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21. Continuous Electroencephalography versus Intermittent Electroencephalography in Patients with Neurological Disorders or Brain Trauma

Continuous Electroencephalography versus Intermittent Electroencephalography in Patients with Neurological Disorders or Brain Trauma Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable (...) . This report may be used for the purposes of research or private study only. It may not be copied, posted on a web site, redistributed by email or stored on an electronic system without the prior written permission of CADTH or applicable copyright owner. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners’ own terms and conditions

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

22. Pelvic Girdle Pain in the Antepartum Population: Physical Therapy Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability, and Health From the Section on Women's Health and the Orthopaedic Section of the American Full Text available with Trip Pro

Pelvic Girdle Pain in the Antepartum Population: Physical Therapy Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability, and Health From the Section on Women's Health and the Orthopaedic Section of the American Pelvic Girdle Pain in the Antepartum Population: Physical Th... : Journal of Women’s Health Physical Therapy ')} You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login (...) , neurological symptoms/signs, fever, and/or systemically unwell. Special considerations for PGP should include symptoms due to uterine abruption or referred pain due to urinary tract infection to the lower abdomen/pelvic or sacral region. Failure to achieve functional improvement, pain that does not reduce with rest, and/or severe, disabling pain would require a medical specialist referral. II. Pelvic floor muscle weakness, a risk factor for PGP, is associated with weakness of the abdominal wall in DRA

2017 American Physical Therapy Association

23. Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and th Full Text available with Trip Pro

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and th To update the 2004 American Academy of Neurology (AAN) guideline for treating new-onset focal or generalized epilepsy with second- and third-generation antiepileptic drugs (AEDs).The 2004 AAN criteria were used to systematically review (...) literature (January 2003-November 2015), classify pertinent studies according to the therapeutic rating scheme, and link recommendations to evidence strength.Several second-generation AEDs are effective for new-onset focal epilepsy. Data are lacking on efficacy in new-onset generalized tonic-clonic seizures, juvenile myoclonic epilepsy, or juvenile absence epilepsy, and on efficacy of third-generation AEDs in new-onset epilepsy.Lamotrigine (LTG) should (Level B) and levetiracetam (LEV) and zonisamide

2018 EvidenceUpdates

24. Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the Full Text available with Trip Pro

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the To update the 2004 American Academy of Neurology guideline for managing treatment-resistant (TR) epilepsy with second- and third-generation antiepileptic drugs (AEDs).2004 criteria were used to systemically review literature (January 2003 (...) to November 2015), classify pertinent studies according to the therapeutic rating scheme, and link recommendations to evidence strength.Forty-two articles were included.The following are established as effective to reduce seizure frequency (Level A): immediate-release pregabalin and perampanel for TR adult focal epilepsy (TRAFE); vigabatrin for TRAFE (not first-line treatment); rufinamide for Lennox-Gastaut syndrome (LGS) (add-on therapy). The following should be considered to decrease seizure frequency

2018 EvidenceUpdates

25. Modeling the Neurological Basis and Characterizing the Neurological Phenotype of Obesity Using Human Neural Stem Cells

and Characterizing the Neurological Phenotype of Obesity Using Human Neural Stem Cells Estimated Study Start Date : September 2017 Estimated Primary Completion Date : January 2022 Estimated Study Completion Date : January 2027 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Intervention/treatment Bariatric Surgery Subjects that have demonstrated extreme response to bariatric surgery. Procedure: Bariatric Surgery Sleeve gastrectomy or Roux-en-Y (...) Modeling the Neurological Basis and Characterizing the Neurological Phenotype of Obesity Using Human Neural Stem Cells Modeling the Neurological Basis and Characterizing the Neurological Phenotype of Obesity Using Human Neural Stem Cells - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2017 Clinical Trials

26. The link between anesthesiology and neurology: a mindful cooperation to improve brain protection. (Abstract)

The link between anesthesiology and neurology: a mindful cooperation to improve brain protection. Preventing neurological injury is mandatory during the perioperative period of any kind of surgery and in the care of critically ill patients in the intensive care unit. During daily practice, both anesthesiologists and neurologists focus on brain protection as an integral part of systemic homeostasis maintenance. This article highlights the intriguing overlap between anesthesiology and neurology (...) in clinical practice along with its potential implications for outcome. Moreover, it focuses on the importance of the complementary expertise of both specialists in maintaining cerebral homeostasis, with the aim of improving outcome. A review of available evidence on anesthesiology and neurology interplay in clinical practice along with its potential implications for outcome has been conducted. Clinical vigilance and the use of shared monitoring and diagnostic technology could allow early recognition

2016 Minerva anestesiologica

27. Erratum to muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy Full Text available with Trip Pro

Erratum to muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy [This corrects the article on p. 262 in vol. 3, PMID: 26605308.].

2016 Annals of Translational Medicine

28. De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation Full Text available with Trip Pro

De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation Disruptions to neuronal mRNA translation are hypothesized to underlie human neurodevelopmental syndromes. Notably, the mRNA translation re-initiation factor DENR is a regulator of eukaryotic translation and cell growth, but its mammalian functions are unknown. Here, we report that Denr influences the migration of murine cerebral cortical neurons in vivo (...) in different ways. Thus, our findings link human brain disorders to impaired mRNA translation re-initiation through perturbations in DENR (OMIM: 604550) function in neurons.Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

2016 Cell reports

29. EFhd2, a Protein Linked to Alzheimer's Disease and Other Neurological Disorders Full Text available with Trip Pro

EFhd2, a Protein Linked to Alzheimer's Disease and Other Neurological Disorders EFhd2 is a conserved calcium binding protein linked to different neurological disorders and types of cancer. Although, EFhd2 is more abundant in neurons, it is also found in other cell types. The physiological function of this novel protein is still unclear, but it has been shown in vitro to play a role in calcium signaling, apoptosis, actin cytoskeleton, and regulation of synapse formation. Recently, EFhd2 (...) was shown to promote cell motility by modulating the activity of Rac1, Cdc42, and RhoA. Although, EFhd2's role in promoting cell invasion and metastasis is of great interest in cancer biology, this review focusses on the evidence that links EFhd2 to Alzheimer's disease (AD) and other neurological disorders. Altered expression of EFhd2 has been documented in AD, Parkinson's disease, Huntington's disease, Amyotrophic Lateral Sclerosis, and schizophrenia, indicating that Efhd2 gene expression is regulated

2016 Frontiers in neuroscience

30. Defects of mutant DNMT1 are linked to a spectrum of neurological disorders. Full Text available with Trip Pro

Defects of mutant DNMT1 are linked to a spectrum of neurological disorders. We report a broader than previously appreciated clinical spectrum for hereditary sensory and autonomic neuropathy type 1E (HSAN1E) and a potential pathogenic mechanism for DNA methyltransferase (DNMT1) mutations. The clinical presentations and genetic characteristics of nine newly identified HSAN1E kinships (45 affected subjects) were investigated. Five novel mutations of DNMT1 were discovered; p.C353F, p.T481P, p.P491L

2015 Brain

31. Neurological Impairment Linked with Cortico-Subcortical Infiltration of Diffuse Low-Grade Gliomas at Initial Diagnosis Supports Early Brain Plasticity Full Text available with Trip Pro

Neurological Impairment Linked with Cortico-Subcortical Infiltration of Diffuse Low-Grade Gliomas at Initial Diagnosis Supports Early Brain Plasticity Diffuse low-grade gliomas (DLGG) are slow-growing brain tumors that in spite of an indolent behavior at onset show a continuous expansion over time and inevitably transform into malignant gliomas. Extensive tumor resections may be performed with preservation of neurological function due to neuroplasticity that is induced by the slow tumor growth (...) . However, DLGG prefer to migrate along subcortical pathways, and white matter plasticity is considerably more limited than gray matter plasticity. Whether signs of functional decompensating white matter that may be found as early as at disease presentation has not been systematically studied. Here, we examined 52 patients who presented with a DLGG at the time of radiological diagnosis. We found a significant correlation between neurological impairment and eloquent cortico-subcortical tumor localization

2015 Frontiers in neurology

32. Community Water Fluoridation At the Levels Recommended By The U.S. Department of Health and Human Services Have Not Been Shown To Have An Effect On Children?s Neurological Development

of 5, and then assessed participants IQ at ages 7, 9, 11, 13, and then again at age 38. These findings show that CWF is safe in regards to neurological development, and it remains an effective and affordable way of reducing dental caries. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Broadbent/2015 1037 patients followed from age 3 to 38. Prospective Cohort Study Key results In children who lived (...) Community Water Fluoridation At the Levels Recommended By The U.S. Department of Health and Human Services Have Not Been Shown To Have An Effect On Children?s Neurological Development UTCAT3055, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Community Water Fluoridation At the Levels Recommended By The U.S. Department of Health and Human Services Have Not Been Shown To Have An Effect On Children’s Neurological

2016 UTHSCSA Dental School CAT Library

33. Observational study: Compared to conventional CPR for in-hospital cardiac arrest, extracorporeal-CPR is associated with improved survival to hospital discharge and more favourable neurological outcome

Observational study: Compared to conventional CPR for in-hospital cardiac arrest, extracorporeal-CPR is associated with improved survival to hospital discharge and more favourable neurological outcome Compared to conventional CPR for in-hospital cardiac arrest, extracorporeal-CPR is associated with improved survival to hospital discharge and more favourable neurological outcome | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you (...) to conventional CPR for in-hospital cardiac arrest, extracorporeal-CPR is associated with improved survival to hospital discharge and more favourable neurological outcome Article Text Therapeutics/Prevention Observational study Compared to conventional CPR for in-hospital cardiac arrest, extracorporeal-CPR is associated with improved survival to hospital discharge and more favourable neurological outcome Lindsay Ryerson , Gonzalo Garcia Guerra , Laurance Lequier Statistics from Altmetric.com Commentary

2016 Evidence-Based Medicine

34. Relationships Between Essential Manganese Biology and Manganese Toxicity in Neurological Disease Full Text available with Trip Pro

Relationships Between Essential Manganese Biology and Manganese Toxicity in Neurological Disease Manganese (Mn) is critical for neurodevelopment but also has been implicated in the pathophysiology of several neurological diseases. We discuss how Mn requirements intersect with Mn biology and toxicity, and how these requirements may be altered in neurological disease. Furthermore, we discuss the emerging evidence that the level of Mn associated with optimal overall efficiency for Mn biology does (...) not necessarily coincide with optimal cognitive outcomes.Studies have linked Mn exposures with urea cycle metabolism and autophagy, with evidence that exposures typically neurotoxic may be able to correct deficiencies in these processes at least short term. The line between Mn-dependent biology and toxicity is thus blurred. Further, new work suggests that Mn exposures correlating to optimal cognitive scores in children are associated with cognitive decline in adults. This review explores relationships between

2017 Current environmental health reports

35. Screening Tools to Identify Adults with Cognitive Impairment Associated with a Neurological Impairment: Diagnostic Accuracy

Screening Tools to Identify Adults with Cognitive Impairment Associated with a Neurological Impairment: Diagnostic Accuracy TITLE: Screening Tools to Identify Adults with Cognitive Impairment Associated with a Neurological Impairment: Diagnostic Accuracy DATE: 7 November 2014 RESEARCH QUESTION What is the diagnostic accuracy of screening tools to identify adults with cognitive impairment associated with a neurological impairment? KEY FINDINGS Two systematic reviews, one randomized controlled (...) trial, and 25 non-randomized studies were identified regarding diagnostic accuracy of screening tools to identify adults with cognitive impairment associated with a neurological impairment. METHODS A limited literature search was conducted on key resources including PubMed, The Cochrane Library (2014, Issue 10), University of York Centre for Reviews and Dissemination (CRD), Pubmed, Medline (OVID), Canadian and major international health technology agencies, as well as a focused Internet search

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

36. Neurologic Complications In Infective Endocarditis: To Anticoagulate Or Not To Anticoagulate

Neurologic Complications In Infective Endocarditis: To Anticoagulate Or Not To Anticoagulate Neurologic Complications In Infective Endocarditis: To Anticoagulate Or Not To Anticoagulate – Clinical Correlations Search Neurologic Complications In Infective Endocarditis: To Anticoagulate Or Not To Anticoagulate July 10, 2015 7 min read By Shannon Chiu, MD Peer Reviewed The annual incidence of infective endocarditis (IE) [1-2]. Neurologic complications are the most severe and frequent [3-4 (...) , or increasing size despite appropriate antibiotics [5,8]. Additional risk factors for embolism in IE include advanced age and S. aureus infection. Importantly, S. aureus prosthetic valve endocarditis is known to be associated with higher overall mortality and severe neurologic complications such as hemorrhagic stroke [3,9-10]. Mechanisms for intracranial hemorrhage (ICH) in patients with IE include hemorrhagic transformation (HT) of ischemic infarct, [11]. Currently, evidence regarding anticoagulants

2015 Clinical Correlations

37. Crowdfunding for stem cell-based interventions to treat neurologic diseases and injuries. (Abstract)

Crowdfunding for stem cell-based interventions to treat neurologic diseases and injuries. To characterize the marketplace for direct-to-consumer (DTC) unproven stem cell-based interventions (SCBI) for neurologic diseases and injuries using crowdfunding data.Search terms were developed from previous empirical studies of DTC businesses and the International Classification of Diseases-11 for neurologic diseases and used to query GoFundMe's internal search engine. Campaigns initiated November 2017 (...) -2018 and seeking SCBI for neurologic diseases and injuries (n = 1,030) were reviewed to identify the number of donors, number of Facebook shares, recipient location, funding pledged, funding requested, underlying neurologic condition, treatment location, and treatment facility name.A total of 1,030 crowdfunding campaigns for SCBI for neurologic diseases and injuries requested $33,449,979 and received $5,057,069 from 38,713 donors. The most common neurologic condition identified was multiple

2019 Neurology

38. A case with neurological abnormalities caused by Rickettsia raoultii in northwestern China. Full Text available with Trip Pro

A case with neurological abnormalities caused by Rickettsia raoultii in northwestern China. The number of new rickettsial species are rapidly increasing, and increasing numbers of Rickettsia raoultii (R. raoultii) infection cases have been detected in humans. However, neurological abnormalities caused by R. raoultii are rarely reported, especially in northwestern China.A 36-year-old Kazakh shepherd with an attached tick on part temporalis, presented with right eyelid droop, lethargy, fever (...) , headache, fever (38.0-41.0 °C) and erythematous rash. The examination of cerebrospinal fluid (CSF) showed cerebrospinal pressure of 200 mm H2O, leukocyte count of 300.0 × 106/L, adenosine deaminase of 2.15 U/L, and total protein concentration of 0.93 g/L. The diagnosis of R. raoultii infection was confirmed by six genetic markers, and semi-quantified by enzyme-linked immunosorbent assay for rickettsial antigen. The patient gradually recovered after treatment with doxycycline and ceftriaxone. R

2019 BMC Infectious Diseases

39. Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model. Full Text available with Trip Pro

Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model. Multiple sclerosis (MS) is an autoimmune demyelinating disease with progressive neurodegeneration and complex etiology likely involving genetic and environmental factors. MS has been associated with Epstein Barr virus (EBV) infection, with patients often showing enhanced responses to EBV antigens. To determine whether abnormal EBV nuclear (...) with this EBNA-1 polypeptide mounted a response against MBP and developed signs of experimental autoimmune encephalitis (EAE). These data support a link between MS and EBV through antibodies that cross-react between EBV proteins and the MBP autoantigen.Copyright © 2019 Elsevier Ltd. All rights reserved.

2019 Journal of Autoimmunity

40. Sleep and neurological autoimmune diseases. (Abstract)

intrusions into wakefulness. The study of sleep disorders in the setting of autoimmune diseases (e.g., narcolepsy, anti-IgLON5 disease, paraneoplastic neurological syndromes) shows that an abnormal immune-mediated (humoral or cellular) response target the neuronal structures (e.g., brainstem, hypothalamus) and neurotransmitters systems (e.g., hypocretin) that regulate sleep resulting in sleep impairment. It is a window to examine the link between the autoimmune system and the sleep regulation (...) Sleep and neurological autoimmune diseases. Neurological autoimmune diseases are characterized by an inappropriate immune response that by mistake targets the nervous system. As a result, patients experiment a number of neurological manifestations that may include insomnia, excessive daytime sleepiness, cataplexy, central hypoventilation, and REM sleep behavior disorder. Polysomnographic evaluation may reveal disorganized sleep architecture involving both NREM and REM sleep, and REM sleep

2019 Neuropsychopharmacology

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