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21. Association Between Neurological Disorders and Death by Suicide in Denmark. (Abstract)

Association Between Neurological Disorders and Death by Suicide in Denmark. Neurological disorders have been linked to suicide, but the risk across a broad spectrum of neurological disorders remains to be assessed.To examine whether people with neurological disorders die by suicide more often than other people and to assess for temporal associations.Nationwide, retrospective cohort study on all persons 15 years or older living in Denmark, from 1980 through 2016 (N = 7 300 395).Medical contact (...) diagnoses, and self-harm.Of the more than 7.3 million individuals observed over 161 935 233 person-years (49.1% males), 35 483 died by suicide (median duration of follow-up, 23.6 years; interquartile range, 10.0-37.0 years; mean age, 51.9 years; SD, 17.9 years). Of those, 77.4% were males, and 14.7% (n = 5141) were diagnosed with a neurological disorder, equivalent to a suicide rate of 44.0 per 100 000 person-years compared with 20.1 per 100 000 person-years among individuals not diagnosed

2020 JAMA

22. Digitally enabled aged care and neurological rehabilitation to enhance outcomes with Activity and MObility UsiNg Technology (AMOUNT) in Australia: A randomised controlled trial Full Text available with Trip Pro

PMCID: DOI: Item in Clipboard Full-text links Cite Abstract Background: Digitally enabled rehabilitation may lead to better outcomes but has not been tested in large pragmatic trials. We aimed to evaluate a tailored prescription of affordable digital devices in addition to usual care for people with mobility limitations admitted to aged care and neurological rehabilitation. Methods and findings: We conducted a pragmatic, outcome-assessor-blinded, parallel-group randomised trial in 3 Australian (...) Digitally enabled aged care and neurological rehabilitation to enhance outcomes with Activity and MObility UsiNg Technology (AMOUNT) in Australia: A randomised controlled trial Digitally Enabled Aged Care and Neurological Rehabilitation to Enhance Outcomes With Activity and MObility UsiNg Technology (AMOUNT) in Australia: A Randomised Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search

2020 EvidenceUpdates

23. Sudden Unexpected Death in Epilepsy Incidence Rates and Risk Factors: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society Full Text available with Trip Pro

. Please read and accept the and check the box to generate a sharing link. I have read and accept the terms and conditions Share URL copied to clipboard View permissions information for this article Practice Guideline Summary: Sudden Unexpected Death in Epilepsy Incidence Rates and Risk Factors: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society .entryAuthor" data-author-container-selector (...) Sudden Unexpected Death in Epilepsy Incidence Rates and Risk Factors: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society Practice Guideline Summary: Sudden Unexpected Death in Epilepsy Incidence Rates and Risk Factors: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society - Cynthia Harden

2017 American Epilepsy Society

24. Survival and Health Care Use After Feeding Tube Placement in Children With Neurologic Impairment Full Text available with Trip Pro

Survival and Health Care Use After Feeding Tube Placement in Children With Neurologic Impairment Children with neurologic impairment (NI) often undergo feeding tube placement for undernutrition or aspiration. We evaluated survival and acute health care use after tube placement in this population.This is a population-based exposure-crossover study for which we use linked administrative data from Ontario, Canada. We identified children aged 13 months to 17 years with a diagnosis of NI undergoing

2019 EvidenceUpdates

25. Continuous Electroencephalography versus Intermittent Electroencephalography in Patients with Neurological Disorders or Brain Trauma

Continuous Electroencephalography versus Intermittent Electroencephalography in Patients with Neurological Disorders or Brain Trauma Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable (...) . This report may be used for the purposes of research or private study only. It may not be copied, posted on a web site, redistributed by email or stored on an electronic system without the prior written permission of CADTH or applicable copyright owner. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners’ own terms and conditions

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

26. Pelvic Girdle Pain in the Antepartum Population: Physical Therapy Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability, and Health From the Section on Women's Health and the Orthopaedic Section of the American Full Text available with Trip Pro

Pelvic Girdle Pain in the Antepartum Population: Physical Therapy Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability, and Health From the Section on Women's Health and the Orthopaedic Section of the American Pelvic Girdle Pain in the Antepartum Population: Physical Th... : Journal of Women’s Health Physical Therapy ')} You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login (...) , neurological symptoms/signs, fever, and/or systemically unwell. Special considerations for PGP should include symptoms due to uterine abruption or referred pain due to urinary tract infection to the lower abdomen/pelvic or sacral region. Failure to achieve functional improvement, pain that does not reduce with rest, and/or severe, disabling pain would require a medical specialist referral. II. Pelvic floor muscle weakness, a risk factor for PGP, is associated with weakness of the abdominal wall in DRA

2017 American Physical Therapy Association

27. Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and th Full Text available with Trip Pro

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and th To update the 2004 American Academy of Neurology (AAN) guideline for treating new-onset focal or generalized epilepsy with second- and third-generation antiepileptic drugs (AEDs).The 2004 AAN criteria were used to systematically review (...) literature (January 2003-November 2015), classify pertinent studies according to the therapeutic rating scheme, and link recommendations to evidence strength.Several second-generation AEDs are effective for new-onset focal epilepsy. Data are lacking on efficacy in new-onset generalized tonic-clonic seizures, juvenile myoclonic epilepsy, or juvenile absence epilepsy, and on efficacy of third-generation AEDs in new-onset epilepsy.Lamotrigine (LTG) should (Level B) and levetiracetam (LEV) and zonisamide

2018 EvidenceUpdates

28. Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the Full Text available with Trip Pro

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the To update the 2004 American Academy of Neurology guideline for managing treatment-resistant (TR) epilepsy with second- and third-generation antiepileptic drugs (AEDs).2004 criteria were used to systemically review literature (January 2003 (...) to November 2015), classify pertinent studies according to the therapeutic rating scheme, and link recommendations to evidence strength.Forty-two articles were included.The following are established as effective to reduce seizure frequency (Level A): immediate-release pregabalin and perampanel for TR adult focal epilepsy (TRAFE); vigabatrin for TRAFE (not first-line treatment); rufinamide for Lennox-Gastaut syndrome (LGS) (add-on therapy). The following should be considered to decrease seizure frequency

2018 EvidenceUpdates

29. Cochlear Implantation in Neurological Patients: Case Report and Literature Survey. (Abstract)

Cochlear Implantation in Neurological Patients: Case Report and Literature Survey. Cochlear implant (CI) is a reliable solution to restore hearing in people with severe-to-profound hearing loss. The device is made up of internal and external components linked transcutaneously through a magnet that may rise specific issues in people who must undergo brain magnetic resonance (MRI) due to neurological diseases. The description of a case of a CI implantee needing MRI has given us the opportunity

2020 Laryngoscope

30. Modeling the Neurological Basis and Characterizing the Neurological Phenotype of Obesity Using Human Neural Stem Cells

and Characterizing the Neurological Phenotype of Obesity Using Human Neural Stem Cells Estimated Study Start Date : September 2017 Estimated Primary Completion Date : January 2022 Estimated Study Completion Date : January 2027 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Intervention/treatment Bariatric Surgery Subjects that have demonstrated extreme response to bariatric surgery. Procedure: Bariatric Surgery Sleeve gastrectomy or Roux-en-Y (...) Modeling the Neurological Basis and Characterizing the Neurological Phenotype of Obesity Using Human Neural Stem Cells Modeling the Neurological Basis and Characterizing the Neurological Phenotype of Obesity Using Human Neural Stem Cells - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2017 Clinical Trials

31. The link between anesthesiology and neurology: a mindful cooperation to improve brain protection. (Abstract)

The link between anesthesiology and neurology: a mindful cooperation to improve brain protection. Preventing neurological injury is mandatory during the perioperative period of any kind of surgery and in the care of critically ill patients in the intensive care unit. During daily practice, both anesthesiologists and neurologists focus on brain protection as an integral part of systemic homeostasis maintenance. This article highlights the intriguing overlap between anesthesiology and neurology (...) in clinical practice along with its potential implications for outcome. Moreover, it focuses on the importance of the complementary expertise of both specialists in maintaining cerebral homeostasis, with the aim of improving outcome. A review of available evidence on anesthesiology and neurology interplay in clinical practice along with its potential implications for outcome has been conducted. Clinical vigilance and the use of shared monitoring and diagnostic technology could allow early recognition

2016 Minerva anestesiologica

32. Erratum to muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy Full Text available with Trip Pro

Erratum to muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy [This corrects the article on p. 262 in vol. 3, PMID: 26605308.].

2016 Annals of Translational Medicine

33. De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation Full Text available with Trip Pro

De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation Disruptions to neuronal mRNA translation are hypothesized to underlie human neurodevelopmental syndromes. Notably, the mRNA translation re-initiation factor DENR is a regulator of eukaryotic translation and cell growth, but its mammalian functions are unknown. Here, we report that Denr influences the migration of murine cerebral cortical neurons in vivo (...) in different ways. Thus, our findings link human brain disorders to impaired mRNA translation re-initiation through perturbations in DENR (OMIM: 604550) function in neurons.Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

2016 Cell reports

34. EFhd2, a Protein Linked to Alzheimer's Disease and Other Neurological Disorders Full Text available with Trip Pro

EFhd2, a Protein Linked to Alzheimer's Disease and Other Neurological Disorders EFhd2 is a conserved calcium binding protein linked to different neurological disorders and types of cancer. Although, EFhd2 is more abundant in neurons, it is also found in other cell types. The physiological function of this novel protein is still unclear, but it has been shown in vitro to play a role in calcium signaling, apoptosis, actin cytoskeleton, and regulation of synapse formation. Recently, EFhd2 (...) was shown to promote cell motility by modulating the activity of Rac1, Cdc42, and RhoA. Although, EFhd2's role in promoting cell invasion and metastasis is of great interest in cancer biology, this review focusses on the evidence that links EFhd2 to Alzheimer's disease (AD) and other neurological disorders. Altered expression of EFhd2 has been documented in AD, Parkinson's disease, Huntington's disease, Amyotrophic Lateral Sclerosis, and schizophrenia, indicating that Efhd2 gene expression is regulated

2016 Frontiers in neuroscience

35. Defects of mutant DNMT1 are linked to a spectrum of neurological disorders. Full Text available with Trip Pro

Defects of mutant DNMT1 are linked to a spectrum of neurological disorders. We report a broader than previously appreciated clinical spectrum for hereditary sensory and autonomic neuropathy type 1E (HSAN1E) and a potential pathogenic mechanism for DNA methyltransferase (DNMT1) mutations. The clinical presentations and genetic characteristics of nine newly identified HSAN1E kinships (45 affected subjects) were investigated. Five novel mutations of DNMT1 were discovered; p.C353F, p.T481P, p.P491L

2015 Brain

36. Neurological Impairment Linked with Cortico-Subcortical Infiltration of Diffuse Low-Grade Gliomas at Initial Diagnosis Supports Early Brain Plasticity Full Text available with Trip Pro

Neurological Impairment Linked with Cortico-Subcortical Infiltration of Diffuse Low-Grade Gliomas at Initial Diagnosis Supports Early Brain Plasticity Diffuse low-grade gliomas (DLGG) are slow-growing brain tumors that in spite of an indolent behavior at onset show a continuous expansion over time and inevitably transform into malignant gliomas. Extensive tumor resections may be performed with preservation of neurological function due to neuroplasticity that is induced by the slow tumor growth (...) . However, DLGG prefer to migrate along subcortical pathways, and white matter plasticity is considerably more limited than gray matter plasticity. Whether signs of functional decompensating white matter that may be found as early as at disease presentation has not been systematically studied. Here, we examined 52 patients who presented with a DLGG at the time of radiological diagnosis. We found a significant correlation between neurological impairment and eloquent cortico-subcortical tumor localization

2015 Frontiers in neurology

37. Community Water Fluoridation At the Levels Recommended By The U.S. Department of Health and Human Services Have Not Been Shown To Have An Effect On Children?s Neurological Development

of 5, and then assessed participants IQ at ages 7, 9, 11, 13, and then again at age 38. These findings show that CWF is safe in regards to neurological development, and it remains an effective and affordable way of reducing dental caries. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Broadbent/2015 1037 patients followed from age 3 to 38. Prospective Cohort Study Key results In children who lived (...) Community Water Fluoridation At the Levels Recommended By The U.S. Department of Health and Human Services Have Not Been Shown To Have An Effect On Children?s Neurological Development UTCAT3055, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Community Water Fluoridation At the Levels Recommended By The U.S. Department of Health and Human Services Have Not Been Shown To Have An Effect On Children’s Neurological

2016 UTHSCSA Dental School CAT Library

38. Observational study: Compared to conventional CPR for in-hospital cardiac arrest, extracorporeal-CPR is associated with improved survival to hospital discharge and more favourable neurological outcome

Observational study: Compared to conventional CPR for in-hospital cardiac arrest, extracorporeal-CPR is associated with improved survival to hospital discharge and more favourable neurological outcome Compared to conventional CPR for in-hospital cardiac arrest, extracorporeal-CPR is associated with improved survival to hospital discharge and more favourable neurological outcome | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you (...) to conventional CPR for in-hospital cardiac arrest, extracorporeal-CPR is associated with improved survival to hospital discharge and more favourable neurological outcome Article Text Therapeutics/Prevention Observational study Compared to conventional CPR for in-hospital cardiac arrest, extracorporeal-CPR is associated with improved survival to hospital discharge and more favourable neurological outcome Lindsay Ryerson , Gonzalo Garcia Guerra , Laurance Lequier Statistics from Altmetric.com Commentary

2016 Evidence-Based Medicine

39. Relationships Between Essential Manganese Biology and Manganese Toxicity in Neurological Disease Full Text available with Trip Pro

Relationships Between Essential Manganese Biology and Manganese Toxicity in Neurological Disease Manganese (Mn) is critical for neurodevelopment but also has been implicated in the pathophysiology of several neurological diseases. We discuss how Mn requirements intersect with Mn biology and toxicity, and how these requirements may be altered in neurological disease. Furthermore, we discuss the emerging evidence that the level of Mn associated with optimal overall efficiency for Mn biology does (...) not necessarily coincide with optimal cognitive outcomes.Studies have linked Mn exposures with urea cycle metabolism and autophagy, with evidence that exposures typically neurotoxic may be able to correct deficiencies in these processes at least short term. The line between Mn-dependent biology and toxicity is thus blurred. Further, new work suggests that Mn exposures correlating to optimal cognitive scores in children are associated with cognitive decline in adults. This review explores relationships between

2017 Current environmental health reports

40. Screening Tools to Identify Adults with Cognitive Impairment Associated with a Neurological Impairment: Diagnostic Accuracy

Screening Tools to Identify Adults with Cognitive Impairment Associated with a Neurological Impairment: Diagnostic Accuracy TITLE: Screening Tools to Identify Adults with Cognitive Impairment Associated with a Neurological Impairment: Diagnostic Accuracy DATE: 7 November 2014 RESEARCH QUESTION What is the diagnostic accuracy of screening tools to identify adults with cognitive impairment associated with a neurological impairment? KEY FINDINGS Two systematic reviews, one randomized controlled (...) trial, and 25 non-randomized studies were identified regarding diagnostic accuracy of screening tools to identify adults with cognitive impairment associated with a neurological impairment. METHODS A limited literature search was conducted on key resources including PubMed, The Cochrane Library (2014, Issue 10), University of York Centre for Reviews and Dissemination (CRD), Pubmed, Medline (OVID), Canadian and major international health technology agencies, as well as a focused Internet search

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

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