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41. Neurologic Complications In Infective Endocarditis: To Anticoagulate Or Not To Anticoagulate

Neurologic Complications In Infective Endocarditis: To Anticoagulate Or Not To Anticoagulate Neurologic Complications In Infective Endocarditis: To Anticoagulate Or Not To Anticoagulate – Clinical Correlations Search Neurologic Complications In Infective Endocarditis: To Anticoagulate Or Not To Anticoagulate July 10, 2015 7 min read By Shannon Chiu, MD Peer Reviewed The annual incidence of infective endocarditis (IE) [1-2]. Neurologic complications are the most severe and frequent [3-4 (...) , or increasing size despite appropriate antibiotics [5,8]. Additional risk factors for embolism in IE include advanced age and S. aureus infection. Importantly, S. aureus prosthetic valve endocarditis is known to be associated with higher overall mortality and severe neurologic complications such as hemorrhagic stroke [3,9-10]. Mechanisms for intracranial hemorrhage (ICH) in patients with IE include hemorrhagic transformation (HT) of ischemic infarct, [11]. Currently, evidence regarding anticoagulants

2015 Clinical Correlations

42. The Neurology and Neuropsychiatry of COVID-19 Full Text available with Trip Pro

in a specialist neurology centre during the peak Italian SARS-CoV-2 pandemic. The authors argue an increase from the usual rates of GBS could be linked to the pandemic. Publication date / reference: 15/05/20 Summary: Case report of a 68-year-old female who developed bilateral ascending limb weakness on day 3 of her admission due to SARS-CoV-2 infection. This progressed to breathing compromise and she did not survive intubation. Publication date / reference: 14/05/2020 Summary: case report of 61-year-old male (...) The Neurology and Neuropsychiatry of COVID-19 The Neurology and Neuropsychiatry of COVID-19 | JNNP blog by SARS-CoV-2 (Credit: CDC / Eckert & Higgins) By Matt Butler, Cameron Watson, Ally Rooney, Jia Song, Jamie Badenoch, Susannah Pick, Mark Ellul, Tom Pollak, Benedict Michael and Tim Nicholson Evidence on the neurological and neuropsychiatric manifestations and complications of COVID-19 infections is emerging and this is likely to accelerate as the pandemic develops and clinical syndromes

2020 JNNP blog

43. Crowdfunding for stem cell-based interventions to treat neurologic diseases and injuries. (Abstract)

Crowdfunding for stem cell-based interventions to treat neurologic diseases and injuries. To characterize the marketplace for direct-to-consumer (DTC) unproven stem cell-based interventions (SCBI) for neurologic diseases and injuries using crowdfunding data.Search terms were developed from previous empirical studies of DTC businesses and the International Classification of Diseases-11 for neurologic diseases and used to query GoFundMe's internal search engine. Campaigns initiated November 2017 (...) -2018 and seeking SCBI for neurologic diseases and injuries (n = 1,030) were reviewed to identify the number of donors, number of Facebook shares, recipient location, funding pledged, funding requested, underlying neurologic condition, treatment location, and treatment facility name.A total of 1,030 crowdfunding campaigns for SCBI for neurologic diseases and injuries requested $33,449,979 and received $5,057,069 from 38,713 donors. The most common neurologic condition identified was multiple

2019 Neurology

44. A case with neurological abnormalities caused by Rickettsia raoultii in northwestern China. Full Text available with Trip Pro

A case with neurological abnormalities caused by Rickettsia raoultii in northwestern China. The number of new rickettsial species are rapidly increasing, and increasing numbers of Rickettsia raoultii (R. raoultii) infection cases have been detected in humans. However, neurological abnormalities caused by R. raoultii are rarely reported, especially in northwestern China.A 36-year-old Kazakh shepherd with an attached tick on part temporalis, presented with right eyelid droop, lethargy, fever (...) , headache, fever (38.0-41.0 °C) and erythematous rash. The examination of cerebrospinal fluid (CSF) showed cerebrospinal pressure of 200 mm H2O, leukocyte count of 300.0 × 106/L, adenosine deaminase of 2.15 U/L, and total protein concentration of 0.93 g/L. The diagnosis of R. raoultii infection was confirmed by six genetic markers, and semi-quantified by enzyme-linked immunosorbent assay for rickettsial antigen. The patient gradually recovered after treatment with doxycycline and ceftriaxone. R

2019 BMC Infectious Diseases

45. Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model. Full Text available with Trip Pro

Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model. Multiple sclerosis (MS) is an autoimmune demyelinating disease with progressive neurodegeneration and complex etiology likely involving genetic and environmental factors. MS has been associated with Epstein Barr virus (EBV) infection, with patients often showing enhanced responses to EBV antigens. To determine whether abnormal EBV nuclear (...) with this EBNA-1 polypeptide mounted a response against MBP and developed signs of experimental autoimmune encephalitis (EAE). These data support a link between MS and EBV through antibodies that cross-react between EBV proteins and the MBP autoantigen.Copyright © 2019 Elsevier Ltd. All rights reserved.

2019 Journal of Autoimmunity

46. Sleep and neurological autoimmune diseases. (Abstract)

intrusions into wakefulness. The study of sleep disorders in the setting of autoimmune diseases (e.g., narcolepsy, anti-IgLON5 disease, paraneoplastic neurological syndromes) shows that an abnormal immune-mediated (humoral or cellular) response target the neuronal structures (e.g., brainstem, hypothalamus) and neurotransmitters systems (e.g., hypocretin) that regulate sleep resulting in sleep impairment. It is a window to examine the link between the autoimmune system and the sleep regulation (...) Sleep and neurological autoimmune diseases. Neurological autoimmune diseases are characterized by an inappropriate immune response that by mistake targets the nervous system. As a result, patients experiment a number of neurological manifestations that may include insomnia, excessive daytime sleepiness, cataplexy, central hypoventilation, and REM sleep behavior disorder. Polysomnographic evaluation may reveal disorganized sleep architecture involving both NREM and REM sleep, and REM sleep

2019 Neuropsychopharmacology

47. Neurological Sleep Disorders and Blood Pressure: Current Evidence. Full Text available with Trip Pro

Neurological Sleep Disorders and Blood Pressure: Current Evidence. Hypertension is a major determinant of cardiovascular morbidity and mortality and is highly prevalent in the general population. While the relationship between sleep apnea and increased blood pressure has been well documented, less recognized is emerging evidence linking sleep-related movement disorders such as restless legs syndrome/periodic limb movements of sleep and sleep-related bruxism with blood pressure (BP (...) ) dysregulation and hypertension. There is also recent literature linking narcolepsy-cataplexy with elevated BP and altered pressor responses, and there are data suggesting abnormal BP control in rapid eye movement sleep behavior disorder. It is thought that neural circulatory mechanisms, sympathetic activation in particular, comprise the predominant mediator underlying elevated BP in these neurological sleep disorders. There is very limited evidence that treating these sleep disorders may be beneficial

2019 Hypertension

48. Characteristics of patients with motor functional neurological disorder in a large UK mental health service: a case-control study. Full Text available with Trip Pro

Characteristics of patients with motor functional neurological disorder in a large UK mental health service: a case-control study. Functional neurological disorder (FND), previously known as conversion disorder, is common and often results in substantial distress and disability. Previous research lacks large sample sizes and clinical surveys are most commonly derived from neurological settings, limiting our understanding of the disorder and its associations in other contexts. We sought (...) occurring functional symptom. mFND patients were more likely to be female, British, married, employed pre-morbidly, to have a carer and a physical health condition, but less likely to have had an inpatient psychiatric admission or to receive benefits. No differences in self-reported sexual or physical abuse rates were observed between groups, although mFND patients were more likely to experience life events linked to inter-personal difficulties.mFND patients have distinct demographic characteristics

2019 Psychological Medicine

49. Is Hirschsprung disease a purely neurological condition? A study of the Actin G2 smooth muscle gene in Hirschsprung disease. (Abstract)

Is Hirschsprung disease a purely neurological condition? A study of the Actin G2 smooth muscle gene in Hirschsprung disease. Hirschsprung disease is a functional obstruction of the gastrointestinal tract due to the congenital absence of ganglion cells in the intermyenteric plexuses of the distal bowel. Gastrointestinal motility requires intact muscular layers as well as neural network connection to function properly. The Actin G2 gene is the main gene encoding actin gamma 2; a smooth muscle (...) . The results of ACTG2 gene analysis showing variation in exons 5, 8 and 10 of the ACTG2 gene in 7 of them (64%). The c.109C > G S345 L was the most frequent occurring in 6 of the 10 patients (54%), the c.171 A > A K119E in 2 and the significant c.108 T > G W357G variation in exon 10 (1 patient) Four patients had a combination of different variants in different exons which were less significant. Allele frequency on a control sample of the South African population showed no comparable pathology link scores

2019 Journal of Pediatric Surgery

50. Presence of anti-BP180 and anti-BP230 in the CSF of patients with bullous pemphigoid and neurologic disease: is there any intrathecal synthesis? (Abstract)

Presence of anti-BP180 and anti-BP230 in the CSF of patients with bullous pemphigoid and neurologic disease: is there any intrathecal synthesis? The association between bullous pemphigoïd (BP) and several neurologic diseases (ND) - cerebrovascular and neurodegenerative diseases - is well known and documented by several epidemiologic studies while a pathophysiology link is still undetermined. Auto-antibodies (Ab) directed against BP180 are more frequently found in patients with dementia

2019 British Journal of Dermatology

51. Demographics and Autoantibody Profiles of Pemphigoid Patients with Underlying Neurologic Diseases. (Abstract)

. To better understand the link between BP and neurologic disease, we evaluated primary demographic features (age, sex, race, ethnicity, and elapsed time between onset of skin symptoms and BP diagnosis), severity of BP, and IgG and IgE autoantibody levels in BP control individuals and patients with BP with preceding Parkinson disease, dementia, and stroke. The main findings of this study are that patients with BP with preceding neurologic disease have a shorter elapsed time between onset of skin disease (...) Demographics and Autoantibody Profiles of Pemphigoid Patients with Underlying Neurologic Diseases. Bullous pemphigoid (BP) is an autoantibody-mediated blistering disease that is often associated with neurologic disease. BP antibodies target two epidermal adhesion molecules, known as BP180 and BP230. Homologues to these proteins are found in the brain, and it is hypothesized that neurologic disease leads to the production of autoantibodies that can cross-react with their cutaneous forms

2019 Journal of Investigative Dermatology

52. Reduced limbic microstructural integrity in functional neurological disorder. (Abstract)

Reduced limbic microstructural integrity in functional neurological disorder. Functional neurological disorder (FND) is a condition at the intersection of neurology and psychiatry. Individuals with FND exhibit corticolimbic abnormalities, yet little is known about the role of white matter tracts in the pathophysiology of FND. This study characterized between-group differences in microstructural integrity, and correlated fiber bundle integrity with symptom severity, physical disability (...) , and illness duration.A diffusion tensor imaging (DTI) study was performed in 32 patients with mixed FND compared to 36 healthy controls. Diffusion-weighted magnetic resonance images were collected along with patient-reported symptom severity, physical disability (Short Form Health Survey-36), and illness duration data. Weighted-degree and link-level graph theory and probabilistic tractography analyses characterized fractional anisotropy (FA) values across cortico-subcortical connections. Results were

2019 Psychological Medicine

53. Liver Transplantation for Propionic Acidemia: A Multicenter-linked Database Analysis. (Abstract)

Liver Transplantation for Propionic Acidemia: A Multicenter-linked Database Analysis. Propionic acidemia (PA) is a rare inborn error of metabolism resulting from deficiency in the enzyme necessary for catabolism of branched-chain amino acids, some odd chain fatty acids and cholesterol. Despite optimal medical management, PA often leads to acute and progressive neurological injury. Reports on liver transplantation (LT) as a cellular therapy are limited and varied. The objective of this study

2020 Journal of Pediatric Gastroenterology and Nutrition

54. Pathogenic SREK1 decrease in Huntington's disease lowers TAF1 mimicking X-linked dystonia parkinsonism. Full Text available with Trip Pro

Pathogenic SREK1 decrease in Huntington's disease lowers TAF1 mimicking X-linked dystonia parkinsonism. Huntington's disease and X-linked dystonia parkinsonism are two monogenic basal ganglia model diseases. Huntington's disease is caused by a polyglutamine-encoding CAG repeat expansion in the Huntingtin (HTT) gene leading to several toxic interactions of both the expanded CAG-containing mRNA and the polyglutamine-containing protein, while X-linked dystonia parkinsonism is caused (...) includes TAF1 as one of its targets. This led us to hypothesize that Huntington's disease and X-linked dystonia parkinsonism pathogeneses converge in TAF1 alteration. We show that diminishing SRSF6 through RNA interference in human neuroblastoma cells leads to a decrease in SREK1 levels, which, in turn, suffices to cause diminished TAF1 levels. We also observed decreased SREK1 and TAF1 levels in striatum of Huntington's disease patients and transgenic model mice. We then generated mice with neuronal

2020 Brain

55. A novel nonsense mutation in the STS gene in a Pakistani family with X-linked recessive ichthyosis: including a very rare case of two homozygous female patients. Full Text available with Trip Pro

A novel nonsense mutation in the STS gene in a Pakistani family with X-linked recessive ichthyosis: including a very rare case of two homozygous female patients. X-linked ichthyosis (XLI; OMIM# 308100) is a recessive keratinization disorder characterized by the presence of dark brown, polygonal, adherent scales on different parts of the body surface. It almost exclusively affects males and the estimated prevalence ranges from 1:2000-6000 in males worldwide. Extracutaneous manifestations (...) , or neurological phenotypes including intellectual disability, autism or attention deficit hyperactivity disorder. Molecular karyotyping was normal and no copy number variation was found. Sanger sequencing identified a novel hemizygous nonsense mutation (c.287G > A; p.W96*), in exon 4 of STS gene in all affected male individuals. In addition, two XLI affected females in the family were found to be homozygous for the identified variant.This study is useful for understanding the genetic basis of XLI

2020 BMC Medical Genetics

56. ATR-16 syndrome: mechanisms linking monosomy to phenotype. Full Text available with Trip Pro

ATR-16 syndrome: mechanisms linking monosomy to phenotype. Deletions removing 100s-1000s kb of DNA, and variable numbers of poorly characterised genes, are often found in patients with a wide range of developmental abnormalities. In such cases, understanding the contribution of the deletion to an individual's clinical phenotype is challenging.Here, as an example of this common phenomenon, we analysed 41 patients with simple deletions of ~177 to ~2000 kb affecting one allele of the well (...) -characterised, gene dense, distal region of chromosome 16 (16p13.3), referred to as ATR-16 syndrome. We characterised deletion extents and screened for genetic background effects, telomere position effect and compensatory upregulation of hemizygous genes.We find the risk of developmental and neurological abnormalities arises from much smaller distal chromosome 16 deletions (~400 kb) than previously reported. Beyond this, the severity of ATR-16 syndrome increases with deletion size, but there is no evidence

2020 Journal of Medical Genetics

57. O-Arm Technology in Spinal, Neurological, Orthopedic, or Trauma Surgery Settings

O-Arm Technology in Spinal, Neurological, Orthopedic, or Trauma Surgery Settings TITLE: O-Arm Technology in Spinal, Neurological, Orthopedic, or Trauma Surgery Settings: Clinical Effectiveness, and Benefits and Harms DATE: 07 August 2013 RESEARCH QUESTIONS 1. What is the clinical effectiveness of O-arm technology used in spinal, neurological, orthopedic, or trauma surgery settings? 2. What are the benefits and harms associated with O-arm technology in patients undergoing spinal, neurological (...) (CRD) databases, Canadian and major international health technology agencies, as well as a focused Internet search. No filters were applied to limit the retrieval by study type. Where possible, retrieval was limited to the human population. The search was also limited to English language documents published between January 1, 2003 and July 29 th , 2013. Internet links were provided, where available. The summary of findings was prepared from the abstracts of the relevant information. Please note

2013 Canadian Agency for Drugs and Technologies in Health - Rapid Review

58. Intraoperative Monitoring During Spinal or Neurological Surgeries

Intraoperative Monitoring During Spinal or Neurological Surgeries TITLE: Intraoperative Monitoring During Spinal or Neurological Surgeries: Clinical Effectiveness and Guidelines DATE: 06 August 2013 RESEARCH QUESTIONS 1. What is the clinical effectiveness of intraoperative monitoring during spinal or neurological surgeries? 2. What are the clinical benefits and harms associated with the use of intraoperative monitoring during spinal or neurological surgeries? 3. What are the evidence-based (...) guidelines for the use of intraoperative monitoring during spinal or neurological surgeries? KEY MESSAGE One systematic review, 14 prospective non-randomized studies, and two evidence-based guidelines were identified regarding the use of intraoperative monitoring during spinal or neurological surgeries. METHODS A focused search (with main concepts appearing in title, abstract or major subject heading) was conducted on key resources including PubMed, The Cochrane Library (2013, Issue 7), University

2013 Canadian Agency for Drugs and Technologies in Health - Rapid Review

59. What relationship do stressful life events, neglect and abuse have with functional neurological disorder (conversion disorder)?

neurological disorder; rather it calls for us to consider the mechanism of the association and to understand how this should influence treatment (and even prevention). Conflicts of interest I was a reviewer for the paper and have previously published papers with several of the authors. Links Primary paper Ludwig L, Pasman JA, Nicholson T, Aybek S, David AS, Tuck S, Kanaan RA, Roelofs K, Carson A, Stone J. (2018) . The Lancet Psychiatry 2018 . The Lancet Psychiatry 2018 Other references Freud S, Breuer J (...) What relationship do stressful life events, neglect and abuse have with functional neurological disorder (conversion disorder)? Functional neurological disorder (conversion disorder) Search National Elf Service Search National Elf Service » » » » What relationship do stressful life events, neglect and abuse have with functional neurological disorder (conversion disorder)? Mar 9 2018 Posted by Functional neurological disorder (conversion disorder) is a common cause of disabling neurological

2018 The Mental Elf

60. Central autoimmune channelopathies: a link between Neurology and Psychiatry

Central autoimmune channelopathies: a link between Neurology and Psychiatry Central autoimmune channelopathies: a link between Neurology and Psychiatry | JNNP blog by Since the recognition of antibodies against voltage – gated potassium channel (VGKC) and their pathogenic implication in central nervous system disorders (such as limbic encephalitis) in 2001, critical immunological and neurological advances have been achieved during the last 15 years. One of the main discoveries has been (...) that these VGKC antibodies usually target proteins outside of the channel protein, which are part of the VGKC complex (e.g. contactin-associated protein 2). Moreover, each specific antibody is associated with distinct clinical phenotypes, which commonly overlap. Clinically the primary neurological syndrome associated with VGKC antibodies is limbic encephalitis, classically presenting with severe memory impairment and secondary hippocampal atrophy. However, recently emerging psychiatric syndromes have been

2016 JNNP blog

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