNET) Developing of Virtual Reality Based Neurologic Examination Teaching Tool(VRNET) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2018 Clinical Trials

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