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21. Modeling the Neurological Basis and Characterizing the Neurological Phenotype of Obesity Using Human Neural Stem Cells

and Characterizing the Neurological Phenotype of Obesity Using Human Neural Stem Cells Estimated Study Start Date : September 2017 Estimated Primary Completion Date : January 2022 Estimated Study Completion Date : January 2027 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Intervention/treatment Bariatric Surgery Subjects that have demonstrated extreme response to bariatric surgery. Procedure: Bariatric Surgery Sleeve gastrectomy or Roux-en-Y (...) Modeling the Neurological Basis and Characterizing the Neurological Phenotype of Obesity Using Human Neural Stem Cells Modeling the Neurological Basis and Characterizing the Neurological Phenotype of Obesity Using Human Neural Stem Cells - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2017 Clinical Trials

22. What relationship do stressful life events, neglect and abuse have with functional neurological disorder (conversion disorder)?

neurological disorder; rather it calls for us to consider the mechanism of the association and to understand how this should influence treatment (and even prevention). Conflicts of interest I was a reviewer for the paper and have previously published papers with several of the authors. Links Primary paper Ludwig L, Pasman JA, Nicholson T, Aybek S, David AS, Tuck S, Kanaan RA, Roelofs K, Carson A, Stone J. (2018) . The Lancet Psychiatry 2018 . The Lancet Psychiatry 2018 Other references Freud S, Breuer J (...) What relationship do stressful life events, neglect and abuse have with functional neurological disorder (conversion disorder)? Functional neurological disorder (conversion disorder) Search National Elf Service Search National Elf Service » » » » What relationship do stressful life events, neglect and abuse have with functional neurological disorder (conversion disorder)? Mar 9 2018 Posted by Functional neurological disorder (conversion disorder) is a common cause of disabling neurological

2018 The Mental Elf

23. Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and th

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and th To update the 2004 American Academy of Neurology (AAN) guideline for treating new-onset focal or generalized epilepsy with second- and third-generation antiepileptic drugs (AEDs).The 2004 AAN criteria were used to systematically review (...) literature (January 2003-November 2015), classify pertinent studies according to the therapeutic rating scheme, and link recommendations to evidence strength.Several second-generation AEDs are effective for new-onset focal epilepsy. Data are lacking on efficacy in new-onset generalized tonic-clonic seizures, juvenile myoclonic epilepsy, or juvenile absence epilepsy, and on efficacy of third-generation AEDs in new-onset epilepsy.Lamotrigine (LTG) should (Level B) and levetiracetam (LEV) and zonisamide

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2018 EvidenceUpdates

24. Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the To update the 2004 American Academy of Neurology guideline for managing treatment-resistant (TR) epilepsy with second- and third-generation antiepileptic drugs (AEDs).2004 criteria were used to systemically review literature (January 2003 (...) to November 2015), classify pertinent studies according to the therapeutic rating scheme, and link recommendations to evidence strength.Forty-two articles were included.The following are established as effective to reduce seizure frequency (Level A): immediate-release pregabalin and perampanel for TR adult focal epilepsy (TRAFE); vigabatrin for TRAFE (not first-line treatment); rufinamide for Lennox-Gastaut syndrome (LGS) (add-on therapy). The following should be considered to decrease seizure frequency

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2018 EvidenceUpdates

25. Neurologic and cognitive outcomes associated with the clinical use of xenon: a systematic review and meta-analysis of randomized-controlled trials

that xenon may be associated with better neurologic outcomes compared with the standard of care therapy in certain specific clinical situations. More clinical trials are needed to determine any potential benefit linked to xenon administration. (...) Neurologic and cognitive outcomes associated with the clinical use of xenon: a systematic review and meta-analysis of randomized-controlled trials Xenon has been shown to have positive neurologic effects in various pre-clinical models. This study systematically reviewed the randomized-controlled trials (RCTs) investigating neurologic and cognitive outcomes associated with the clinical use of xenon.We searched PubMed, CENTRAL, EMBASE, CINAHL, elibrary.ru (for Russian studies), Google Scholar

2018 EvidenceUpdates

26. Relationships Between Essential Manganese Biology and Manganese Toxicity in Neurological Disease (PubMed)

Relationships Between Essential Manganese Biology and Manganese Toxicity in Neurological Disease Manganese (Mn) is critical for neurodevelopment but also has been implicated in the pathophysiology of several neurological diseases. We discuss how Mn requirements intersect with Mn biology and toxicity, and how these requirements may be altered in neurological disease. Furthermore, we discuss the emerging evidence that the level of Mn associated with optimal overall efficiency for Mn biology does (...) not necessarily coincide with optimal cognitive outcomes.Studies have linked Mn exposures with urea cycle metabolism and autophagy, with evidence that exposures typically neurotoxic may be able to correct deficiencies in these processes at least short term. The line between Mn-dependent biology and toxicity is thus blurred. Further, new work suggests that Mn exposures correlating to optimal cognitive scores in children are associated with cognitive decline in adults. This review explores relationships between

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2017 Current environmental health reports

27. Continuous Electroencephalography versus Intermittent Electroencephalography in Patients with Neurological Disorders or Brain Trauma

Continuous Electroencephalography versus Intermittent Electroencephalography in Patients with Neurological Disorders or Brain Trauma Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable (...) . This report may be used for the purposes of research or private study only. It may not be copied, posted on a web site, redistributed by email or stored on an electronic system without the prior written permission of CADTH or applicable copyright owner. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners’ own terms and conditions

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

28. Screening Tools to Identify Adults with Cognitive Impairment Associated with a Neurological Impairment: Diagnostic Accuracy

Screening Tools to Identify Adults with Cognitive Impairment Associated with a Neurological Impairment: Diagnostic Accuracy TITLE: Screening Tools to Identify Adults with Cognitive Impairment Associated with a Neurological Impairment: Diagnostic Accuracy DATE: 7 November 2014 RESEARCH QUESTION What is the diagnostic accuracy of screening tools to identify adults with cognitive impairment associated with a neurological impairment? KEY FINDINGS Two systematic reviews, one randomized controlled (...) trial, and 25 non-randomized studies were identified regarding diagnostic accuracy of screening tools to identify adults with cognitive impairment associated with a neurological impairment. METHODS A limited literature search was conducted on key resources including PubMed, The Cochrane Library (2014, Issue 10), University of York Centre for Reviews and Dissemination (CRD), Pubmed, Medline (OVID), Canadian and major international health technology agencies, as well as a focused Internet search

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

29. Survival and Health Care Use After Feeding Tube Placement in Children With Neurologic Impairment. (PubMed)

Survival and Health Care Use After Feeding Tube Placement in Children With Neurologic Impairment. Children with neurologic impairment (NI) often undergo feeding tube placement for undernutrition or aspiration. We evaluated survival and acute health care use after tube placement in this population.This is a population-based exposure-crossover study for which we use linked administrative data from Ontario, Canada. We identified children aged 13 months to 17 years with a diagnosis of NI undergoing

2019 Pediatrics

30. Characteristics of patients with motor functional neurological disorder in a large UK mental health service: a case-control study. (PubMed)

Characteristics of patients with motor functional neurological disorder in a large UK mental health service: a case-control study. Functional neurological disorder (FND), previously known as conversion disorder, is common and often results in substantial distress and disability. Previous research lacks large sample sizes and clinical surveys are most commonly derived from neurological settings, limiting our understanding of the disorder and its associations in other contexts. We sought (...) occurring functional symptom. mFND patients were more likely to be female, British, married, employed pre-morbidly, to have a carer and a physical health condition, but less likely to have had an inpatient psychiatric admission or to receive benefits. No differences in self-reported sexual or physical abuse rates were observed between groups, although mFND patients were more likely to experience life events linked to inter-personal difficulties.mFND patients have distinct demographic characteristics

2019 Psychological Medicine

31. Presence of anti-BP180 and anti-BP230 in the CSF of patients with bullous pemphigoid and neurologic disease: is there any intrathecal synthesis? (PubMed)

Presence of anti-BP180 and anti-BP230 in the CSF of patients with bullous pemphigoid and neurologic disease: is there any intrathecal synthesis? The association between bullous pemphigoïd (BP) and several neurologic diseases (ND) - cerebrovascular and neurodegenerative diseases - is well known and documented by several epidemiologic studies while a pathophysiology link is still undetermined. Auto-antibodies (Ab) directed against BP180 are more frequently found in patients with dementia

2019 British Journal of Dermatology

32. Crowdfunding for stem cell-based interventions to treat neurologic diseases and injuries. (PubMed)

Crowdfunding for stem cell-based interventions to treat neurologic diseases and injuries. To characterize the marketplace for direct-to-consumer (DTC) unproven stem cell-based interventions (SCBI) for neurologic diseases and injuries using crowdfunding data.Search terms were developed from previous empirical studies of DTC businesses and the International Classification of Diseases-11 for neurologic diseases and used to query GoFundMe's internal search engine. Campaigns initiated November 2017 (...) -2018 and seeking SCBI for neurologic diseases and injuries (n = 1,030) were reviewed to identify the number of donors, number of Facebook shares, recipient location, funding pledged, funding requested, underlying neurologic condition, treatment location, and treatment facility name.A total of 1,030 crowdfunding campaigns for SCBI for neurologic diseases and injuries requested $33,449,979 and received $5,057,069 from 38,713 donors. The most common neurologic condition identified was multiple

2019 Neurology

33. Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model. (PubMed)

Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model. Multiple sclerosis (MS) is an autoimmune demyelinating disease with progressive neurodegeneration and complex etiology likely involving genetic and environmental factors. MS has been associated with Epstein Barr virus (EBV) infection, with patients often showing enhanced responses to EBV antigens. To determine whether abnormal EBV nuclear (...) with this EBNA-1 polypeptide mounted a response against MBP and developed signs of experimental autoimmune encephalitis (EAE). These data support a link between MS and EBV through antibodies that cross-react between EBV proteins and the MBP autoantigen.Copyright © 2019 Elsevier Ltd. All rights reserved.

2019 Journal of Autoimmunity

34. A case with neurological abnormalities caused by Rickettsia raoultii in northwestern China. (PubMed)

A case with neurological abnormalities caused by Rickettsia raoultii in northwestern China. The number of new rickettsial species are rapidly increasing, and increasing numbers of Rickettsia raoultii (R. raoultii) infection cases have been detected in humans. However, neurological abnormalities caused by R. raoultii are rarely reported, especially in northwestern China.A 36-year-old Kazakh shepherd with an attached tick on part temporalis, presented with right eyelid droop, lethargy, fever (...) , headache, fever (38.0-41.0 °C) and erythematous rash. The examination of cerebrospinal fluid (CSF) showed cerebrospinal pressure of 200 mm H2O, leukocyte count of 300.0 × 106/L, adenosine deaminase of 2.15 U/L, and total protein concentration of 0.93 g/L. The diagnosis of R. raoultii infection was confirmed by six genetic markers, and semi-quantified by enzyme-linked immunosorbent assay for rickettsial antigen. The patient gradually recovered after treatment with doxycycline and ceftriaxone. R

2019 BMC Infectious Diseases

35. Sleep and neurological autoimmune diseases. (PubMed)

intrusions into wakefulness. The study of sleep disorders in the setting of autoimmune diseases (e.g., narcolepsy, anti-IgLON5 disease, paraneoplastic neurological syndromes) shows that an abnormal immune-mediated (humoral or cellular) response target the neuronal structures (e.g., brainstem, hypothalamus) and neurotransmitters systems (e.g., hypocretin) that regulate sleep resulting in sleep impairment. It is a window to examine the link between the autoimmune system and the sleep regulation (...) Sleep and neurological autoimmune diseases. Neurological autoimmune diseases are characterized by an inappropriate immune response that by mistake targets the nervous system. As a result, patients experiment a number of neurological manifestations that may include insomnia, excessive daytime sleepiness, cataplexy, central hypoventilation, and REM sleep behavior disorder. Polysomnographic evaluation may reveal disorganized sleep architecture involving both NREM and REM sleep, and REM sleep

2019 Neuropsychopharmacology

36. Neurological Sleep Disorders and Blood Pressure: Current Evidence. (PubMed)

Neurological Sleep Disorders and Blood Pressure: Current Evidence. Hypertension is a major determinant of cardiovascular morbidity and mortality and is highly prevalent in the general population. While the relationship between sleep apnea and increased blood pressure has been well documented, less recognized is emerging evidence linking sleep-related movement disorders such as restless legs syndrome/periodic limb movements of sleep and sleep-related bruxism with blood pressure (BP (...) ) dysregulation and hypertension. There is also recent literature linking narcolepsy-cataplexy with elevated BP and altered pressor responses, and there are data suggesting abnormal BP control in rapid eye movement sleep behavior disorder. It is thought that neural circulatory mechanisms, sympathetic activation in particular, comprise the predominant mediator underlying elevated BP in these neurological sleep disorders. There is very limited evidence that treating these sleep disorders may be beneficial

2019 Hypertension

37. Stopping Donepezil may be linked to nursing home placement for people with Alzheimer’s disease, but a “cause and effect” not conclusive

of cholinesterase inhibitors and urges caution in discontinuing the drug in patients who are on established tolerated dosages. Professor Martin Rossor, Professor of Clinical Neurology, University College London; NIHR National Director for Dementia Research; Director, NIHR Queen Square Dementia Biomedical Research Unit Categories Tools Preview Based on NHS Choices Close Useful Links Related Sites Follow Us Get NIHR Signals by email Stay up to date with the latest health research through our monthly bulletin (...) Stopping Donepezil may be linked to nursing home placement for people with Alzheimer’s disease, but a “cause and effect” not conclusive Stopping Donepezil may be linked to nursing home placement for people with Alzheimer’s disease, but a “cause and effect” not conclusive Discover Portal Discover Portal Stopping Donepezil may be linked to nursing home placement for people with Alzheimer’s disease, but a “cause and effect” not conclusive Published on 11 December 2015 doi: This follow up study

2018 NIHR Dissemination Centre

38. Stopping Donepezil may be linked to nursing home placement for people with Alzheimer’s disease, but a “cause and effect” not conclusive

of cholinesterase inhibitors and urges caution in discontinuing the drug in patients who are on established tolerated dosages. Professor Martin Rossor, Professor of Clinical Neurology, University College London; NIHR National Director for Dementia Research; Director, NIHR Queen Square Dementia Biomedical Research Unit Categories Tools Preview Based on NHS Choices Close Useful Links Related Sites Follow Us Get NIHR Signals by email Stay up to date with the latest health research through our monthly bulletin (...) Stopping Donepezil may be linked to nursing home placement for people with Alzheimer’s disease, but a “cause and effect” not conclusive Stopping Donepezil may be linked to nursing home placement for people with Alzheimer’s disease, but a “cause and effect” not conclusive Discover Portal Discover Portal Stopping Donepezil may be linked to nursing home placement for people with Alzheimer’s disease, but a “cause and effect” not conclusive Published on 11 December 2015 doi: This follow up study

2018 NIHR Dissemination Centre

39. Neurological Impairment Linked with Cortico-Subcortical Infiltration of Diffuse Low-Grade Gliomas at Initial Diagnosis Supports Early Brain Plasticity (PubMed)

Neurological Impairment Linked with Cortico-Subcortical Infiltration of Diffuse Low-Grade Gliomas at Initial Diagnosis Supports Early Brain Plasticity Diffuse low-grade gliomas (DLGG) are slow-growing brain tumors that in spite of an indolent behavior at onset show a continuous expansion over time and inevitably transform into malignant gliomas. Extensive tumor resections may be performed with preservation of neurological function due to neuroplasticity that is induced by the slow tumor growth (...) . However, DLGG prefer to migrate along subcortical pathways, and white matter plasticity is considerably more limited than gray matter plasticity. Whether signs of functional decompensating white matter that may be found as early as at disease presentation has not been systematically studied. Here, we examined 52 patients who presented with a DLGG at the time of radiological diagnosis. We found a significant correlation between neurological impairment and eloquent cortico-subcortical tumor localization

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2015 Frontiers in neurology

40. Defects of mutant DNMT1 are linked to a spectrum of neurological disorders. (PubMed)

Defects of mutant DNMT1 are linked to a spectrum of neurological disorders. We report a broader than previously appreciated clinical spectrum for hereditary sensory and autonomic neuropathy type 1E (HSAN1E) and a potential pathogenic mechanism for DNA methyltransferase (DNMT1) mutations. The clinical presentations and genetic characteristics of nine newly identified HSAN1E kinships (45 affected subjects) were investigated. Five novel mutations of DNMT1 were discovered; p.C353F, p.T481P, p.P491L

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2015 Brain

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