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181. Is Beauty in the Hand of the Writer? Influences of Aesthetic Preferences through Script Directions, Cultural, and Neurological Factors: A Literature Review (PubMed)

Is Beauty in the Hand of the Writer? Influences of Aesthetic Preferences through Script Directions, Cultural, and Neurological Factors: A Literature Review Human experience surrounding the appreciation of beauty is not static. Many factors such as script direction and cultural differences directly impact whether, how and why we consider images beautiful. In an earlier study, Pérez González showed that 19th-century Iranian and Spanish professional photographers manifest lateral biases linked

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2017 Frontiers in psychology

182. Cyberinfrastructure for Open Science at the Montreal Neurological Institute (PubMed)

Cyberinfrastructure for Open Science at the Montreal Neurological Institute Data sharing is becoming more of a requirement as technologies mature and as global research and communications diversify. As a result, researchers are looking for practical solutions, not only to enhance scientific collaborations, but also to acquire larger amounts of data, and to access specialized datasets. In many cases, the realities of data acquisition present a significant burden, therefore gaining access (...) to public datasets allows for more robust analyses and broadly enriched data exploration. To answer this demand, the Montreal Neurological Institute has announced its commitment to Open Science, harnessing the power of making both clinical and research data available to the world (Owens, 2016a,b). As such, the LORIS and CBRAIN (Das et al., 2016) platforms have been tasked with the technical challenges specific to the institutional-level implementation of open data sharing, including: Comprehensive

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2017 Frontiers in neuroinformatics

183. Traumatic Brain Injury Induces Genome-Wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological Disorders (PubMed)

and brain elicited by TBI provides proof of concept information for development of biomarkers of TBI based on composite genomic patterns. By intersecting with human genome-wide association studies, many TBI signature genes and network regulators identified in our rodent model were causally associated with brain disorders with relevant link to TBI. The overall results show that concussive brain injury reprograms genes which could lead to predisposition to neurological and psychiatric disorders (...) Traumatic Brain Injury Induces Genome-Wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological Disorders The complexity of the traumatic brain injury (TBI) pathology, particularly concussive injury, is a serious obstacle for diagnosis, treatment, and long-term prognosis. Here we utilize modern systems biology in a rodent model of concussive injury to gain a thorough view of the impact of TBI on fundamental aspects of gene regulation, which have

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2017 EBioMedicine

184. Host genetic background influences diverse neurological responses to viral infection in mice (PubMed)

the phenotypic consequences of TMEV infection in the Collaborative Cross (CC) mouse population. We evaluated 5 different CC strains for outcomes of long-term infection (3 months) and acute vs. early chronic infection (7 vs. 28 days post-infection), using neurological and behavioral phenotyping tests and histology. We correlated phenotypic observations with haplotypes of genomic regions previously linked to TMEV susceptibility to test the hypothesis that genomic diversity within CC mice results in variable (...) Host genetic background influences diverse neurological responses to viral infection in mice Infection by Theiler's murine encephalomyelitis virus (TMEV) is a model for neurological outcomes caused by virus infection because it leads to diverse neurological conditions in mice, depending on the strain infected. To extend knowledge on the heterogeneous neurological outcomes caused by TMEV and identify new models of human neurological diseases associated with antecedent infections, we analyzed

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2017 Scientific reports

185. Multifractality, interactivity, and the adaptive capacity of the human movement system: a perspective for advancing the conceptual basis of neurologic physical therapy (PubMed)

Multifractality, interactivity, and the adaptive capacity of the human movement system: a perspective for advancing the conceptual basis of neurologic physical therapy Physical therapists seek to optimize movement as a means of reducing disability and improving health. The short-term effects of interventions designed to optimize movement ultimately are intended to be adapted for use across various future patterns of behavior, in potentially unpredictable ways, with varying frequency (...) support for the idea that patterns of motor behavior occurring in the moment are inextricably linked in complex, physiologic ways to patterns of motor behavior occurring over much longer periods. The human movement system appears to be particularly tuned to multifractal fluctuation patterns and exhibits the ability to reorganize its output in response to external stimulation embedded with multifractal features.As a fundamental feature of human movement, multifractality opens new avenues

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2017 Journal of neurologic physical therapy : JNPT

186. Radically truncated MeCP2 rescues Rett syndrome-like neurological defects (PubMed)

Radically truncated MeCP2 rescues Rett syndrome-like neurological defects Heterozygous mutations in the X-linked MECP2 gene cause the neurological disorder Rett syndrome. The methyl-CpG-binding protein 2 (MeCP2) protein is an epigenetic reader whose binding to chromatin primarily depends on 5-methylcytosine. Functionally, MeCP2 has been implicated in several cellular processes on the basis of its reported interaction with more than 40 binding partners, including transcriptional co-repressors (...) domain survive for over one year with only mild symptoms. This minimal protein is able to prevent or reverse neurological symptoms when introduced into MeCP2-deficient mice by genetic activation or virus-mediated delivery to the brain. Thus, despite evolutionary conservation of the entire MeCP2 protein sequence, the DNA and co-repressor binding domains alone are sufficient to avoid Rett syndrome-like defects and may therefore have therapeutic utility.

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2017 Nature

187. Dorsal and Ventral Hippocampus Differentiate in Functional Pathways and Differentially Associate with Neurological Disease-Related Genes during Postnatal Development (PubMed)

Dorsal and Ventral Hippocampus Differentiate in Functional Pathways and Differentially Associate with Neurological Disease-Related Genes during Postnatal Development The dorsal and ventral regions of the hippocampus are important in cognitive and emotional processing, respectively. Various approaches have revealed the differential molecular and structural characteristics, and functional roles of the hippocampus. Recent RNA sequencing (RNA-seq) technology has enriched our understanding (...) developmental ages representing the postnatally maturing hippocampus. Genes associated with particular functional pathways and marker genes for particular neurological diseases were found to be distinctively segregated within either the dorsal or ventral hippocampus at specific or at all developmental ages examined. We also report novel molecular markers enriched in the dorsal or ventral hippocampus. Taken together, this study provides insights into the molecular mechanisms underlying physiological

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2017 Frontiers in molecular neuroscience

188. Effect of blood pressure variability on early neurological deterioration in single small subcortical infarction with parental arterial disease (PubMed)

Effect of blood pressure variability on early neurological deterioration in single small subcortical infarction with parental arterial disease Early neurological deterioration (END) is not uncommon in acute single small subcortical infarct (SSSI), especially in those with parental arterial disease (PAD). The purpose of this study was to elucidate the effect of BP variability on the development of END as well as functional outcome at 90 days in SSSI and to determine whether the effect is linked

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2017 eNeurologicalSci

189. Preliminary Evidence for an Association between the Composition of the Gut Microbiome and Cognitive Function in Neurologically-Healthy Older Adults (PubMed)

Preliminary Evidence for an Association between the Composition of the Gut Microbiome and Cognitive Function in Neurologically-Healthy Older Adults Dysbiosis of the gut microbiome is implicated in numerous human health conditions. Animal studies have linked microbiome disruption to changes in cognitive functioning, although no study has examined this possibility in neurologically healthy older adults.Participants were 43 community-dwelling older adults (50-85 years) that completed a brief (...) Verrucomicrobia and attention/executive function measures.The current findings suggest that composition of the gut microbiome is associated with cognitive test performance in neurologically healthy older adults. Future studies are needed to confirm these findings and explore possible mechanisms. (JINS, 2017, 23, 700-705).

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2017 Journal of the International Neuropsychological Society : JINS

190. Vitamin D and Neurological Diseases: An Endocrine View (PubMed)

with the maintenance of glucose homeostasis, cardiovascular morbidity, autoimmunity, inflammation, and cancer. In parallel, growing evidence has recognized that a multimodal association links vitamin D system to brain development, functions and diseases. With vitamin D deficiency reaching epidemic proportions worldwide, there is now concern that optimal levels of vitamin D in the bloodstream are also necessary to preserve the neurological development and protect the adult brain. The aim of this review (...) Vitamin D and Neurological Diseases: An Endocrine View Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and receptors involved in genomic and non-genomic effects. In addition to classical bone-related effects, this system has also been shown to activate multiple molecular mediators and elicit many physiological functions. In vitro and in vivo studies have, in fact, increasingly focused on the "non-calcemic" actions of vitamin D, which are associated

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2017 International journal of molecular sciences

191. Cohort study: Elderly in-hospital cardiac arrest patients who are resuscitated with neurological recovery experience favourable long-term survival similar to non-arrest heart failure patients

Cohort study: Elderly in-hospital cardiac arrest patients who are resuscitated with neurological recovery experience favourable long-term survival similar to non-arrest heart failure patients Elderly in-hospital cardiac arrest patients who are resuscitated with neurological recovery experience favourable long-term survival similar to non-arrest heart failure patients | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can (...) cardiac arrest patients who are resuscitated with neurological recovery experience favourable long-term survival similar to non-arrest heart failure patients Article Text Prognosis Cohort study Elderly in-hospital cardiac arrest patients who are resuscitated with neurological recovery experience favourable long-term survival similar to non-arrest heart failure patients T Jared Bunch Statistics from Altmetric.com Commentary on: Chan PS , Nallamothu BK , Krumholz HM , et al . American Heart Association

2013 Evidence-Based Medicine (Requires free registration)

192. Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons. (PubMed)

Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons. Amyotrophic lateral sclerosis (ALS) is the most common adult-onset neuromuscular disorder characterised by selective loss of motor neurons leading to fatal paralysis. Current therapeutic approaches are limited in their effectiveness. Substantial advances in understanding ALS disease mechanisms has come from the identification (...) the effects of SOD1G93A were potentiated in the double transgenic line (DAOR199W/SOD1G93A). Although overall survival was not affected, onset of neurological signs was significantly earlier in female double transgenic animals than their female SOD1G93A littermates (125 days vs 131 days, P = 0.0239). In summary, some significant in vivo effects of DAOR199W on motor neuron function (i.e. kyphosis and loss of motor neurons) were detected which were most marked in females and could contribute to the earlier

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2017 PLoS ONE

193. Multispecies mass mortality of marine fauna linked to a toxic dinoflagellate bloom. (PubMed)

of animals examined at necropsy. Reports of marine fauna presenting signs of neurological dysfunction were also supportive of exposure to these neurotoxins. The event reported here represents the first well-documented case of multispecies mass mortality of marine fish, birds and mammals linked to a PST-producing algal bloom. (...) Multispecies mass mortality of marine fauna linked to a toxic dinoflagellate bloom. Following heavy precipitation, we observed an intense algal bloom in the St. Lawrence Estuary (SLE) that coincided with an unusually high mortality of several species of marine fish, birds and mammals, including species designated at risk. The algal species was identified as Alexandrium tamarense and was determined to contain a potent mixture of paralytic shellfish toxins (PST). Significant levels of PST were

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2017 PLoS ONE

194. Links Between Perception of Temporal Order Judgment and Causality in Schizophrenia

Links Between Perception of Temporal Order Judgment and Causality in Schizophrenia Links Between Perception of Temporal Order Judgment and Causality in Schizophrenia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Links Between Perception of Temporal Order Judgment and Causality in Schizophrenia (TOCAS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03432000 Recruitment Status : Recruiting First Posted : February 13

2018 Clinical Trials

195. Is Tau Protein Linked to Mobility Function?

Is Tau Protein Linked to Mobility Function? Is Tau Protein Linked to Mobility Function? - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Is Tau Protein Linked to Mobility Function? (SYNERGY) The safety (...) Forest University Health Sciences Study Details Study Description Go to Brief Summary: This project will provide new data to address an important question linking Alzheimer's disease neuropathology to physical disability. Condition or disease Alzheimer Disease Physical Activity Detailed Description: Impaired mobility is strongly linked to cognitive function and vice versa. Cognitive functions are strongly associated with mobility function, most commonly assessed using gait speed. In the Health ABC

2018 Clinical Trials

196. Switching generic antiepileptic drug manufacturer not linked to seizures: A case-crossover study

Switching generic antiepileptic drug manufacturer not linked to seizures: A case-crossover study With more antiepileptic drugs (AED) becoming available in generic form, we estimated the risk of seizure-related events associated with refilling generic AEDs and the effect of switching between different manufacturers of the same generic drug.We designed a population-based case-crossover study using the Medicaid Analytic eXtract and a US commercial health insurance database. We identified 83,001 (...) was associated with an elevated risk of seizure-related event; however, there was no additional risk from switching during that refill to a different manufacturer. Generic AEDs available to US patients, with Food and Drug Administration-validated bioequivalence, appear to be safe clinical choices.© 2016 American Academy of Neurology.

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2016 EvidenceUpdates

197. A Study to Evaluate the Safety and Tolerability of V114 and Prevnar 13â„¢ in Healthy Infants (V114-031/PNEU-LINK)

A Study to Evaluate the Safety and Tolerability of V114 and Prevnar 13â„¢ in Healthy Infants (V114-031/PNEU-LINK) A Study to Evaluate the Safety and Tolerability of V114 and Prevnar 13™ in Healthy Infants (V114-031/PNEU-LINK) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. A Study to Evaluate the Safety and Tolerability of V114 and Prevnar 13™ in Healthy Infants (V114-031/PNEU-LINK) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov

2018 Clinical Trials

198. Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. (PubMed)

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Intelligence is highly heritable1 and a major determinant of human health and well-being2. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in intelligence3-7, but much about its genetic underpinnings remains to be discovered. Here, we present a large-scale genetic association study of intelligence (n = 269,867), identifying 205 associated (...) to nervous system development and synaptic structure. We confirm previous strong genetic correlations with multiple health-related outcomes, and Mendelian randomization analysis results suggest protective effects of intelligence for Alzheimer's disease and ADHD and bidirectional causation with pleiotropic effects for schizophrenia. These results are a major step forward in understanding the neurobiology of cognitive function as well as genetically related neurological and psychiatric disorders.

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2018 Nature Genetics

199. Disrupted N-linked glycosylation as a disease mechanism in deficiency of ADA2. (PubMed)

Disrupted N-linked glycosylation as a disease mechanism in deficiency of ADA2. 29936104 2018 11 14 1097-6825 142 4 2018 Oct The Journal of allergy and clinical immunology J. Allergy Clin. Immunol. Disrupted N-linked glycosylation as a disease mechanism in deficiency of ADA2. 1363-1365.e8 S0091-6749(18)30902-3 10.1016/j.jaci.2018.05.038 Lee Pui Y PY Division of Immunology, Boston Children's Hospital, Boston, Mass; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital (...) Department of Neurosurgery, Boston Children's Hospital, Boston, Mass. Rivkin Michael J MJ Department of Neurology, Psychiatry and Radiology, Boston Children's Hospital, Boston, Mass. Pai Sung-Yun SY Division of Hematology-Oncology, Boston Children's Hospital, Boston, Mass; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Mass. Lyons Todd T Division of Emergency Medicine, Boston Children's Hospital, Boston, Mass. Sundel Robert P RP Division of Immunology, Boston Children's Hospital

2018 Journal of Allergy and Clinical Immunology

200. Is interleukin-6 the link between low LDL cholesterol and increased non-cardiovascular mortality in the elderly? (PubMed)

Is interleukin-6 the link between low LDL cholesterol and increased non-cardiovascular mortality in the elderly? 29682295 2019 01 30 2053-3624 5 1 2018 Open heart Open Heart Is interleukin-6 the link between low LDL cholesterol and increased non-cardiovascular mortality in the elderly? e000789 10.1136/openhrt-2018-000789 DiNicolantonio James J JJ Mid America Heart Institute, Kansas, USA. McCarty Mark F MF Catalytic Longevity, Encinitas, California, USA. eng Editorial 2018 04 13 England Open (...) Biomarkers Prev. 2016 Aug;25(8):1231-9 27277846 Lancet. 1987 Aug 8;2(8554):298-301 2886765 Neurology. 2007 Mar 6;68(10):737-42 17182976 Metabolism. 1988 Sep;37(9):859-65 3419323 Arch Gerontol Geriatr. 2017 Nov;73:257-262 28866452 Lancet. 2012 Mar 31;379(9822):1214-24 22421340 BMJ. 1994 Feb 5;308(6925):373-9 8124144 J Natl Cancer Inst. 1982 Nov;69(5):989-96 6957662 Curr Opin Clin Nutr Metab Care. 2002 Mar;5(2):153-8 11844981 Ann Rheum Dis. 2017 Nov;76(11):1949-1952 28916714 Am J Epidemiol. 1992 Jun 1;135

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2018 Open heart

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